Application of compound Click148 in preparing medicine for treating cerebrovascular disease

A cerebrovascular disease and compound technology, applied in the field of drugs for the treatment of cerebrovascular disease, can solve problems such as single curative effect, and achieve the effects of improving neurological symptoms, significantly protecting brain nerves, and reducing the volume of cerebral infarction

Active Publication Date: 2015-04-22
SUZHOU UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new drug for the treatment of cerebrovascular diseases, so as to solve the problem that the existing drugs have a single curative effect and can only provide partial protection.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of compound Click148 in preparing medicine for treating cerebrovascular disease
  • Application of compound Click148 in preparing medicine for treating cerebrovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Protective effect of Clik148 on focal ischemic brain injury in rats

[0018] Male SD rats were then divided into control group (sham operation group), model group, Clik148 high, medium and low dose groups (12.5, 25 and 50 nmol), 10 in each group. The rat model of permanent middle cerebral artery occlusion (MCAO) was established by suture method. Clik148 was injected into the cerebral ventricle before ischemia, with different concentrations and equal volumes. After 24 hours of ischemia, 5-point scoring method (the higher the score, the more obvious the neurological deficit) was used to measure the neurological function, and the effect of Clik148 on the volume of cerebral infarction was observed by TTC staining.

[0019] figure 1 Clik148 reduces the neurological symptom score of rats with cerebral ischemia, using a 5-point scoring method, the higher the score, the more obvious the neurological deficit (mean±SD, n=10). The intracerebroventricular injection of Clik148 bef...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an application of a compound in preparing a medicine for treating a cerebrovascular disease. The structural formula of the compound is shown in the specification. The compound has a certain protective effect on cerebral ischemic injury, and can obviously improve neurological deficits caused by cerebral ischemia and reduces brain infarct volume.

Description

technical field [0001] The invention relates to a medicine for treating cerebrovascular diseases, in particular to a new application of compound Clik148. Background technique [0002] Cerebral stroke is a group of diseases whose main clinical manifestations are cerebral tissue ischemia and hemorrhagic injury symptoms, also known as stroke or cerebrovascular accident. The disease has an acute onset, high disability rate and high mortality rate, and is one of the most important diseases that endanger human health in the world today. Stroke is mainly divided into two categories: hemorrhagic stroke (cerebral hemorrhage or subarachnoid hemorrhage) and ischemic stroke (ischemic brain injury, including cerebral infarction and cerebral thrombosis). Stroke is the most common. [0003] At present, the clinical treatment of ischemic stroke mainly adopts drug therapy, including thrombolysis, vasodilator and anti-platelet aggregation. The above-mentioned drugs for the treatment of isc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/336A61P9/00A61P9/10A61P7/02
Inventor 张慧灵杨磊罗宇胜沼信彦石童和美
Owner SUZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap