75 results about "Thrombolysin" patented technology

The invention relates to the technical field of food processing, and particularly discloses a heart and cerebral vessel health care composition with thrombolytic and antithrombotic functions and a preparation method thereof. The composition consists of the following raw materials: sorbitol, red yeast rice, freeze-dried natto powder, earthworm protein peptide, vitamin C, American ginseng peptide, magnesium stearate, an angelica sinensis extract, rice bran fatty alkanol, vitamin B1, vitamin B2, a turmeric extract and a compound coloring agent. The preparation method comprises the following steps: mixing the raw materials except magnesium stearate in a double-cone mixer; magnesium stearate is added for continuous mixing, and a hollow capsule shell is filled with the mixed material. The composition disclosed by the invention forms a multi-dimensional synergistic system for smoothing blood vessels, purifying blood and improving blood flow, the defect of single effect of an existing product is overcome, the health-care effect of heart and cerebral vessels is remarkably improved, and the effect is stable and controllable; in addition, the preparation method has the advantages of being simple and controllable in process and suitable for industrial production.

The application discloses a four-stage paddle thrombus-removing micro robot, a preparation method and a magnetic field driving thrombus-removing micro robot system, relates to the technical field of micro robots, and comprises a conical drill bit, a main straight rod and a four-stage paddle group, wherein the conical drill bit is made of a biodegradable material; the bottom of the conical drill bit is connected with the main straight rod; the main straight rod is internally provided with a thrombolytic drug; the four-stage paddle group is arranged on the outer circumferential surface of the main straight rod in an axial direction; the paddle group comprises three paddle blades which are centrally symmetrical to the axis of the main straight rod; the paddle blades in the adjacent two-stage paddle groups are arranged in a staggered manner; the paddle blades are of a round head structure; the thickness of the paddle blades gradually increases from outside to inside; and the surface of the micro robot is coated with a magnetic film and is subjected to directional magnetization treatment. The application can obtain strong movement ability and stable movement state under the accurate control of a movement system, realizes intravascular drilling and crushing of a thrombus, and can biodegrade and release the thrombolytic drug after surgery, so as to solve the problem of downstream vascular embolism after drilling.

The invention provides a liquid phase tandem time-of-flight mass spectrometry detection method for the content of tirofiban in liver tissue, and belongs to the technical field of detection. According to the present invention, the concentration of tirofiban in the liver tissue is detected through the liquid phase tandem time-of-flight mass spectrometry, such that the characteristics of low detection limit, immediate analysis, high sensitivity, good repeatability, good indoor reproducibility and high accuracy are provided, the matrix effect is substantially reduced, the recovery rate is improved, and the precise detection of tirofiban is achieved. The method is successfully applied to detection of tirofiban in liver tissues in a clinical animal experiment stage, has important clinical significance for monitoring the in-vivo content of tirofiban after medication, avoids occurrence of postoperative related complications in serious interventional therapy, and has a good clinical application prospect. And side effects such as poor thrombolysis effect caused by insufficient medication and bleeding caused by excessive medication are prevented.

The invention provides a cobalt-iridium metal complex, nanoparticles, a preparation method and application, and belongs to the technical field of photodynamic therapy drugs. The structural formula of the cobalt-iridium metal complex is shown as a formula (I). The invention also provides a preparation method of the cobalt-iridium metal complex. The invention also provides nanoparticles, the cobalt-iridium metal complex prepared by the invention has a chemiluminescence property, so that the cobalt-iridium metal complex can simultaneously realize photo-thermal, photodynamic and ultrasonic synergistic thrombolysis treatment effects, and the oxidation resistance of the cobalt-iridium metal complex has a remarkable curative effect on a vascular injury part. The complex provided by the invention has good photo-thermal, photodynamic and ultrasonic response capabilities, and can overcome the problems of short excitation wavelength of exciting light and limited light penetration depth required by the existing metal iridium complex. Experiments show that the material has a good treatment effect on thrombus.

