Traditional Chinese medicine formula for treating rheumatism bone diseases and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine formula for treating rheumatism bone diseases. The traditional Chinese medicine formula comprises the following raw material medicines in parts by weight: 10g or 40g of pangolin, 10g or 15g of pseudo-ginseng, 10g or 15g of dragon's blood, 15g or 20g of angelica sinensis, 15g of rhizoma drynariae and 10g or 15g of teasel root. According to the principle of monarch, minister, assistant and guide, the formula is scientific, the compatibility is reasonable, all the components are synergistic, and the traditional Chinese medicine composition has the effects of treating wind-cold-dampness arthralgia, arthralgia, sore and ulcer pyogenic infections, soreness and weakness of waist and knees, falling injury and osteoarticular soreness, can safely, quickly and efficiently remove wind, cold, dampness, heat, toxicity and stasis in the body, and achieves the effects of treating and preventing diseases, and has no toxic or side effects. The effects of supporting healthy energy, promoting metabolism and enhancing the immunity of the organism are achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine formula for treating rheumatic bone disease and a preparation method thereof. BACKGROUND

[0002] Rheumatic bone disease is a chronic disease that invades joints, bones, muscles and their surrounding soft tissues, mainly manifested as joint pain, swelling, stiffness and dysfunction. The disease is mainly caused by autoimmune abnormalities, and common types include rheumatoid arthritis, ankylosing spondylitis, etc., which has genetic predisposition, and the pathogenesis involves multiple factors such as genetics, environment and immune response.

[0003] Traditional disease improvement anti-rheumatic drugs have a slow effect and mainly play a role in slowly controlling the disease; non-steroidal anti-inflammatory drugs can only anti-inflammatory and analgesic, and cannot effectively prevent the progression of the disease; glucocorticoids have a quick effect, but have large side effects. Therefore, the current western medicine still cannot fundamentally and effectively treat rheumatic bone disease.

[0004] Although traditional Chinese medicine has certain curative effect, it has a slow effect, insignificant curative effect, long treatment course, and although a small number of patients can be cured, most patients can only relieve symptoms and cannot effectively control the development of the disease. Therefore, a traditional Chinese medicine formula for treating rheumatic bone disease and a preparation method thereof are provided. SUMMARY

[0005] Therefore, the embodiments of the present application provide a traditional Chinese medicine formula for treating rheumatic bone disease and a preparation method thereof to solve or alleviate the technical problems in the prior art, and at least provide a beneficial choice.

[0006] The technical scheme of the embodiments of the present application is as follows: a traditional Chinese medicine formula for treating rheumatic bone disease, comprising raw medicinal materials in the following weight parts: Galerita 10g or 40g, Sanqi 10g or 15g, Dragon's Blood 10g or 15g, Angelica 15g or 20g, Drynaria 15g and Corydalis 10g or 15g.

[0007] In some embodiments, the traditional Chinese medicine formula for treating rheumatic bone disease comprises raw medicinal materials in the following weight parts: Safflower 10g, Astragalus 40g, Radix Rehmanniae Preparata 30g, Cornu Cervi Degelatinatum 10g, Sarcandra glabra 10g, Fructus Psoraleae 10g, Stachys 10g, Papaya 10g, Leech 15g, Radix et Rhizoma Bistortae 10g, Rhizoma et Radix Polygoni Avicularis 60g, Pueraria 50g, Fructus Crataegi 60g, Lysimachia 30g, Herba Plantaginis 30g, Herba Taraxaci 30g and Coix 60g.

[0008] A preparation method of a traditional Chinese medicine formula for treating rheumatic bone disease, based on the traditional Chinese medicine formula for treating rheumatic bone disease described above, comprises the following preparation steps: S1, except for the quick rinse of the mud and sand, avoid soaking to cause the loss of effective ingredients, then the cleaned medicine is flatly laid on the bamboo screen and dried, or 50℃ low temperature drying for 2 hours to moisture content <12%; S2, before crushing, the pangolin, earth yuan, antler glue, kudzu root, rare rhubarb, stretch tendon grass, bone supplement, hawthorn and yiren need special treatment, then the angelica, safflower, astragalus, pangolin, radix rehmanniae preparata, sanqi, antler glue, bone fracture, continue to break, xianlingpi, bone supplement, stretch tendon grass, papaya, leech, earth yuan, rare rhubarb, kudzu root, blood, hawthorn, money grass, plantain, dandelion and yiren are crushed to 80 mesh; S3, after the coarse residue of various powders is crushed to pass through 80 mesh screen, the mixed powder is obtained by using equal incremental method; S4, the mixed powder is sterilized by ultraviolet irradiation for 15 minutes or 70℃ drying for 30 minutes, and is packed in sealed bags according to the daily dose of 12g and stored in cold storage; S5, the total amount of each medicine powder is 530g, then 636g-795g of honey is needed, the refined honey is cooled to 60℃, then each medicine powder is added and stirred, and kneaded to the state of "holding it into a group, touching it immediately scattered", then the medicine group is formed; S6, then the medicine group is rubbed into a 2cm diameter strip, cut into 12g / segment, coated with sesame oil in the palm to prevent sticking, and rotated to rub into smooth pellets, the pellets are dried for 48 hours or low temperature dried at 40℃ for 2 hours, the surface of the pellets is hardened, then the pellets are sealed with wax paper and individually wrapped, and stored in a cool and dry place.

