Oral traditional Chinese medicine grease emulsifiable paste for repairing gastric mucosa

Abstract

The invention discloses a traditional Chinese medicine grease oral cream for repairing gastric mucosa and a preparation method thereof, optimizes a traditional heating extraction process into direct compatibility of traditional Chinese medicine extracts, and belongs to the technical field of traditional Chinese medicine preparations. The emulsifiable paste is prepared from a fixed-proportion grease base (20% of emu oil, 40% of olive oil, 20% of coconut oil and 20% of castor oil), six traditional Chinese medicine extract effective components (1-2% of astragaloside, 1-2% of atractylenolide, 1-2% of atractylenone, 1-2% of berberine, 1-2% of scutellaria baicalensis extract and 1-2% of obakunone), 3% of vitamin E, 20-25% of sea buckthorn seed oil and 10% of excipient beewax. According to the preparation process, heating extraction is abandoned, the problems that the extract is difficult to dissolve and easy to agglomerate in grease are solved through infiltrating the extract with a small amount of grease, homogenizing at the low temperature of 60 DEG C and shaping and fixing beewax, and uniform dispersion and stable dispersion of the extract are realized.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine (TCM) preparation technology, specifically to a TCM oil-based oral cream for repairing gastric mucosa and its preparation method. Addressing the problems of traditional TCM oil-based creams requiring heating for extraction and resulting in incomplete dissolution of components, this invention optimizes the process by directly combining TCM extracts with a low-temperature homogenization process to achieve formulation stability. It combines the adhesive properties of natural oils with the targeted repair efficacy of TCM extracts, while highlighting the core role of vitamin E in repairing gastric mucosal scars. This provides a novel TCM preparation for the clinical treatment and long-term management of gastric mucosal injuries. Background Technology

[0002] Existing treatments for gastric mucosal injury suffer from several drawbacks, including cumbersome extraction processes using sliced ​​Chinese herbs, high rates of loss of active ingredients, and difficulty in fully dissolving some components. Furthermore, traditional formulations lack targeted additions of functional ingredients that promote mucosal scar repair, leading to scar tissue formation after mucosal repair, which in turn reduces gastric mucosal motility and limits the repair effect. Additionally, direct extraction from sliced ​​Chinese herbs can result in residues in the preparation, affecting uniformity and the user experience.

[0003] Based on this, the present invention abandons the traditional heating extraction process and selects high-purity Chinese herbal extracts for direct formulation, which greatly improves the utilization rate of effective ingredients; vitamin E is added as the core ingredient to promote the repair of gastric mucosal scars and enhance the synergistic effect of mucosal protection and repair; the optimized preparation process is a small amount of oil immersion + 60°C low-temperature homogenization, which solves the problems of the extract being difficult to dissolve and easy to agglomerate in oil, and the uniform dispersion of the extract is achieved by beeswax fixation, taking into account both the stability of the formulation and the efficacy. Summary of the Invention

[0004] Purpose of the invention To address the problems of cumbersome preparation processes, incomplete dissolution of Chinese herbal ingredients, and poor formulation uniformity in existing Chinese herbal oil creams, and to compensate for the lack of targeted mucosal scar repair components in traditional formulations, this invention provides an oral Chinese herbal oil cream for repairing gastric mucosa, which combines direct formulation of extracts with low-temperature homogenization and a preparation method thereof.

[0005] The core objective is to achieve comprehensive efficacy in anti-inflammation, sterilization, mucosal scar repair, and barrier reconstruction through precise formulation of high-purity traditional Chinese medicine extracts combined with the core scar repair function of vitamin E. A small amount of oil infiltration followed by a 60℃ low-temperature homogenization process is employed to solve the problem of dissolving and dispersing extracts in an oil-based substrate. Beeswax fixation ensures the long-term stability of the formulation while preserving the adhesive properties of natural oils, providing a more efficient and stable treatment option for gastric mucosal injuries. It particularly addresses the clinical pain point of scar formation after mucosal repair and is suitable for the treatment and management of various gastric mucosal injury conditions.

[0006] The oral cream containing traditional Chinese medicine oil of the present invention is composed of a fixed ratio of oil base, effective components of traditional Chinese medicine extract, vitamin E, sea buckthorn seed oil and excipient beeswax. The proportions of each component have been experimentally verified to ensure that the extract is evenly dispersed, the formulation is stable and the efficacy is synergistic. All proportions are based on the total mass of the oil base.

[0007] The lipid base serves as the core carrier of the formulation, with a fixed ratio of 20% emu oil, 40% olive oil, 20% coconut oil, and 20% castor oil. This ratio has been optimized to ensure that the functions of each lipid complement each other, forming a stable, mucosa-friendly carrier system. This system can quickly form a protective lipid film on the gastric mucosa surface and provide a stable dispersion environment for the extract and functional components, thus balancing mucosal protection and the physical stability of the formulation.

[0008] Six carefully selected high-purity Chinese herbal extracts are used as the core active ingredients: astragaloside A, atractylodes lactone, atractylone, berberine, scutellaria baicalensis extract, and berberine. The amount of each extract added is 1%-2% of the total mass of the oil base. This ratio ensures that each extract can be evenly dispersed in the oil through wetting, while achieving an effective therapeutic concentration. Each component targets and exerts its anti-inflammatory, antibacterial, and gastric mucosa repair effects, forming a synergistic system.

[0009] Vitamin E is the core functional ingredient, added at 3% of the total mass of the oil base, primarily for repairing gastric mucosal scars, while also synergistically enhancing mucosal protection. Sea buckthorn seed oil is a fat-soluble repair ingredient, added at 20%-25% of the total mass of the oil base, forming a triple mucosal protection and repair system with the oil base and traditional Chinese medicine extracts.

[0010] Beeswax was selected as the sole excipient, with a fixed addition amount of 10% of the total mass of the oil-based base. This ratio not only achieves the cream-like form of the formulation but also ensures the uniform dispersion of the poorly soluble extract within the oil-based base, preventing extract aggregation and stratification. Furthermore, beeswax itself has mucosal lubrication and protective properties, which aligns with the overall efficacy of the formulation.

[0011] Emu oil: Rich in unsaturated fatty acids, anti-inflammatory active factors, and various vitamins, it has a strong affinity for mucous membranes. After oral administration, it quickly forms a uniform protective lipid film on the surface of the gastric mucosa, isolating it from the stimulation of gastric acid and pepsin; it inhibits the NF-κB inflammatory signaling pathway, reduces the release of inflammatory factors, and alleviates mucosal congestion and edema; it improves gastric mucosal microcirculation, provides nutritional support for mucosal repair, and accelerates the regeneration of damaged epithelial cells.

[0012] Olive oil contains high levels of polyphenols (hydroxytyrosol, oleuropein) and natural vitamin E, making it a powerful antioxidant that scavenge oxygen free radicals in the gastric mucosa, inhibit lipid peroxidation, and protect the structural integrity of epithelial cells. It also inhibits the activity of inflammatory enzymes such as COX-2 and LOX, reducing the synthesis of inflammatory mediators; enhances the stability of the mucus-bicarbonate barrier, reduces gastric acid permeation, and regulates local immunity in the gastric mucosa, promoting the resolution of inflammation.

[0013] Coconut oil: More than 90% of it consists of medium-chain fatty acids (lauric acid, caprylic acid, etc.). Lauric acid can destroy the cell membranes of pathogenic bacteria such as Helicobacter pylori, effectively inhibiting the colonization and reproduction of pathogenic bacteria and regulating the balance of gastrointestinal flora. Medium-chain fatty acids are easily digested and absorbed without causing gastrointestinal tract retention. The oil matrix lubricates the gastric mucosa, reducing the friction and irritation of food residue on the damaged mucosa and relieving stomach discomfort.

[0014] Castor oil: Its core component is ricinoleic acid, which inhibits the expression of inflammation-related genes, reduces the release of pro-inflammatory factors, promotes the secretion of anti-inflammatory factors, and regulates the inflammatory microenvironment of the mucosa. It works synergistically with other oils to form a continuous and stable lipid film, enhancing the integrity of the mucosal barrier. It relieves gastrointestinal smooth muscle spasms, reduces stomach pain and bloating, and has no laxative effect in this formulation, retaining only anti-inflammatory and mucosal protective effects.

[0015] Sea buckthorn seed oil: Rich in unsaturated fatty acids, sea buckthorn flavonoids, vitamin E, phytosterols, etc. Unsaturated fatty acids replenish the lipid components of mucosal epithelial cell membranes and quickly repair damaged cell membranes; sea buckthorn flavonoids dilate blood vessels, improve gastric mucosal microcirculation, increase blood supply, and promote the excretion of inflammatory factors; vitamin E and phytosterols work synergistically to fight inflammation, promote the proliferation and differentiation of epithelial cells, accelerate the healing of erosions and ulcers, reduce scar formation, and at the same time regulate the body's immunity and enhance the mucosal defense ability.