The invention relates to a composition for preventing cardiovascular and cerebrovascular diseases and a preparation method thereof, and belongs to the technical field of health food. The composition for preventing cardiovascular and cerebrovascular diseases is prepared from the following components in parts by weight: 20 to 100 parts of dihydroquercetin, 100 to 300 parts of red yeast rice, 50 to 150 parts of nattokinase, 50 to 200 parts of earthworm protein, 100 to 300 parts of hawthorn fruit extract, 100 to 300 parts of radix puerariae extract and 100 to 300 parts of sea-buckthorn extract. The composition prepared by the invention has the characteristics of lowering lipid, dissolving thrombus and protecting heart and blood vessels.

This invention provides a thrombolytic catheter system for cerebral venous sinus, relating to the field of medical device technology. It includes a microcatheter and a blocking guidewire. The microcatheter has a drug injection structure and side holes. The side holes have several through-holes distributed circumferentially and axially. The blocking guidewire includes a guidewire body and a blocking portion connected to the guidewire body. By using the microcatheter and blocking guidewire, during use, the blocking guidewire is inserted into the microcatheter, and the blocking portion at the end of the guidewire seals the end of the catheter. Thus, during thrombolytic drug injection, the drug only flows out from the through-holes of the catheter. Multiple through-holes are provided circumferentially and axially. This closed design, where thrombolytic drug flows only from the side holes, increases the contact area between the thrombolytic drug and the thrombus, thereby increasing the probability of vascular patency and reducing catheterization time. This solves problems related to the difficulty of removing cerebral venous sinus thrombi, venous reflux during catheter-based thrombolysis, and intracranial infection.

The invention provides an iridium metal conjugate, a water-soluble nanoparticle, a preparation method and application in ultrasonic thrombolysis, and belongs to the technical field of sonodynamic therapeutic drugs. The structural formula of the iridium metal conjugate is as shown in formula (I). The invention also provides a preparation method of the iridium metal conjugate. The invention also provides a nanoparticle, and the iridium metal conjugate prepared by the invention has a chemiluminescence property, so that the iridium metal conjugate can realize chemiluminescence imaging-assisted ultrasonic synergistic thrombolysis therapy. The conjugate provided by the invention has a good sonodynamic effect, and can overcome the defect of poor sonodynamic effect required by the existing sonosensitizer. Experiments show that the material has a good treatment effect in thrombolysis treatment.

The application discloses a kind of blood thrombus biological pharmaceutical compositions containing peptide and preparation method thereof, belong to the technical field of biological medicine containing peptide.The composition includes earthworm protein, natto kinase, inulin-soybean peptide covalent modifier, peanut peptide and sodium alginate-chitosan double embedding adjuvant.Preparation method is through the construction inulin-soybean peptide covalent modifier and sodium alginate-chitosan double embedding process, solve the technical problems such as low oral bioavailability of polypeptide thrombolytic component, difficulty in dissolving old thrombus, high risk of bleeding, realize the synergistic effect of thrombolysis, vascular repair and safety.

This invention relates to the field of biomedicine, and particularly to a hirudin gene, expression vector, engineered bacteria, recombinant protein, and its applications and production methods, all possessing anticoagulant, thrombolytic, and antioxidant effects. The nucleotide sequence of the hirudin gene is shown in SEQ ID NO: 1. The amino acid sequence of the recombinant protein is shown in SEQ ID NO: 2. The recombinant protein of the hirudin gene provided by this invention, possessing anticoagulant, thrombolytic, and antioxidant effects, exhibits a high concentration of recombinant hirudin, significantly increasing the yield of recombinant hirudin. The recombinant hirudin also demonstrates strong in vitro anticoagulant and thrombolytic activity, indicating broad market prospects.

