15 results about "Enteric disease" patented technology

Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.

The present application relates to a crystal form of a compound of formula (I) and a preparation method and application thereof. Specifically, the present application provides a crystal form of a compound of formula (I), which has good stability, good drug efficacy, and good safety, and can be used for preparing a drug for treating or preventing feline transmissible enteric disease virus infection or coronavirus infection caused diseases.

The present invention relates to a combination vaccine comprising the antigens: a) Cryptosporidium parvum gp40; b) inactivated bovine rotavirus; c) inactivated bovine coronavirus; and d) E. coli fimbrial adhesins F5 and F41. In addition, the invention relates to methods for the preparation of the vaccine, methods for vaccinating ruminants against infection by Cryptosporidium parvum, bovine rotavirus, bovine coronavirus and E. coli, and to a kit-of-parts at least comprising a container comprising the at least one antigen according to the invention.

The invention discloses application of a dibenzo nitrogen heterocyclic compound in preparation of a medicine for treating gastrointestinal diseases, and relates to the technical field of medicinal chemistry. A large amount of screening and verification show that the dibenzo nitrogen heterocyclic compound with the structural general formula can significantly reduce core pathological characteristics of gastric ulcer, such as significant reduction of ulcer lesion, significant reduction of bleeding degree and specific reduction of mucosal edema, and has an ulcer inhibition rate of 36.51%-47.22% for a gastric ulcer animal model. A new thought and a new choice are provided for the development of medicines for treating gastrointestinal diseases.

Provided herein are pharmaceutical compositions comprising a bacterial population. The bacterial population comprises one bacterial strains or at least two bacterial strains. Such pharmaceutical compositions can be administered to a subject for prevention and / or treatment of dysbiosis and dysbiosis associated conditions and diseases, such as infant gastrointestinal diseases.

The present invention provides methods and systems to accurately detect and measure levels of endogenous antibodies, for examples endogenous IgA, to particular antigens in a biological sample from a companion animal, which is useful to diagnose inflammatory conditions, including bowel disease (IBD), gastrointestinal infections, and food sensitivities in companion animals, e.g., dogs or cats, and to distinguish among such gastrointestinal disorders. Such methods and systems identify whether a sample from the patient is associated with an inflammatory condition, infection, and / or food sensitivity condition, by using non-invasive means, thus conveniently providing information useful for guiding treatment decisions.

This invention discloses a strain of *Bacillus belyceae* with broad-spectrum antibacterial activity and its application in the prevention and treatment of necrotic enteritis in poultry. The *Bacillus belyceae* strain provided by this invention (… Bacillus from Velez The genome of strain GDG25CB056 is approximately 3.91 Mb in size, contains no virulence factors, and is rich in gene clusters encoding non-ribosomal peptides and polyketide synthases. Studies have confirmed that this strain exhibits significant growth advantages, strong tolerance to high temperatures, gastric acid, and bile salts, which facilitates intestinal colonization. It can produce siderophores and various enzymes, and has overcome the technical bottleneck of a narrow antibacterial spectrum, possessing broad-spectrum antibacterial activity, especially strong specific antagonistic activity against Clostridium perfringens. In vivo experiments have shown that this strain can significantly reduce the Clostridium perfringens load in the cecum of chicks with necrotizing enterocolitis, alleviate intestinal congestion and swelling, repair damaged intestinal villi, and enhance mucosal barrier function, providing a safe and efficient strain resource for the prevention and treatment of bacterial enteric diseases.

This application relates to a composition for preventing, improving, or treating gastrointestinal diseases comprising a strain of the genus Corynebacterium, a culture thereof, and threonine. Since the composition according to this application has been confirmed to have excellent anti-Helicobacter pylori efficacy in cell experiments, efficacy in improving gastrointestinal diseases in animal experiments, and efficacy in the synthesis of gastric mucus, the composition may be used as a pharmaceutical composition for preventing or treating gastrointestinal diseases, as a feed for preventing or improving gastric ulcers, or as a feed composition.

The disclosure relates generally to bacterial strains of the genus Christensenella, e.g., Christensenella sp. P152-H6d bacterial strains, and compositions comprising such bacterial strains. The disclosure further relates to methods of using such bacterial strains and compositions for preventing or treating a disorder, e.g., an inflammatory disorder, a gastrointestinal disorder, a metabolic disorder, and / or dysbiosis.

The utility model provides an automatic feeding and water discharging feeding machine, which relates to the technical field of livestock breeding and comprises a placing table and a placing plate movably arranged on the surface of the placing table, a storage barrel is fixedly mounted on the surface of the placing plate, the automatic feeding and water discharging feeding machine further comprises a scraping plate arranged on the side face of the placing plate, and a fixing assembly is arranged in the scraping plate. The scraping plate is fixed to the side face of the containing plate through a fixing assembly, and collecting assemblies are further arranged on the two sides of the containing table. According to the automatic discharging and water discharging feeding machine, the motor and the placing plate drive the scraping plate fixed to the side face of the placing plate to rotate, so that the inner wall of the annular trough is scraped, food residues in the trough are cleaned, the food residues can be effectively removed, food deterioration is prevented, breeding of insect pests and pathogens is reduced, and the risk of disease transmission is reduced; therefore, the harm to the health of the sheep is reduced, and gastrointestinal diseases are reduced.

This invention relates to an antibody that binds to the enteric alkaline phosphatase (iAP) protein. The antibody can be used to detect and treat gastrointestinal diseases. TIFF2026516499000030.tif73170

In particular, this invention refers to a composition comprising a probiotic combination comprising: a) at least one strain of the genus Lactobacillus selected from the species Lactobacillus plantarum; and c) at least one strain belonging to the genus Bifidobacterium selected from the species Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium infantis; wherein said composition is for use in a method for the prevention and / or treatment of chronic inflammatory bowel disease (Inflammatory Bowel Disease IBD).

Provided is a technology that can effectively inhibit the growth of Clostridium perfringens. According to the present invention, the growth of Clostridium perfringens can be inhibited. Furthermore, according to the present invention, by inhibiting the growth of this bacterium, it is possible to contribute to the prevention and improvement of various diseases and unhealthy conditions in which this bacterium is involved in the onset or exacerbation of the disease. For example, if the number of bacteria of this bacterium in the living body, such as the digestive tract, can be suppressed, it can directly contribute to the prevention and improvement of diseases and unhealthy conditions in which toxins from this bacterium are involved in the intestines (e.g., food poisoning, non-food-toxic diarrhea, necrotizing enteritis, hemorrhagic enteritis, etc.). SOLUTION: A growth inhibitor of Clostridium perfringens containing agarooligosaccharide as an active ingredient.

The present invention relates to a vaccine composition comprising non live antigens from: a) E.coli; b) bovine rotavirus; c) bovine coronavirus; wherein the antigens are formulated in an adjuvant having a continuous phase that is aqueous. In addition, the invention relates to methods for the preparation of the vaccine composition and to methods for vaccinating ruminants against infection by bovine rotavirus, bovine coronavirus and E. coli.