119 results about "Thrombolysin" patented technology

The invention discloses a method for training a thrombolysis adaptability evaluation model and a related product. The method comprises the following steps: acquiring brain perfusion image data, a brain perfusion parameter map, clinical data and treatment data; performing region-of-interest extraction on the cerebral perfusion parameter map to obtain an attention map containing a core infarction region and an ischemic penumbra sensing region; multiplying the brain perfusion image data by the attention map to obtain weighted brain perfusion image data; the first labeling information and the second labeling information are used for labeling whether thrombolysis treatment is carried out or not and labeling the effect grade after thrombolysis treatment is carried out; and inputting the weighted brain perfusion image data, the brain perfusion parameter diagram, the clinical data, the first annotation information and the second annotation information into a thrombolysis adaptability evaluation model as training data so as to train the thrombolysis adaptability evaluation model. By utilizing the scheme disclosed by the invention, the thrombolysis adaptability and treatment effect prediction accuracy can be improved, and a more reliable basis is provided for clinical decision making.

The invention relates to the technical field of thrombus mining robots, in particular to a micron robot with an asymmetric cilia structure, a preparation method and application. The micro-robot is of an asymmetric composite structure and is composed of a smooth hemisphere and a cilia-shaped structure, sandwich type layered arrangement of a PLGE cilia-shaped nano structure, an MNPs interlayer and a PS sphere core is formed on the surface and the interior of the micro-robot from outside to inside, and cooperative regulation and control of morphology and functions are achieved by regulating and controlling the material proportion of PS and PLGE. The thrombus mining robot shows an efficient thrombolysis effect in a plurality of in-vitro and in-vivo models, and rapid fibrinolysis, deep thrombus penetration and efficient mining of single red blood cells are realized, so that the limitation of a traditional thrombolysis agent is overcome. In addition, the thrombus digging robot has excellent biocompatibility and biological safety, has no obvious cytotoxicity or damage to main organs, and supports the safety of the thrombus digging robot in clinical application.

The invention discloses a balloon catheter pressure applying device for thrombus treatment and vascular embolism, and relates to the technical field of medical instruments, the balloon catheter pressure applying device comprises a first catheter, the first catheter is sleeved with a second catheter, the front end of the second catheter is fixedly connected with a memory metal net bag, the second catheter is sleeved with a third catheter, and the third catheter is fixedly connected with a memory metal net bag. A fourth catheter is fixedly connected to the outer side of the third catheter, a rear balloon is fixedly connected to the outer side of the front end of the air delivery pipe, an exhaust head is fixedly connected to the front end of the first catheter, a front balloon is fixedly connected to the outer side of the exhaust head, and a thrombus removing assembly used for assisting in removing thrombus is arranged on the outer side of the front end of the first catheter. According to the thrombus treatment vascular embolism balloon catheter, the thrombus dissolving medicine in the medicine storage balloon membrane is squeezed out through the pressure applying device, the thrombus dissolving medicine can penetrate through the memory metal net bag to move to the embolism position, thrombus is dissolved, and the thrombus can be better removed through cooperation with the thrombus removing assembly.

Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and / or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase.

The invention relates to the technical field of food processing, and particularly discloses a heart and cerebral vessel health care composition with thrombolytic and antithrombotic functions and a preparation method thereof. The composition consists of the following raw materials: sorbitol, red yeast rice, freeze-dried natto powder, earthworm protein peptide, vitamin C, American ginseng peptide, magnesium stearate, an angelica sinensis extract, rice bran fatty alkanol, vitamin B1, vitamin B2, a turmeric extract and a compound coloring agent. The preparation method comprises the following steps: mixing the raw materials except magnesium stearate in a double-cone mixer; magnesium stearate is added for continuous mixing, and a hollow capsule shell is filled with the mixed material. The composition disclosed by the invention forms a multi-dimensional synergistic system for smoothing blood vessels, purifying blood and improving blood flow, the defect of single effect of an existing product is overcome, the health-care effect of heart and cerebral vessels is remarkably improved, and the effect is stable and controllable; in addition, the preparation method has the advantages of being simple and controllable in process and suitable for industrial production.

