204 results about "Thrombolysin" patented technology

The invention discloses an intelligent thrombus suction and cutting system, and belongs to the field of medical instruments. According to the system, the design of double pressure sensors and the intelligent pressure feedback control technology are adopted, and the suction state (blood suction, thrombus suction or complete blockage) is accurately recognized by monitoring pressure changes in a negative pressure pump pipeline and a suction catheter in real time and combining historical data analysis. The system automatically adjusts parameters of a pipeline control valve, a negative pressure pump, a peristaltic pump and the like according to the parameters, and intelligent optimization control over the suction process is achieved. The innovative integrated design of the double-cavity catheter integrates the functions of suction and thrombus breaking, when the complete blockage state is judged, the thrombus breaking program can be automatically or manually started, thrombus is quickly broken through high-speed liquid impact or thrombolysis medicine injection, and long-time suction catheter blockage is effectively prevented. The system obviously improves the thrombus aspiration efficiency, reduces the blood loss amount of a patient, optimizes the operation process, and has a good clinical application prospect.

The invention discloses a thrombolysis prediction method based on deep learning and multi-modal fusion, and belongs to the technical field of thrombolysis prediction, and the method comprises the steps: S1, collecting an MRI image of a patient with ischemic cerebral apoplexy, and constructing a cerebral apoplexy automatic segmentation model; s2, carrying out image registration; s3, lesion segmentation; and S4, thrombolysis prediction. According to the cerebral apoplexy automatic segmentation model based on the gating parallel Mama network, the long-distance dependency relationship in the image can be effectively captured, ischemic cerebral apoplexy lesions can be rapidly and accurately segmented, and the lesion identification efficiency and accuracy are greatly improved; according to the algorithm provided by the invention, the linear time complexity is realized, the computing resource consumption is greatly reduced, and the bottleneck of the prior art is broken through; according to the cerebral apoplexy thrombolysis prediction model based on the multi-modal data, scientific automatic decision support is provided for judging whether the patient is suitable for thrombolysis treatment or not, and the quality and safety of medical decision are improved.

The invention relates to the technical field of nano-drugs, in particular to low-intensity focused ultrasound response nanoparticles for enhancing thrombus targeting and penetration, a preparation method of the nanoparticles and application of the nanoparticles in anti-thrombus treatment. The low-intensity focused ultrasound response nanoparticle for enhancing thrombus targeting and penetration comprises a platelet membrane shell, and a core is formed by wrapping perfluoropentane and L-arginine with polylactic acid-glycolic acid copolymer-polyethylene glycol. The platelet membrane ensures that the nanoparticles specifically target a thrombus part; under the stimulation of LIFU, the nanobubbles penetrate through the deep layer of thrombus, L-arginine is oxidized into L-citrulline, and nitric oxide is formed. Meanwhile, the LIFU triggers liquid-gas phase change and nitric oxide release, the ultrasonic cavitation effect is enhanced through the synergistic effect, thrombus structures including red blood cells, blood platelets and fibrin are specifically attacked, and efficient thrombolysis treatment is achieved. According to the technical scheme, the technical problem that the thrombolysis effect of ultrasonic nanoparticles is not ideal can be solved, and good clinical application prospects are achieved.

The invention relates to the field of nano medicines, in particular to a targeted medicine as well as a preparation method and application thereof. The invention provides a targeted drug. The targeted drug comprises a tissue-type plasminogen activator and a targeted peptide. Thrombus targeting modification is directly carried out on a thrombolytic drug rtPA which is most widely applied clinically by utilizing a chemical method, the defects of narrow treatment time window, high dosage and high bleeding risk of the rtPA are remarkably improved, the preparation process is simple and controllable, materials required for preparation are easy to obtain, the cost is low, and the application prospect is wide. The toxic effect and degradation problems of materials such as compounds are eliminated, other instruments and equipment are not needed in the treatment process, and clinical transformation application of thrombus targeted rtPA becomes possible.

