11 results about "Epilepsy treatment" patented technology

The invention discloses a closed-loop deep brain regulation and control system for epilepsy treatment, and the system comprises an electroencephalogram signal collection module which collects neural electrophysiological signals in real time by implanting a recording electrode in a cerebral cortex or hippocampal brain area; the electroencephalogram signal real-time analysis module is used for outputting the epileptic seizure period prediction probability xi through a seven-layer full-connection neural network based on the 33-dimensional feature vector so as to realize epileptic seizure early warning; when the zeta is greater than or equal to a threshold value, the electrical stimulation regulation and control module is used for triggering electrical stimulation, filtering out a frequency band required to be regulated and controlled according to filtering, calculating and predicting electrical stimulation intensity and then correcting and outputting pulse stimulation, so that personalized electrical stimulation regulation and control are carried out on a specific frequency band, and detection is continuously carried out until the frequency band becomes normal; and the medicine intervention module is used for triggering a micro-injection pump to carry out medicine infusion through a pulse signal. According to the system, epilepsy treatment is improved from empirical parameter adjustment to accurate regulation and control based on real-time nerve physiological signals, and a safer and more effective treatment choice is provided for a drug-refractory epilepsy patient.

This invention discloses a method for locating epileptogenic zones based on high-frequency oscillations and connectivity, comprising the following steps: 1. Acquiring SEEG data and selecting representative channels; 2. Filtering to acquire 54-200Hz signals and selecting baseline and target data; 3. Acquiring normalized high-frequency energy; 4. Calculating time and energy coefficients to obtain a high-frequency epileptogenicity index; 5. Filtering to acquire 12-45Hz signals; 6. Calculating nonlinear regression analysis; 7. Calculating total intensity; 8. Defining and calculating the connectivity high-frequency epileptogenicity index and evaluating performance. This invention can accurately locate epileptogenic zones in patients with different seizure patterns, and has potential application value in epilepsy treatment.

The invention discloses an epilepsy treatment system based on traditional Chinese medicine time medicine. The epilepsy treatment system comprises a time conversion module used for converting Beijing time input by a user into corresponding ancient twelve hours; the pathological model database is used for storing a corresponding relationship between epileptic seizure hours and disease meridians recorded on the basis of 'Shenzhou Qianjinjin prescription. Fright epilepsy' in Tang Grandsi to form a pathological model which completely covers twelve hours; the five-acupoint compatibility module is used for automatically calling five-element attributes of the well acupoint, the spring acupoint, the delivery acupoint, the meridian acupoint and the he acupoint and reinforcing and reducing rules according to a disease meridian and hour matching result, and generating a recommended acupoint selection scheme; the user interaction interface is used for providing an input box to receive the Beijing time of disease attack of the patient, and an output interface displays disease meridian names and acupuncture points, the optimal time selection time range and a five-acupuncture-point list. The method can be used for personalized treatment of epilepsy.

The invention belongs to the technical field of electrophysiological signal detection, and particularly relates to an electrical stimulation system, nerve regulation and control equipment and epilepsy treatment equipment. The electrical stimulation system includes: a classifier; the input end of the classifier is input characteristics of signals after electrical stimulation, and the output end of the classifier is classification results of electrical stimulation effectiveness; wherein the input characteristics comprise the stimulation channel proportion of the attack energy change before and after the electrical stimulation and / or the condition that the stimulation channel covers the strong connection node. The stimulation mode and the stimulation effect are associated and bound according to the data characteristics of the electroencephalogram signals, the effectiveness of the stimulation mode can be effectively predicted in vitro or before equipment implantation, and then the stimulation mode is adjusted.

The purpose of this invention is to provide a new treatment method for epilepsy that solves the problems of current epilepsy treatment and has long-term effects. The present invention is a method of treating a disease, comprising inducing hypothermia or hypometabolism in a subject. Thermoregulatory or metabolic regulatory neurons are stimulated in the step of inducing hypothermia or hypometabolism in the subject. Q neurons are stimulated in the step of inducing hypothermia or hypometabolism in the subject.