[0009] In some embodiments, in S2, the pangolin and earth yuan are roasted over low heat until slightly yellow and brittle, which facilitates crushing; The antler glue is crushed into soybean size particles for preventing sticking in the crusher; The kudzu root, rare rhubarb and stretch tendon grass are cut into 1cm segments to improve the crushing efficiency; The bone supplement, hawthorn and yiren need low temperature drying to prevent oil bleeding.

[0010] In some embodiments, in S5, the steps of adding each medicine powder are as follows, S51, the refined honey is poured into a stainless steel basin, the antler glue powder and bone supplement powder are added first, and the honey is stirred with a wooden spoon to form a uniform glue solution, then the blood powder is added and continuously stirred until no particles are left; S52, the pangolin powder is added in two times and stirred quickly, then the earth yuan powder and leech powder are added and stirred until no dry powder is left; S53, the sanqi powder and bone fracture powder are added at the same time, and are stirred by folding method, then the radix rehmanniae preparata powder, hawthorn powder, yiren powder and continue to break powder are added in sequence, the radix rehmanniae preparata contains sugar which is easy to stick, and the combination with the fruit acid of hawthorn can prevent hardening; S54, after mixing the Astragalus root powder, Angelica sinensis powder and Papaya powder, add them into the honey liquid and stir until absorbed. Then sprinkle the Pueraria powder and the diluted Rhubarb powder into the mixture and stir quickly; S55, gently sieve the Dandelion powder and Safflower powder onto the surface of the honey liquid. Stir with a silica gel spatula. Then add the Herba Dispori, Lycopus lucidus Turcz. powder and Rhizoma Stachys japonica powder into the mixture and stir well.

[0011] In some embodiments, the traditional Chinese medicine formula for treating rheumatism and bone disease comprises the following raw medicinal materials by weight: Ranunculus japonicus 60g, Taxillus sutchuenensis 15g, Prunella vulgaris 60g, Sparganium stoloniferum 10g, Polyscias fruticosa 10g, Arisaema erubescens 9g, Zanthoxylum ailanthoides 10g, Herba Dispori 10g, Herba Artemisiae 10g, Radix Angelicae Pubescentis 15g, Radix et Rhizoma Aconiti 10g, Laurus nobilis 10g, Ramulus Cinnamomi 15g, Eucommia ulmoides 10g, Herba Thuidium 15g, Ilicis latifoliae Folium 10g, Radix Achyranthis Bidentatae 60g, Atractylodes lancea 15g, Spatholobus suberectus 30g, Herba Lobeliae 15g, Fructus Momordicae 10g, Semen Platycladi 10g, Clove 9g, and Camphor 5g.

[0012] A preparation method of a traditional Chinese medicine formula for treating rheumatism and bone disease, based on the traditional Chinese medicine formula for treating rheumatism and bone disease described above, characterized in that it comprises the following preparation steps: S100, pre-treat the medicinal materials of Hemitheconyx, Dragon's Blood, Sarcandra glabra, Radix Achyranthis Bidentatae, Eucommia ulmoides, Dipsacus asper, and Clove; S101, place Hemitheconyx, Dragon's Blood, Panax notoginseng, Sarcandra glabra, and Radix Achyranthis Bidentatae in a first brewing tank. Then add 500ml of 60-degree white wine into the brewing tank and seal it for 48 hours. The white wine should be submerged in the medicinal materials by 2cm. The animal medicines need to be dissolved in high-concentration white wine to dissolve the fat-soluble components. S102, place Eucommia ulmoides, Dipsacus asper, Spatholobus suberectus, and Atractylodes lancea in a second brewing tank. Then add 400ml of white wine into the second brewing tank and soak for 24 hours to release glycosides. S103, place Ranunculus japonicus, Taxillus sutchuenensis, Prunella vulgaris, Sparganium stoloniferum, Polyscias fruticosa, Arisaema erubescens, Zanthoxylum ailanthoides, Herba Dispori, Herba Artemisiae, Radix Angelicae Pubescentis, Laurus nobilis, Herba Thuidium, Ilicis latifoliae Folium, and Herba Lobeliae in a third brewing tank. Then add 300ml of white wine into the second brewing tank and soak for 12 hours. S104, combine the leaching liquids of S101, S102, and S103, and squeeze the medicinal residues to extract the juice. Mix them and stand for 12 hours. Then take the supernatant for use, and obtain the medicinal liquor. S105, take 200g of Sophora japonica honey and simmer it over low heat until it reaches 116℃. Then cool it to 60℃ for standby. Slowly pour the medicinal liquor into the Sophora japonica honey while stirring in the same direction until the wine and honey are well mixed. Add the concentrated juice of Radix et Rhizoma Aconiti, Fructus Momordicae powder, and Semen Platycladi powder into the mixture. Heat it over low heat to 50℃ and stir for 20 minutes. Turn off the heat and let the temperature drop to 40°C. Camphor powder is pre-dissolved in ethanol to form camphor ethanol solution. Add camphor ethanol solution and clove powder, and stir gently until well mixed. When the back of the spoon is lifted and the liquid drips slowly in a line, it forms a paste.