[0016] Astragaloside A: The core active ingredient of Astragalus membranaceus, it activates the PI3K / Akt cell proliferation signaling pathway, significantly promotes the division and proliferation of gastric mucosal epithelial cells, and accelerates the epithelialization of damaged mucosa; it inhibits apoptosis of mucosal epithelial cells and protects the integrity of mucosal tissue; it promotes gastric mucus secretion, increases the thickness and viscosity of the mucus layer, and enhances the mucus-bicarbonate barrier; for atrophic gastritis, it can promote the regeneration of gastric mucosal intrinsic glands, reverse the pathological changes of mucosal atrophy and thinning, and reduce the risk of cancer.

[0017] Atractylodes lactone: The core active ingredient of Atractylodes macrocephala, it has the effects of invigorating qi and strengthening the spleen, protecting the gastric mucosa, inhibiting excessive gastric acid secretion, reducing the stimulation of gastric acid on damaged mucosa; regulating the function of gastrointestinal smooth muscle, improving gastric motility, relieving abdominal distension and belching; enhancing the antioxidant capacity of gastric mucosa, scavenging oxygen free radicals, reducing oxidative stress damage, and promoting the repair of mucosal epithelial cells and enhancing the mucosal barrier function.

[0018] Atractylodes ketone: The core active ingredient of Atractylodes lancea, it has the effects of drying dampness and strengthening the spleen, antibacterial and anti-inflammatory. It has a significant inhibitory effect on pathogenic bacteria in the gastrointestinal tract such as Helicobacter pylori, reducing the invasion of pathogenic bacteria on the mucosa; reducing gastric mucosal congestion, edema and erosion, relieving inflammatory response; improving gastrointestinal digestive function, reducing the stimulation of food accumulation on the mucosa, and creating a good internal environment for mucosal repair.

[0019] Berberine: The core active ingredient of Coptis chinensis / Phellodendron amurense, it effectively penetrates the cell membrane of Helicobacter pylori, interferes with bacterial DNA replication and metabolism, kills pathogenic bacteria and destroys their biofilm, enhancing antibacterial effects; it inhibits the activation and infiltration of inflammatory cells, reduces the release of pro-inflammatory factors, and blocks inflammation-mediated mucosal damage from the source; it has a significant effect on controlling inflammatory infections of erosive gastritis and gastric ulcers, and quickly relieves mucosal inflammation.

[0020] Scutellaria baicalensis extract: With baicalin and baicalein as the core components, it disrupts the cell membrane structure of pathogenic bacteria, inhibits bacterial DNA replication, and forms a potent antibacterial system in synergy with berberine, showing significant effects on mucosal inflammation caused by mixed infections; it inhibits inflammatory signaling pathways such as NF-κB and MAPK, reduces the synthesis of inflammatory factors and mediators, and rapidly controls mucosal congestion and edema; it effectively scavenge oxygen free radicals, inhibits lipid peroxidation, protects the mitochondrial function of mucosal epithelial cells, and reduces cell apoptosis.

[0021] Phellodendron chinense: The core active ingredient of Phellodendron amurense, it works synergistically with berberine to fight bacteria, especially showing a significant inhibitory effect on drug-resistant Helicobacter pylori; it inhibits the activity of inflammation-related enzymes, reduces the release of inflammatory mediators, and alleviates severe mucosal inflammation; it regulates local immunity of the gastric mucosa, enhances the body's resistance to pathogens, and at the same time inhibits excessive immune responses, avoiding further damage to the mucosa caused by immune damage.

[0022] Vitamin E is a fat-soluble core repair component. Its core function is to inhibit the formation of scar tissue and soften existing scars after gastric mucosal injury healing. By downregulating the expression of pro-fibrotic factors such as TGF-β1, it inhibits excessive fibroblast activation, reduces abnormal collagen fiber deposition, and minimizes gastric mucosal scar formation at its source. Simultaneously, it promotes the orderly arrangement of collagen fibers, softens existing mucosal scars, and restores the normal elasticity and peristaltic function of the gastric mucosa. Furthermore, vitamin E can promote the proliferation and differentiation of gastric mucosal epithelial cells, accelerate the healing of damaged mucosal wounds, and enhance the mucosal barrier's reconstruction ability. Synergistically, it works with the natural antioxidants in sea buckthorn seed oil and olive oil to reduce the interference of oxidative stress on mucosal repair and improve the overall repair effect.

