31 results about "Epilepsy treatment" patented technology

The invention discloses an epilepsy activity detecting method and system based on functional imaging. The detecting method comprises the following steps of S1, selecting an object to be researched; S2, performing MRI, EEG and PET data acquiring; S3, performing data processing and analysis; and S4, constructing an epilepsy activity detecting system. The detecting method and system are mainly in accordance with respects of positioning detection of epilepsy activity, description of a propagation network of epilepsy activity, establishment of an epilepsy multimodality image database and the like,imaging evaluating indicators are provided for epilepsy activity positioning and propagation, expected results have important assistant directive function for clinical diagnosis and selection of treatment schemes and operation schemes of epilepsy, the clinical diagnosis capacity for epilepsy positioning is improved, and the epilepsy treatment effect is increased.

The invention discloses a closed-loop system used for epilepsy treatment. The closed-loop system includes an electroencephalogram signal amplification module, a control unit, a stimulation module and a video module, wherein the electroencephalogram signal amplification module is used for collecting an electroencephalogram signal of a target to be detected; the state of the electroencephalogram signal is judged by the control unit, and the control unit controls the stimulation module to generate pulse current to stimulate the target to be detected to restrain epileptic seizure and further, closed loop regulation and control can be realized. The closed-loop system has the following functions: multichannel data with high sampling frequency can be obtained in a real-time manner through an amplifier, real-time drawing is carried out, epilepsy early warning is realized based on electroencephalogram signals, and epilepsy can be automatically restrained through electrostimulation with designated parameters after early warning. The invention provides a close-loop electrostimulation treatment system for patients suffering from intractable epilepsy, and the closed-loop system effectively reduces frequency of epileptic seizure, alleviates the intensity of epileptic seizure, and improves the living quality of patients.

The invention provides a multi-channel wireless closed-loop electrical nerve stimulation system for treating epilepsy. According to the multi-channel wireless closed-loop electrical nerve stimulationsystem, collecting electrodes and stimulation electrodes are implanted in multiple areas of the cerebral cortex or the deep brain region to collect and monitor electrical nerve physiological signals of the areas in real time, then, multi-dimension characteristics such as the time domain, the frequency domain and the complexity of the electrical nerve signals are extracted, the obtained characteristics are used as input of an individual two-stage classifier to detect epilepsy signals in real time, and electrical stimulation is applied to the corresponding epileptic seizure area according to thedetected result to inhibit epileptic seizure. Compared with a conventional system for treating epilepsy, the multi-channel closed-loop electrical nerve stimulation system has the advantages that detecting and treating are conducted in multiple areas, an epilepsy detection algorithm is high in performance and low in power consumption, and side effects brought by additional electrical stimulation are reduced; a good platform is provided for exploration and implementation of multi-area nerve loop electrical stimulation on treatment of epilepsy, and novel clinical epilepsy treatment equipment isexpected to be developed.

The invention discloses a targeted nano-magnetic resonance contrast agent for brain epileptic foci, preparation and application thereof. The magnetic resonance contrast agent comprises a target functional molecule, a fluorescent marker and a nano-carrier. The target functional molecule is short peptide that has high affinity to epileptic focus area high expression P-glycoprotein. The fluorescent marker is encapsulated in the nano-carrier by means of covalent connection, and the short peptide is in connection with polyethylene glycol on a nanoparticle surface through covalent connection. The contrast agent can combine the short peptide with the epileptic focus area high expression P-glycoprotein through intravenous injection, promotes gathering of the nano-carrier at epileptic foci, and makes MRI T2 weighted imaged focus area show significant low signal, thereby accurately and visually display idiopathic / cryptogenic epilepsy foci. The contrast agent is conducive to clinical improvement of the treatment accuracy and safety, evaluation of the efficacy of anti-epilepsy treatment means, and assessment of the prognosis of epilepsy patients.

A method of building a machine learning pipeline for predicting the efficacy of anti-epilepsy drug treatment regimens is provided. The method includes providing electronic health records data; constructing a patient cohort from the electronic health records data by selecting patients based on a defined target variable indicating anti-epilepsy drug treatment regimen efficacy; constructing a set features found in or derived from the electronic health records data; electronically processing the patient cohort to identify a subset of the features that are predictive for anti-epilepsy drug treatment regimen efficacy for inclusion in predictive models configured for generating predictions representative of efficacy for a plurality of anti-epilepsy drug treatment regimens; and training the predictive computerized model to generate predictions representative of efficacy for a plurality of anti-epilepsy drug treatment regimens for the patients based on the defined target variable indicating anti-epilepsy drug treatment regimen efficacy.

The invention discloses a sleep apnea prevention system used during the epilepsy treatment process. The system comprises a pneumogastric nerve stimulator and an upper airway muscle stimulator, wherein the pneumogastric nerve stimulator comprises a first electrode, a first pulse generator, a respiration parameter collecting device, a first processor and a first communication module, and the first electrode winds the pneumogastric nerve; the upper airway muscle stimulator comprises a second pulse generator, a second processor, an awakening module, a second electrode and a second communication module, and the second electrode is positioned at the upper airway muscle. According to the system, through communication and control over the two implanted stimulators, the purpose of preventing apnea generated by a patient during sleep in the treatment process of epilepsy is achieved.

The invention discloses an application of interleukin33 in the preparation of epilepsy treatment drugs. Action and potential mechanisms of the interleukin33 on epileptic newborn mice are disclosed, and a new technological means is provided for clinic treatment of neonate epilepsy.

The invention discloses a traditional Chinese medicine preparation for treating epilepsy and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is characterized by being prepared from the raw materials of buthus martensi karsch scorpion, tabasheer, bile arisaema, gastrodia tubers, lapis chloriti, cicada slough, prepared rehmannia roots, incised notopterygium rhizomes or roots, divaricate saposhnikovia roots, ephedra sinica stapf and licorice roots. The preparation method comprises the following steps: pretreating the preparation raw materials, then crushing the pretreated preparation materials so as to obtain medicinal powder, screening the medicinal powder with a 100-mesh sieve, performing uniform mixing, then charging the uniformly mixed medicinal powder into capsules according to 0.45 g / capsule, and performing bottling and packaging so as to obtain finished products. Through clinical verification, the traditional Chinese medicine preparation is remarkable in epilepsy treatment effect, and has an extremely good effect of treating excessive phlegm-fire inside type epilepsy after determination. In addition, the evaluation of the traditional Chinese medicine preparation on use safety, untoward reactions and contraindications is better than that of drugs sold in the market. The traditional Chinese medicine preparation is simple in preparation method, easy to operate and convenient in industrialized production and popularization.

The invention discloses an epilepsy treatment medicine. The medicine comprises, by weight, 1-5 parts of rutin, 6-14 parts of resveratrol, 11-19 parts of cuscohygrine and 15-23 parts of aminophylline. The medicine is prepared through the following steps: mixing and grinding resveratrol and cuscohygrine, adding an aminophylline solution, carrying out stirring treatment at 52 DEG C for 30-33 min, carrying out ultrasonic treatment at 45 DEG C under an ultrasonic power of 700 W for 20 min, adding the rutin, carrying out microwave treatment under a microwave power of 800 W for 3 min, stirring the obtained mixture at 63 DEG C until the mixture is dryness, and granulating the dry mixture. The medicine is used for treating epilepsy, reaches the purpose of treatment of both symptoms and root causes, has the advantages of fast effect, good long-term effect, difficult recurrence, no toxic or side effects, no allergic reactions, high cure rate and low price, and can be easily accepted by patients.

The invention relates to new application of drugs, and provides application of fructose in antiepileptic drug preparation. A LiCl-Pilo epileptogenic rat model is utilized for carrying out a blind method pharmacodynamic test on five kinds of different drugs including the fructose, fructose diphosphate, sodium valproate sustained release tablets, fructose diphosphate+fructose (1:1) and fructose diphosphate+fructose (1:1), and a result indicates that the fructose is superior to the other drugs, the anti-epileptic effect of the fructose is more excellent than that of the fructose diphosphate, and the anti-epileptic effect of independent use of the fructose is more excellent than that of fructose and fructose diphosphate combination drugs. The fructose can be used for preparing the anti-epileptic drugs, new drugs are provided for epilepsy treatment, the fructose is used for preparing the anti-epileptic drugs, active ingredients are single, the medical dosage is reduced, the toxic and side effect is small, the drugs can be taken by a patient conveniently, and great clinical application value is achieved.

The invention provides a 3-acylamino-N-arylbenzamide compound and pharmaceutically acceptable salt thereof. The synthesis of the compound is divided into different synthetic blocks by adopting a convergent synthetic route and a target compound can be quickly prepared in batches through docking combination. The experiment proves that the compound provided by the invention has the advantages that the epileptic seizure latency induced by pentylenetetrazol can be significantly prolonged and the grade and mortality rate of epileptic seizures are reduced; a threshold of epileptic seizure induced bymaximum electroshock can be significantly increased and the mortality rate is reduced; in addition, a seizure threshold of refractory epilepsy can be obviously increased; besides, no obvious toxic orside effects are found, which indicates that the 3-acylamino-N-arylbenzamide compound can relieve or control epileptic seizures or even has a certain therapeutic effect on the refractory epilepsy which cannot be effectively treated by traditional drugs, so that the compound can be applied to the preparation of antiepileptic drugs. The compound disclosed by the invention has the advantages of easily-obtained raw materials for synthesizing, simple operation, high process scalability, suitability for industrial production and capability of providing a novel drug for epilepsy treatment. The structure of a general formula I is shown in the description.

The invention discloses a traditional Chinese medicinal composition for treating epilepsy and a preparation method thereof, and belongs to the technical field of epilepsy treatment. The composition is mainly prepared from the raw materials in parts by weight: 5-50 parts of divaricate saposhnikovia roots, 10-50 parts of mint, 5-50 parts of herba schizonepetae, 10-100 parts of notopterygium, 5-50 parts of radix angelicae pubescentis, 5-50 parts of fructus forsythia, 3-30 parts of asarum, 5-150 parts of liquorice and 5-50 parts of red peony roots. The method comprises the following steps of (1) weighing raw materials and selecting, cleaning and airing the raw materials; (2) steaming, naturally cooling and then drying the raw materials; and (3) mixing the dried raw materials evenly and crushing to obtain the powdery raw material, adding refined honey water to the powdery raw material for stirring evenly to prepare a tablet, a granule, a pill or an oral liquid. The invention aims at providing the traditional Chinese medicinal composition for treating epilepsy, which is scientific in compatibility and convenient to eat and has a function of strengthening internal organs, and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is used for treating epilepsy.

The invention belongs to the technical field of pharmacy, and particularly relates to a method for treating epilepsy by a traditional Chinese medicine composition containing CBD (cannabidiol). The method comprises the following steps: firstly, determining composition and components by weight of the traditional Chinese medicine composition, and extracting industrial hemp raw materials from the traditional Chinese medicine composition independently to obtain a high-purity CBD extract; mixing and extracting the rest traditional Chinese medicines and performing decoction three times; mixing decoctions, concentrating the decoctions into thick paste, adding the CBD extract, uniformly stirring the mixture, and performing vacuum drying at low temperature; pulverizing a product, performing sieving to obtain fine powder, adding a wetting agent to prepare a soft material, granulating the soft material, and performing filling to form capsules. According to Provisions for New Drug Approval and The Technical Guidelines for the Acute Toxicity test of traditional Chinese Medicine and Natural Medicine, the traditional Chinese medicine composition containing CBD is subjected to acute toxicity experiment evaluation, safety of the traditional Chinese medicine composition is determined, actual case analysis shows that the traditional Chinese medicine composition has a remarkable effect on epilepsy treatment and is widely applicable to people.

The invention discloses a novel epilepsy treatment drug preparation device. The preparation device comprises a transverse motion device, a photoelectric device, a lifting device and a clamping device,wherein the photoelectric device is arranged on the transverse motion device, the lifting device is arranged at the lower end of the transverse motion device, and the clamping device is connected tothe lower end of the lifting device; and the transverse motion device comprises a first matrix, a transverse motion electric motor is fixedly arranged in the left side end surface of the first matrix,a transverse motion screw rod is in power connection with the left end of the transverse motion electric motor, a first sealing ring is arranged between the transverse motion screw rod and the left side end surface of the first matrix, a second matrix is arranged on the left side of the first matrix, the left end of the transverse motion screw rod is rotatably and cooperatively connected to the right side end surface of the second matrix through a bearing, a guiding rod is fixedly arranged on the upper side, between the opposite end surfaces of the first matrix and the second matrix, of the transverse motion screw rod, and a threaded block is connected to the transverse motion screw rod in a threaded cooperation manner.

The invention discloses a novel epilepsy treatment drug preparation device. The preparation device comprises a transverse motion device, a photoelectric device, a lifting device and a clamping device,wherein the photoelectric device is arranged on the transverse motion device, the lifting device is arranged at the lower end of the transverse motion device, and the clamping device is connected tothe lower end of the lifting device; and the transverse motion device comprises a first matrix, a transverse motion electric motor is fixedly arranged in the left side end surface of the first matrix,a transverse motion screw rod is in power connection with the left end of the transverse motion electric motor, a first sealing ring is arranged between the transverse motion screw rod and the left side end surface of the first matrix, a second matrix is arranged on the left side of the first matrix, the left end of the transverse motion screw rod is rotatably and cooperatively connected to the right side end surface of the second matrix through a bearing, a guiding rod is fixedly arranged on the upper side, between the opposite end surfaces of the first matrix and the second matrix, of the transverse motion screw rod, and a threaded block is connected to the transverse motion screw rod in a threaded cooperation manner.

The invention discloses an application of borneol in preparing an epilepsy treatment drug, mainly an application of the borneol in combination with western medicine which has a therapeutical effect in epilepsy in preparing the epilepsy treatment drug. The invention also discloses the drug comprising the borneol. The drug comprises the western medicine and the borneol, the borneol content is 1 to 10 g when the western medicine content is one third to one time of single dosage of the western medicine in treating the epilepsy. According to the application of the borneol in preparing the epilepsy treatment drug, a new application of the borneol is discovered, the western medicine absorption is increased, the western medicine is prompted to enter blood-brain, the western medicine concentration entering the blood-brain is prompted, the treatment effect of the western medicine is improved, meanwhile accumulation of the western medicine at the periphery of a brain is reduced, adverse effects are reduced, and accordingly the dosage of the western medicine is reduced to be one third of the original dosage, the adverse effects are further reduced, economical burden of a patient is reduced, pain from the adverse effects are reduced, and a patient is easy to accept.

The invention belongs to the field of traditional Chinese medicinal preparation and provides a medicine for treating epilepsy. The medicine for treating the epilepsy comprises poria with hostwood, tabasheer, polygala tenuifolia, cinnabar, acorus tatarinowii, selfheal, curcuma aromatica, pheretima aspergillum, dragon bone, white paeony root and salviae miltiorrhizae. The medicine for treating the epilepsy has the beneficial effects of quick effect, low toxic or side effect and ideal epilepsy treatment effect.

The invention discloses a traditional Chinese medicine formula for treating primary epilepsy and a preparation method thereof, and the traditional Chinese medicine formula comprises the following components by weight: 30 g of borax, 10 g of compound of glauber-salt and liquorice, 3 g of borneol and 3 g of cinnabar. The traditional Chinese medicine is used for treating epilepsy, side effects can be avoided, the epilepsy treatment effect is good, and the traditional Chinese medicine is low in cost, high in practicability and suggested to be used and popularized.

The invention discloses application of alpinia zerumbet essential oil. The application specifically refers to application of the alpinia zerumbet essential oil in preparation of drugs or health products for treating and preventing central nervous system diseases. It is found for the first time that the alpinia zerumbet essential oil can improve symptoms of animals with nervous system diseases such as epilepsy in a zebra fish in-vivo model, when the concentration of the alpinia zerumbet essential oil ranges from 1 microgram / ml to 6 microgram / ml, the anti-epilepsy treatment efficiency is increased along with increase of the concentration, concentration dependence is shown, and EC50 is 2.86 microgram / ml. The present invention has good lipid solubility, is easy to pass through the blood brain barrier, thus having the characteristics of increased or improved toxicological safety (i.e. Reduced toxicity), increased or improved metabolic stability, longer half-life or less side effects, while producing similar or increased biological activity.

The invention provides an epilepsy treatment instrument and a control method thereof. The epilepsy treatment instrument comprises an electroencephalogram monitoring module, a current perfusion module,an analysis and control module and a power module; the electroencephalogram monitoring module comprises potential detection electrodes, each potential detection electrode is correspondingly providedwith a voltage amplification circuit, and the output ends of the potential detection electrodes are connected with the input ends of the voltage amplification circuits; the current perfusion module comprises direct current perfusion devices, each direct current perfusion device comprises a first electrode, a second electrode and a direct current microcurrent generation device, the first electrodesare connected with the positive poles of the direct current microcurrent generation devices, and the second electrodes are connected with the negative poles of the direct current microcurrent generation devices; the output ends of the voltage amplification circuits are connected with the input end of the analysis and control module, and the output end of the analysis and control module is in control connection with the direct current microcurrent generation devices; the power module supplies power to the electroencephalogram monitoring module, the current perfusion module and the analysis andcontrol module. The epilepsy treatment instrument is used for treating the epilepsy disease and can reduce the damage of epilepsy treatment to the brain nervous system.

The invention provides a traditional Chinese medicine composition and application thereof, a medicine containing the composition for epilepsy treatment and a preparation method. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 5-15 parts of moth cocoon, 8-10 parts of calculus bovis, 50-70 parts of tabasheer, 85-95 parts of radix curcumae, 10-20 parts of cinnabaris and 40-50 parts of alumen. The traditional Chinese medicine composition provided by the invention can be applied to preparing the epilepsy treatment medicine. The prepared epilepsy treatment medicine provided by the invention can effectively reduce epileptic seizure of a pilocarpine rat and improve cognition, and the toxic and side effects of the medicine are small, so that the damage to neurons can be effectively reduced.

The invention relates to a midazolam and sodium valproate medical composition and a preparation method thereof, and belongs to the technical field of pharmaceutical science and pharmaceutics. According to the midazolam and sodium valproate medical composition, main medicines are sodium valproate and midazolam, auxiliary materials are alkoxy polyethylene glycol and medical auxiliary materials, wherein the midazolam can be replaced with midazolam medical salt, and the preparation formulation of the medical composition is aerosol. According to the midazolam and sodium valproate medical composition, two traditional epilepsy treatment medicines including the sodium valproate and the midazolam are combined, and the aerosol is prepared for emergency treatment when epilepsy breaks out; and throughnasal administration, the midazolam and sodium valproate medical composition takes effect quickly and is convenient to use, and safety and validity of separated administration of the sodium valproateand the midazolam can be effectively improved.

The present invention provides methods related to Wolf-Hirschhorn syndrome (WHS), in particular to a 197 kbp chromosomal deletion useful for selecting a patient for anti-seizure therapy (e.g., cannabidiol, vitamin B6, and butyrate), for selecting a particular anti-seizure therapy, and for predicting the response of a subject to a particular anti-seizure therapy.

The invention discloses an epilepsy treatment drug and a preparation method thereof. The drug is prepared from rhizoma typhonii, herba asari, rhizoma coptidis, radix et rhizoma rhei, dragon bone, concha ostreae and radix angelicae sinensis in a certain weight ratio. The drug has functions of dispelling wind phlegm, relieving muscular spasm, removing heat toxins, eliminating indigestion, replenishing and harmonizing blood, regulating the middle warmer, relieving spasm, removing stasis and moisturizing pathogenic dryness to loosen the bowel, and takes effect quickly and has good curative effectwhen used for treating epilepsy, and epilepsy relapse is prevented.

The invention relates to an epilepsy treating drug, which is characterized by comprising 5 g of scorpion, 10 g of periostracum cicadae, 10 g of bombyx batryticatus, and 1 g of centipede. The production method comprises that the epilepsy treating drug is taken through water decoction, and one dose of the epilepsy treating drug is taken a day. According to the present invention, with the epilepsy treating drug, the problems of high side effect, addiction, long treatment time, high recurrence rate after drug discontinuance, incapable cure and the like of the existing epilepsy treating drug are solved, and the epilepsy treating drug of the present invention is suitable for epilepsy treatment.

The invention discloses a Chinese patent medicine for treating epilepsy. The Chinese patent medicine is prepared from, by weight, 10-18 parts of Solidago decurrens, 8-14 parts of Radix Melastomae, 8-16 parts of dahurian angelica root, 6-14 parts of Radix Angelicae Pubescentis, 6-12 parts of fructus cnidii, 5-12 parts of pearl powder, 5-10 parts of aconite root, 5-12 parts of Poria cocos, 5-10 parts of gecko, 3-8 parts of hemp seed, 3-8 parts of radix bupleuri, 3-10 parts of dragon's blood, 4-10 parts of coix seed, 2-8 parts of Bauhinia championii Benth and 1-5 parts of white paeony root. The Chinese patent medicine can promote epilepsy treatment and restoration through inducing resuscitation, activating blood circulation, dissipating blood stasis, cooling blood and stopping bleeding, and clinic practices prove that the Chinese patent medicine has a very good curative effect.

The invention discloses a traditional Chinese medicine for treating epilepsy. The traditional Chinese medicine comprises, by weight, 12 to 15 parts of grassleaf sweetflag rhizome, 15 parts of bile arisaema, 12 to 15 parts of turmeric root tuber, 15 parts of red sage root, 12 parts of nutgrass galingale rhizome, 6 to 8 parts of scorpion, 12 to 15 parts of stiff silkworm, 1 part of bezoar, 18 to 20 parts of hawkbill turtle, 12 to 15 parts of earthworm, 12 to 15 parts of tall gastrodia tuber, 15 to 20 parts of fried jujube kernel, 12 parts of processed rhizoma pinelliae and 20 parts of felwort. The traditional Chinese medicine has effects of eliminating phlegm and dredging orifices, relieving dizziness and convulsion, clearing liver and purging fire, sweeping phlegm and stopping epilepsia, promoting blood circulation to remove blood stasis, eliminating phlegm and dredging collaterals, restoring consciousness and invigorating spleen, and eliminating phlegm and calming nerves, and has satisfactory epilepsy treatment effects.