The invention discloses a limb restraint device for epilepsy treatment, and belongs to the technical field of epilepsy treatment, the limb restraint device comprises a treatment bed, a bed plate is mounted on the surface of the treatment bed, and a neck restraint mechanism for restraining the neck of a patient is mounted on the surface of the bed plate; two big arm restraining mechanisms for restraining the big arms of a patient are installed on the surface of the bed board, a forearm restraining mechanism for restraining the forearms of the patient is installed on one side of each big arm restraining mechanism, and a leg restraining mechanism for restraining the legs of the patient is installed on the surface of the bed board; a waist restraining mechanism used for restraining the waist of a patient is installed on the surface of the treatment bed, a rubber headrest is arranged on one side of the neck restraining mechanism, and a plurality of self-locking type universal wheels are installed at the bottom of the treatment bed. On the basis of assisting treatment of the epilepsy patient, the limbs, the waist and the neck of the patient can be fixed and limited, and adjustment can be carried out according to different figures of the patient.

The present application relates to a kind of novel Hedgehog signal pathway inhibitor and preparation method thereof, the Hedgehog signal pathway inhibitor has the structure shown in formula (I).The Hedgehog signal pathway inhibitor of the present application can effectively inhibit SMO receptor activity, and block SHH signal pathway. With good effect of blocking the seizure caused by excessive or super-synchronous neuron discharge in brain. As epilepsy treatment candidate drug has good application prospect.

The present application belongs to the technical field of physiological electrical signals, and particularly relates to a method for adjusting model parameters based on electroencephalogram signals and an epilepsy treatment device. First, a loss factor is obtained according to the phase state of training data, that is, a missed detection rate and a detection delay time are obtained according to seizure period data, a false alarm number is obtained according to inter-period data, and an alarm time is obtained according to pre-seizure data. Then, based on the loss factor, candidate parameters are obtained. Finally, the parameters of the detection model are adjusted according to the candidate parameters. The loss factor is combined with the phase state of the data, and then the parameters of the model are trained. According to the detection requirements, the phase state of the data sample and the adaptive detection model can be selected, so that the model parameters and the data characteristics are more matched, and the weight of the sample category does not need to be considered.

The invention is suitable for the technical field of epilepsy treatment, and provides a Chinese herbal medicine formula for epilepsy treatment and a preparation method, the Chinese herbal medicine formula comprises moxibustion components and wine-processed components; the moxibustion component comprises sinomenium acutum, dogwood and tuber fleeceflower stem; the wine-processed components comprise longhorn beetles and rice wine; the preparation method comprises the following steps: S1, taking whole sinomenium acutum, dogwood and tuber fleeceflower stem according to the proportion, mixing and drying; s2, cutting: cutting into slices according to a 0.1 mm standard, placing the slices in an outdoor leguminous crop field at night, drying the slices in a shady and dry place in the daytime without being exposed to rain for two weeks continuously, and finally airing the slices for later use; s3, taking a proper amount of the raw medicine, adding the raw medicine, boiling with low fire, and concentrating to obtain a moxibustion component; and S4, taking a part of longhorn beetles, adding rice wine, and soaking for seven days to obtain the wine-processed component. The prepared Chinese herbal medicine formula can replace traditional western medicine products, long-term medicine taking is not needed, the cure rate is 95% or above, and no side effect exists.

The present invention relates to a lidocaine hydrochloride nasal composition associated with pharmacologically acceptable components in a portion of 1 ml to 1.8 ml of a highly concentrated, stable, clear transparent solution, with concentrations of lidocaine hydrochloride varying from around 1000 mcg / 0.05 ml to around 1500 mcg / 0.05 ml per drop, with a pH varying between around 6.0 and around 7.0 and a viscosity varying from around 1 to 100 cps, said combination being suitable for systemic intranasal release, administered in drops or assisted devices - metered dose inhalers, mDIs, around (0.05 ml to 0.20 ml) or (0.0166 ml to 0.05 ml = 1 to 3) being the necessary minimum for a therapeutic effect. Use thereof is recommended for mammals heavier than 200 g.

The invention discloses a kit for predicting sodium valproate treatment response based on TPH2 gene polymorphism and a method and application thereof, and belongs to the technical field of individualized medication for children epilepsy treatment. The method comprises the following steps: S01, collecting a biological sample of a child epilepsy patient, and extracting genome DNA; s02, detecting the genotype of the rs4570625 site of the TPH2 gene in the genome DNA (Deoxyribose Nucleic Acid); s03, people suitable for sodium valproate treatment are selected according to the genotypes, and the GG genotype patients are suitable for sodium valproate standard dosage maintenance treatment; a non-GG genotype patient adopts an adjusted sodium valproate scheme or a sodium valproate substitute medicine. The invention further provides a corresponding kit and application. According to the invention, the TPH2 gene polymorphism is introduced into the prediction of the VPA treatment response of the child epilepsy, and the individualized medication of the VPA treatment of the child epilepsy is accurately guided.