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Application of PR-957 in preparing drugs for treating cerebral ischemia-reperfusion injury

A technology of cerebral ischemia reperfusion, 1.PR-957, applied in the field of medicine

Active Publication Date: 2018-06-15
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on cerebral ischemia-reperfusion loss that it is used for treatment in the prior art

Method used

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  • Application of PR-957 in preparing drugs for treating cerebral ischemia-reperfusion injury
  • Application of PR-957 in preparing drugs for treating cerebral ischemia-reperfusion injury
  • Application of PR-957 in preparing drugs for treating cerebral ischemia-reperfusion injury

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Embodiment Construction

[0029] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0030] Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Accordingly, values ​​modified by language such as "about", "approximately" and the like are not limited to the exact value itself. In some embodiments, "about" means that the corrected value is allowed to vary within the range of plus or minus ten percent (10%), for example, "about 100" means any value between 90 and 110. Furthermore, in the expression "about the first value to the second value", both values ​​of the first value and the second value are corrected approximately at the same time. In some cases, the language of approximation may relate...

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Abstract

The invention provides application of PR-957 in preparing drugs for treating cerebral ischemia-reperfusion injury. The technical scheme is that an MCAO animal model is taken as an experimental subjectand the role of immune proteasome in cerebral ischemic stroke is investigated by using the PR-957. The experimental results show that PR-957 therapy leads to lowering transcription level in ROR gammat and IL-17 by reducing the phosphorylation level of STAT3, so that Th17 differentiation is inhibited, cerebral inflammatory response is reduced, cerebral infarction volume is reduced and neurological dysfunction is alleviated. Therefore, the PR-957 plays a key role in regulating the inflammatory state of helper T cells of the cerebral ischemic stroke in mice and can be used as a therapeutic means of relieving brain injury of the cerebral ischemia-reperfusion injury.

Description

technical field [0001] The present invention relates to the technical field of medicine, and further relates to the new medical application of substances, in particular to the application of PR-957 in the preparation of medicine for treating cerebral ischemia-reperfusion injury. Background technique [0002] Ischemic stroke is a general term for brain tissue necrosis caused by cerebral blood supply insufficiency caused by stenosis or occlusion of cerebral blood supply arteries. In the pathogenesis of ischemic stroke, the damage caused is a multi-link cascade effect, involving multiple damage mechanisms. In addition to tissue infarction and inflammatory response caused by ischemia itself, reperfusion after ischemia Further damage to tissue cells is also an inevitable stage of ischemic stroke. [0003] Reperfusion after ischemia has serious damage to brain tissue. During cerebral ischemia, the bioelectricity of brain cells changes, and pathological slow waves appear. After a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/07A61K9/08A61P9/10A61P29/00A61P25/00
CPCA61K9/0019A61K9/08A61K38/07A61K47/40
Inventor 郝峻巍马晓峰郭英陈秀菊李道静
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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