[0023] This invention abandons the traditional Chinese medicine heating extraction process and adopts direct formulation of extracts. Through a process of small-volume oil infiltration + 60℃ low-temperature homogenization + beeswax immobilization, it solves the problems of poor solubility and easy aggregation of extracts in oils, ensuring the homogeneity and stability of the formulation while retaining the pharmacological activity of all components. The specific steps are as follows:

[0024] Weigh each oil precisely according to the fixed ratio (20% emu oil, 40% olive oil, 20% coconut oil, and 20% castor oil), add them to a clean stainless steel mixing bowl, set the mixing speed to 300-500 rpm, and mix for 20-30 minutes at 25-30℃ until the oils are fully mixed and uniform, forming a mixed oil base with uniform color, no layering, and no sedimentation; separate 5%-10% of the mixed oil base for later use, and keep the remaining oil in the mixing bowl at a warm temperature for later use.

[0025] Accurately weigh astragaloside A, atractylodes lactone, atractylone, berberine, scutellaria baicalensis extract, berberine (1%-2% each), and vitamin E (3%) according to the formula. Add all the ingredients together to the small amount of oil prepared above. Set the stirring speed to 400-600 r / min and stir at room temperature for 15-20 minutes to ensure that all the extracts and vitamin E are completely impregnated in the small amount of oil, forming an impregnated system without obvious particles. This avoids the problem of agglomeration and uneven dispersion that may occur when the extracts are directly added to a large amount of oil.

[0026] Add the above-mentioned impregnation system to the remaining mixed oil base, heat the mixing tank to 60°C (constant temperature), set the stirring speed to 300-400 r / min, stir for 20-25 minutes, and simultaneously use a high-speed shear homogenizer for homogenization (speed 8000-10000 r / min, homogenization time 5-8 minutes) to initially homogenize the impregnated extract and vitamin E in the oil base, forming a homogeneous oil phase system.

[0027] Accurately weigh the sea buckthorn seed oil according to the ratio (20%-25%), add it to the oil phase system at a constant temperature of 60℃, maintain the stirring speed at 300-400r / min, stir for 10-15 minutes, and then homogenize again using a high-speed shear homogenizer (speed 8000-10000r / min, homogenization time 5 minutes) to ensure that the sea buckthorn seed oil is fully integrated with the oil phase system and that the extract is free from local agglomeration.

[0028] Weigh out beeswax precisely according to a fixed ratio (10%) and add it to the oil phase system at a constant temperature of 60°C. Maintain a stirring speed of 300-400 r / min and continue heating and stirring for 10-15 minutes until the beeswax is completely dissolved. Then, use a high-pressure homogenizer to homogenize (pressure 20-25 MPa, homogenization times 2) to fully integrate the beeswax with the oil phase system and further refine the extract particles, so as to achieve uniform dispersion and stable dispersion of the poorly soluble extract in the oil base.

[0029] Turn off the heating device (remove the heat source), maintain a stirring speed of 100-200 r / min, and allow the formulation system to cool naturally to room temperature (25-30℃) while stirring. Through the solidification and shaping of beeswax, the poorly soluble extract is permanently fixed in the oil base, avoiding the extract from separating and agglomerating. After cooling, the formulation is subjected to quality testing (appearance, particle size distribution, stability, content of active ingredients, etc.). After passing the test, it is filled and sealed to obtain a traditional Chinese medicine oil-based oral cream for repairing the gastric mucosa.

[0030] This invention, through direct formulation of extracts, process optimization, and component upgrades, offers the following significant advantages compared to traditional formulations:

[0031] The process abandons the traditional Chinese medicine slicing and heating extraction process, and instead uses high-purity traditional Chinese medicine extracts for direct formulation, avoiding the decomposition and loss of effective components during heating, and increasing the utilization rate of effective components to over 90%. The preparation process is simplified, the production cycle is shortened, and it is more suitable for large-scale industrial production.

[0032] The entire process employs a 60℃ low-temperature homogenization process, without any high-temperature treatment steps, thus fully preserving the heat-sensitive active ingredients (such as polyphenols, flavonoids, and vitamins) in the herbal extracts, vitamin E, natural oils, and sea buckthorn seed oil, ensuring that the anti-inflammatory, scar repair, and barrier reconstruction effects of each ingredient are fully realized.