The invention discloses an inulin gel compound loaded with Prussian blue nano-enzyme and nattokinase and application of the inulin gel compound in treatment of inflammatory bowel disease, the compound is formed by blending the Prussian blue nano-enzyme, the nattokinase and inulin, the Prussian blue nano-enzyme with multiple antioxidant enzyme activities is used for removing a large amount of active oxygen in cells, and the nattokinase is used for treating inflammatory bowel disease. The level of inflammatory factors is reduced, oxidative stress is relieved, and intestinal inflammation is treated; the nattokinase not only can inhibit the formation of intestinal microthrombus and effectively dissolve thrombus through the excellent thrombolysis capability of the nattokinase, but also can synergistically and effectively treat inflammatory bowel diseases through the intestinal microbiota regulation capability of the nattokinase; in addition, the inulin, the Prussian blue nano-enzyme and the nattokinase jointly realize the regulation of intestinal microbiota of the patient with the inflammatory bowel disease, so that the anxiety and depression symptoms related to the inflammatory bowel disease are effectively relieved through microbiota-intestine-brain axis. In general, the invention provides a creative example for treating the inflammatory bowel disease and related intestinal internal and external complications thereof.

The invention discloses a method for training a thrombolysis adaptability evaluation model and a related product. The method comprises the following steps: acquiring brain perfusion image data, a brain perfusion parameter map, clinical data and treatment data; performing region-of-interest extraction on the cerebral perfusion parameter map to obtain an attention map containing a core infarction region and an ischemic penumbra sensing region; multiplying the brain perfusion image data by the attention map to obtain weighted brain perfusion image data; the first labeling information and the second labeling information are used for labeling whether thrombolysis treatment is carried out or not and labeling the effect grade after thrombolysis treatment is carried out; and inputting the weighted brain perfusion image data, the brain perfusion parameter diagram, the clinical data, the first annotation information and the second annotation information into a thrombolysis adaptability evaluation model as training data so as to train the thrombolysis adaptability evaluation model. By utilizing the scheme disclosed by the invention, the thrombolysis adaptability and treatment effect prediction accuracy can be improved, and a more reliable basis is provided for clinical decision making.

The invention relates to the technical field of medical instruments, and discloses a vascular surgery clinical thrombolysis catheter fixing device which comprises a single-cavity tube, a fixing mechanism arranged at the top of the single-cavity tube and a clamping mechanism arranged on the outer side of the fixing mechanism. The fixing mechanism is used for fixing the skin of a patient and the top end of the single-cavity tube, and the clamping mechanism is used for fixing the tail end of the guide wire; the fixing mechanism comprises a connector arranged at the top of the single-cavity pipe, a sliding groove formed in the middle of the connector, two sliding blocks symmetrically arranged on the two sides of the sliding groove, telescopic units arranged at the bottoms of the sliding blocks and used for transmitting the acting force of the sliding blocks, a connecting plate arranged at the bottom of the sliding groove and two tension springs symmetrically arranged on the two sides of the connecting plate. By arranging the fixing mechanism, the device can be adjusted to adapt to the body surface so as to adapt to the joint, the neck or the groin and other areas, the fixing device can restrain the tail end of the guide wire, and axial sliding or radial deflection of the guide wire caused by external force interference is avoided.

The utility model relates to the technical field of medical instruments, and discloses a pigtail thrombolysis catheter which comprises a catheter body and a plugging piece. The far end part of the tube body is curled to form a drug delivery part, the far end of the drug delivery part is provided with a tube opening, and the drug delivery part is suitable for deforming under the action of external force and restoring after the external force is removed. The multiple through holes are formed in the tube wall of the drug delivery part at intervals. The plugging piece comprises a flexible guide wire and a ball body arranged at the far end of the flexible guide wire, and the flexible guide wire is suitable for extending into the pipe body to the ball body to plug the pipe opening. Through the administration part, physical thrombus breaking and medicine thrombolysis means can be combined, the thrombus breaking progress can be accelerated to a great extent, so that an ideal clinical effect is achieved, the use mode of the tube body and the plugging piece is simple, the thrombolysis difficulty is reduced, meanwhile, the consumable cost is also reduced, and the application range is wide. And the method has good economical efficiency and potential of being suitable for wide popularization.

A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.

Provided are a targeted drug and a preparation method therefor and the use thereof. The targeted drug comprises a tissue-type plasminogen activator and a targeting peptide. Thrombus-targeting modification is directly performed on thrombolytic drug rtPA, which has the widest clinical application, by means of a chemical method. The defects of rtPA in terms of a narrow therapeutic time window, a high medication dosage and a high hemorrhage risk are significantly improved. The preparation process is simple and controllable, and the materials required for the preparation are readily available and cost-effective. The toxic effects and degradation problems of materials such as compounds are eliminated. In addition, the treatment process does not require other instruments and devices, which makes the clinical transformation and use of the thrombus-targeting rtPA possible.