[0013] In some embodiments, in S100, Pangolin scales are roasted until yellow and then crushed and passed through a 120-mesh sieve to improve transdermal absorption. Indonesian dragon's blood powder needs to be passed through a 100-mesh sieve to avoid irritating the skin with particles; After thinly slicing Drynaria fortunei and Achyranthes bidentata, they are dried at 55°C and then pulverized and passed through an 80-mesh sieve. Eucommia ulmoides and Dipsacus asperoides need to be pulverized for a long time until there are no fibrous materials. Cloves and camphor should be pulverized separately in a sealed container. Lobelia chinensis and Prunella vulgaris can be easily crushed after being dried in the shade and gently rubbed. First, decoct Aconitum carmichaelii for 30 minutes to reduce its toxicity, then concentrate the juice for later use to destroy aconitine. The kernel of Momordica cochinchinensis is removed from its shell, simmered in white wine, and then pulverized. This process is used to reduce toxicity and activate the medicinal properties. Slightly stir-fry the impatient seeds to reduce their harshness.

[0014] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions: This invention allows for both internal and external application of the formula. Based on the principles of monarch, minister, assistant, and guide, the formula is scientifically formulated and rationally matched, with each component synergistically enhancing its effects. It is effective in treating wind-cold-dampness syndrome, joint pain, sores and carbuncles, lower back and knee weakness, injuries from falls, and bone and joint pain. It can safely, quickly, and effectively remove wind, cold, dampness, heat, toxins, and blood stasis from the body, achieving the effects of treating diseases, preventing diseases, strengthening the body's resistance, promoting metabolism, and enhancing the body's immunity.

[0015] The above overview is for illustrative purposes only and is not intended to be limiting in any way. Detailed Implementation

[0016] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention.

[0017] It should be noted that the terms "first", "second", "symmetrical", "array", "provided with", "provided in" and the like are only used for distinguishing description and position description purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first", "symmetrical" and the like can explicitly or implicitly include one or more of the features; similarly, for some features that are not limited in number by the words "two", "three" and the like, it should be noted that the features also belong to explicitly or implicitly including one or more feature numbers.

[0018] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "fixing" and the like should be understood in a broad sense; for example, it can be fixed connection, or detachable connection, or integral molding; it can be mechanical connection, it can be direct connection, it can be welding, or it can be indirect connection through an intermediate medium, or it can be the internal communication of two elements or the interaction relationship between two elements.

[0019] The embodiments of the present application will be described in detail below.

[0020] Embodiment one The present application provides a kind of traditional Chinese medicine formula for treating rheumatic bone disease, comprising by the following weight parts of raw medicinal materials: Pangolin 40g, Sanqi 10g, Dragon's Blood 10g, Danggui 20g, Rubus parvifolius 15g and Duhuo 15g.

[0021] In this embodiment, specifically, comprising by the following weight parts of raw medicinal materials: Shuhua 10g, Huangqi 40g, Renshen 30g, Lujiaojiao 10g, Xianlingspi 10g, Buguzhi 10g, Shenchigan 10g, Mugua 10g, Shuizhi 15g, Tuoyuan 10g, Shimosuocao 60g, Gegen 50g, Shanzha 60g, Jinqiancao 30g, Cheqiancao 30g, Pugongying 30g and Yiren 60g.

[0022] A preparation method of a traditional Chinese medicine formula for treating rheumatic bone disease, based on the above-mentioned traditional Chinese medicine formula for treating rheumatic bone disease, comprising the following preparation steps: S1, except that Lujiaojiao and Dragon's Blood are not washed, the rest of the medicinal materials need to be quickly washed to remove sand, to avoid soaking to cause loss of effective ingredients, then the cleaned medicinal materials are flatly laid on bamboo screen and dried, or dried at 50 DEG C for 2 hours to water content <12%; S2. Before pulverizing, pangolin scales, earthworms, deer antler glue, kudzu root, *Siegesbeckia orientalis*, *Lycopodium clavatum*, psoralea corylifolia, hawthorn, and coix seed need to be specially treated. Then, angelica, safflower, astragalus, pangolin scales, rehmannia glutinosa, notoginseng, deer antler glue, *Drynaria fortunei*, *Dipsacus asper*, epimedium, psoralea corylifolia, *Lycopodium clavatum*, papaya, leech, earthworms, *Siegesbeckia orientalis*, kudzu root, dragon's blood, hawthorn, lysimachia christinae, plantain, dandelion, and coix seed are pulverized through an 80-mesh sieve. S3. After the coarse residue of various powders is re-crushed until it all passes through an 80-mesh sieve, it is mixed using an equal-volume incremental method to obtain a mixed powder; S4. Sterilize the mixed powder by irradiating it with ultraviolet light for 15 minutes or by baking it at 70°C for 30 minutes, and then divide it into 12g daily doses and seal them in bags for refrigeration. S5. If the total amount of each medicinal powder is 530g, then 636g-795g of honey is needed. When the honey is cooled to 60℃, add each medicinal powder in batches and stir. Knead until it reaches the state of "forming a ball when squeezed, but crumbling when touched", thus forming a medicinal ball. S6. After that, roll the dough into a strip with a diameter of 2cm, cut it into 12g / segment, apply sesame oil to the palm of your hand to prevent sticking, rotate and roll it into a smooth ball, air dry the ball for 48 hours or bake at a low temperature of 40℃ for 2 hours. After the surface of the ball hardens, seal it with wax paper and wrap it individually, and store it in a cool and dry place.

[0023] In this embodiment, specifically in S2, the pangolin and earthworm need to be roasted over low heat until they turn slightly yellow and brittle, so that they can be crushed. Deer antler glue is crushed into soybean-sized particles and used in an anti-sticking grinder; Cut kudzu root, Siegesbeckia orientalis, and Lycopodium clavatum into 1cm sections to improve grinding efficiency; Psoralea corylifolia, hawthorn, and coix seed need to be dried at low temperatures to prevent oil from being released.

[0024] In this embodiment, specifically, in step S5, the steps of adding each medicinal powder in stages are as follows: S51. Pour the refined honey into a stainless steel bowl, first add the deer antler glue powder and psoralea powder, stir in one direction with a wooden spoon until the colloid is completely dissolved and a uniform liquid is formed, then add the blood dragon powder and continue stirring until there are no particles left. S52. Add the pangolin powder in two batches, stirring quickly while adding. Then add the earthworm powder and leech powder, stirring until there is no dry powder. S53, add Panax notoginseng powder and Drynaria fortunei powder at the same time, stir using the folding method, and then add Rehmannia glutinosa powder, hawthorn powder, Coix seed powder and Dipsacus asper powder in sequence. Rehmannia glutinosa contains sugar and is easy to stick, and when combined with the fruit acid of hawthorn, it can prevent hardening. S54, add the mixture of astragalus powder, angelica powder and papaya powder, and stir until the honey is absorbed. Then add kudzu root powder and siegesweet powder in batches and stir quickly. S55. Gently sift dandelion powder and safflower powder onto the surface of the honey liquid. After stirring with a silicone spatula, add the angelica powder, lysimachia powder, and lysimachia powder last, and mix well.

[0025] In this embodiment, specifically, Core pathogenesis: Deficiency of liver and kidney is the root cause, while obstruction by blood stasis, phlegm, and dampness is the manifestation; 1. Liver and kidney deficiency Symptoms: Soreness and weakness in the lower back and knees, bone degeneration (Drynaria fortunei, Dipsacus asper, and deer antler glue are effective for this condition); Physiological basis: The kidneys govern bones and produce marrow, while the liver governs tendons and vessels. Kidney deficiency leads to malnourishment of bone marrow, and liver deficiency leads to weakness and flaccidity of tendons, resulting in decreased joint stability and imbalanced cartilage metabolism.

[0026] 2. Blood stasis obstructing the collaterals Symptoms: Localized stinging pain and limited mobility (pangolin scales, leeches, earthworms, and dragon's blood are the main treatments for this condition); Pathological process: microcirculatory disturbance → tissue hypoxia → release of inflammatory factors (such as TNF-α, IL-1β) → degradation of cartilage matrix.

[0027] 3. Phlegm-dampness obstruction Symptoms: Joint swelling and heaviness (significance of the combination of 60g of Job's tears and 60g of Siegesbeckia orientalis); Mechanism: Dampness and turbidity stagnate internally → synovial hyperplasia → joint effusion → mechanical compression of nerves and blood vessels.

[0028] 4. Secondary lesions The vicious cycle of inflammation and degeneration: Dandelion and plantain clear local heat toxins and inhibit the COX-2 pathway to reduce redness and swelling; 5. Myofascial adhesions: Kudzu root can relieve muscle tension and pain in the neck, shoulders, back and waist.

[0029] In this embodiment, specifically, 1. Blood-activating and stasis-removing group 2. Liver and Kidney Tonifying Group Deer antler glue + Drynaria fortunei: Deer antler glue replenishes essence and marrow (containing bone morphogenetic protein BMP), while Drynaria fortunei promotes osteocyte differentiation and synergistically increases bone density.

[0030] Dipsacus + Epimedium: Dipsacus saponins repair ligament collagen, while Epimedium icariin inhibits osteoclast activity.

[0031] 3. Dampness-removing and meridian-clearing group Coix seed + Siegesbeckia orientalis (60g each): Coix seed ester inhibits the NF-κB pathway and alleviates synovitis, while Siegesbeckia orientalis alkaloids reduce IL-6 levels.

[0032] Papaya + Lycopodium clavatum: Papain softens adhesive connective tissue, and Lycopodium clavatum water extract relaxes skeletal muscle spasms.

[0033] 4. Special compatibility and synergistic effect Kudzu root 50g + Hawthorn 60g: Kudzu root flavonoids dilate vertebral artery blood flow, and hawthorn ursolic acid dissolves cholesterol crystals, together treating cervical and lumbar degeneration; Astragalus 40g + Angelica sinensis 20g: Angelica sinensis polysaccharides activate hematopoietic progenitor cells, astragalus saponins enhance NK cell activity, and replenish both qi and blood to resist tissue atrophy.

[0034] In this embodiment, specifically, I. Comparison of Osteoarthritis Treatment Data (Oral Chinese Medicine Compound vs. Glucosamine Sulfate) 120 OA patients were randomly assigned to groups and treated for 12 weeks. Pain control: Pangolin and dragon's blood inhibit the TGF-β1 / Smad pathway, reduce subchondral bone fibrosis, and decrease the release of the inflammatory factor IL-1β; Functional recovery: Pueraria lobata flavonoids expand joint microcirculation, while the Angelica sinensis-Astragalus membranaceus combination activates NK cells and promotes cartilage matrix synthesis.

[0035] II. Comparison of Treatment Data for Lumbar Disc Herniation (Oral Chinese Medicine Compound vs. Traction Therapy) Study model: 80 LDH patients, treatment period of 6 months. Volume reduction: Hirudin dissolves protruding thrombi around the nucleus pulposus, and Dipsacus saponins promote collagen repair of the annulus fibrosus; Nerve decompression: The combination of white peony root and licorice root inhibits TNF-α-mediated nerve root edema and reduces mechanical compression.

[0036] III. Improvement data of biochemical indicators (comparison before and after treatment) Test samples: serum inflammatory markers and bone metabolism indicators Anti-inflammatory effect: The combination of Siegesbeckia orientalis and Coix seed blocks the NF-κB pathway and inhibits the synthesis of IL-6 in synovium; Bone metabolism balance: Deer antler gelatin BMP protein + bone drynaria flavonoids bidirectionally regulate osteoblast / osteoclast activity.

[0037] Duration of therapeutic effect: In the 3-month follow-up after discontinuation of the traditional Chinese medicine group, the WOMAC score rebound rate was <8% (compared to >25% in the control group). The rate of reduction in intervertebral disc volume was positively correlated with the improvement in neurological function (r=0.72, P=0.003).

[0038] This compound formula achieves simultaneous treatment of joints and lumbar spine through a triple mechanism of "breaking up blood stasis, anti-inflammation, and nourishing bones," and is especially suitable for degenerative bone diseases complicated with soft tissue adhesions (such as comorbid OA and LDH). However, endangered medicinal materials such as pangolins need to be replaced with earthworm (20g) + sappanwood (15g) to balance ethics and efficacy.

[0039] IV. Safety and Application Warnings Toxicity control of pangolins / leeches: Pangolins need to be processed to reduce toxicity (scalding with sand and quenching with vinegar), and leeches need to be dried at low temperature to break down enzymes, so as to avoid bleeding caused by raw consumption; Contraindications: Pregnant women (blood-breaking drugs may induce uterine contractions), peptic ulcers (hirudin may induce perforation), thrombocytopenia; Long-term monitoring: Prothrombin time (PT) is measured every 4 weeks to prevent bleeding tendencies.

[0040] Example 2 This invention provides a traditional Chinese medicine formula for treating rheumatic bone diseases, comprising the following raw materials in parts by weight: Pangolin scales 10g, Panax notoginseng 15g, dragon's blood 15g, Angelica sinensis 15g, Drynaria fortunei 15g, and Dipsacus asper 10g.

[0041] In this embodiment, specifically, it includes the following raw materials in parts by weight: 60g of Cat's Claw Herb, 15g of Loranthus parasiticus, 60g of Prunella vulgaris, 10g of Sparganium rhizome, 10g of False Kelp, 9g of Arisaema cum Bile, 10g of Zanthoxylum nitidum, 10g of Gynostemma pentaphyllum, 10g of Artemisia capillaris, 15g of Angelica pubescens, 10g of Prepared Aconitum carmichaelii, 10g of Lindera strychnifolia, 15g of Cinnamomum cassia, 10g of Eucommia ulmoides, 15g of Scutellaria barbata, 10g of Citrus reticulata leaf, 60g of Achyranthes bidentata, 15g of Atractylodes lancea, 30g of Spatholobus suberectus, 15g of Lobelia chinensis, 10g of Momordica cochinchinensis, 10g of Impatiens balsamina, 9g of Syzygium aromaticum, and 5g of Camphor.

[0042] A method for preparing a traditional Chinese medicine formula for treating rheumatic bone diseases, based on the aforementioned traditional Chinese medicine formula for treating rheumatic bone diseases, is characterized by comprising the following preparation steps: S100, pangolin scales, dragon's blood, drynaria, achyranthes, eucommia, dipsacus, clove, camphor, lobelia, prunella vulgaris, processed aconite, momordica cochinchinensis and impatiens were pre-treated with medicinal materials. S101, pangolin scales, dragon's blood, Panax notoginseng, Drynaria fortunei and Achyranthes bidentata are placed in the first brewing pot. Then, 500ml of 60-degree liquor is added to the brewing pot and sealed for 48 hours. The liquor should submerge the medicinal materials by 2cm. The fat-soluble components of animal medicines need to be dissolved in high-concentration liquor. S102, Eucommia ulmoides, Dipsacus asper, Spatholobus suberectus, Atractylodes lancea and Angelica sinensis are placed in the second brewing tank. 400ml of white wine is added to the second brewing tank and soaked for 24 hours to release glycosides. S103, catpaw grass, taxillus, summer grass, sparganium stoloniferum, alocasia cucullata, alocasia cucullata, two face needle, ghost drawing, liu jinuo, dangshen, cassia twig, half branch orchid, mountain orange leaf and half lotus are placed in the third brewing tank, and 300ml of white wine is put into the second brewing tank for 12 hours; S104, the leaching liquid of S101, S102 and S103 is combined, and the dregs are squeezed to get juice. After mixing, stand for 12 hours, take the supernatant for standby, and get the medicinal liquor; S105, take 200g of locust flower honey, heat to 116℃, cool to 60℃ for standby; Slowly pour the medicinal liquor into the locust flower honey, stir in the same direction while pouring until the wine and honey are mixed; Take the concentrated juice of prepared monkshood, wood pigeon powder and acute nucleus powder and add them to the mixture. Heat to 50℃ and stir for 20 minutes; Turn off the fire and cool to 40℃. Form camphor ethanol liquid in camphor powder pre-soluble ethanol liquid. Add camphor ethanol liquid and clove powder and stir evenly. Spoon back to form a line and slowly drop to form a paste.

[0043] In this embodiment, specifically, in S100, After the pangolin is roasted and crushed through a 120 mesh screen, the transdermal absorption rate is improved; Indonesian blood stasis needs to be ground through a 100 mesh screen to avoid stimulating the skin; After bone broken and achy phyllode are cut into thin slices and dried at 55℃, they are crushed through an 80 mesh screen; Du Zhong and Xuduan need to be crushed for a long time without filamentous material. Clove and camphor are sealed and crushed separately; Half lotus and summer grass are dried in the shade and crushed by rubbing; Prepare the concentrated juice of prepared monkshood, which is decocted for 30 minutes to reduce toxicity, for standby, which is used to destroy aconitine; Wood pigeon is shelled and crushed after being cooked with white wine, which is used to reduce toxicity and activate drug properties; Acute nucleus is slightly roasted to reduce its harshness.

[0044] In this embodiment, specifically, Core pathogenesis: cold dampness and blood stasis block meridians, and muscles and bones lose nourishment; 1. Cold dampness stagnation Performance: joint cold pain, cold aggravation (prepared monkshood, cassia twig, clove warm and dispel cold evil); Pathological basis: low temperature induces microcirculation disorder → tissue hypoxia → inflammatory factors (PGE2, bradykinin) accumulation → pain sensitization.

[0045] 2. Blood stasis blocking meridians Performance: local induration, stabbing pain (pangolin, blood stasis, sparganium stoloniferum breaking blood stasis and removing tumor); Mechanism: Chronic injury leads to collagen fiber hyperplasia → fascial adhesion → compression of nerves and blood vessels.

[0046] 3. Accumulation of phlegm and toxins Manifestations: Subcutaneous nodules, swelling (using herbs such as cat's claw grass, prunella vulgaris, and arisaema cum bile to resolve phlegm and dissipate nodules); Process: Accumulation of metabolic waste → Granulation formation → TGF-β1 activation of fibroblasts.

[0047] In this embodiment, specifically, 1. Warming the meridians and dispelling cold group 2. Blood Stasis and Mass Removal Group Pangolin scales + dragon's blood + Momordica cochinchinensis: Pangolin protease dissolves fibrin network, dragon's blood extract promotes angiogenesis, and Momordica cochinchinensis saponins dissolve calcifications.

[0048] Sparganium + Artemisia annua: Total flavonoids from Sparganium inhibit fibroblast proliferation, while coumarin from Artemisia annua softens scar tissue.

[0049] 3. Phlegm-resolving and nodule-dispersing group Cat's Claw Grass + Prunella Vulgaris + Arisaema cum Bile: Cat's Claw Grass saponins degrade hyaluronic acid, Prunella Vulgaris oleanolic acid inhibits granulomas, and Arisaema cum Bile alkaloids dissolve mucus plugs.

[0050] 4. Special synergistic formulation Camphor + Zanthoxylum nitidum: Camphor activates TRPM8 receptors to produce a cold and numbing sensation, while Zanthoxylum nitidum's benzophenanthridine base blocks pain transmission, thus synergistically relieving pain. 5. 60g of Achyranthes bidentata + 30g of Spatholobus suberectus: Achyranthes bidentata's ecdysone targets and repairs tendons, while Spatholobus suberectus's flavonoids increase blood supply to callus and treat old injuries.

[0051] In this embodiment, specifically, I. Comparison of Clinical Efficacy (Traditional Chinese Medicine Patch vs. Flurbiprofen Patch) 120 patients with knee osteoarthritis, treatment cycle 4 weeks Rapid analgesia: Aconitum carmichaelii (aconitine blocks sodium channels) and camphor (activates TRPM8 receptors) work together to block pain transmission, taking effect in 5 minutes; Anti-inflammatory and swelling-reducing: Dragon's blood extract inhibits the TNF-α / IL-6 pathway and reduces capillary permeability; Dissolving adhesions: Pangolin protease dissolves the fibrin network, and sparganium flavonoids inhibit fibroblast proliferation.

[0052] II. Imaging and Biochemical Improvement 1. Ultrasonic test results Synovial membrane repair: Prunella vulgaris oleanolic acid inhibits synovial cell proliferation and reduces IL-1β release; Blood supply improvement: Caulis Spatholobi flavones promote angiogenesis, and Achyranthes dodecandra ecdysterone accelerates tendon microcirculation reconstruction.

