Use of sparstolonin B (sparstolonin B) for preparing medicine for treating cerebral hemorrhage

A technology of sparstoloninb and triangular lactone, which is applied in the field of medicine

Inactive Publication Date: 2016-11-02
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report about the anti-cerebral hemorrhage effect of Sparstolonin B

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of sparstolonin B (sparstolonin B) for preparing medicine for treating cerebral hemorrhage
  • Use of sparstolonin B (sparstolonin B) for preparing medicine for treating cerebral hemorrhage
  • Use of sparstolonin B (sparstolonin B) for preparing medicine for treating cerebral hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The present invention demonstrates that sparstolonin B (SsnB) has the effect of treating cerebral hemorrhage through the following experiments.

[0014] 1. Experimental materials

[0015] 1.1 Animals C57BL / 6J mice, male, weighing 20-25 g, were provided by the Experimental Animal Center of Third Military Medical University.

[0016] 1.2 Main equipment Stereotaxic instrument (Stoelting Co., USA), micro syringe pump (Stoelting Co., USA), electronic analytical balance (Shanghai Tianping Instrument Factory, FA1004), electric heating oven (Shanghai Pudong Yuexin Scientific Instruments) factory, 202A-1), desktop high-speed low-temperature centrifuge (Eppendorf5810R, Germany), fluorescence microscope (Olympus BX60, Japan), image acquisition and analysis system (Olympus DP70, Japan), microplate reader (Beckman, USA), cell culture Bottle and Transwell culture system (Corning, USA)

[0017] 1.3 Main reagents Chloral hydrate, DMSO, trypsin, hemoglobin (Hb) (Sigma, USA), DMEM / F12,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the medicine technical field, and especially relates to an application of Sparstolonin B in the preparation of drugs for treating cerebral hemorrhage. It has been proved by animal experiments that Sparstolonin B has a strong protective effect on mouse brain after cerebral hemorrhage, is capable of prominently repairing the neurologic impairment of mice with cerebral hemorrhage, obviously reliving the cerebral edema, and inhibiting the inflammatory responses around the hematoma tissues, thus increases the survival rate of mice with cerebral hemorrhage, and prominently increases the survival rate of damaged nerve cells of hemoglobin induced microglia. Thus Sparstolonin B can be used to prepare drugs for treating cerebral hemorrhage.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new application of sparstolonin B (Sparstolonin B) in the preparation of anti-cerebral hemorrhage drugs. Background technique [0002] Sparstolonin B (SsnB), the structural formula is as follows: [0003] [0004] Molecular formula C15H8O5, yellow needle crystal (petroleum ether-ethyl acetate), molecular weight 268, soluble in chloroform, ethyl acetate, methanol. [0005] The compound is extracted and isolated from the tuber of Scripus yagara Ohwi. For its preparation method, please refer to our declared patent (Liang Qiaoli, Wu Qinan, Fan Daping, Duan Jinzheng, Gao Yu. Anti-atherosclerosis black trilatex lactone compound and its preparation method, patent number ZL 2009 1 0033686.3), and at the same time It was found that SsnB is a TLR2 and TLR4 blocker, which can block the inflammatory signal transmission mediated by TLR2 and TLR4, and has a significant inhibitory effect ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61P7/04A61P9/10
Inventor 梁侨丽杨清武王艳春李军
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap