34results about How to "Improve neurological deficits" patented technology

The invention provides a method for simultaneously detecting main components of paeoniflorin, beta ecdysterone, laetrile, mulberroside A, caffeic acid, ferulic acid, salvianolic acid B, astragaloside, formononetin, cryptotanshinone and tanshinone IIA of a Naoxintong capsule in a plasma sample by a liquid chromatography-tandem mass spectrometry (HPLC-MS / MS). In a liquid chromatogram, a mobile phase consists of acetonitrile and a formic acid aqueous solution of which the volume fraction is 0.1%, and gradient elution is used. A mass spectrum uses a quick positive and negative ions switching and analyzing mode and an MRM (Multiple Reaction Monitoring) scanning manner. After the Naoxintong capsule is taken, the situations of the changes of the blood-medicine concentration of several kinds of main components in the plasma of a rat are detected at the same time. The methodological survey results indicate that the established method conforms to determination requirements on biological samples in a body; the method is good in sensitivity, high in specificity, stable, reliable, and suitable for detecting substances with lower contents.

The invention relates to a method for determining fingerprint spectrum of traditional Chinese medicine for treating coronary heart disease. The method comprises the following steps: preparing a test solution, preparing a reference solution, and carrying out gradient elution under the chromatographic conditions that an Agilent ZORBAX Extend C18 chromatographic column is used as a filling agent, a mobile phase A is methanol and a mobile phase B is 0.4% phosphoric acid water solution; determining under conditions that the flow velocity is at 1.0ml / min, the column temperature is at 35 DEG C and the detection wavelength is 230-240nm, thus obtaining the fingerprint spectrum of traditional Chinese medicine. The method has the characteristics of being simple and convenient, good in reproducibility, more in characteristic peaks, accurate and reliable, and the like, and the quality of the traditional Chinese medicine preparation can be controlled effectively by the established fingerprint spectrum.

The invention provides an application of artesunate in preparing medicine for treating and preventing central nerve injury. The artesunate has the facilitating function on the multiplication of neural stem cells cultured in a vitro, meanwhile infarct lesions of a big mouse with cerebral infarction is effectively reduced, and the neurologic impairment caused by cerebral apoplexy is improved. The artesunate is safe and free of obvious toxic and side effects.

The invention relates to application of a salvianolic acid A composition in preparing medicines for protecting ischemic brain tissue damage. The composition is prepared from 94-97% of salvianolic acid A, 0.1-1.5% of alkannic acid, 0.1-1.5% of rosmarinic acid, 0.1-1.5% of salvianolic acid B and 0.1-2.0% of salvianolic acid C.

The invention provides application of PR-957 in preparing drugs for treating cerebral ischemia-reperfusion injury. The technical scheme is that an MCAO animal model is taken as an experimental subjectand the role of immune proteasome in cerebral ischemic stroke is investigated by using the PR-957. The experimental results show that PR-957 therapy leads to lowering transcription level in ROR gammat and IL-17 by reducing the phosphorylation level of STAT3, so that Th17 differentiation is inhibited, cerebral inflammatory response is reduced, cerebral infarction volume is reduced and neurological dysfunction is alleviated. Therefore, the PR-957 plays a key role in regulating the inflammatory state of helper T cells of the cerebral ischemic stroke in mice and can be used as a therapeutic means of relieving brain injury of the cerebral ischemia-reperfusion injury.

The invention discloses an application of interleukin33 in the preparation of epilepsy treatment drugs. Action and potential mechanisms of the interleukin33 on epileptic newborn mice are disclosed, and a new technological means is provided for clinic treatment of neonate epilepsy.

The invention relates to a traditional Chinese medicine composition and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 21 to 39 parts of herba cistanche, 8 to 16 parts of fructus alpiniae oxyphyllae, 7 to 13 parts of radix et rhizoma rhodiolae crenulatae, 7 to 13 parts of radix polygalae, and 4 to 8 parts of rhizoma coptidis. The traditional Chinese medicine composition is safe and effective, and can improve a cognitive function and slow down dementia development, thereby improving the daily living capacity and a social function of a patient and improving the life quality.