The invention relates to the technical field of thrombus mining robots, in particular to a micron robot with an asymmetric cilia structure, a preparation method and application. The micro-robot is of an asymmetric composite structure and is composed of a smooth hemisphere and a cilia-shaped structure, sandwich type layered arrangement of a PLGE cilia-shaped nano structure, an MNPs interlayer and a PS sphere core is formed on the surface and the interior of the micro-robot from outside to inside, and cooperative regulation and control of morphology and functions are achieved by regulating and controlling the material proportion of PS and PLGE. The thrombus mining robot shows an efficient thrombolysis effect in a plurality of in-vitro and in-vivo models, and rapid fibrinolysis, deep thrombus penetration and efficient mining of single red blood cells are realized, so that the limitation of a traditional thrombolysis agent is overcome. In addition, the thrombus digging robot has excellent biocompatibility and biological safety, has no obvious cytotoxicity or damage to main organs, and supports the safety of the thrombus digging robot in clinical application.

The invention discloses a balloon catheter pressure applying device for thrombus treatment and vascular embolism, and relates to the technical field of medical instruments, the balloon catheter pressure applying device comprises a first catheter, the first catheter is sleeved with a second catheter, the front end of the second catheter is fixedly connected with a memory metal net bag, the second catheter is sleeved with a third catheter, and the third catheter is fixedly connected with a memory metal net bag. A fourth catheter is fixedly connected to the outer side of the third catheter, a rear balloon is fixedly connected to the outer side of the front end of the air delivery pipe, an exhaust head is fixedly connected to the front end of the first catheter, a front balloon is fixedly connected to the outer side of the exhaust head, and a thrombus removing assembly used for assisting in removing thrombus is arranged on the outer side of the front end of the first catheter. According to the thrombus treatment vascular embolism balloon catheter, the thrombus dissolving medicine in the medicine storage balloon membrane is squeezed out through the pressure applying device, the thrombus dissolving medicine can penetrate through the memory metal net bag to move to the embolism position, thrombus is dissolved, and the thrombus can be better removed through cooperation with the thrombus removing assembly.

The invention discloses a natto peptide sea cucumber polysaccharide liposome for synergistically improving cardiovascular health and a preparation method and application thereof, belongs to the field of active peptide delivery systems, and aims to solve the stability problem of natto oligopeptide in gastrointestinal digestive tracts. The phytosterol and the vitamin E are filled between phospholipid double layers of the liposome to support a gap between the phospholipid double layers, and the ratio of the phytosterol to the vitamin E is (1-3): 1, so that the natto oligopeptide liposome has the effects that the storage of the natto oligopeptide and the stability of the natto oligopeptide in gastrointestinal and digestive tracts can be improved, the bioavailability of the natto oligopeptide liposome is improved, and the bioavailability of the natto oligopeptide liposome is improved. The traditional Chinese medicine composition has synergistic effects in the aspects of anticoagulation, thrombolysis and blood fat reduction, and has a good cardiovascular protection effect.

Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and / or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase.

The invention relates to the technical field of thrombolysis drug delivery instruments, and discloses an expandable thrombolysis stent and a thrombolysis device.The expandable thrombolysis stent is characterized in that a stent body which is formed by connecting a plurality of drug catheters in parallel and is in a quasi-cylindrical shape is arranged on the periphery of a central tube of a first slender tubular component; according to the expandable thrombolysis stent and the thrombolysis device, when thrombolysis medicine is poured, the expandable stent main body can be expanded in a thrombus, so that the thrombolysis medicine can be injected into the thrombus, and the thrombus can be injected into the thrombolysis medicine through the medicine catheter, and the thrombolysis medicine can be injected into the thrombus through the medicine injection through holes. Therefore, medicine perfusion can be carried out at the optimal position, full contact with thrombus is carried out, the thrombolysis efficiency is further improved, and efficient thrombolysis is achieved. According to the expandable thrombolysis stent and the thrombolysis device, when thrombolysis medicine is perfused, various thrombolysis point positions can be provided for thrombus due to the fact that the medicine injection through holes are formed in the medicine catheter, and therefore the thrombolysis targeting performance and efficiency are improved.

