161 results about "Thrombolysin" patented technology

The invention discloses a method for training a thrombolysis adaptability evaluation model and a related product. The method comprises the following steps: acquiring brain perfusion image data, a brain perfusion parameter map, clinical data and treatment data; performing region-of-interest extraction on the cerebral perfusion parameter map to obtain an attention map containing a core infarction region and an ischemic penumbra sensing region; multiplying the brain perfusion image data by the attention map to obtain weighted brain perfusion image data; the first labeling information and the second labeling information are used for labeling whether thrombolysis treatment is carried out or not and labeling the effect grade after thrombolysis treatment is carried out; and inputting the weighted brain perfusion image data, the brain perfusion parameter diagram, the clinical data, the first annotation information and the second annotation information into a thrombolysis adaptability evaluation model as training data so as to train the thrombolysis adaptability evaluation model. By utilizing the scheme disclosed by the invention, the thrombolysis adaptability and treatment effect prediction accuracy can be improved, and a more reliable basis is provided for clinical decision making.

The invention relates to the technical field of medical instruments, and discloses a vascular surgery clinical thrombolysis catheter fixing device which comprises a single-cavity tube, a fixing mechanism arranged at the top of the single-cavity tube and a clamping mechanism arranged on the outer side of the fixing mechanism. The fixing mechanism is used for fixing the skin of a patient and the top end of the single-cavity tube, and the clamping mechanism is used for fixing the tail end of the guide wire; the fixing mechanism comprises a connector arranged at the top of the single-cavity pipe, a sliding groove formed in the middle of the connector, two sliding blocks symmetrically arranged on the two sides of the sliding groove, telescopic units arranged at the bottoms of the sliding blocks and used for transmitting the acting force of the sliding blocks, a connecting plate arranged at the bottom of the sliding groove and two tension springs symmetrically arranged on the two sides of the connecting plate. By arranging the fixing mechanism, the device can be adjusted to adapt to the body surface so as to adapt to the joint, the neck or the groin and other areas, the fixing device can restrain the tail end of the guide wire, and axial sliding or radial deflection of the guide wire caused by external force interference is avoided.

The utility model relates to the technical field of medical instruments, and discloses a pigtail thrombolysis catheter which comprises a catheter body and a plugging piece. The far end part of the tube body is curled to form a drug delivery part, the far end of the drug delivery part is provided with a tube opening, and the drug delivery part is suitable for deforming under the action of external force and restoring after the external force is removed. The multiple through holes are formed in the tube wall of the drug delivery part at intervals. The plugging piece comprises a flexible guide wire and a ball body arranged at the far end of the flexible guide wire, and the flexible guide wire is suitable for extending into the pipe body to the ball body to plug the pipe opening. Through the administration part, physical thrombus breaking and medicine thrombolysis means can be combined, the thrombus breaking progress can be accelerated to a great extent, so that an ideal clinical effect is achieved, the use mode of the tube body and the plugging piece is simple, the thrombolysis difficulty is reduced, meanwhile, the consumable cost is also reduced, and the application range is wide. And the method has good economical efficiency and potential of being suitable for wide popularization.

The invention relates to the technical field of thrombus mining robots, in particular to a micron robot with an asymmetric cilia structure, a preparation method and application. The micro-robot is of an asymmetric composite structure and is composed of a smooth hemisphere and a cilia-shaped structure, sandwich type layered arrangement of a PLGE cilia-shaped nano structure, an MNPs interlayer and a PS sphere core is formed on the surface and the interior of the micro-robot from outside to inside, and cooperative regulation and control of morphology and functions are achieved by regulating and controlling the material proportion of PS and PLGE. The thrombus mining robot shows an efficient thrombolysis effect in a plurality of in-vitro and in-vivo models, and rapid fibrinolysis, deep thrombus penetration and efficient mining of single red blood cells are realized, so that the limitation of a traditional thrombolysis agent is overcome. In addition, the thrombus digging robot has excellent biocompatibility and biological safety, has no obvious cytotoxicity or damage to main organs, and supports the safety of the thrombus digging robot in clinical application.