This invention provides a dual-function thrombolysis and thrombolysis device, comprising a multi-lumen tube, a thrombolysis mesh, and a movable cannula; the multi-lumen tube and the movable cannula slide relative to each other axially; the multi-lumen tube has an aspiration chamber, a control wire chamber, and a distally closed thrombolysis chamber; the thrombolysis mesh includes a membrane and a control wire; the membrane includes a tubular body, a tubular channel one, and a tubular channel two; the tubular body is fitted over the distal end of the multi-lumen tube, and its two axially open edges are respectively provided with a wire-passing channel around the tubular body, and its circumferential surface has a side hole one and a side hole two; the tubular channel one connects the side hole one and the thrombolysis chamber; the tubular channel two connects the side hole two and the aspiration chamber; the control wire passes through the wire-passing channel to form a support ring, and its first end is fixed to the movable cannula, and its second end passes through the control wire chamber; in the delivery state, the thrombolysis mesh is retracted inside the movable cannula. This invention enables simultaneous thrombolysis and thrombectomy in a single intervention, improving thrombus removal efficiency and effectiveness, and reducing damage to the patient's body.

A device for the coordinated regulation of rotating and pulsed magnetic fields includes: a magnetic field generating unit, magnetic thrombolytic particles, a control system, and a positioning and navigation module. This invention employs a synergistic design of coaxially nested rotating and pulsed magnetic fields, utilizing both the rotating magnetic field to provide mechanical shearing and the pulsed magnetic field to activate the fibrinolytic system. This synergistic effect not only achieves non-invasive and precise targeted treatment but also overcomes the efficiency bottleneck of a single magnetic field. Combined with real-time image closed-loop feedback and dynamic parameter adjustment, this strategy effectively resolves the contradiction between the difficulty of particle retention and powerful thrombolysis, improving thrombolysis efficiency by more than 30% and achieving efficient, non-invasive, and precise treatment.

The invention discloses a PAI-1 protein targeting peptide compound (called P peptide for short) with a thrombus dissolving effect and application thereof, and belongs to the field of biological medicine. The PAI-1 targeted thrombolytic polypeptide compound comprises P1, P2, P3 and P4, and is characterized in that the compound is derived from a core structure 'X-Asp-Glu-Leu-Cys-X-Tyr-Tyr-X-X-Cys-X' (cyclization is performed through a disulfide bond between Cys, and X represents any type of amino acid), and the compound can be specifically bound with a key binding site of PAI-1. The polypeptide can significantly reduce the inhibitory effect of PAI-1 on plasminogen activators (tPA, uPA), enhance the activity of a fibrinolytic system, and generate in-vivo and in-vitro thrombolysis effects. The polypeptide compounds P1, P2, P3 and P4 not only have a thrombolysis effect, but also can reduce the expression level of pro-inflammatory cytokines (IL-1beta, TNF-alpha, IL-6 and the like), which shows that the polypeptide compounds also have an anti-inflammatory effect. In conclusion, the polypeptide compound can be used for preparing a PAI-1 antagonist, a thrombolytic agent and an anti-inflammatory agent related to thrombus.

The present invention relates to a polypeptide derived from natural tridegin by structural modification, which may serve as an inhibitor of plasma coagulation factor XIIIa, and to pharmaceutical compositions comprising such polypeptide. The present invention further refers to such polypeptide or pharmaceutical composition for use in a method for treating or preventing a thrombotic event in a patient. Moreover, the invention relates to an endoprosthesis or an enzyme-linked immunosorbent assay (ELISA) plate coated with a polypeptide of the present invention. Furthermore, the invention also encompasses a recombinant fusion protein comprising this polypeptide linked to a fibrinolytic enzyme such as streptokinase, nattokinase or tPAs via a flexible peptide linker containing a thrombin-cleavable site. This construct allows selective inhibition of FXIIIa within a thrombus, while enabling thrombin-triggered release of the fibrinolytic enzyme to induce localized fibrinolysis, thereby achieving targeted dual-action thrombolytic therapy.