The invention relates to the medicine technical field, and especially relates to an application of Sparstolonin B in the preparation of drugs for treating cerebral hemorrhage. It has been proved by animal experiments that Sparstolonin B has a strong protective effect on mouse brain after cerebral hemorrhage, is capable of prominently repairing the neurologic impairment of mice with cerebral hemorrhage, obviously reliving the cerebral edema, and inhibiting the inflammatory responses around the hematoma tissues, thus increases the survival rate of mice with cerebral hemorrhage, and prominently increases the survival rate of damaged nerve cells of hemoglobin induced microglia. Thus Sparstolonin B can be used to prepare drugs for treating cerebral hemorrhage.

The invention provides a Guanxinshutong capsule content detection method using quantitative analysis of multi-components by single-marker (QAMS). According to the present invention, the chromatographic conditions comprise that the chromatographic column uses an octadecyl-bonded silica gel column as a filler, methanol is adopted as a mobile phase A, a 0.4% formic acid aqueous solution is adopted as a mobile phase B, a volume ratio of the mobile phase A to the mobile phase B is 3-90:97-10, linear gradient elution is performed, the detection wavelength is 280 nm, the column temperature is 35 DEG C, and the sample injection volume is 5 [mu]L; the content detection method can simultaneously determine the contents of gallic acid, danshensu sodium, protocatechuic acid, protocatechuic aldehyde, vanillin, rosmarinic acid, salvianolic acid B, eugenol, cryptotanshinone and tanshinone IIA in the Guanxinshutong capsule; and the detection method has characteristics of simpleness, accuracy, efficiency, good reproducibility, and good stability.

The invention belongs to the technical field of medicine and particularly relates to a traditional Chinese medicine for treating diabetes combined with cerebral infarction. The traditional Chinese medicine is composed of the following traditional Chinese medicine components of, by weight, 5-7 parts of pedicalaris decora Franch, 10-14 parts of floribunda actinidia chinensis, 10-14 parts of polygonatum, 10-14 parts of roots of intermediate peashrub, 10-14 parts of roots of Chinese eriosema, 10-14 parts of stachys geobombycis, 10-14 parts of red peony roots, 7-11 parts of motherwort, 1.8-2.2 parts of leeches, 5-7 parts of cattail pollen, 7-11 parts of green tangerine peels, 7-11 parts of amplexicaul cynanchum and 5-7 parts of liquorice. By means of the traditional Chinese medicine for treating the diabetes combined with the cerebral infarction, the blood glucosecan be obviously reduced, neurologic impairment of cerebral infarction patients can be improved, the clinic efficacy is remarkable, and the safety of medication is good.

The invention discloses an application of glucogalactooligosaccharide in preparation of a medicine for treating and / or preventing ischemia-reperfusion injury. The glucogalactooligosaccharide disclosed by the invention can be used for remarkably relieving postoperative liver injury, kidney injury, brain injury and the like of ischemia reperfusion mice, is safe and non-toxic, has a strong drug effect, and has a very good medicinal prospect in prevention and treatment of ischemia reperfusion injury.

The invention discloses a medicine for treating acute cerebral hemorrhage. Rheum officinale, pollen typhae, caulis spatholobi and borneol are taken as raw materials. According to different characteristics of all the raw materials, the raw materials are extracted and prepared into an injection. The medicine provided by the invention has an excellent function of treating acute cerebral hemorrhage and can be used for obviously improving hemiplegia sign caused by cerebral hemorrhage, reducing intracerebral hematoma area and relieving encephaledema and secondary harm to nerve cells; the death rate is reduced, the survival quality is increased, the neurologic impairment is relieved, the moisture content in brain tissue is obviously reduced, the activity of superoxide dismutase in brain is increased, the occurrence of the lipid peroxidation is restrained, and the diuresis function is achieved; and the coagulation time of blood and the bleeding-stopping time at bleeding moment are efficiently shortened.

The invention relates to the field of medicine, and discloses the application of anti-platelet thrombolysin in the preparation of anti-inflammatory drugs. Experiments have confirmed that the anti-platelet thrombolysin of the present invention can inhibit the interaction between platelets and leukocytes mediated by αMβ2 integrin, reduce the aggregation between neutrophils, and also reduce the combination between platelets and neutrophils, Thereby play the role of inhibiting inflammation, has a good prospect of clinical application.