The invention discloses a balloon catheter pressure applying device for thrombus treatment and vascular embolism, and relates to the technical field of medical instruments, the balloon catheter pressure applying device comprises a first catheter, the first catheter is sleeved with a second catheter, the front end of the second catheter is fixedly connected with a memory metal net bag, the second catheter is sleeved with a third catheter, and the third catheter is fixedly connected with a memory metal net bag. A fourth catheter is fixedly connected to the outer side of the third catheter, a rear balloon is fixedly connected to the outer side of the front end of the air delivery pipe, an exhaust head is fixedly connected to the front end of the first catheter, a front balloon is fixedly connected to the outer side of the exhaust head, and a thrombus removing assembly used for assisting in removing thrombus is arranged on the outer side of the front end of the first catheter. According to the thrombus treatment vascular embolism balloon catheter, the thrombus dissolving medicine in the medicine storage balloon membrane is squeezed out through the pressure applying device, the thrombus dissolving medicine can penetrate through the memory metal net bag to move to the embolism position, thrombus is dissolved, and the thrombus can be better removed through cooperation with the thrombus removing assembly.

Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and / or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase.

The invention relates to the technical field of thrombolysis drug delivery instruments, and discloses an expandable thrombolysis stent and a thrombolysis device.The expandable thrombolysis stent is characterized in that a stent body which is formed by connecting a plurality of drug catheters in parallel and is in a quasi-cylindrical shape is arranged on the periphery of a central tube of a first slender tubular component; according to the expandable thrombolysis stent and the thrombolysis device, when thrombolysis medicine is poured, the expandable stent main body can be expanded in a thrombus, so that the thrombolysis medicine can be injected into the thrombus, and the thrombus can be injected into the thrombolysis medicine through the medicine catheter, and the thrombolysis medicine can be injected into the thrombus through the medicine injection through holes. Therefore, medicine perfusion can be carried out at the optimal position, full contact with thrombus is carried out, the thrombolysis efficiency is further improved, and efficient thrombolysis is achieved. According to the expandable thrombolysis stent and the thrombolysis device, when thrombolysis medicine is perfused, various thrombolysis point positions can be provided for thrombus due to the fact that the medicine injection through holes are formed in the medicine catheter, and therefore the thrombolysis targeting performance and efficiency are improved.

The invention provides an ultrasonic thrombolysis treatment device. The ultrasonic thrombolysis treatment device is in a strip shape, and in the using state, the ultrasonic thrombolysis treatment device is spirally wound around the outer wall of a blood vessel section (100) where thrombus is located; or the ultrasonic thrombolysis treatment device is formed into a plane shape, the ultrasonic thrombolysis treatment device wraps the outer wall of the blood vessel section (100) in the using state, the ultrasonic thrombolysis treatment device comprises a plurality of piezoelectric modules (200) which are arranged in a scattered mode, the piezoelectric modules (200) can be controlled to emit ultrasonic waves, and the ultrasonic thrombolysis treatment device is used for treating the blood vessel section (100). The ultrasound is enabled to be emitted from a plurality of locations in a focused manner into the vessel section (100) to ablate the thrombus.

The invention relates to the technical field of food processing, and particularly discloses a heart and cerebral vessel health care composition with thrombolytic and antithrombotic functions and a preparation method thereof. The composition consists of the following raw materials: sorbitol, red yeast rice, freeze-dried natto powder, earthworm protein peptide, vitamin C, American ginseng peptide, magnesium stearate, an angelica sinensis extract, rice bran fatty alkanol, vitamin B1, vitamin B2, a turmeric extract and a compound coloring agent. The preparation method comprises the following steps: mixing the raw materials except magnesium stearate in a double-cone mixer; magnesium stearate is added for continuous mixing, and a hollow capsule shell is filled with the mixed material. The composition disclosed by the invention forms a multi-dimensional synergistic system for smoothing blood vessels, purifying blood and improving blood flow, the defect of single effect of an existing product is overcome, the health-care effect of heart and cerebral vessels is remarkably improved, and the effect is stable and controllable; in addition, the preparation method has the advantages of being simple and controllable in process and suitable for industrial production.