The utility model provides a multifunctional internal fistula thrombus taking-out device which comprises a first pipe fitting, a second pipe fitting, a third pipe fitting and a fourth pipe fitting. A second pipe fitting; the thrombolysis pipe fitting is arranged on the outer side of the second pipe fitting in a sleeving mode and is internally hollow to form a medicine cavity, and a plurality of medicine outlet holes communicating with the medicine cavity are formed in the outer wall of the far end of the thrombolysis pipe fitting in a penetrating mode; the crushing mechanism comprises a positioning piece connected with the far end of the thrombolysis pipe fitting and movably arranged on the outer side of the second pipe fitting in a sleeving mode, a driving pipe movably arranged on the outer side of the thrombolysis pipe fitting in a sleeving mode and located on the near end side of the positioning piece, and a plurality of crushing pieces connected between the far end of the driving pipe and the positioning piece, and the positioning piece is limited by a limiting structure when moving towards the far end. A plurality of thrombus in the internal fistula blood vessel can be effectively treated, the incision of the thrombus extraction operation can be greatly reduced, and the damage to the blood vessel is reduced.

The invention relates to an ultrasonic thrombolysis system capable of realizing real-time cavitation dose monitoring and self-adaptive acoustic beam regulation and control. The ultrasonic thrombolysis system comprises a thrombolysis main control unit which can configure a thrombolysis working state of a thrombolysis probe unit so as to perform in-vitro ultrasonic thrombolysis on a target area, and in the process of performing thrombolysis on a thrombus area by using a treatment sound beam, the thrombolysis main control unit configures the thrombolysis probe unit to receive a treatment echo signal and transmits the treatment echo signal to the thrombolysis probe unit. The current cavitation dose is monitored in real time based on the received treatment echo signal; and based on the monitored current cavitation dose, the thrombolysis main control unit at least adjusts the sound power of the treatment sound beam emitted by the thrombolysis probe unit until the current cavitation dose is matched with the target cavitation dose. According to the invention, the cavitation dosage during thrombolysis can be monitored in real time, the thrombolysis treatment acoustic beam can be subjected to self-adaptive acoustic beam regulation and control, and the reliability and thrombolysis efficiency of ultrasonic thrombolysis are improved.

The invention discloses plasmin based on hermetia illucens and application thereof, and belongs to the technical field of biology. The plasmin based on the hermetia illucens is obtained by grinding and centrifuging larvae of the hermetia illucens in a PBS (Phosphate Buffer Solution) and extracting supernate. The invention further provides application of the plasmin based on the hermetia illucens in preparation of thrombolytic drugs. The plasmin is extracted from the hermetia illucens, and the hermetia illucens is short in breeding cycle, high in reproductive capacity, capable of being massively extracted in a short time and low in cost; the extracted plasmin has a remarkable thrombolysis effect and has a very good utilization value; the plasmin can be used for directly dissolving thrombus and degrading fibrinogen.

The invention discloses a medicine injection device capable of realizing automatic thrombolysis administration, which comprises a driving device, a mounting control valve, a thrombolysis medicine bag, a thrombolysis catheter and an injector, the driving device is provided with the mounting control valve, the mounting control valve is connected with the thrombolysis medicine bag, the mounting control valve is connected with the thrombolysis catheter, the mounting control valve is connected with the injector, and the injector is connected with the thrombolysis medicine bag. The driving device comprises a motor and a sensor, the motor is connected with the installation control valve, the sensor is connected with the injector, and the sensor is connected with the motor. By the adoption of the technical scheme, the medicine injection device which is convenient and rapid and capable of achieving automatic thrombolysis medicine administration is manufactured, automatic medicine taking or medicine injection can be achieved by automatically controlling steering of the installation control valve installed on the driving device, and meanwhile an interval medicine administration mode is designed according to the characteristics of thrombolysis medicine administration. And the interval administration time, the pulse amount and the pulse administration rate can be conveniently set clinically, so that personalized thrombolysis administration is realized, and more effective thrombolysis treatment is realized.