The application discloses a four-stage paddle thrombus-removing micro robot, a preparation method and a magnetic field driving thrombus-removing micro robot system, relates to the technical field of micro robots, and comprises a conical drill bit, a main straight rod and a four-stage paddle group, wherein the conical drill bit is made of a biodegradable material; the bottom of the conical drill bit is connected with the main straight rod; the main straight rod is internally provided with a thrombolytic drug; the four-stage paddle group is arranged on the outer circumferential surface of the main straight rod in an axial direction; the paddle group comprises three paddle blades which are centrally symmetrical to the axis of the main straight rod; the paddle blades in the adjacent two-stage paddle groups are arranged in a staggered manner; the paddle blades are of a round head structure; the thickness of the paddle blades gradually increases from outside to inside; and the surface of the micro robot is coated with a magnetic film and is subjected to directional magnetization treatment. The application can obtain strong movement ability and stable movement state under the accurate control of a movement system, realizes intravascular drilling and crushing of a thrombus, and can biodegrade and release the thrombolytic drug after surgery, so as to solve the problem of downstream vascular embolism after drilling.

The utility model relates to the field of thrombolysis treatment boxes, and discloses a movable thrombolysis treatment box which comprises a box body, two drawers are connected in the box body in a sliding mode, two cabinet doors are connected to the front side of the box body in a rotating mode, a sharp instrument box is connected in the box body in a rotating mode, and a pull rod is connected to the rear side of the sharp instrument box in a rotating mode. A pressing rod is rotatably connected to the front side of the pull rod, a bottom plate is rotatably connected to the bottom of the pressing rod, the front side of the bottom plate is rotatably connected to the bottom of the sharp instrument box, inner shells are rotatably connected to the left side and the right side of the inner wall of the sharp instrument box, sliding rods are slidably connected to the interiors of the inner shells, and first baffles are fixedly connected to the tops of the sliding rods. According to the sharp instrument box, the pull rod is lifted to drive the pressing rod to downwards press the bottom plate, and the sliding rod is pulled to enable the baffle plate I to compress the spring I, so that sharp instruments in the sharp instrument box can be quickly emptied, time and labor are saved, the working efficiency is effectively improved, and the whole sharp instrument box is prevented from being taken out.

The invention provides a liquid phase tandem time-of-flight mass spectrometry detection method for the content of tirofiban in liver tissue, and belongs to the technical field of detection. According to the present invention, the concentration of tirofiban in the liver tissue is detected through the liquid phase tandem time-of-flight mass spectrometry, such that the characteristics of low detection limit, immediate analysis, high sensitivity, good repeatability, good indoor reproducibility and high accuracy are provided, the matrix effect is substantially reduced, the recovery rate is improved, and the precise detection of tirofiban is achieved. The method is successfully applied to detection of tirofiban in liver tissues in a clinical animal experiment stage, has important clinical significance for monitoring the in-vivo content of tirofiban after medication, avoids occurrence of postoperative related complications in serious interventional therapy, and has a good clinical application prospect. And side effects such as poor thrombolysis effect caused by insufficient medication and bleeding caused by excessive medication are prevented.

The invention provides a cobalt-iridium metal complex, nanoparticles, a preparation method and application, and belongs to the technical field of photodynamic therapy drugs. The structural formula of the cobalt-iridium metal complex is shown as a formula (I). The invention also provides a preparation method of the cobalt-iridium metal complex. The invention also provides nanoparticles, the cobalt-iridium metal complex prepared by the invention has a chemiluminescence property, so that the cobalt-iridium metal complex can simultaneously realize photo-thermal, photodynamic and ultrasonic synergistic thrombolysis treatment effects, and the oxidation resistance of the cobalt-iridium metal complex has a remarkable curative effect on a vascular injury part. The complex provided by the invention has good photo-thermal, photodynamic and ultrasonic response capabilities, and can overcome the problems of short excitation wavelength of exciting light and limited light penetration depth required by the existing metal iridium complex. Experiments show that the material has a good treatment effect on thrombus.

The invention relates to a composition for preventing cardiovascular and cerebrovascular diseases and a preparation method thereof, and belongs to the technical field of health food. The composition for preventing cardiovascular and cerebrovascular diseases is prepared from the following components in parts by weight: 20 to 100 parts of dihydroquercetin, 100 to 300 parts of red yeast rice, 50 to 150 parts of nattokinase, 50 to 200 parts of earthworm protein, 100 to 300 parts of hawthorn fruit extract, 100 to 300 parts of radix puerariae extract and 100 to 300 parts of sea-buckthorn extract. The composition prepared by the invention has the characteristics of lowering lipid, dissolving thrombus and protecting heart and blood vessels.

