The invention relates to the technical field of beverage processing and in particular relates to a health-care compound fruit and vegetable beverage and a preparation method thereof. By adopting a single-factor testing method, the optimal formula percentage of raw materials is obtained through sensory evaluation and determination of light transmittance, pH (Potential of Hydrogen), soluble solids and total sugar: 27 percent to 29 percent of snow pear juice, 10 percent to 15 percent of sweet tamarind juice, 26 percent to 28 percent of mangosteen juice, 30 percent to 32 percent of tomato juice, 33 percent to 35 percent of carrot juice, 3 percent to 5 percent of ginger juice, 3 percent to 4 percent of brown sugar, 4 percent to 5 percent of proteoglycan, 0.029 percent to 0.031 percent of citric acid, 0.01 percent to 0.03 percent of a color protection agent, 5 percent to 7 percent of a compound enzyme and 3 percent to 5 percent of a flavor enzyme; the health-care compound fruit and vegetable beverage is prepared through the steps of treating the raw materials, carrying out enzymolysis, blending, sterilizing and the like. The beverage provided by the invention has the most scientific and reasonable raw material formula and maintains a natural fruit and vegetable flavor; the beverage is fresh and mellow, is sour, sweet and palatable and is high in nutrient value and long in shelf life; the health-care compound fruit and vegetable beverage has various health-care effects of clearing heat and removing toxicity, promoting the secretion of saliva or body fluid to quench thirst, nourishing stomach and spleen, detoxifying and maintaining beauty, dispelling cold and the like.