The invention discloses an antithrombotic drug derived carbon dot as well as a preparation method and application thereof. Comprising the steps that an antithrombotic drug is selected as a precursor, the antithrombotic drug comprises at least one of an antiplatelet drug with a pharmacodynamic group, an anticoagulant drug with a pharmacodynamic group and a fibrinolytic drug with a pharmacodynamic group, the molecular weight of the antithrombotic drug is 100-2000 Da, and the thermal stability decomposition temperature is larger than or equal to 200 DEG C; the pharmacodynamic groups comprise at least one of sulfonic acid groups, acetoxy groups, indole rings and coumarin structures; performing gradient carbonization treatment on the precursor in a plurality of temperature zones, wherein the plurality of temperature zones comprise a low-temperature zone capable of retaining pharmacodynamic groups, a medium-temperature zone for regulating and controlling a carbon hybridization ratio and a high-temperature zone for performing heteroatom doping; and performing purification and drying treatment to obtain the antithrombotic drug derived carbon dots. Through the preparation method, the antithrombotic drug derived carbon dots with a thrombolysis function and high safety can be obtained, and the problem that the curative effect and safety of an existing antithrombotic drug are unbalanced is solved.

The invention relates to the technical field of medical apparatuses and instruments, and provides an ultrasonic thrombolysis guide wire and a treatment system.The ultrasonic thrombolysis guide wire comprises a guide wire body; an ultrasonic transmitting terminal; and the piezoelectric vibration mode transducer is arranged on the ultrasonic transmitting end. According to the ultrasonic thrombolysis guide wire provided by the invention, multidirectional emission of ultrasound can be realized, the coverage range of a sound field on thrombus is widened, and the thrombus can be effectively treated in cooperation with an ultrasonic contrast agent and thrombolysis drugs. The multi-directional ultrasonic emission can be realized by the single transducer, the use of the transducer is reduced, the overall size of the guide wire is smaller, and the requirement of intravascular thrombolysis miniaturization is more easily met. In addition, based on the advantages of the piezoelectric vibration type transducer, the piezoelectric vibration type transducer can emit low-frequency ultrasound under the condition that the small size is maintained, and the applicability is higher.

1. Name of the product in this design: Intelligent Thrombolysis Box. 2. Purpose of this design: for medical use, to dissolve blood clots. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. Other situations requiring explanation: The key design points of the top view are fully demonstrated in the submitted views, so the top view is omitted; the bottom view is not commonly used, so the bottom view is omitted.

The utility model discloses a visual minimally invasive thrombolysis catheter system which comprises a catheter body and a tail end structure, the tail end structure is arranged at the front end of the catheter body, and the tail end structure comprises a medicine releasing body, an ultrasonic micro-vibration head and a miniature wide-angle lens; the ultrasonic micro-vibration head is of an annular structure, and the ultrasonic micro-vibration head of the annular structure is connected with an external ultrasonic generator through a wire. The miniature wide-angle lens is arranged at the front end of the ultrasonic micro-vibration head, the miniature wide-angle lens is connected with external display equipment through the optical fiber, and the wire and the optical fiber extend in a cavity in the catheter body; the drug release body is of an annular structure, and the ultrasonic micro-vibration head and the miniature wide-angle lens are located on the outer side of the front end of the drug release body of the annular structure. According to the utility model, the visualization of the thrombus position is realized, the accuracy of the drug release position is ensured, the thrombolysis efficiency is improved, the thrombolysis time is shortened, the complication risk is reduced, and the visualization of the drug thrombolysis effect can be realized.

The application discloses a liquid inlet device of a thrombolytic catheter, which comprises a catheter main body, a sealed box and a propelling assembly. The outer side of the catheter main body is sleeved with an outer pipe, the inner side surface of the outer pipe is provided with a flow guide groove, the inner bottom wall of the flow guide groove is provided with a plurality of flow guide holes, the outer pipe end part located on the outer side of a human body is fixedly connected with a flow guide ring which is internally hollow, each flow guide groove is communicated with the inner part of the flow guide ring, the sealed box is placed with a bag body which internally contains an anticoagulant liquid, the sealed box is communicated with the inner part of the flow guide ring through a branch pipe, and the propelling assembly is communicated with the inner part of the sealed box through a connecting pipe. The sealed box is inflated through the propelling assembly, the air pressure is enhanced to extrude the bag body when the gas enters the sealed box, the anticoagulant liquid in the bag body is slowly and continuously flowed into a plurality of flow guide grooves through the branch pipe, and then is flowed out of a blood vessel cavity, so that the formation of a cavity intramural thrombus is reduced, and then the whole blood vessel cavity continuously has a trace amount of anticoagulant drug, which can effectively dissolve the thrombus in the blood vessel cavity and on the outer wall of the thrombolytic catheter.