[0033] By using a process of "small amount of oil infiltration + double-layer homogenization", the problem of poorly soluble Chinese medicine extracts easily agglomerating and unevenly dispersing in an oil base is completely solved. Combined with 10% beeswax as a fixative, the extract is uniformly dispersed in the formulation, ensuring that the active ingredients are evenly distributed on the gastric mucosa surface after the formulation is taken, and targeting the damaged area.

[0034] The addition of extracts such as atractylodes lactone, atractylone, and berberine forms a more comprehensive anti-inflammatory and antibacterial system with the original ingredients. Vitamin E, as the core ingredient, focuses on mucosal scar repair. It works synergistically with sea buckthorn seed oil, olive oil, and traditional Chinese medicine extracts to achieve a quadruple effect of "physical protection + anti-inflammatory and antibacterial + scar repair + barrier reconstruction". It has a more significant therapeutic effect on various gastric mucosal injuries, especially addressing the clinical pain point of scar formation after gastric mucosal repair.

[0035] Through beeswax fixation and low-temperature homogenization, the formulation is a uniform cream with no layering, no sedimentation, no graininess, and excellent physical stability. The extract is uniformly fixed in the oil base, with no precipitation of active ingredients. The shelf life at room temperature can reach more than 18 months, making storage and transportation more convenient.

[0036] With no residue of Chinese herbal medicine, the preparation has a smooth taste and no bitterness, improving patient medication compliance; all ingredients are high-purity extracts and natural products, with a scientific ratio, no irritating ingredients, and an extremely low incidence of adverse reactions, making it suitable for all types of people (including patients with chronic gastritis) to take according to the course of treatment. Detailed Implementation Example

[0037] 1. Raw material weighing: Based on a total oil base mass of 1000g, weigh the oil base raw materials (emu oil 200g, olive oil 400g, coconut oil 200g, castor oil 200g); each of the following Chinese herbal extracts: 1.5% (astragaloside A 15g, atractylodes lactone 15g, atractylone 15g, berberine 15g, scutellaria baicalensis extract 15g, berberine 15g); vitamin E 3% (30g); sea buckthorn seed oil 22% (220g); beeswax 10% (100g).

[0038] 2. Preparation of mixed oil base: Add the above oil to a mixing tank and stir at 400 r / min and 25-30℃ for 25 minutes. Take out a small amount of 80g of oil for later use, and keep the remaining 920g warm for later use.

[0039] 3. Infiltration treatment: Add all the Chinese herbal extracts and vitamin E to 80g of prepared oil, stir at 500r / min at room temperature for 18 minutes to form a completely infiltrated, particle-free system.

[0040] 4. Low-temperature homogenization: Add the impregnation system to the remaining 920g of oil, heat to 60℃, stir at 350r / min for 22 minutes, and homogenize for 6 minutes using a high-speed shear homogenizer (9000r / min).

[0041] 5. Adding sea buckthorn seed oil and second homogenization: Add 220g of sea buckthorn seed oil, stir at 350r / min for 12 minutes, and homogenize for 5 minutes using a high-speed shear homogenizer (9000r / min).

[0042] 6. Beeswax dissolution and homogenization: Add 100g of beeswax, stir at 350r / min for 12 minutes until completely dissolved, and homogenize twice using a high-pressure homogenizer (22MPa).

[0043] 7. Cooling and filling: Remove the heat source, stir at 150 r / min to cool to room temperature, fill and seal after passing quality inspection to obtain the finished product. Example

[0044] 1. Raw material weighing: Based on a total oil base mass of 1000g, the raw materials for the oil base are the same as in Example 1; 1% of each Chinese herbal extract (10g each); 3% of vitamin E (30g); 20% of sea buckthorn seed oil (200g); 10% of beeswax (100g).

[0045] 2. Preparation of mixed oil base: Stir at 450r / min and 25-30℃ for 20 minutes, take out 50g of oil for later use, and keep the remaining 950g warm for later use.

[0046] 3. Infiltration treatment: Add all extracts and vitamin E to 50g of reserved oil, stir at 450r / min at room temperature for 15 minutes to form a fully infiltrated system.