The present invention provides a nanoscale MOF with pH-responsive function for targeted dual-drug thrombolysis and a preparation method thereof. Hollow mineralized nanoscale calcium carbonate powder is mixed with γ-cyclodextrin and a potassium ion compound, ultrasonically dispersed, and then incubated to form a cyclodextrin MOF embedded with calcium carbonate. An RGD polypeptide is grafted onto the surface of the cyclodextrin MOF embedded with calcium carbonate to obtain MOF-RGD. The grafted MOF-RGD is impregnated into ethanol containing an anticoagulant drug, air-dried, and then mixed with a thrombolytic drug, so that the thrombolytic drug is loaded on the surface of the nanoscale MOF to obtain a pH-responsive targeted nanoscale MOF. The present invention forms a nanoscale MOF with a targeted function, which combines thrombolysis and anticoagulation, and realizes the treatment and prevention of deep vein thrombosis.

The application discloses a four-stage paddle thrombus-removing micro robot, a preparation method and a magnetic field driving thrombus-removing micro robot system, relates to the technical field of micro robots, and comprises a conical drill bit, a main straight rod and a four-stage paddle group, wherein the conical drill bit is made of a biodegradable material; the bottom of the conical drill bit is connected with the main straight rod; the main straight rod is internally provided with a thrombolytic drug; the four-stage paddle group is arranged on the outer circumferential surface of the main straight rod in an axial direction; the paddle group comprises three paddle blades which are centrally symmetrical to the axis of the main straight rod; the paddle blades in the adjacent two-stage paddle groups are arranged in a staggered manner; the paddle blades are of a round head structure; the thickness of the paddle blades gradually increases from outside to inside; and the surface of the micro robot is coated with a magnetic film and is subjected to directional magnetization treatment. The application can obtain strong movement ability and stable movement state under the accurate control of a movement system, realizes intravascular drilling and crushing of a thrombus, and can biodegrade and release the thrombolytic drug after surgery, so as to solve the problem of downstream vascular embolism after drilling.

The utility model relates to the field of thrombolysis treatment boxes, and discloses a movable thrombolysis treatment box which comprises a box body, two drawers are connected in the box body in a sliding mode, two cabinet doors are connected to the front side of the box body in a rotating mode, a sharp instrument box is connected in the box body in a rotating mode, and a pull rod is connected to the rear side of the sharp instrument box in a rotating mode. A pressing rod is rotatably connected to the front side of the pull rod, a bottom plate is rotatably connected to the bottom of the pressing rod, the front side of the bottom plate is rotatably connected to the bottom of the sharp instrument box, inner shells are rotatably connected to the left side and the right side of the inner wall of the sharp instrument box, sliding rods are slidably connected to the interiors of the inner shells, and first baffles are fixedly connected to the tops of the sliding rods. According to the sharp instrument box, the pull rod is lifted to drive the pressing rod to downwards press the bottom plate, and the sliding rod is pulled to enable the baffle plate I to compress the spring I, so that sharp instruments in the sharp instrument box can be quickly emptied, time and labor are saved, the working efficiency is effectively improved, and the whole sharp instrument box is prevented from being taken out.

The invention provides a liquid phase tandem time-of-flight mass spectrometry detection method for the content of tirofiban in liver tissue, and belongs to the technical field of detection. According to the present invention, the concentration of tirofiban in the liver tissue is detected through the liquid phase tandem time-of-flight mass spectrometry, such that the characteristics of low detection limit, immediate analysis, high sensitivity, good repeatability, good indoor reproducibility and high accuracy are provided, the matrix effect is substantially reduced, the recovery rate is improved, and the precise detection of tirofiban is achieved. The method is successfully applied to detection of tirofiban in liver tissues in a clinical animal experiment stage, has important clinical significance for monitoring the in-vivo content of tirofiban after medication, avoids occurrence of postoperative related complications in serious interventional therapy, and has a good clinical application prospect. And side effects such as poor thrombolysis effect caused by insufficient medication and bleeding caused by excessive medication are prevented.

