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Application of interleukin 33 in the preparation of drugs for treating epilepsy

A technology for interleukin and epilepsy, applied in the field of biomedicine, can solve problems such as lack of understanding

Active Publication Date: 2019-11-22
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the biological activity of IL-33 in diseases has become more and more clear, the role and underlying mechanism of IL-33 in epilepsy are still poorly understood

Method used

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  • Application of interleukin 33 in the preparation of drugs for treating epilepsy
  • Application of interleukin 33 in the preparation of drugs for treating epilepsy
  • Application of interleukin 33 in the preparation of drugs for treating epilepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Fifteen seven-day-old Sprague-Dawley (SD) rats were randomly divided into three groups, 5 rats in each group, and the three groups were: simple control group (Sham group), simple convulsion group (RS group) and IL-33 Convulsion group (RS+IL-33 group). The modeling steps are as follows: put the RS group and the RS+IL-33 group in a transparent and visible closed glass experimental cabin, leave a small hole on the top of the cabin, inject 0.04ml of trifluoroethyl ether into the hole each time, and quickly seal the top of the cabin . Observe the convulsions of the rats in the cabin, and before the convulsions of the rats are relieved but not back to normal, continue to inject an equal dose of trifluoroethyl ether into the cabin through the small hole on the top of the cabin, so that they are in a state of persistent convulsions. Start timing from the first convulsive attack of the rat, and take out the rat after 30 minutes of the convulsive onset, and convulse once a day f...

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Abstract

The invention discloses an application of interleukin33 in the preparation of epilepsy treatment drugs. Action and potential mechanisms of the interleukin33 on epileptic newborn mice are disclosed, and a new technological means is provided for clinic treatment of neonate epilepsy.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an application of interleukin-33 in the preparation of drugs for treating epilepsy. Background technique [0002] Epilepsy is the third most common chronic neuropathic disorder in the world. It is characterized by persistent electrical discharges produced by predisposing constitutions. Epilepsy affects many people of different ages, especially neonates and children. Although the drugs and surgical operations for the treatment of epilepsy are improving day by day, there are still few studies on the process and mechanism of individual epileptic discharges, and effective treatment methods and means are quite scarce. Therefore, it is necessary to fully study the pathological changes of epilepsy and seek better treatments. is imminent. [0003] The basic pathological changes of epileptic seizures include neuronal damage, synaptic sprouting, synaptic remodeling in the hippocampus, and infla...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/20A61P25/08
CPCA61K38/20
Inventor 陈溪萍高原陶陆阳
Owner SUZHOU UNIV
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