The invention belongs to the technical field of acupuncture point electrical stimulation instruments, and particularly relates to a cerebral stroke acupuncture point electrical stimulation instrumentbased on Bluetooth communication. By aiming at the problems that an existing cerebral stroke treatment way is poor, specific frequency and intensity can not be used for carrying out treatment, a traditional operation way is complex, a temperature is overhigh after long-time working and cooling can not be effectively carried out, the invention now puts forward the following scheme that the cerebralstroke acupuncture point electrical stimulation instrument comprises an electric pulse stimulation instrument, wherein the electric pulse stimulation instrument comprises a shell, a Bluetooth communication module, a processing control module, a boosting and discharging module and a power supply module; the Bluetooth communication module, the processing control module, the boosting and dischargingmodule and the power supply module are all positioned in the shell; the electric pulse stimulation instrument is connected with an electrode plate; and the electric pulse stimulation instrument and the Bluetooth communication module are wirelessly connected. The cerebral stroke acupuncture point electrical stimulation instrument is simple to operate, and can use the specific frequency and intensity to carry out treatment, control regulation is automatically carried out through wireless transmission, cooling can be evenly and effectively carried out, and a situation that a use effect is affected since the temperature is overhigh is avoided.

The invention relates to the medicine technical field, and especially relates to an application of Sparstolonin B in the preparation of drugs for treating cerebral hemorrhage. It has been proved by animal experiments that Sparstolonin B has a strong protective effect on mouse brain after cerebral hemorrhage, is capable of prominently repairing the neurologic impairment of mice with cerebral hemorrhage, obviously reliving the cerebral edema, and inhibiting the inflammatory responses around the hematoma tissues, thus increases the survival rate of mice with cerebral hemorrhage, and prominently increases the survival rate of damaged nerve cells of hemoglobin induced microglia. Thus Sparstolonin B can be used to prepare drugs for treating cerebral hemorrhage.

The invention provides a Guanxinshutong capsule content detection method using quantitative analysis of multi-components by single-marker (QAMS). According to the present invention, the chromatographic conditions comprise that the chromatographic column uses an octadecyl-bonded silica gel column as a filler, methanol is adopted as a mobile phase A, a 0.4% formic acid aqueous solution is adopted as a mobile phase B, a volume ratio of the mobile phase A to the mobile phase B is 3-90:97-10, linear gradient elution is performed, the detection wavelength is 280 nm, the column temperature is 35 DEG C, and the sample injection volume is 5 [mu]L; the content detection method can simultaneously determine the contents of gallic acid, danshensu sodium, protocatechuic acid, protocatechuic aldehyde, vanillin, rosmarinic acid, salvianolic acid B, eugenol, cryptotanshinone and tanshinone IIA in the Guanxinshutong capsule; and the detection method has characteristics of simpleness, accuracy, efficiency, good reproducibility, and good stability.

The invention discloses an anti-brain stroke solid oral preparation. The preparation comprises active ingredients and pharmaceutically acceptable auxiliary materials, wherein the active ingredients comprise aspirin and chlorzoxazone. The solid oral preparation can prevent enlargement of infarct size and has good curative effects of improving neurologic impairments of patients suffering from progressive stroke and restoring the activity of daily living, and severe adverse reactions are not caused in the treatment process.

The invention discloses an application of a compound in preparing a medicine for treating a cerebrovascular disease. The structural formula of the compound is shown in the specification. The compound has a certain protective effect on cerebral ischemic injury, and can obviously improve neurological deficits caused by cerebral ischemia and reduces brain infarct volume.

The invention discloses the application of a traditional Chinese medicine composition in the preparation of medicine for treating cerebral small vessel disease, which belongs to the field of traditional Chinese medicine application and consists of raw materials such as ginseng, leech, wood beetle, frankincense, red peony root and the like. The medicine of the invention improves cognitive dysfunction of patients with cerebral small vessel disease, improves memory, reduces plasma Hcy level, and has no obvious side effect.