The invention belongs to the field of natural compounds, and particularly relates to application of VMO1 protein in toxicity resistance, oxidation resistance, thrombolysis and sperm motility regulation. According to the specific technical scheme, the application of the VMO1 protein in preparation of drugs for inhibiting bacteria, resisting toxicity, resisting oxidation and improving or reducing sperm motility is provided, and the amino acid sequence of the VMO1 protein is shown as SEQ NO ID: 1. It is found for the first time that the VMO1 protein extracted from frog follicles not only can inhibit the activity of pseudomonas aeruginosa, but also can resist toxicity, and meanwhile, the VMO1 protein has a good antioxidant effect, a thrombus dissolving effect and a bidirectional sperm motility adjusting effect. Therefore, the VMO1 protein has huge pharmaceutical potential.

The application provides an interventional thrombolytic treatment perfusion device, which comprises a catheter and a guide wire, wherein the guide wire comprises a guide wire connecting assembly, a spring, a guide wire body, a plug and a guide wire soft segment connected in sequence, the guide wire passes through the catheter and is fixed with one end of the catheter through the guide wire connecting assembly, and the plug closes the other end of the catheter under the action of the spring. Compared with the prior art, the interventional thrombolytic treatment perfusion device of the application avoids the falling of the guide wire during use, avoids the damage to the blood vessel when the catheter enters the thrombus, and makes the distribution of the drug at the thrombus more uniform and the release more accurate, so that the effect of fast, uniform and accurate thrombolytic treatment is achieved.

This invention provides a thrombolytic catheter system for cerebral venous sinus, relating to the field of medical device technology. It includes a microcatheter and a blocking guidewire. The microcatheter has a drug injection structure and side holes. The side holes have several through-holes distributed circumferentially and axially. The blocking guidewire includes a guidewire body and a blocking portion connected to the guidewire body. By using the microcatheter and blocking guidewire, during use, the blocking guidewire is inserted into the microcatheter, and the blocking portion at the end of the guidewire seals the end of the catheter. Thus, during thrombolytic drug injection, the drug only flows out from the through-holes of the catheter. Multiple through-holes are provided circumferentially and axially. This closed design, where thrombolytic drug flows only from the side holes, increases the contact area between the thrombolytic drug and the thrombus, thereby increasing the probability of vascular patency and reducing catheterization time. This solves problems related to the difficulty of removing cerebral venous sinus thrombi, venous reflux during catheter-based thrombolysis, and intracranial infection.

The present invention relates to a fluorescent probe based on a lanthanide metal organic framework, a preparation method and an application, and belongs to the field of nanomaterial technology. The fluorescent probe provided by the present invention is obtained by covalently cross-linking a lanthanide metal organic framework with a neutrophil elastin binding peptide and a P-selectin binding peptide, and the surface of the lanthanide metal organic framework is modified with a tetracyclic antibiotic and arginine. The fluorescent probe prepared by the present invention specifically targets activated platelets and neutrophils, does not affect cell survival rate, does not cause hemolysis of red blood cells, and can be applied to the preparation of diagnostic products for thrombotic diseases. The use of a fluorescent probe loaded with urokinase achieves stable and efficient delivery of urokinase, inhibits platelet aggregation, slows down blood clot contraction, has a good thrombolytic effect, and has the potential to be used in the preparation of drugs for the treatment of thrombotic diseases. The materials required for the present invention are easy to obtain, the preparation method is simple, and a new method is provided for the diagnosis and treatment of thrombotic diseases.

The invention provides an iridium metal conjugate, a water-soluble nanoparticle, a preparation method and application in ultrasonic thrombolysis, and belongs to the technical field of sonodynamic therapeutic drugs. The structural formula of the iridium metal conjugate is as shown in formula (I). The invention also provides a preparation method of the iridium metal conjugate. The invention also provides a nanoparticle, and the iridium metal conjugate prepared by the invention has a chemiluminescence property, so that the iridium metal conjugate can realize chemiluminescence imaging-assisted ultrasonic synergistic thrombolysis therapy. The conjugate provided by the invention has a good sonodynamic effect, and can overcome the defect of poor sonodynamic effect required by the existing sonosensitizer. Experiments show that the material has a good treatment effect in thrombolysis treatment.

The application discloses a kind of blood thrombus biological pharmaceutical compositions containing peptide and preparation method thereof, belong to the technical field of biological medicine containing peptide.The composition includes earthworm protein, natto kinase, inulin-soybean peptide covalent modifier, peanut peptide and sodium alginate-chitosan double embedding adjuvant.Preparation method is through the construction inulin-soybean peptide covalent modifier and sodium alginate-chitosan double embedding process, solve the technical problems such as low oral bioavailability of polypeptide thrombolytic component, difficulty in dissolving old thrombus, high risk of bleeding, realize the synergistic effect of thrombolysis, vascular repair and safety.

