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Application of a traditional Chinese medicine composition in preparation of medicine for reducing plasma cysteine ​​level of cerebral small vessel disease

A technology of cysteine ​​and cerebral small blood vessels, which is applied in drug combinations, cardiovascular system diseases, active ingredients of hydroxyl compounds, etc., can solve the problems of hidden onset of cerebral small vessel diseases, difficulties in early detection, and unobvious clinical symptoms

Active Publication Date: 2020-06-23
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cerebral small vessel disease has the characteristics of insidious onset and difficulty in early detection. Patients are not easy to detect, and the clinical symptoms are not obvious, but it will gradually cause cognitive decline, daily life ability and executive function decline.

Method used

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  • Application of a traditional Chinese medicine composition in preparation of medicine for reducing plasma cysteine ​​level of cerebral small vessel disease
  • Application of a traditional Chinese medicine composition in preparation of medicine for reducing plasma cysteine ​​level of cerebral small vessel disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] a) The raw material drug formula is:

[0074] Ginseng 39.6g Leech 72.6g Wood Beetle 46.2g Frankincense 13.2g Paeoniae Rubra 33g Dalbergia 13.2g Sandalwood 13.2g Scorpion 19.8g Cicada slough 46.2g Centipede 6.6g Borneol 33g Fried Suanzaoren 33g;

[0075] b) Crushing process of medicinal materials:

[0076] The scorpion, leech, centipede, ground beetle and cicada slough five kinds of insect medicines, which are cleaned, washed and processed, are formulated according to the prescription and crushed by a pulverizer. The fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 30 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are prepared;

[0077] c) Extraction concentration and drying process:

[0078] Add water to extract the volatile oil of Jiangxiang and sandalw...

Embodiment 2

[0083] a) The raw material drug formula is:

[0084] Ginseng 59.4g Leech 52.8g Wood Beetle 46.2g Frankincense 13.2g

[0085] Radix Paeoniae Alba 33g Dalbergia 13.2g Sandalwood 13.2g Scorpion 39.6g

[0086] Cicada slough 46.2g centipede 6.6g borneol 33g fried jujube kernel 33g

[0087] b) Crushing process of medicinal materials:

[0088] The scorpion, leech, centipede, ground beetle and cicada slough five kinds of insect medicines, which are cleaned, washed and processed, are formulated according to the prescription and crushed by a pulverizer. The fineness of the powder reaches more than 80 mesh; The powder after powder is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the powder is less than 70 µm;

[0089] c) Extraction concentration and drying process:

[0090] Add water to extract the volatile oil of Jiangxiang and sandalwood, and then extract with water. Add appropriate amount of water to decoct the red peony...

Embodiment 3

[0094] Embodiment 3: the preparation of pill

[0095] a) The raw material drug formula is:

[0096] Ginseng 39.6g Leech 66g Wood Beetle 46.2g Frankincense 13.2g

[0097] Radix Paeoniae Alba 33g Dalbergia 13.2g Sandalwood 13.2g Scorpio 46.2g

[0098] Cicada slough 46.2g Centipede 6.6g Borneol 33g Fried Suanzaoren 33g

[0099] b) Crushing process of medicinal materials:

[0100] The scorpion, leech, centipede, ground beetle and cicada slough five kinds of insect medicines, which are cleaned, washed and processed, are formulated according to the prescription and crushed by a pulverizer. The fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is 10 µm;

[0101] c) Extraction concentration and drying process:

[0102] Add water to extract the volatile oil of Jiangxiang and sandalwood, and then extract with water. Add appropriate ...

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Abstract

The invention discloses the application of a traditional Chinese medicine composition in the preparation of medicine for treating cerebral small vessel disease, which belongs to the field of traditional Chinese medicine application and consists of raw materials such as ginseng, leech, wood beetle, frankincense, red peony root and the like. The medicine of the invention improves cognitive dysfunction of patients with cerebral small vessel disease, improves memory, reduces plasma Hcy level, and has no obvious side effect.

Description

technical field [0001] The invention belongs to the field of medicine application, and in particular relates to the application of a traditional Chinese medicine composition. Background technique [0002] Cerebral small vessel disease (SVD) refers to cerebral ischemic or hemorrhagic damage caused by intracranial arterioles and arterioles. Cerebral small vessel disease has the characteristics of insidious onset and difficulty in early detection. Patients are not easy to detect, and the clinical symptoms are not obvious, but it will gradually cause cognitive decline, daily life ability and executive function decline. The concept of cerebrovascular disease was first proposed at the 2007 International Stroke Conference and the European Stroke Conference. Research on cerebrovascular disease is an in-depth study of cerebrovascular disease, which is helpful for further understanding the mechanism of cerebrovascular disease and promoting the development of cerebrovascular disease. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61P9/10A61P25/00A61K31/045A61K35/62A61K35/64A61K35/646A61K35/648
Inventor 常丽萍魏聪张晓凤刘翠王猛
Owner HEBEI YILING MEDICINE INST
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