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Application of Sparstolonin B in preparation of drugs for treating cerebral hemorrhage

A technology of sparstoloninb and triangular lactone, which is applied in the field of medicine

Inactive Publication Date: 2014-08-13
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report about the anti-cerebral hemorrhage effect of Sparstolonin B

Method used

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  • Application of Sparstolonin B in preparation of drugs for treating cerebral hemorrhage
  • Application of Sparstolonin B in preparation of drugs for treating cerebral hemorrhage
  • Application of Sparstolonin B in preparation of drugs for treating cerebral hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The present invention demonstrates that sparstolonin B (SsnB) has the effect of treating cerebral hemorrhage through the following experiments.

[0016] 1. Experimental materials

[0017] 1.1 Animals C57BL / 6J mice, male, weighing 20-25 g, were provided by the Experimental Animal Center of Third Military Medical University.

[0018] 1.2 Main equipment Stereotaxic instrument (Stoelting Co., USA), micro syringe pump (Stoelting Co., USA), electronic analytical balance (Shanghai Tianping Instrument Factory, FA1004), electric heating oven (Shanghai Pudong Yuexin Scientific Instruments) factory, 202A-1), desktop high-speed low-temperature centrifuge (Eppendorf5810R, Germany), fluorescence microscope (Olympus BX60, Japan), image acquisition and analysis system (Olympus DP70, Japan), microplate reader (Beckman, USA), cell culture Bottle and Transwell culture system (Corning, USA)

[0019] 1.3 Main reagents Chloral hydrate, DMSO, trypsin, hemoglobin (Hb) (Sigma, USA), DMEM / F12,...

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Abstract

The invention relates to the medicine technical field, and especially relates to an application of Sparstolonin B in the preparation of drugs for treating cerebral hemorrhage. It has been proved by animal experiments that Sparstolonin B has a strong protective effect on mouse brain after cerebral hemorrhage, is capable of prominently repairing the neurologic impairment of mice with cerebral hemorrhage, obviously reliving the cerebral edema, and inhibiting the inflammatory responses around the hematoma tissues, thus increases the survival rate of mice with cerebral hemorrhage, and prominently increases the survival rate of damaged nerve cells of hemoglobin induced microglia. Thus Sparstolonin B can be used to prepare drugs for treating cerebral hemorrhage.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new application of sparstolonin B (Sparstolonin B) in the preparation of anti-cerebral hemorrhage drugs. Background technique [0002] Sparstolonin B (SsnB), the structural formula is as follows: [0003] [0004] Molecular formula C15H8O5, yellow needle crystal (petroleum ether-ethyl acetate), molecular weight 268, soluble in chloroform, ethyl acetate, methanol. [0005] The compound is extracted and isolated from the tuber of Scripus yagara Ohwi. Its preparation method can be found in the patent we declared (Liang Qiaoli, Wu Qinan, Fan Daping, Duan Jinzhen, Gao Yu. Anti-atherosclerotic black trilatex lactone compound and its preparation method, patent number ZL2009 1 0033686.3), and found SsnB is a TLR2 and TLR4 blocker, which can block the inflammatory signal transmission mediated by TLR2 and TLR4, and has a significant inhibitory effect on the inflammatory response of h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P7/04A61P9/10
Inventor 梁侨丽杨清武王艳春李军
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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