This invention relates to the field of biomedicine, and particularly to a hirudin gene, expression vector, engineered bacteria, recombinant protein, and its applications and production methods, all possessing anticoagulant, thrombolytic, and antioxidant effects. The nucleotide sequence of the hirudin gene is shown in SEQ ID NO: 1. The amino acid sequence of the recombinant protein is shown in SEQ ID NO: 2. The recombinant protein of the hirudin gene provided by this invention, possessing anticoagulant, thrombolytic, and antioxidant effects, exhibits a high concentration of recombinant hirudin, significantly increasing the yield of recombinant hirudin. The recombinant hirudin also demonstrates strong in vitro anticoagulant and thrombolytic activity, indicating broad market prospects.

The invention belongs to the technical field of earthworm preparations, and discloses an earthworm protein gel candy and a preparation method of the earthworm protein gel candy. 300 parts of apple pectin; 1800 parts of a sorbitol solution; 1000 parts of erythritol is used as a raw material; 4 parts of stevioside; 480 parts of xylitol; 200 g of earthworm protein freeze-dried powder; 20 parts of L-arginine hydrochloride; 300 parts of purified water; 5 parts of citric acid; 20 parts of concentrated fruit juice and natural essence; 5 parts of sodium citrate; and 5 parts of potassium sorbate. According to the local dragon protein gel candy, the L-arginine promotes NO synthesis and accelerates microcirculation improvement; a fruit flavor masking technology is adopted, so that most of unpleasant odors are eliminated, and the gel matrix has long-acting thrombolysis activity and stability; due to beta-cyclodextrin microencapsulation, the gastric solubility of earthworm protein is reduced, the targeted release rate of intestinal tracts is increased, and the activity retention rate of plasmin is increased; the water activity is less than or equal to 0.62, the microbial proliferation is inhibited, and no salmonella / staphylococcus aureus is detected.

This invention provides a dual-function thrombolysis and thrombolysis device, comprising a multi-lumen tube, a thrombolysis mesh, and a movable cannula; the multi-lumen tube and the movable cannula slide relative to each other axially; the multi-lumen tube has an aspiration chamber, a control wire chamber, and a distally closed thrombolysis chamber; the thrombolysis mesh includes a membrane and a control wire; the membrane includes a tubular body, a tubular channel one, and a tubular channel two; the tubular body is fitted over the distal end of the multi-lumen tube, and its two axially open edges are respectively provided with a wire-passing channel around the tubular body, and its circumferential surface has a side hole one and a side hole two; the tubular channel one connects the side hole one and the thrombolysis chamber; the tubular channel two connects the side hole two and the aspiration chamber; the control wire passes through the wire-passing channel to form a support ring, and its first end is fixed to the movable cannula, and its second end passes through the control wire chamber; in the delivery state, the thrombolysis mesh is retracted inside the movable cannula. This invention enables simultaneous thrombolysis and thrombectomy in a single intervention, improving thrombus removal efficiency and effectiveness, and reducing damage to the patient's body.

A device for the coordinated regulation of rotating and pulsed magnetic fields includes: a magnetic field generating unit, magnetic thrombolytic particles, a control system, and a positioning and navigation module. This invention employs a synergistic design of coaxially nested rotating and pulsed magnetic fields, utilizing both the rotating magnetic field to provide mechanical shearing and the pulsed magnetic field to activate the fibrinolytic system. This synergistic effect not only achieves non-invasive and precise targeted treatment but also overcomes the efficiency bottleneck of a single magnetic field. Combined with real-time image closed-loop feedback and dynamic parameter adjustment, this strategy effectively resolves the contradiction between the difficulty of particle retention and powerful thrombolysis, improving thrombolysis efficiency by more than 30% and achieving efficient, non-invasive, and precise treatment.

The invention discloses a PAI-1 protein targeting peptide compound (called P peptide for short) with a thrombus dissolving effect and application thereof, and belongs to the field of biological medicine. The PAI-1 targeted thrombolytic polypeptide compound comprises P1, P2, P3 and P4, and is characterized in that the compound is derived from a core structure 'X-Asp-Glu-Leu-Cys-X-Tyr-Tyr-X-X-Cys-X' (cyclization is performed through a disulfide bond between Cys, and X represents any type of amino acid), and the compound can be specifically bound with a key binding site of PAI-1. The polypeptide can significantly reduce the inhibitory effect of PAI-1 on plasminogen activators (tPA, uPA), enhance the activity of a fibrinolytic system, and generate in-vivo and in-vitro thrombolysis effects. The polypeptide compounds P1, P2, P3 and P4 not only have a thrombolysis effect, but also can reduce the expression level of pro-inflammatory cytokines (IL-1beta, TNF-alpha, IL-6 and the like), which shows that the polypeptide compounds also have an anti-inflammatory effect. In conclusion, the polypeptide compound can be used for preparing a PAI-1 antagonist, a thrombolytic agent and an anti-inflammatory agent related to thrombus.

The present invention relates to a polypeptide derived from natural tridegin by structural modification, which may serve as an inhibitor of plasma coagulation factor XIIIa, and to pharmaceutical compositions comprising such polypeptide. The present invention further refers to such polypeptide or pharmaceutical composition for use in a method for treating or preventing a thrombotic event in a patient. Moreover, the invention relates to an endoprosthesis or an enzyme-linked immunosorbent assay (ELISA) plate coated with a polypeptide of the present invention. Furthermore, the invention also encompasses a recombinant fusion protein comprising this polypeptide linked to a fibrinolytic enzyme such as streptokinase, nattokinase or tPAs via a flexible peptide linker containing a thrombin-cleavable site. This construct allows selective inhibition of FXIIIa within a thrombus, while enabling thrombin-triggered release of the fibrinolytic enzyme to induce localized fibrinolysis, thereby achieving targeted dual-action thrombolytic therapy.

The utility model provides a multifunctional internal fistula thrombus taking-out device which comprises a first pipe fitting, a second pipe fitting, a third pipe fitting and a fourth pipe fitting. A second pipe fitting; the thrombolysis pipe fitting is arranged on the outer side of the second pipe fitting in a sleeving mode and is internally hollow to form a medicine cavity, and a plurality of medicine outlet holes communicating with the medicine cavity are formed in the outer wall of the far end of the thrombolysis pipe fitting in a penetrating mode; the crushing mechanism comprises a positioning piece connected with the far end of the thrombolysis pipe fitting and movably arranged on the outer side of the second pipe fitting in a sleeving mode, a driving pipe movably arranged on the outer side of the thrombolysis pipe fitting in a sleeving mode and located on the near end side of the positioning piece, and a plurality of crushing pieces connected between the far end of the driving pipe and the positioning piece, and the positioning piece is limited by a limiting structure when moving towards the far end. A plurality of thrombus in the internal fistula blood vessel can be effectively treated, the incision of the thrombus extraction operation can be greatly reduced, and the damage to the blood vessel is reduced.

The invention relates to an ultrasonic thrombolysis system capable of realizing real-time cavitation dose monitoring and self-adaptive acoustic beam regulation and control. The ultrasonic thrombolysis system comprises a thrombolysis main control unit which can configure a thrombolysis working state of a thrombolysis probe unit so as to perform in-vitro ultrasonic thrombolysis on a target area, and in the process of performing thrombolysis on a thrombus area by using a treatment sound beam, the thrombolysis main control unit configures the thrombolysis probe unit to receive a treatment echo signal and transmits the treatment echo signal to the thrombolysis probe unit. The current cavitation dose is monitored in real time based on the received treatment echo signal; and based on the monitored current cavitation dose, the thrombolysis main control unit at least adjusts the sound power of the treatment sound beam emitted by the thrombolysis probe unit until the current cavitation dose is matched with the target cavitation dose. According to the invention, the cavitation dosage during thrombolysis can be monitored in real time, the thrombolysis treatment acoustic beam can be subjected to self-adaptive acoustic beam regulation and control, and the reliability and thrombolysis efficiency of ultrasonic thrombolysis are improved.

The invention discloses plasmin based on hermetia illucens and application thereof, and belongs to the technical field of biology. The plasmin based on the hermetia illucens is obtained by grinding and centrifuging larvae of the hermetia illucens in a PBS (Phosphate Buffer Solution) and extracting supernate. The invention further provides application of the plasmin based on the hermetia illucens in preparation of thrombolytic drugs. The plasmin is extracted from the hermetia illucens, and the hermetia illucens is short in breeding cycle, high in reproductive capacity, capable of being massively extracted in a short time and low in cost; the extracted plasmin has a remarkable thrombolysis effect and has a very good utilization value; the plasmin can be used for directly dissolving thrombus and degrading fibrinogen.