The invention discloses a fermented soybean fermentation process for high-yield plasmin and thrombolysis application thereof. According to the method, black beans are used as raw materials, water is added for soaking and sterilization, bacillus subtilis is added, the mixture is put into a constant-temperature and constant-humidity incubator for fermentation, according to plasmin activity, the fermentation temperature, humidity, time, inoculation amount, loading capacity and solid-liquid ratio are subjected to a single-factor test, the solid-state fermentation conditions are optimized, and the plasmin solid-state fermentation effect is improved. An optimal solid-state fermentation process is determined by combining an orthogonal test, high-plasmin-yield fermented soybean is obtained through an ultralow-temperature freeze-drying technology, and finally, the safety and thrombolysis effect of the plasmin of the fermented soybean are verified through in-vivo and in-vitro thrombolysis experiments. Compared with the traditional processing process, the fermented soybean processed by the method disclosed by the invention has the advantages that the influence of seasonal and environmental conditions is reduced by utilizing the principle of pure fermentation, the quality stability of the fermented soybean is improved, and meanwhile, the production of the fermented soybean with high plasmin yield lays a foundation for the development of thrombolytic drugs.

The invention discloses a thrombus extraction stent system and a preparation method and application thereof, and belongs to the technical field of medical instruments.The thrombus extraction stent system comprises an expansion stent, a micro catheter and a thrombolysis medicine, and the method comprises the steps that the target dosage of the thrombolysis medicine is determined according to angiography data of target thrombus; determining a first target printing parameter of the thrombolytic drug according to the target dose of the thrombolytic drug; according to the first target printing parameters, a medicine layer containing thrombolytic medicine is formed on the expansion stent through 3D printing, the expansion stent is placed in the micro-catheter, and the thrombectomy stent system is prepared. The technical problem that the thrombolysis medicine cannot be accurately released according to the actual condition of thrombus in the conventional thrombus extraction process is solved.

The embodiment of the invention relates to the technical field of instruments for removing obstruction in blood vessels, in particular to a coronary thrombolysis catheter and a coronary thrombolysis assembly suitable for an ultrasonic guided intervention technology. The catheter includes a catheter assembly disposed to enter the aorta and extend into the left ventricle. The medicine conveying pipe is arranged in the catheter assembly and is arranged to be capable of conveying thrombolytic medicine into the thrombus of the coronary artery through the catheter assembly. The balloon is arranged outside the catheter assembly and can expand after being filled with water, so that the space between the catheter assembly and the aorta is sealed, the thrombolytic medicine cannot flow out of the coronary artery, and thrombus is dissolved. The catheter assembly is configured to allow blood within the left ventricle to flow out through the catheter assembly. According to the catheter, the thrombolytic drug can stay in the coronary artery for a long time, so that the thrombolytic effect and targeting performance are improved, the thrombolytic drug conveyed to the coronary artery is prevented from leaking to the whole body through the aorta, the influence of the thrombolytic drug on the whole body blood coagulation mechanism is reduced, the risk of cerebral hemorrhage and bleeding of other visceral organs is reduced, and the safety of thrombolytic treatment is improved.

Provided is a thrombolytic agent for ‘intravascular thrombus’, and more particularly, to a thrombolytic agent having a thrombo-recognition domain and a thrombolytic domain. It also relates to a polypeptide for thrombolysis of an intravascular thrombus, a gene for that polypeptide, and a pharmaceutical composition containing the same. The polypeptide that recognizes ‘intravascular thrombus’ and dissolves thrombus of the present invention is characterized in that it consists of a thrombolytic domain comprising the amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2 and a thrombo-recognition domain comprising the amino acid sequence set forth in SEQ ID NO: 3 or SEQ ID NO: 4. According to the present invention, the polypeptide for dissolving thrombus by recognizing ‘intravascular thrombus’ dissolves thrombus in the blood of a mammal without serious bleeding side effects has a preventive and therapeutic effect on thrombosis, thus preventing thrombosis and related diseases.

The application provides a thrombus-targeting diagnosis and treatment integrated nano probe, which comprises a core-shell structure, the core of the core-shell structure is bismuth, and the shell is expanded pore silicon dioxide wrapping bismuth; a chemical medicine for treating thrombus is loaded in the pore channel of the expanded pore silicon dioxide, and a thrombus-targeting polypeptide is connected to the surface of the expanded pore silicon dioxide; the amino acid sequence of the thrombus-targeting polypeptide is GPRPVTSEIHLK. The application not only improves the drug loading capacity of the core-shell nano probe by forming the expanded pore Bi@SiO2 particle with Bi as the core and SiO2 as the shell, but also makes the probe capable of enriching at the thrombus site by using the targeting effect of the thrombus-targeting polypeptide, so as to construct a targeted nano drug delivery system with targeted imaging and photo-thermal-chemical synergistic thrombolysis, accurately treat the thrombus, and realize the diagnosis and treatment integration of the thrombus.

The invention belongs to the technical field of medical treatment, and particularly relates to a pulse and ultrasonic energy time sequence synergistic drug delivery method and system. The pulse and ultrasonic energy time sequence synergistic administration method is characterized by comprising the following steps: (1) suspending medicament injection, and only washing with cooling liquid for 2-4 seconds; (2) the conveying of the cooling liquid is suspended, the medicament is sprayed for 0.5-1.5 seconds, and meanwhile, the ultrasound continuously works; (3) suspending injection of the medicament, re-inputting the cooling liquid, and continuing for 2-4 seconds; and (4) repeating the steps (1), (2) and (3) until completion. The system has the advantages that through pulse type drug delivery and time sequence cooperative control, periodic targeted release of high-concentration drugs is achieved, the drug utilization rate and the thrombolysis effect are remarkably improved, drug permeation is enhanced through the ultrasonic cavitation effect, and meanwhile the heat dissipation requirement of the system is met.

The invention belongs to the technical field of thrombus removal, and discloses a sublingual sympathetic nerve targeting-based thrombus removal method, which can promote the loosening, decomposition or dissolution of thrombus by applying selective stimulation to a sublingual area and inducing the change of hemodynamics or endogenous fibrinolytic system. The supralingual sympathetic nerve can be acted by combining electrical stimulation, ultrasonic, optical or thermal means, and synergistic thrombus cleaning can be realized by matching with a drug carrier or ultrasonic microbubbles sensitive to stimulation. According to the method, autonomous adjustment can be achieved through closed-loop control, and the method can also be used in cooperation with conventional means such as mechanical thrombus extraction and medicine thrombolysis. Compared with the prior art, the medicine dosage and systemic side effects can be reduced, the operation risk is reduced, the thrombus removing efficiency is remarkably improved, and the good clinical application prospect is achieved.

The application discloses a catheter, a thrombolytic device and a fluid control method, and belongs to the field of medical devices. The catheter comprises: an elongated tubular body for percutaneous placement in a body lumen of a target object; the inside of the elongated tubular body is used for arranging an energy source member; the elongated tubular body comprises a delivery lumen, a first lumen and a second lumen; the delivery lumen is used for conveying a first fluid; the elongated tubular body has a distal region provided with a delivery port; one end of the delivery port is in communication with the body lumen, and the other end is in communication with the delivery lumen to convey the first fluid into the body lumen; at least one of the first lumen and the second lumen is arranged around the outer periphery of the energy source member, and the first lumen and the second lumen are in fluid communication at the distal region to flow a second fluid for cooling the energy source member between the first lumen and the second lumen. The technical scheme provided by the application can control the temperature of the energy source and reduce the influence of heat generation of the energy source on the activity of the drug.