[0053] 2. Changes in serum markers Anti-inflammatory core: Scutellaria barbata flavones block the NF-κB pathway and inhibit matrix metalloproteinase expression; Cartilage protection: Radix Drynariae flavones promote TIMP-1 synthesis and delay cartilage matrix degradation.

[0054] Three, time-effect relationship and triple technical action Yuzuyu: 60-degree Baijiu extracts the fat-soluble components of the Chinese giant salamander, increasing bioavailability by 3.2 times; Honey-guided sustained release: honey forms a microporous membrane, prolonging drug action to 8 hours; Camphor promotes penetration: increases transdermal rate by 3.8 times (verified by Franz diffusion cell).

[0055] Four, safety and contraindications Contraindicated groups: people with skin ulcers, allergic constitution, and coagulation dysfunction.

[0056] This prescription achieves multidimensional repair of osteoarthritis through "targeted progressive action": Instant pain relief layer (0-1 hour): camphor + Radix Aconiti Preparata paralyzes peripheral nerves; Anti-inflammatory and stasis-eliminating layer (1-24 hours): dragon's blood + cat's claw inhibits the IL-6 / TNF-α pathway; Regeneration and repair layer (1-4 weeks): Radix Drynariae + Achyranthes promotes collagen synthesis and reconstructs tendon blood supply.

[0057] The above is only a specific implementation of the present application, but the protection scope of the present application is not limited thereto, and any person skilled in the art can easily think of various changes or replacements within the technical scope disclosed by the present application, which should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A traditional Chinese medicine formula for treating rheumatic bone disease, characterized in that, Comprise by the following weight parts of raw medicinal materials: Pangolin 10g or 40g, Sanqi 10g or 15g, Dragon's Blood 10g or 15g, Angelica 15g or 20g, Drynaria 15g and Dipsacus 10g or 15g.

2. The Chinese medicine formula for treating rheumatoid arthritic disease according to claim 1, wherein, Comprise by the following weight parts of raw medicinal materials: Safflower 10g, Astragalus 40g, Radix Rehmanniae Preparata 30g, Cornu Cervi Degelatinatum 10g, Epimedium 10g, Fructus Psoraleae 10g, Rhizoma Sinodendri 10g, Chaenomelis Fructus 10g, Hirudo 15g, Rubi Parvifolii Herba 10g, Rubus parvifolius 60g, Pueraria 50g, Crataegus 60g, Lysimachia 30g, Plantaginis Herba 30g, Herba Taraxaci 30g and Coicis Semen 60g.

3. A method for preparing a traditional Chinese medicine formula for treating rheumatoid arthritic disease, based on the traditional Chinese medicine formula for treating rheumatoid arthritic disease according to any one of claim 1 and claim 2, characterized in that, Comprise the following preparation steps: S1, Except Cornu Cervi Degelatinatum and Dragon's Blood, the rest of medicinal materials need to be quickly washed to remove the sand, avoid soaking to cause the loss of effective components, then the cleaned medicinal materials are flatly laid on bamboo screen to dry, or 50℃ low temperature drying for 2 hours to water content <12%; S2, before crushing, the Pangolin, Rubi Parvifolii Herba, Cornu Cervi Degelatinatum, Pueraria, Rubus parvifolius, Rhizoma Sinodendri, Fructus Psoraleae, Crataegus and Coicis Semen need to be specially treated, then Angelica, Safflower, Astragalus, Pangolin, Radix Rehmanniae Preparata, Sanqi, Cornu Cervi Degelatinatum, Drynaria, Dipsacus, Epimedium, Fructus Psoraleae, Rhizoma Sinodendri, Chaenomelis Fructus, Hirudo, Rubi Parvifolii Herba, Rubus parvifolius, Pueraria, Dragon's Blood, Crataegus, Lysimachia, Plantaginis Herba, Herba Taraxaci and Coicis Semen are crushed to pass 80 mesh screen; S3, after the coarse residue of various powders is crushed to pass 80 mesh screen, the mixed powder is obtained by using equal incremental method; S4, the mixed powder is sterilized by ultraviolet irradiation for 15 minutes or 70℃ drying for 30 minutes, and is packed in sealed bags according to 12g daily dose, and is stored in cold storage; S5, if the total amount of various medicinal powders is 530g, then 636g-795g of honey is needed, the refined honey is cooled to 60℃, then is added to various medicinal powders in batches and stirred, and is kneaded to the state of "holding it into a lump, touching it to scatter", then the medicinal mass is formed; S6, then the medicinal mass is rubbed into 2cm diameter strips, is cut into 12g / segment, is coated with sesame oil on the palm to prevent sticking, is rotated to rub into smooth pellets, the pellets are dried for 48 hours or are low temperature dried at 40℃ for 2 hours, the surface of the pellets is hardened, then the pellets are sealed with wax paper and are individually wrapped, and are stored in cool and dry place.

4. The preparation method of the traditional Chinese medicine formula for treating rheumatic diseases according to claim 3, characterized in that: In S2, the Pangolin and Rubi Parvifolii Herba need to be roasted with small fire until slightly yellow and brittle, which is beneficial to crushing; Cornu Cervi Degelatinatum is crushed into soybean size particles to prevent sticking in the crusher; Pueraria, Rubus parvifolius and Rhizoma Sinodendri are cut into 1cm segments to improve the crushing efficiency; Fructus Psoraleae, Crataegus and Coicis Semen need to be low temperature dried to prevent oil exuding.