The invention discloses a medicine injection device capable of realizing automatic thrombolysis administration, which comprises a driving device, a mounting control valve, a thrombolysis medicine bag, a thrombolysis catheter and an injector, the driving device is provided with the mounting control valve, the mounting control valve is connected with the thrombolysis medicine bag, the mounting control valve is connected with the thrombolysis catheter, the mounting control valve is connected with the injector, and the injector is connected with the thrombolysis medicine bag. The driving device comprises a motor and a sensor, the motor is connected with the installation control valve, the sensor is connected with the injector, and the sensor is connected with the motor. By the adoption of the technical scheme, the medicine injection device which is convenient and rapid and capable of achieving automatic thrombolysis medicine administration is manufactured, automatic medicine taking or medicine injection can be achieved by automatically controlling steering of the installation control valve installed on the driving device, and meanwhile an interval medicine administration mode is designed according to the characteristics of thrombolysis medicine administration. And the interval administration time, the pulse amount and the pulse administration rate can be conveniently set clinically, so that personalized thrombolysis administration is realized, and more effective thrombolysis treatment is realized.

The invention discloses an antithrombotic drug derived carbon dot as well as a preparation method and application thereof. Comprising the steps that an antithrombotic drug is selected as a precursor, the antithrombotic drug comprises at least one of an antiplatelet drug with a pharmacodynamic group, an anticoagulant drug with a pharmacodynamic group and a fibrinolytic drug with a pharmacodynamic group, the molecular weight of the antithrombotic drug is 100-2000 Da, and the thermal stability decomposition temperature is larger than or equal to 200 DEG C; the pharmacodynamic groups comprise at least one of sulfonic acid groups, acetoxy groups, indole rings and coumarin structures; performing gradient carbonization treatment on the precursor in a plurality of temperature zones, wherein the plurality of temperature zones comprise a low-temperature zone capable of retaining pharmacodynamic groups, a medium-temperature zone for regulating and controlling a carbon hybridization ratio and a high-temperature zone for performing heteroatom doping; and performing purification and drying treatment to obtain the antithrombotic drug derived carbon dots. Through the preparation method, the antithrombotic drug derived carbon dots with a thrombolysis function and high safety can be obtained, and the problem that the curative effect and safety of an existing antithrombotic drug are unbalanced is solved.

The invention relates to the technical field of medical apparatuses and instruments, and provides an ultrasonic thrombolysis guide wire and a treatment system.The ultrasonic thrombolysis guide wire comprises a guide wire body; an ultrasonic transmitting terminal; and the piezoelectric vibration mode transducer is arranged on the ultrasonic transmitting end. According to the ultrasonic thrombolysis guide wire provided by the invention, multidirectional emission of ultrasound can be realized, the coverage range of a sound field on thrombus is widened, and the thrombus can be effectively treated in cooperation with an ultrasonic contrast agent and thrombolysis drugs. The multi-directional ultrasonic emission can be realized by the single transducer, the use of the transducer is reduced, the overall size of the guide wire is smaller, and the requirement of intravascular thrombolysis miniaturization is more easily met. In addition, based on the advantages of the piezoelectric vibration type transducer, the piezoelectric vibration type transducer can emit low-frequency ultrasound under the condition that the small size is maintained, and the applicability is higher.

1. Name of the product in this design: Intelligent Thrombolysis Box. 2. Purpose of this design: for medical use, to dissolve blood clots. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. Other situations requiring explanation: The key design points of the top view are fully demonstrated in the submitted views, so the top view is omitted; the bottom view is not commonly used, so the bottom view is omitted.

The invention discloses a nerve intervention thrombectomy and thrombolysis device and belongs to the technical field of nerve thrombectomy, the nerve intervention thrombectomy and thrombolysis device comprises a guider and a puncture tube connected to the guider in a penetrating mode, one side of the guider is connected with a guiding tube in a penetrating mode, and the guiding tube is arranged at the center position of the puncture tube in a penetrating mode; the other side of the guider is connected with a central tube in a penetrating mode, a positioning hole is formed in the guiding tube, and the central tube is connected to the central position of the guiding tube in a penetrating mode through the positioning hole. The diameter of the central tube is smaller than that of the guide tube; a positioning mechanism which assists the central tube and the guide tube in penetrating connection is arranged in the guider; when the thrombus taking and thrombolysis device is used, the central tube can be quickly and accurately connected into the guide tube in a penetrating manner, so that a thrombolysis medicament can accurately act on blocked thrombus, and the thrombus taking and thrombolysis treatment effect is improved.