The invention provides an ultrasonic thrombolysis treatment device. The ultrasonic thrombolysis treatment device is in a strip shape, and in the using state, the ultrasonic thrombolysis treatment device is spirally wound around the outer wall of a blood vessel section (100) where thrombus is located; or the ultrasonic thrombolysis treatment device is formed into a plane shape, the ultrasonic thrombolysis treatment device wraps the outer wall of the blood vessel section (100) in the using state, the ultrasonic thrombolysis treatment device comprises a plurality of piezoelectric modules (200) which are arranged in a scattered mode, the piezoelectric modules (200) can be controlled to emit ultrasonic waves, and the ultrasonic thrombolysis treatment device is used for treating the blood vessel section (100). The ultrasound is enabled to be emitted from a plurality of locations in a focused manner into the vessel section (100) to ablate the thrombus.

An ultrasound-assisted thrombolysis device is provided. The ultrasound-assisted thrombolysis device 100 includes a catheter 110, a first ultrasonic module 120, a second ultrasonic module 130, and a control device 140. The first ultrasonic module 120 and the second ultrasonic module 130 are installed in the catheter 110 and electrically connected to the control device 140. The first ultrasonic module 120 is used to emit ultrasonic waves toward the thrombus to dissolve the thrombus, and the second ultrasonic module 130 is used to emit ultrasonic waves toward the thrombus and measure the distance between the catheter 110 and the thrombus. The control device 140 controls the first ultrasonic module 120 and the second ultrasonic module 130 based on the measured distance.

The invention relates to the technical field of food processing, and particularly discloses a heart and cerebral vessel health care composition with thrombolytic and antithrombotic functions and a preparation method thereof. The composition consists of the following raw materials: sorbitol, red yeast rice, freeze-dried natto powder, earthworm protein peptide, vitamin C, American ginseng peptide, magnesium stearate, an angelica sinensis extract, rice bran fatty alkanol, vitamin B1, vitamin B2, a turmeric extract and a compound coloring agent. The preparation method comprises the following steps: mixing the raw materials except magnesium stearate in a double-cone mixer; magnesium stearate is added for continuous mixing, and a hollow capsule shell is filled with the mixed material. The composition disclosed by the invention forms a multi-dimensional synergistic system for smoothing blood vessels, purifying blood and improving blood flow, the defect of single effect of an existing product is overcome, the health-care effect of heart and cerebral vessels is remarkably improved, and the effect is stable and controllable; in addition, the preparation method has the advantages of being simple and controllable in process and suitable for industrial production.

The present invention relates to the field of medical equipment, and provides a thrombus removal device, which comprises a conveying assembly and a thrombus removal bracket, wherein the conveying assembly comprises an end, an inner tube, an intermediate tube, an outer tube and a suction catheter, wherein the end is connected to one end of the inner tube, the intermediate tube is movably sleeved with the inner tube, the outer tube is movably sleeved with the intermediate tube, a drug spraying hole is provided on the tube wall of the outer tube, the outer tube is suitable for conveying thrombolytic drugs to be sprayed from the drug spraying hole, the suction catheter is movably sleeved with the outer tube, and the suction catheter is suitable for aspirating thrombus; one end of the thrombus removal bracket is connected to the end, and the other end is connected to one end of the intermediate tube adjacent to the end, the thrombus removal bracket is sleeved on the outside of the inner tube and the intermediate tube, and the thrombus removal bracket moves with the inner tube and the intermediate tube to be exposed outside the outer tube or received inside the outer tube. The present invention improves the thrombus removal effect and efficiency through a combination of thrombolysis and mechanical thrombus removal.

The present invention provides a pharmaceutical composition comprising a binary conjugate DC009 and a pharmaceutically acceptable carrier, wherein DC009 is a conjugate of a thrombolytic peptide (Pro-Ala-Lys) and a tetrahydroisoquinoline compound having two C1-4 alkyl groups conjugated via a lysine linker. The pH of the composition is less than 6.5, preferably about pH 2 to 5.5. The composition may contain pharmaceutically acceptable excipients such as mannitol, sorbitol, sucrose, lactose or trehalose.

The present invention provides a nanoscale MOF with pH-responsive function for targeted dual-drug thrombolysis and a preparation method thereof. Hollow mineralized nanoscale calcium carbonate powder is mixed with γ-cyclodextrin and a potassium ion compound, ultrasonically dispersed, and then incubated to form a cyclodextrin MOF embedded with calcium carbonate. An RGD polypeptide is grafted onto the surface of the cyclodextrin MOF embedded with calcium carbonate to obtain MOF-RGD. The grafted MOF-RGD is impregnated into ethanol containing an anticoagulant drug, air-dried, and then mixed with a thrombolytic drug, so that the thrombolytic drug is loaded on the surface of the nanoscale MOF to obtain a pH-responsive targeted nanoscale MOF. The present invention forms a nanoscale MOF with a targeted function, which combines thrombolysis and anticoagulation, and realizes the treatment and prevention of deep vein thrombosis.