The invention provides a cobalt-iridium metal complex, nanoparticles, a preparation method and application, and belongs to the technical field of photodynamic therapy drugs. The structural formula of the cobalt-iridium metal complex is shown as a formula (I). The invention also provides a preparation method of the cobalt-iridium metal complex. The invention also provides nanoparticles, the cobalt-iridium metal complex prepared by the invention has a chemiluminescence property, so that the cobalt-iridium metal complex can simultaneously realize photo-thermal, photodynamic and ultrasonic synergistic thrombolysis treatment effects, and the oxidation resistance of the cobalt-iridium metal complex has a remarkable curative effect on a vascular injury part. The complex provided by the invention has good photo-thermal, photodynamic and ultrasonic response capabilities, and can overcome the problems of short excitation wavelength of exciting light and limited light penetration depth required by the existing metal iridium complex. Experiments show that the material has a good treatment effect on thrombus.

The invention relates to a composition for preventing cardiovascular and cerebrovascular diseases and a preparation method thereof, and belongs to the technical field of health food. The composition for preventing cardiovascular and cerebrovascular diseases is prepared from the following components in parts by weight: 20 to 100 parts of dihydroquercetin, 100 to 300 parts of red yeast rice, 50 to 150 parts of nattokinase, 50 to 200 parts of earthworm protein, 100 to 300 parts of hawthorn fruit extract, 100 to 300 parts of radix puerariae extract and 100 to 300 parts of sea-buckthorn extract. The composition prepared by the invention has the characteristics of lowering lipid, dissolving thrombus and protecting heart and blood vessels.

The invention belongs to the field of natural compounds, and particularly relates to application of VMO1 protein in toxicity resistance, oxidation resistance, thrombolysis and sperm motility regulation. According to the specific technical scheme, the application of the VMO1 protein in preparation of drugs for inhibiting bacteria, resisting toxicity, resisting oxidation and improving or reducing sperm motility is provided, and the amino acid sequence of the VMO1 protein is shown as SEQ NO ID: 1. It is found for the first time that the VMO1 protein extracted from frog follicles not only can inhibit the activity of pseudomonas aeruginosa, but also can resist toxicity, and meanwhile, the VMO1 protein has a good antioxidant effect, a thrombus dissolving effect and a bidirectional sperm motility adjusting effect. Therefore, the VMO1 protein has huge pharmaceutical potential.

The application provides an interventional thrombolytic treatment perfusion device, which comprises a catheter and a guide wire, wherein the guide wire comprises a guide wire connecting assembly, a spring, a guide wire body, a plug and a guide wire soft segment connected in sequence, the guide wire passes through the catheter and is fixed with one end of the catheter through the guide wire connecting assembly, and the plug closes the other end of the catheter under the action of the spring. Compared with the prior art, the interventional thrombolytic treatment perfusion device of the application avoids the falling of the guide wire during use, avoids the damage to the blood vessel when the catheter enters the thrombus, and makes the distribution of the drug at the thrombus more uniform and the release more accurate, so that the effect of fast, uniform and accurate thrombolytic treatment is achieved.

This invention provides a thrombolytic catheter system for cerebral venous sinus, relating to the field of medical device technology. It includes a microcatheter and a blocking guidewire. The microcatheter has a drug injection structure and side holes. The side holes have several through-holes distributed circumferentially and axially. The blocking guidewire includes a guidewire body and a blocking portion connected to the guidewire body. By using the microcatheter and blocking guidewire, during use, the blocking guidewire is inserted into the microcatheter, and the blocking portion at the end of the guidewire seals the end of the catheter. Thus, during thrombolytic drug injection, the drug only flows out from the through-holes of the catheter. Multiple through-holes are provided circumferentially and axially. This closed design, where thrombolytic drug flows only from the side holes, increases the contact area between the thrombolytic drug and the thrombus, thereby increasing the probability of vascular patency and reducing catheterization time. This solves problems related to the difficulty of removing cerebral venous sinus thrombi, venous reflux during catheter-based thrombolysis, and intracranial infection.