5. The method for preparing the traditional Chinese medicine formula for treating rheumatic bone diseases according to claim 3, characterized in that: In S5, the steps of adding various medicinal powders in batches are as follows, S51, the refined honey is poured into a stainless steel basin, Cornu Cervi Degelatinatum powder and Fructus Psoraleae powder are first added, and are stirred with a wooden spoon in one direction until the colloid is completely dissolved to form uniform glue liquid, then Dragon's Blood powder is added, and is continuously stirred until no particle residue is left; S52, Pangolin powder is added in two times and is quickly stirred, then Rubi Parvifolii Herba powder and Hirudo powder are added, and are stirred until no dry powder is left; S53, Sanqi powder and Drynaria powder are added at the same time, are stirred by folding method, then Radix Rehmanniae Preparata powder, Crataegus powder, Coicis Semen powder and Dipsacus powder are added in sequence, Radix Rehmanniae Preparata contains sugar which is easy to stick, and the combination of sugar and fruit acid in Crataegus can prevent hardening; S54, after the mixture of Astragalus powder, Angelica powder and Papaya powder, stir to absorb honey, after this, Pueraria powder and thin Rhubarb powder is added, stir well; S55, dandelion powder and safflower powder gently sieve into the surface of honey, after stirring with silica gel spatula, finally add Xianlingpi powder, money grass powder and St.John's wort powder, stir well.

6. The Chinese medicine formula for treating rheumatoid arthritic disease according to claim 1, wherein, It comprises the following raw medicinal materials by weight: catpaw grass 60g, taxillus 15g, spica prunellae 60g, sparganium stoloniferum 10g, pseudo-phellodendron 10g, aconitum 9g, zanthoxylum ailanthoides 10g, gendarussa humilis 10g, angelica pubescens 15g, radix lophatheri 10g, euonymus alatus 60g, atractylodes lancea 15g, morinda officinalis 15g, lobelia 15g, semen ecliptae 10g, semen stirpae 10g, clove 9g and camphor 5g.

7. A method for preparing a traditional Chinese medicine formula for treating rheumatoid arthritic disease, based on the traditional Chinese medicine formula for treating rheumatoid arthritic disease according to any one of claim 1 and claim 6, characterized in that, It comprises the following preparation steps: S100, pre-treatment of medicinal materials of pangolin, dragon's blood, drynaria, achyranthes bidentata, eucommia ulmoides, dipsacus asper, clove, camphor, lobelia, spica prunellae, aconitum, semen ecliptae and semen stirpae; S101, put pangolin, dragon's blood, panax notoginseng, achyranthes bidentata and eucommia ulmoides into the first brewing tank, then add 500ml of 60-degree liquor into the brewing tank and seal for 48 hours, the liquor should be submerged in the medicinal materials by 2cm, and the high-concentration liquor is used to dissolve the fat-soluble components of animal medicines; S102, put eucommia ulmoides, dipsacus asper, atractylodes lancea and angelica into the second brewing tank, and add 400ml of liquor into the second brewing tank for 24 hours to soak and release glycosides; S103, put catpaw grass, taxillus, spica prunellae, sparganium stoloniferum, pseudo-phellodendron, aconitum, zanthoxylum ailanthoides, gendarussa humilis, angelica pubescens, radix lophatheri, euonymus alatus and lobelia into the third brewing tank, and add 300ml of liquor into the second brewing tank for 12 hours; S104, combine the leaching liquor of S101, S102 and S103, squeeze the residue to get juice, mix them and stand for 12 hours, then take the supernatant for use, and get medicinal liquor; S105, take 200g of locust flower honey, heat it to 116℃, and cool it to 60℃ for standby; Slowly pour the medicinal liquor into the locust flower honey, and stir in the same direction until the honey and liquor are mixed; Add the concentrated juice of aconitum, semen ecliptae and semen stirpae into the mixture, heat it to 50℃ and stir for 20 minutes; Turn off the fire and cool it to 40℃, then add camphor ethanol solution, clove powder and stir gently; If you pull up the spoon with the back of the spoon to form a line and then slowly drop it, the paste will be formed.

8. The method for preparing the traditional Chinese medicine formula for treating rheumatic bone diseases according to claim 7, characterized in that: In S100, Pangolin is roasted and then crushed to 120 mesh to improve the transdermal absorption rate; Indonesian dragon's blood is directly powdered and needs to be sieved to 100 mesh to avoid stimulating the skin; Achyranthes bidentata and eucommia ulmoides are cut into thin slices, dried at 55℃, and then crushed to 80 mesh; Dipsacus asper and eucommia ulmoides need to be crushed for a long time to remove the silk-like material, and clove and camphor are crushed separately in a sealed container; Lobelia and spica prunellae are dried in the shade and then crushed by rubbing; Aconitum is decocted for 30 minutes to reduce its toxicity, and the concentrated juice is used to destroy the aconitine; Semen ecliptae is shelled and then crushed after being boiled in liquor to reduce its toxicity and activate its medicinal properties; Semen stirpae is lightly roasted to reduce its harshness.

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