The application discloses a four-stage paddle thrombus-removing micro robot, a preparation method and a magnetic field driving thrombus-removing micro robot system, relates to the technical field of micro robots, and comprises a conical drill bit, a main straight rod and a four-stage paddle group, wherein the conical drill bit is made of a biodegradable material; the bottom of the conical drill bit is connected with the main straight rod; the main straight rod is internally provided with a thrombolytic drug; the four-stage paddle group is arranged on the outer circumferential surface of the main straight rod in an axial direction; the paddle group comprises three paddle blades which are centrally symmetrical to the axis of the main straight rod; the paddle blades in the adjacent two-stage paddle groups are arranged in a staggered manner; the paddle blades are of a round head structure; the thickness of the paddle blades gradually increases from outside to inside; and the surface of the micro robot is coated with a magnetic film and is subjected to directional magnetization treatment. The application can obtain strong movement ability and stable movement state under the accurate control of a movement system, realizes intravascular drilling and crushing of a thrombus, and can biodegrade and release the thrombolytic drug after surgery, so as to solve the problem of downstream vascular embolism after drilling.

The utility model relates to the field of thrombolysis treatment boxes, and discloses a movable thrombolysis treatment box which comprises a box body, two drawers are connected in the box body in a sliding mode, two cabinet doors are connected to the front side of the box body in a rotating mode, a sharp instrument box is connected in the box body in a rotating mode, and a pull rod is connected to the rear side of the sharp instrument box in a rotating mode. A pressing rod is rotatably connected to the front side of the pull rod, a bottom plate is rotatably connected to the bottom of the pressing rod, the front side of the bottom plate is rotatably connected to the bottom of the sharp instrument box, inner shells are rotatably connected to the left side and the right side of the inner wall of the sharp instrument box, sliding rods are slidably connected to the interiors of the inner shells, and first baffles are fixedly connected to the tops of the sliding rods. According to the sharp instrument box, the pull rod is lifted to drive the pressing rod to downwards press the bottom plate, and the sliding rod is pulled to enable the baffle plate I to compress the spring I, so that sharp instruments in the sharp instrument box can be quickly emptied, time and labor are saved, the working efficiency is effectively improved, and the whole sharp instrument box is prevented from being taken out.

The invention provides a liquid phase tandem time-of-flight mass spectrometry detection method for the content of tirofiban in liver tissue, and belongs to the technical field of detection. According to the present invention, the concentration of tirofiban in the liver tissue is detected through the liquid phase tandem time-of-flight mass spectrometry, such that the characteristics of low detection limit, immediate analysis, high sensitivity, good repeatability, good indoor reproducibility and high accuracy are provided, the matrix effect is substantially reduced, the recovery rate is improved, and the precise detection of tirofiban is achieved. The method is successfully applied to detection of tirofiban in liver tissues in a clinical animal experiment stage, has important clinical significance for monitoring the in-vivo content of tirofiban after medication, avoids occurrence of postoperative related complications in serious interventional therapy, and has a good clinical application prospect. And side effects such as poor thrombolysis effect caused by insufficient medication and bleeding caused by excessive medication are prevented.

The invention discloses a PICC (Peripherally Inserted Central Catheter) thrombolysis device which comprises a connector connected with a PICC pipeline; the liquid storage tank is connected with the connector; the negative pressure pipe generates a negative pressure environment in the connector; a first connector, a second connector and a third connector are arranged on the connector, the first connector and the second connector are arranged at the two ends of the connector respectively, a branch pipe is arranged on the connector, the third connector is arranged on the branch pipe, the liquid storage tank is connected to the second connector, and the negative pressure pipe is connected to the third connector; the liquid storage tank is filled with urokinase liquid; a sealing plate is arranged in the connecting cavity and seals the second connector. A first push rod is arranged on the negative pressure pipe, after the first push rod is pressed down, the sealing plate moves to the third connector to seal the third connector, the second connector is opened, and urokinase liquid enters the connector; the method has the advantage of being convenient to operate.

The invention provides a cobalt-iridium metal complex, nanoparticles, a preparation method and application, and belongs to the technical field of photodynamic therapy drugs. The structural formula of the cobalt-iridium metal complex is shown as a formula (I). The invention also provides a preparation method of the cobalt-iridium metal complex. The invention also provides nanoparticles, the cobalt-iridium metal complex prepared by the invention has a chemiluminescence property, so that the cobalt-iridium metal complex can simultaneously realize photo-thermal, photodynamic and ultrasonic synergistic thrombolysis treatment effects, and the oxidation resistance of the cobalt-iridium metal complex has a remarkable curative effect on a vascular injury part. The complex provided by the invention has good photo-thermal, photodynamic and ultrasonic response capabilities, and can overcome the problems of short excitation wavelength of exciting light and limited light penetration depth required by the existing metal iridium complex. Experiments show that the material has a good treatment effect on thrombus.

The invention relates to a composition for preventing cardiovascular and cerebrovascular diseases and a preparation method thereof, and belongs to the technical field of health food. The composition for preventing cardiovascular and cerebrovascular diseases is prepared from the following components in parts by weight: 20 to 100 parts of dihydroquercetin, 100 to 300 parts of red yeast rice, 50 to 150 parts of nattokinase, 50 to 200 parts of earthworm protein, 100 to 300 parts of hawthorn fruit extract, 100 to 300 parts of radix puerariae extract and 100 to 300 parts of sea-buckthorn extract. The composition prepared by the invention has the characteristics of lowering lipid, dissolving thrombus and protecting heart and blood vessels.

The invention belongs to the field of natural compounds, and particularly relates to application of VMO1 protein in toxicity resistance, oxidation resistance, thrombolysis and sperm motility regulation. According to the specific technical scheme, the application of the VMO1 protein in preparation of drugs for inhibiting bacteria, resisting toxicity, resisting oxidation and improving or reducing sperm motility is provided, and the amino acid sequence of the VMO1 protein is shown as SEQ NO ID: 1. It is found for the first time that the VMO1 protein extracted from frog follicles not only can inhibit the activity of pseudomonas aeruginosa, but also can resist toxicity, and meanwhile, the VMO1 protein has a good antioxidant effect, a thrombus dissolving effect and a bidirectional sperm motility adjusting effect. Therefore, the VMO1 protein has huge pharmaceutical potential.

The utility model provides an ultrasonic thrombolysis catheter. The ultrasonic thrombolysis catheter comprises an infusion basket, a driving mechanism and an ultrasonic assembly. The infusion basket comprises a plurality of infusion catheters, and a hollow structure is defined by the infusion catheters. The driving mechanism is used for controlling the infusion basket to expand and open or close in the radial direction. The ultrasonic assembly comprises a plurality of ultrasonic electrodes, and the ultrasonic electrodes are fixed in the hollow structure of the infusion basket. During use, the infusion basket which is initially in a closed state is conveyed to a lesion position, and the infusion basket is expanded and opened through the driving mechanism, so that blood flows through thrombus. Thrombolysis medicine enters each infusion catheter and is conveyed to diseased tissue through the infusion holes in the infusion catheters, the thrombolysis medicine is accurately released to thrombus, accurate thrombolysis is achieved, and the dosage of the thrombolysis medicine is reduced. Meanwhile, the ultrasonic electrode is communicated with an ultrasonic generator, so that the ultrasonic generator generates ultrasonic waves, and the ultrasonic waves accelerate point dissolution by unfastening and diluting a fibrin chain, so that more drug receptor sites are exposed.

The invention relates to the technical field of food processing, and in particular to a natto-okra product and a preparation method thereof. The invention combines the nutritional components and unique flavors of natto and okra, and prepares a natto-okra block with rich nutrition and unique taste through freeze-drying technology. The raw materials of the natto-okra product include freeze-dried natto, freeze-dried okra, seasoning and oligomaltose syrup. Through a specific freeze-drying process and mixed molding technology, the nutrition, flavor and color of the raw materials are retained, and the shelf life is extended. The preparation method includes freeze-dried preparation of natto and okra, raw material mixing, molding and solidification, packaging and storage, etc. The process is simple, easy to operate, and suitable for industrial production. The product not only has the health benefits of natto, such as thrombolysis, intestinal regulation, etc., but also integrates the health benefits of okra, such as stomach-strengthening and intestinal regulation, and immunity enhancement. The product of the invention is suitable as a snack or cooking side dish, and has a broad market prospect.