The utility model discloses an intravenous thrombolysis bed with a thrombolysis medicine dosage calculation function, and relates to the technical field of medical treatment. The nursing bed comprises a base, a rotating mechanism is arranged at the top of the base, a transverse plate is arranged at the top of the rotating mechanism, an adjusting mechanism is arranged at the top of the transverse plate, and a bed plate is movably connected to the top of the adjusting mechanism. According to the intravenous thrombolysis bed, a clinical common thrombolysis medicine calculation formula is set on the control panel, so that the calculation module can calculate the dosage of the thrombolysis medicine according to different intravenous medicines, the intravenous thrombolysis bed has the function of calculating the dosage of the thrombolysis medicine, the transverse plate can be rotated by adopting the rotating mechanism, and the thrombolysis medicine dosage can be calculated by adopting the rotating mechanism. By adopting the adjusting mechanism, the inclination angles of the fixed plate and the right side plate on the bed plate can be adjusted, so that the shape of the bed plate is changed, and the use requirements of different body positions of the patient can be met.

The present invention relates to a fluorescent probe based on a lanthanide metal organic framework, a preparation method and an application, and belongs to the field of nanomaterial technology. The fluorescent probe provided by the present invention is obtained by covalently cross-linking a lanthanide metal organic framework with a neutrophil elastin binding peptide and a P-selectin binding peptide, and the surface of the lanthanide metal organic framework is modified with a tetracyclic antibiotic and arginine. The fluorescent probe prepared by the present invention specifically targets activated platelets and neutrophils, does not affect cell survival rate, does not cause hemolysis of red blood cells, and can be applied to the preparation of diagnostic products for thrombotic diseases. The use of a fluorescent probe loaded with urokinase achieves stable and efficient delivery of urokinase, inhibits platelet aggregation, slows down blood clot contraction, has a good thrombolytic effect, and has the potential to be used in the preparation of drugs for the treatment of thrombotic diseases. The materials required for the present invention are easy to obtain, the preparation method is simple, and a new method is provided for the diagnosis and treatment of thrombotic diseases.

The invention provides an iridium metal conjugate, a water-soluble nanoparticle, a preparation method and application in ultrasonic thrombolysis, and belongs to the technical field of sonodynamic therapeutic drugs. The structural formula of the iridium metal conjugate is as shown in formula (I). The invention also provides a preparation method of the iridium metal conjugate. The invention also provides a nanoparticle, and the iridium metal conjugate prepared by the invention has a chemiluminescence property, so that the iridium metal conjugate can realize chemiluminescence imaging-assisted ultrasonic synergistic thrombolysis therapy. The conjugate provided by the invention has a good sonodynamic effect, and can overcome the defect of poor sonodynamic effect required by the existing sonosensitizer. Experiments show that the material has a good treatment effect in thrombolysis treatment.

The application discloses a kind of blood thrombus biological pharmaceutical compositions containing peptide and preparation method thereof, belong to the technical field of biological medicine containing peptide.The composition includes earthworm protein, natto kinase, inulin-soybean peptide covalent modifier, peanut peptide and sodium alginate-chitosan double embedding adjuvant.Preparation method is through the construction inulin-soybean peptide covalent modifier and sodium alginate-chitosan double embedding process, solve the technical problems such as low oral bioavailability of polypeptide thrombolytic component, difficulty in dissolving old thrombus, high risk of bleeding, realize the synergistic effect of thrombolysis, vascular repair and safety.

