Compound probiotic bacteria, fungicide and application of compound probiotic bacteria in preparation of fungicide for preventing and treating candida albicans vaginitis
A compound probiotic and candida technology, applied in the field of microbiology, can solve the problems of high recurrence rate of antibiotics and drug dependence, achieve the effects of down-regulating cellular immune overstimulation, reducing vaginal cleanliness, and great application prospects
Active Publication Date: 2020-09-11
深圳华大基因农业控股有限公司
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Problems solved by technology
[0003] In the traditional treatment plan, antibiotics are the main means of clinical treatment of candida
Method used
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Embodiment 1
[0042] Embodiment 1: The post-modeling treatment formula of this embodiment. Take Lactobacillus plantarum SD-H9 (LP bacteria powder, the number of live bacteria is not less than 10 11 cfu / g), Lactobacillus reuteri WX-94 (LY bacteria powder, the number of live bacteria is not less than 10 10 cfu / g), Lactobacillus rhamnosus SD-L9 (LR bacteria powder, the number of live bacteria is not less than 10 9 cfu / g) into the calibrated container, add a small amount of sodium chloride injection and stir to dissolve, then make up to 13mL of sodium chloride injection, and mix well.
[0043] The suspension solutions containing two of the above-mentioned probiotics are used as comparative examples respectively below, as follows:
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The invention discloses compound probiotic bacteria, a fungicide and application of the compound probiotic bacteria in preparation of the fungicide for preventing and treating candida albicans vaginitis. The compound probiotic bacteria contains Lactobacillus plantarum SD-H9, Lactobacillus reuteri WX-94 and Lactobacillus rhamnosus SD-L8 which are preserved in China General Microbiological Culture Collection Center (CGMCC) and respectively have the preservation numbers of CGMCC NO.16649, CGMCC NO.15062 and CGMCC NO.16650. The compound probiotic bacteria fungicide contains the following components in parts by mass: 80-90 parts of the compound probiotic bacteria, 6-8 parts of isomalto-oligosaccharide and 0.5-1 part of cyclodextrin. The compound probiotic bacteria and the compound probiotic bacteria fungicide provided by the invention are capable of effectively reducing inflammatory reaction and relieving and improving symptoms of the candida albicans vaginitis and have great application and development prospects in prevention and treatment of female reproductive tract infectious diseases such as the candida albicans vaginitis.
Description
technical field [0001] The invention belongs to the technical field of microorganisms, and in particular relates to a compound probiotic, bacterial agent and its application in the preparation of bacterial agent for preventing and treating Candida albicans vaginitis. Background technique [0002] Vaginal candidiasis (VVC) is a common vaginal mucosal fungal infection in women of childbearing age. According to statistics, about 3 / 4 of women of childbearing age in China have suffered from the disease at least once, and Candida albicans is the main cause of the disease. Pathogenic bacteria (accounting for 60%-80%). Several factors can affect a woman's susceptibility to C. albicans, the most common being fluctuating hormone levels and antibiotic use. More than 75% of women have suffered from the disease at least once in their lives, and about 10% of them can be transformed into recurrent candidal vaginitis (RVVC), that is, encountering more than 4 episodes of candidal vaginitis ...
Claims
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Login to view more IPC IPC(8): C12N1/20A61K35/747A61P31/10A61P15/02C12R1/25C12R1/225
CPCC12N1/20A61K35/747A61P31/10A61P15/02C12R2001/25C12N1/205C12R2001/225A61K2300/00
Inventor 蒋蕊赵山岑刘松玲代晓霜王明明罗晓莎任军丽
Owner 深圳华大基因农业控股有限公司
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