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Polyurethaneurea hydrogel and preparation methods therefor

A technology of polyurethane urea and hydrogel, which is applied in the field of biomedical polymer materials and supramolecular chemistry, can solve problems such as failure, reduced activity of bioactive components, tissue damage, etc., and achieve the effect of convenient processing and application and providing mechanical properties

Inactive Publication Date: 2014-01-22
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the deformation of all SMPs (including the water-responsive SMPs that have been reported so far) needs to be produced at a higher temperature (the T of the polymer) g or T m above), it is easy to cause the activity of bioactive components (such as proteins and drugs, etc.) on the surface or inside of the material to be greatly reduced or even invalidated.
At the same time, most of the current SMPs are heat-sensitive, and their deformation recovery also needs to be carried out at a higher temperature, which is easy to cause damage to the tissues around the implantation site.

Method used

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  • Polyurethaneurea hydrogel and preparation methods therefor
  • Polyurethaneurea hydrogel and preparation methods therefor
  • Polyurethaneurea hydrogel and preparation methods therefor

Examples

Experimental program
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Embodiment 1

[0043] A kind of high-strength polyurethane urea hydrogel provided by the present embodiment, its synthetic route is:

[0044] ;

[0045] In the formula, R represents the alkyl or aromatic group between the two isocyanate groups in the diisocyanate, R' represents the alkyl or aromatic group between the two amine groups in the diamine, Represents polyethylene glycol (PEG), its molecular weight is 200 ~ 20000 g / mol; n is the degree of polymerization.

[0046] The specific steps of synthesis are: adding diisocyanate OCN-(CH 2 ) 12 -NCO, then add 5 μl catalyst dibutyltin dilaurate, and react at 80 °C for 2 h. Then add diamine H to the reaction flask 2 N-(CH 2 ) 6 -NH 2 , and stirred for 3 h at 20 °C under nitrogen protection. Strictly control the molar ratio of the reaction raw materials, that is, PEG: diisocyanate: diamine = 1:2:1. After the reaction, the obtained solution with high viscosity was precipitated in n-hexane to obtain a white flocculent solid. The produc...

Embodiment 2

[0059] This embodiment provides a synthetic method of high-strength polyurethane urea hydrogel, and the specific steps are as follows:

[0060] Add diisocyanate IPDI to the PEG acetone solution with a molecular weight of 10000 g / mol, and then add 5 μl catalyst stannous octoate, and react at 50 °C for 3 h. Then, the diamine 3,3′-methylenediphenylamine was added into the reaction flask, and stirred under nitrogen protection at 40 °C for 3 h. Strictly control the molar ratio of the reaction raw materials, that is, PEG: diisocyanate: diamine = 1:2:1. After the reaction, the obtained solution with high viscosity was precipitated in ether to obtain a white flocculent solid. The product is dried and dissolved in chloroform, and then poured into a mold for molding. After the solvent is evaporated and dried, it is allowed to swell in distilled water until the swelling balance is reached, and a polyurethane urea hydrogel is obtained.

[0061] The characteristic of this example is to u...

Embodiment 3

[0063] The high-strength polyurethane urea hydrogel provided in this example. The concrete steps of its synthetic method are as follows:

[0064] Add the diisocyanate 1,3-diisocyanate to the PEG acetone solution with a molecular weight of 200 g / mol, and then add 5 μl catalyst pyridine, and react at 80 °C for 3 h. Then add diamine to the reaction flask , stirred and reacted under nitrogen atmosphere at 40 °C for 3 h. Strictly control the molar ratio of the reaction raw materials, that is, PEG: diisocyanate: diamine = 1:2:1. After the reaction, the obtained solution with high viscosity was precipitated in n-hexane to obtain a white flocculent solid. The product is dried and dissolved in methanol, and then poured into a mold for molding. After the solvent is evaporated and dried, it is allowed to swell in distilled water until the swelling balance is reached, and a polyurethane urea hydrogel is obtained.

[0065] The characteristic of this embodiment is to use aromatic diisocy...

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Abstract

The invention relates to polyurethaneurea hydrogel and preparation methods therefor. The preparation methods comprise two preparation methods. The first preparation methods is as follows: diisocyanate and catalysts are added in a polyethylene glycol (PEG) organic solution for reaction, then diamine chain extender is added, and products are obtained in the organic solvent after precipitation, wherein, the molar ratio of PEG, diisocyanate and diamine is 1:2:1. The second preparation method is as follows: N,N'-dicarbonyl diimidazole is added in a PEG organic solution for reaction, then excess diamine chain extender is added, macromolecules with amidogens at two ends are obtained, finally, diisocyanate is added, and products are obtained in the organic solvent after precipitation, wherein, the molar ratio of PEG and diisocyanate is 1:2. The polyurethaneurea hydrogel has advantages of large elongation and high tensile strength, and has shape memory functions. The polyurethaneurea hydrogel has application prospects at aspects of biomedical hydrogel, tissue engineering, hydrogel support materials, biomedical devices with shape memory functions and the like.

Description

technical field [0001] The invention relates to the fields of biomedical polymer materials and supramolecular chemistry, in particular to a polyurethane urea hydrogel with excellent mechanical properties and capable of realizing water or heat-responsive shape memory functions and a preparation method thereof. Background technique [0002] A hydrogel is a substance that swells in water but does not dissolve. In the past few decades, a lot of work has been devoted to the research of hydrogels, which can be widely used in biomedicine, such as drug carriers, wound dressings, cartilage replacement, artificial kidney membranes and other medical device. However, due to the weak mechanical properties of hydrogels in the swollen state, their applications are greatly limited. Because as a biomedical material, in addition to having certain biosimilarity and compatibility, it also needs to have excellent mechanical strength, stability and deformation recovery performance under externa...

Claims

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Application Information

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IPC IPC(8): C08G18/66C08G18/48C08G18/32C08J3/075
CPCC08G18/10C08G18/3228C08G18/4833C08G18/5045C08G18/8019C08G2210/00C08G2280/00C08J3/075C08J2375/08C08G18/3243
Inventor 郭明雨崔玉琳檀梅
Owner SUZHOU UNIV
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