Preparation method of P-type molecular sieve-chitosan-sodium alga acid-potassium diformate slow-release antibacterial agent

The technology of antibacterial agent and molecular sieve is applied in the field of preparation of P-type molecular sieve-chitosan-sodium alginate-potassium diformate slow-release antibacterial agent, which can solve the problem of inability to reach the end of the intestinal tract and poor slow-release antibacterial effect. and other problems, to achieve the effect of good development and utilization prospects

Active Publication Date: 2019-05-10
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Potassium diformate, as an efficient and environmentally friendly antibacterial agent, can inhibit the growth of Escherichia coli in the intestines of animals, but it decomposes quickly in the stomach and cannot reach the end of the intestinal tract, and cannot play a role in the end of the intestinal tract. To solve this problem One problem, we choose P-type molecular sieve as the carrier of potassium diformate, in order to achieve the effect of sustained release, but P-type molecular sieve can only produce adsorption with potassium diformate, and the slow-release antibacterial effect is not good, while chitosan is A green, non-toxic, harmless polymer material, containing amino grou

Method used

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  • Preparation method of P-type molecular sieve-chitosan-sodium alga acid-potassium diformate slow-release antibacterial agent
  • Preparation method of P-type molecular sieve-chitosan-sodium alga acid-potassium diformate slow-release antibacterial agent
  • Preparation method of P-type molecular sieve-chitosan-sodium alga acid-potassium diformate slow-release antibacterial agent

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Embodiment

[0023] Utilizing the structural characteristics of P-type molecular sieve octahedral cages and the characteristics of surface active hydroxyl groups, it is compounded with chitosan and sodium alginate that have chemical reactions such as hydrolysis, carboxymethylation, oxidation, reduction, condensation and complexation, and has Potassium diformate with good biocompatibility can be effectively adsorbed and grafted, which can target enteropathogenic Escherichia coli (EPEC), enterotoxigenic Escherichia coli (ETEC), enteroinvasive Escherichia coli (EIEC), intestinal hemorrhage coli (EHEC), enteroadhesive Escherichia coli (EAEC) and diffusely adherent Escherichia coli (DAEC), etc., to control intestinal pH.

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Abstract

The invention discloses a P-type molecular sieve-chitosan-sodium alga acid-potassium diformate compound and a method for forming a livestock antibacterial agent with a slow-release effect. The defectsare overcome that heavy metal in a silver zeolite antibacterial agent easily deposits in an organism and cannot be applied to fodder, and potassium diformate as an acidifying agent cannot exert effects in the intestinal tract. With a P-type molecular sieve being a carrier, chitosan and sodium alga acid are sued a bridge. Potassium diformate as the acidifying agent is adsorbed, and the livestock slow-release antibacterial agent is prepared. Acidity detection and in-vitro antibacterial testing show that the slow-release antibacterial agent has slow-release performance, has an excellent antibacterial effect on escherichia coli, and can prevent and treat a diarrheal disease caused by escherichia coli.

Description

technical field [0001] The invention relates to a preparation method for compounding P-type molecular sieves, chitosan, sodium alginate and potassium diformate to prepare slow-release antibacterial agents. Background technique [0002] Guangxi stilbene is the best ore found in the world so far, the raw material is easy to mine, and it can be used as the precursor of synthetic molecular sieve after acidification. The method uses acidified stilbite as a raw material, and prepares P-type zeolite molecular sieves through a hydrothermal synthesis method, controlling reaction time, reaction temperature and other conditions. Using P-type zeolite molecular sieve as carrier, chitosan as intermediate and sodium alginate as coating film, P-type molecular sieve slow-release antibacterial agent was prepared by hydrothermal synthesis. [0003] Potassium diformate, as an efficient and environmentally friendly antibacterial agent, can inhibit the growth of Escherichia coli in the intestine...

Claims

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Application Information

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IPC IPC(8): A61K47/61A61K47/52A61K31/19A61P31/04
Inventor 陈南春孟祥俭郭小炜解庆林王秀丽
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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