The invention discloses a pig blood deproteinized extract enteric-soluble capsule and a preparation process thereof, and belongs to the technical field of biological products. The pig blood deproteinized extract enteric-soluble capsule consists of a capsule content and a capsule shell, wherein the capsule content is prepared from the following raw materials in parts by weight: 45 to 65 parts of pig blood deproteinized extract powder, 21 to 33 parts of compressible starch, 4 to 7 parts of carboxymethyl starch sodium, 8 to 12 parts of starch slurry, 2 to 3 parts of magnesium stearate and talc powder, and 0.07 to 0.11 part of methylparaben and ethylparaben; and the capsule shell is an enteric-soluble capsule shell. The pig blood deproteinized extract enteric-soluble capsule has stable property, is convenient to use clinically, and can be used as a first-choice orally administered medicament for treating and adjunctively treating cerebrovascular diseases, and improving neurologic impairment and peripheral blood disorder symptoms caused by cerebral circulation insufficiency and craniocerebra trauma.

The invention belongs to the technical field of medicine, and specifically relates to a traditional Chinese medicine for treating diabetes complicated with cerebral infarction. The traditional Chinese medicine is composed of the following traditional Chinese herbals in parts by weight: 5 to 7 parts of American ginseng, 10 to 14 parts of radix codonopsis, 10 to 14 parts of pseudostellaria root, 10 to 14 parts of glehnia root, 10 to 14 parts of Chinese yam, 10 to 14 parts of prepared rehmannia root, 10 to 14 parts of red sage root, 7 to 11 parts of safflower, 1.8 to 2.2 parts of gadfly, 5 to 7 parts of pangolin, 7 to 11 parts of bitter orange, 7 to 11 parts of banksia rose, and 5 to 7 parts of licorice. The provided traditional Chinese medicine can prominently reduce blood sugar, and repair the neurologic impairment of cerebral infarction patients, the clinical effect is prominent, and the drug application safety is high.

The invention relates to a pharmaceutical composition for preventing and treating cerebral apoplexy. The composition comprises the following components of ginseng, radix aconiti carmichaeli, lucid ganoderma, safflower carthamus, artificial musk, bear gall, pearl, venenum bufonis, borneol and calculus bovis. The composition can obviously improve neurological impairment, relieve the degree of encephaledema and reduce the area of cerebral infarction, and the effect is possibly related to the medicine for relieving oxidative stress and protecting brain tissues from being damaged by oxygen free radicals.

The invention provides a method for simultaneously detecting main components of paeoniflorin, beta ecdysterone, laetrile, mulberroside A, caffeic acid, ferulic acid, salvianolic acid B, astragaloside, formononetin, cryptotanshinone and tanshinone IIA of a Naoxintong capsule in a plasma sample by a liquid chromatography-tandem mass spectrometry (HPLC-MS / MS). In a liquid chromatogram, a mobile phase consists of acetonitrile and a formic acid aqueous solution of which the volume fraction is 0.1%, and gradient elution is used. A mass spectrum uses a quick positive and negative ions switching and analyzing mode and an MRM (Multiple Reaction Monitoring) scanning manner. After the Naoxintong capsule is taken, the situations of the changes of the blood-medicine concentration of several kinds of main components in the plasma of a rat are detected at the same time. The methodological survey results indicate that the established method conforms to determination requirements on biological samples in a body; the method is good in sensitivity, high in specificity, stable, reliable, and suitable for detecting substances with lower contents.

The invention discloses an anti-brain stroke solid oral preparation. The preparation comprises active ingredients and pharmaceutically acceptable auxiliary materials, wherein the active ingredients comprise aspirin and chlorzoxazone. The solid oral preparation can prevent enlargement of infarct size and has good curative effects of improving neurologic impairments of patients suffering from progressive stroke and restoring the activity of daily living, and severe adverse reactions are not caused in the treatment process.

The invention discloses an application of interleukin33 in the preparation of epilepsy treatment drugs. Action and potential mechanisms of the interleukin33 on epileptic newborn mice are disclosed, and a new technological means is provided for clinic treatment of neonate epilepsy.

The invention discloses an application of glucogalactooligosaccharide in the preparation of medicines for treating and / or preventing ischemia-reperfusion injury. The galactooligosaccharides described are: the galactooligosaccharides of the present invention can significantly reduce postoperative liver injury, kidney injury, and brain injury in ischemia-reperfusion mice, and are safe, non-toxic, and have strong drug effects. , has good medicinal prospects in preventing and treating ischemia-reperfusion injury.