Medicine for treating acute cerebral hemorrhage and preparation method thereof

A drug and an acute technology are applied in the field of drugs for the treatment of acute cerebral hemorrhage and their preparation, which can solve the problems of unsatisfactory clinical effects, and achieve the effects of reducing the area of ​​intracerebral hematoma, protecting the effect and improving the signs of hemiplegia.

Inactive Publication Date: 2012-08-08
钱家美
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because these drugs only treat a certain link of the complex pathogenesis of cerebral hemorrhage, the clinical effect is not satisfactory. Therefore, there is an urgent need for a clinical treatment for the complex pathogenesis of acute cerebral hemorrhage, with definite curative effect, convenience, safety and stable quality. emergency medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0016] Weigh 90g of rhubarb, 170g of Puhuang, 140g of Caulis Spatholobus, and 1g of borneol as raw materials. The above four flavors, rhubarb are crushed into coarse particles, add 8 times the amount of 70% ethanol, heat and reflux for extraction three times, each time for 1 hour, combine the ethanol extract, recover ethanol under reduced pressure and concentrate to a relative density of 1.10-1.12 (50°C), Stir and add 4% gelatin solution until no precipitation occurs, then add ethanol to make the alcohol content reach 80%, refrigerate for 24 hours, recover ethanol under reduced pressure and concentrate to a relative density of 1.30-1.35 (60°C), at 80°C, 6.86Kpa Vacuum-dried to obtain rhubarb dry extract. Puhuang and Caulis Spatholobus were crushed, then added 10 times the amount of 80% ethanol to reflux and extracted three times, each time for 2 hours, combined with alcohol extraction and rolled, recovered ethanol under reduced pressure and concentrated to a relative density o...

Embodiment 2

[0018] Weigh rhubarb 110g, Puhuang 140g, Caulis Spatholobus 150g, and Borneol 1.2g as raw materials. The above four flavors, rhubarb are crushed into coarse grains, add 6 times the amount of 80% ethanol, heat and reflux for extraction twice, each time for 2 hours, combine the ethanol extract, recover ethanol under reduced pressure and concentrate to a relative density of 1.10-1,12 (50 ℃), stir and add 4% gelatin solution until no precipitation occurs, add ethanol to make the alcohol content reach 80%, refrigerate for 48 hours, recover ethanol under reduced pressure and concentrate to a relative density of 1.30-1.35 (60 ℃), at 80 ℃, 6.86Kpa Bian vacuum-dried to obtain rhubarb dry extract. Puhuang and Caulis Spatholobus were crushed, then 8 times the amount of 85% ethanol was added to reflux extraction three times, each time for 2 hours, the ethanol extracts were combined, the ethanol was recovered under reduced pressure and concentrated to a relative density of 1.10-1.12 (50°C)...

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PUM

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Abstract

The invention discloses a medicine for treating acute cerebral hemorrhage. Rheum officinale, pollen typhae, caulis spatholobi and borneol are taken as raw materials. According to different characteristics of all the raw materials, the raw materials are extracted and prepared into an injection. The medicine provided by the invention has an excellent function of treating acute cerebral hemorrhage and can be used for obviously improving hemiplegia sign caused by cerebral hemorrhage, reducing intracerebral hematoma area and relieving encephaledema and secondary harm to nerve cells; the death rate is reduced, the survival quality is increased, the neurologic impairment is relieved, the moisture content in brain tissue is obviously reduced, the activity of superoxide dismutase in brain is increased, the occurrence of the lipid peroxidation is restrained, and the diuresis function is achieved; and the coagulation time of blood and the bleeding-stopping time at bleeding moment are efficiently shortened.

Description

technical field [0001] The invention relates to a medicine for treating acute cerebral hemorrhage and a preparation method thereof. Background technique [0002] Cerebral hemorrhage has a sudden onset, a dangerous condition, and a very high mortality rate. It is the most serious type of acute cerebrovascular disease and is currently one of the most fatal diseases in middle-aged and elderly people. Because of its extremely high death and disability rate, governments and health departments of various countries attach great importance to its prevention and control work. Epidemiological surveys show that the prevalence of cerebrovascular disease is 500-700 / 100,000 population, which is basically consistent with domestic and foreign statistics. In some cities in my country, it is as high as 1,000 / 100,000 population, and the annual incidence rate is 165-245 / 100,000 population. According to statistics from 57 countries of the World Health Organization (WHO) Cerebrovascular Disease ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P9/10A61P7/04
Inventor 钱家美
Owner 钱家美
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