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Nanogold-containing antibacterial cream

A technology of nano-gold and antibacterial cream, which is applied in the field of antibacterial cream containing nano-gold, can solve the problems of complex process, difficult wound treatment and repair of nano-gold solution, and the antibacterial performance needs to be further improved, and achieves simple process, excellent broad-spectrum and the like. Antibacterial, strong patient adaptability

Inactive Publication Date: 2016-12-07
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The gold nanoparticles synthesized in the above report need dialysis treatment, the process is more complicated, and the process needs to be further simplified; the simple gold nanometer solution is not easy to be used in clinical wound treatment and repair, and the antibacterial performance needs to be further improved
[0006] At present, there is no public literature at home and abroad to report antibacterial cream dressings made of gold nanoparticles

Method used

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  • Nanogold-containing antibacterial cream
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  • Nanogold-containing antibacterial cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] This embodiment is used to illustrate the antibacterial cream containing nano gold of the present invention and its preparation method.

[0056] Formula of antibacterial cream (by weight percentage): 4,6-2 amino-2-mercaptopyrimidine / metformin as two-component modified gold nanoparticles: 0.01%; stearic acid: 14%, white petrolatum: 5% ; Liquid paraffin: 15%; Glycerin: 10%; Tween 80: 5%; the balance of water.

[0057] Preparation steps:

[0058] (1) Mix stearic acid, white vaseline, and liquid paraffin evenly, and heat to 50° C. to obtain an oil phase;

[0059] (2) Mix 4,6-2amino-2-mercaptopyrimidine / metformin as a two-component modified gold nanoparticle, glycerol, and Tween 80, and heat to 80°C to prepare an aqueous phase;

[0060] (3) Slowly add the oil phase to the water phase and stir for saponification to form an oil-in-water emulsified mixture. When the mixture is below 60° C., stir evenly to obtain the antibacterial cream containing nano-gold.

[0061] The prep...

Embodiment 2

[0078] This embodiment is used to illustrate the antibacterial cream containing nano gold of the present invention and its preparation method.

[0079] The formula of antibacterial cream (by weight percentage): 4,6-2 amino-2-mercaptopyrimidine / metformin as two-component modified gold nanoparticles: 1%; glyceryl stearate: 3%; lanolin: 5%; stearic acid: 10%; white petrolatum: 3%; liquid paraffin: 10%; glycerin: 10%; the balance water.

[0080] Preparation steps:

[0081] (1) Mix stearic acid, white vaseline, and liquid paraffin evenly, and heat to 80° C. to obtain an oil phase;

[0082] (2) Mix 4,6-2amino-2-mercaptopyrimidine / metformin as a two-component modified gold nanoparticle, glycerol, and glyceryl stearate evenly, and heat to 50°C to prepare an aqueous phase;

[0083] (3) Slowly add the oil phase to the water phase and stir for saponification to form an oil-in-water emulsified mixture. When the mixture is below 50° C., stir evenly to obtain the antibacterial cream conta...

Embodiment 3

[0092] This embodiment is used to illustrate the antibacterial cream containing nano gold of the present invention and its preparation method.

[0093] The formula (by weight percentage) of antibacterial cream: nanometer gold-platinum (gold content 80% atomic percentage, platinum content 20% atomic percentage) bimetallic nanoparticle: 0.04%; Glyceryl stearate: 3%; Alcohol: 2%; stearic acid: 10%; white petrolatum: 5%; liquid paraffin: 15%; glycerin: 5%; the balance is water.

[0094] Preparation steps:

[0095] (1) Mix cetyl alcohol, stearic acid, white vaseline, and liquid paraffin evenly, and heat to 60° C. to obtain an oil phase;

[0096] (2) Mix nano-gold-platinum bimetallic nanoparticles, glycerin, and glyceryl stearate evenly, and heat to 60° C. to obtain an aqueous phase;

[0097] (3) Slowly add the oil phase to the water phase and stir for saponification to form an oil-in-water emulsified mixture. When the mixture is below 60° C., stir evenly to obtain the antibacteri...

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Abstract

The invention provides nanogold-containing antibacterial cream which is prepared from the following components in percentage by weight: 24 to 34 percent of an oil phase, 3 to 5 percent of an emulsifier, 5 to 10 percent of a humectant, 0.001 to 1 percent of antibacterial nanogold-containing nano particles, 0 to 0.01 percent of a preservative and water. The antibacterial cream is excellent in broad-spectrum antibacterial property; the toxicity to human body cells is much lower than that of commercially available antibacterial cream containing nanosilver or other silver ions; with the cream, a patient does not have a pain feeling, and the cream is higher in patient applicability, can be applied to treatment of various burns and scalds, bedsore infections, various wound infections, skin inflammations such as tinea of feet and hands, gynecological diseases such as female genital tract inflammation, cervicitis and cervical erosion, and anorectal diseases such as proctitis, and also can be cooperated for conventional wound dressing.

Description

technical field [0001] The invention relates to an antibacterial cream, in particular to an antibacterial cream containing nano gold, and a preparation method and application of the antibacterial cream. Background technique [0002] When treating a patient's wound, it is necessary to cover the wound with a dressing to prevent bacterial ingress and moisture loss. Although traditional dressings such as gauze and cotton pads have a protective effect on the wound surface, they have no moisturizing effect. For some wounds, when the traditional dressing is removed, the dressing is easy to adhere to the wound tissue, causing secondary wound damage. Cream dressings or medicines can overcome some shortcomings of traditional dressings. Creams are easy to clean, have affinity for skin surface secretions, do not hinder the evaporation of skin surface moisture, and are more comfortable after application. Creams have been widely used in the medical field. It is used in the treatment of s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K33/24A61K47/22A61K47/36A61P17/02A61P17/00A61P15/00A61P1/00A61L15/18A61L15/46A61L15/42
CPCA61K9/06A61K33/24A61K47/36A61K47/44A61L26/0023A61L26/0066A61L2300/102A61L2300/404A61L2300/802A61K2300/00C08L5/08
Inventor 蒋兴宇孟宏宇张伟
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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