This invention relates to the field of biomedicine, and particularly to a hirudin gene, expression vector, engineered bacteria, recombinant protein, and its applications and production methods, all possessing anticoagulant, thrombolytic, and antioxidant effects. The nucleotide sequence of the hirudin gene is shown in SEQ ID NO: 1. The amino acid sequence of the recombinant protein is shown in SEQ ID NO: 2. The recombinant protein of the hirudin gene provided by this invention, possessing anticoagulant, thrombolytic, and antioxidant effects, exhibits a high concentration of recombinant hirudin, significantly increasing the yield of recombinant hirudin. The recombinant hirudin also demonstrates strong in vitro anticoagulant and thrombolytic activity, indicating broad market prospects.

The invention relates to the technical field of medicines, in particular to thrombolysis plaque-dissolving blood pressure clearing tablet sugar, which is prepared from the following raw materials in parts by weight: 15 to 20 parts of garlic, 15 to 20 parts of fresh ginger and 15 to 20 parts of fructus crataegi. 20-25 parts by weight of mint; 20-25 parts by weight of vanilla, 10-15 parts by weight of honey and 10-15 parts by weight of pectin; the blood pressure clearing tablet sugar capable of dissolving thrombus and plaque comprises the following raw materials in parts by weight: 100-200 parts of garlic, 100-200 parts of fresh ginger, 2000-2500 ml of lemon juice, 10-15 parts of vitamin C and 10-15 parts of vitamin E. According to the blood pressure clearing tablet sugar capable of dissolving thrombus and plaque, disclosed by the invention, the garlic and the fresh ginger are soaked in the lemon juice in advance, and then the raw materials such as the mint, the vanilla and the honey are added into the lemon juice, so that the spicy degree of the garlic and the fresh ginger can be reduced, and the mouth feel of consumers can be improved.

The invention belongs to the technical field of earthworm preparations, and discloses an earthworm protein gel candy and a preparation method of the earthworm protein gel candy. 300 parts of apple pectin; 1800 parts of a sorbitol solution; 1000 parts of erythritol is used as a raw material; 4 parts of stevioside; 480 parts of xylitol; 200 g of earthworm protein freeze-dried powder; 20 parts of L-arginine hydrochloride; 300 parts of purified water; 5 parts of citric acid; 20 parts of concentrated fruit juice and natural essence; 5 parts of sodium citrate; and 5 parts of potassium sorbate. According to the local dragon protein gel candy, the L-arginine promotes NO synthesis and accelerates microcirculation improvement; a fruit flavor masking technology is adopted, so that most of unpleasant odors are eliminated, and the gel matrix has long-acting thrombolysis activity and stability; due to beta-cyclodextrin microencapsulation, the gastric solubility of earthworm protein is reduced, the targeted release rate of intestinal tracts is increased, and the activity retention rate of plasmin is increased; the water activity is less than or equal to 0.62, the microbial proliferation is inhibited, and no salmonella / staphylococcus aureus is detected.

This invention provides a dual-function thrombolysis and thrombolysis device, comprising a multi-lumen tube, a thrombolysis mesh, and a movable cannula; the multi-lumen tube and the movable cannula slide relative to each other axially; the multi-lumen tube has an aspiration chamber, a control wire chamber, and a distally closed thrombolysis chamber; the thrombolysis mesh includes a membrane and a control wire; the membrane includes a tubular body, a tubular channel one, and a tubular channel two; the tubular body is fitted over the distal end of the multi-lumen tube, and its two axially open edges are respectively provided with a wire-passing channel around the tubular body, and its circumferential surface has a side hole one and a side hole two; the tubular channel one connects the side hole one and the thrombolysis chamber; the tubular channel two connects the side hole two and the aspiration chamber; the control wire passes through the wire-passing channel to form a support ring, and its first end is fixed to the movable cannula, and its second end passes through the control wire chamber; in the delivery state, the thrombolysis mesh is retracted inside the movable cannula. This invention enables simultaneous thrombolysis and thrombectomy in a single intervention, improving thrombus removal efficiency and effectiveness, and reducing damage to the patient's body.