[0047] 4. Low-temperature homogenization: Add the remaining 950g of oil, heat to 60℃, stir at 300r / min for 20 minutes, and homogenize for 5 minutes using a high-speed shear homogenizer (8000r / min).

[0048] 5. Adding sea buckthorn seed oil and second homogenization: Add 200g of sea buckthorn seed oil, stir at 300r / min for 10 minutes, and homogenize for 5 minutes using a high-speed shear homogenizer (8000r / min).

[0049] 6. Beeswax dissolution and homogenization: Add 100g of beeswax, stir at 300r / min for 10 minutes until completely dissolved, and homogenize twice using a high-pressure homogenizer (20MPa).

[0050] 7. Cooling and filling: Remove the heat source, stir at 120r / min to cool to room temperature, and fill and seal after passing quality inspection. Example

[0051] 1. Raw material weighing: Based on a total oil base mass of 1000g, the raw materials for the oil base are the same as in Example 1; 2% of each Chinese herbal extract (20g each); 3% of vitamin E (30g); 25% of sea buckthorn seed oil (250g); 10% of beeswax (100g).

[0052] 2. Preparation of mixed oil base: Stir at 350r / min and 25-30℃ for 30 minutes, take out 100g of a small amount of oil for later use, and keep the remaining 900g warm for later use.

[0053] 3. Infiltration treatment: Add all extracts and vitamin E to 100g of reserved oil, stir at 600r / min at room temperature for 20 minutes to form a fully infiltrated system.

[0054] 4. Low-temperature homogenization: Add the remaining 900g of oil, heat to 60℃, stir at 400r / min for 25 minutes, and homogenize for 8 minutes using a high-speed shear homogenizer (10000r / min).

[0055] 5. Adding sea buckthorn seed oil and second homogenization: Add 250g of sea buckthorn seed oil, stir at 400r / min for 15 minutes, and homogenize for 5 minutes using a high-speed shear homogenizer (10000r / min).

[0056] 6. Beeswax dissolution and homogenization: Add 100g of beeswax, stir at 400r / min for 15 minutes until completely dissolved, and homogenize twice using a high-pressure homogenizer (25MPa).

[0057] 7. Cooling and filling: Remove the heat source, stir at 180 r / min to cool to room temperature, and fill and seal after passing quality inspection.

Claims

1. A traditional Chinese medicine oil-based oral cream for repairing gastric mucosa, characterized in that, It is composed of a fixed-ratio oil base, effective components of traditional Chinese medicine extracts, vitamin E, and excipients; the oil base consists of 20% emu oil, 40% olive oil, 20% coconut oil, and 20% castor oil (based on the total mass of the oil base); the effective components of the traditional Chinese medicine extracts include astragaloside A, atractylodes lactone, atractylone, berberine, scutellaria baicalensis extract, and berberine; the excipient is beeswax, and vitamin E is the core functional additive.

2. The herbal oil-based oral cream according to claim 1, characterized in that, The effective components of each Chinese herbal extract are added at 1%-2% of the total mass of the oil base; vitamin E is added at 3% of the total mass of the oil base; sea buckthorn seed oil is added at 20%-25% of the total mass of the oil base; and beeswax is added at 10% of the total mass of the oil base (fixed ratio).

3. The method for preparing the oral cream of traditional Chinese medicine oil according to claim 1, characterized in that, Abandoning the heating extraction process of traditional Chinese medicine, this method uses direct formulation of extracts, achieving uniform dispersion of the extracts through a small amount of oil infiltration and low-temperature homogenization. The specific steps include: (1) Weigh emu oil, olive oil, coconut oil and castor oil in proportion and mix them to obtain a mixed oil base. Take a small amount of oil for later use. (2) Add all the active ingredients of the Chinese herbal extracts and vitamin E to a small amount of oil and stir thoroughly to ensure that the extracts are fully soaked; (3) Add the soaked extract system to the remaining mixed oil base, heat to 60°C and stir to homogenize; (4) Add beeswax, heat and stir at 60°C until the beeswax is completely dissolved, and then homogenize again; (5) Remove the heat source, keep stirring until the system cools to room temperature, so that the extract is evenly dispersed and fixed by beeswax excipients, and fill into a traditional Chinese medicine oil oral cream.

4. The use of the oral cream of traditional Chinese medicine oil according to any one of claims 1-3 in the preparation of drugs for repairing gastric mucosal damage and treating superficial gastritis / erosive gastritis / atrophic gastritis / gastric ulcer.