A device for the coordinated regulation of rotating and pulsed magnetic fields includes: a magnetic field generating unit, magnetic thrombolytic particles, a control system, and a positioning and navigation module. This invention employs a synergistic design of coaxially nested rotating and pulsed magnetic fields, utilizing both the rotating magnetic field to provide mechanical shearing and the pulsed magnetic field to activate the fibrinolytic system. This synergistic effect not only achieves non-invasive and precise targeted treatment but also overcomes the efficiency bottleneck of a single magnetic field. Combined with real-time image closed-loop feedback and dynamic parameter adjustment, this strategy effectively resolves the contradiction between the difficulty of particle retention and powerful thrombolysis, improving thrombolysis efficiency by more than 30% and achieving efficient, non-invasive, and precise treatment.

The invention discloses a PAI-1 protein targeting peptide compound (called P peptide for short) with a thrombus dissolving effect and application thereof, and belongs to the field of biological medicine. The PAI-1 targeted thrombolytic polypeptide compound comprises P1, P2, P3 and P4, and is characterized in that the compound is derived from a core structure 'X-Asp-Glu-Leu-Cys-X-Tyr-Tyr-X-X-Cys-X' (cyclization is performed through a disulfide bond between Cys, and X represents any type of amino acid), and the compound can be specifically bound with a key binding site of PAI-1. The polypeptide can significantly reduce the inhibitory effect of PAI-1 on plasminogen activators (tPA, uPA), enhance the activity of a fibrinolytic system, and generate in-vivo and in-vitro thrombolysis effects. The polypeptide compounds P1, P2, P3 and P4 not only have a thrombolysis effect, but also can reduce the expression level of pro-inflammatory cytokines (IL-1beta, TNF-alpha, IL-6 and the like), which shows that the polypeptide compounds also have an anti-inflammatory effect. In conclusion, the polypeptide compound can be used for preparing a PAI-1 antagonist, a thrombolytic agent and an anti-inflammatory agent related to thrombus.

The present invention relates to a polypeptide derived from natural tridegin by structural modification, which may serve as an inhibitor of plasma coagulation factor XIIIa, and to pharmaceutical compositions comprising such polypeptide. The present invention further refers to such polypeptide or pharmaceutical composition for use in a method for treating or preventing a thrombotic event in a patient. Moreover, the invention relates to an endoprosthesis or an enzyme-linked immunosorbent assay (ELISA) plate coated with a polypeptide of the present invention. Furthermore, the invention also encompasses a recombinant fusion protein comprising this polypeptide linked to a fibrinolytic enzyme such as streptokinase, nattokinase or tPAs via a flexible peptide linker containing a thrombin-cleavable site. This construct allows selective inhibition of FXIIIa within a thrombus, while enabling thrombin-triggered release of the fibrinolytic enzyme to induce localized fibrinolysis, thereby achieving targeted dual-action thrombolytic therapy.

The utility model provides a multifunctional internal fistula thrombus taking-out device which comprises a first pipe fitting, a second pipe fitting, a third pipe fitting and a fourth pipe fitting. A second pipe fitting; the thrombolysis pipe fitting is arranged on the outer side of the second pipe fitting in a sleeving mode and is internally hollow to form a medicine cavity, and a plurality of medicine outlet holes communicating with the medicine cavity are formed in the outer wall of the far end of the thrombolysis pipe fitting in a penetrating mode; the crushing mechanism comprises a positioning piece connected with the far end of the thrombolysis pipe fitting and movably arranged on the outer side of the second pipe fitting in a sleeving mode, a driving pipe movably arranged on the outer side of the thrombolysis pipe fitting in a sleeving mode and located on the near end side of the positioning piece, and a plurality of crushing pieces connected between the far end of the driving pipe and the positioning piece, and the positioning piece is limited by a limiting structure when moving towards the far end. A plurality of thrombus in the internal fistula blood vessel can be effectively treated, the incision of the thrombus extraction operation can be greatly reduced, and the damage to the blood vessel is reduced.