Novel passive target skin whitening efficacy nanoemulsion for night and daylight and method of preparing the same
A skin whitening and nanoemulsion technology, applied in skin care preparations, cosmetic preparations, pharmaceutical formulas, etc., can solve the problems of high irritation, difficult transdermal absorption, unreasonable formulations, etc., and achieves significant effects, physical and chemical A stable effect
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[0057] Example 1: Nanoemulsion with skin whitening effect for night use (taking the preparation of 100g as an example)
[0058] 1. Use an analytical balance to accurately weigh out 0.688g of sodium hydroxide and 0.543g of citric acid, and place them in a 100mL Erlenmeyer flask that has been decontaminated, then add 33.15g of triple distilled water to fully dissolve them, weigh and add 3.297 in sequence g L-ascorbic acid 2-glucoside, after completely dissolving, add 3.080g β-raspberry ketone glucoside, 3.080g nicotinamide, 3.080g α-arbutin, 3.080g β-arbutin and 2.0mg cysteamine in sequence Acid (*β-raspberry ketone glucoside, nicotinamide, α-arbutin, β-arbutin and cysteine need to be dissolved and then added separately, not at the same time); the above substances can be dissolved Perform ultrasonic vibration in a CQ-10 ultrasonic vibrator to accelerate the dissolution; after the solution is completely dissolved, the pH of the solution is determined to be 6.2±0.2. If there is a de...
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[0066] Example 2: Daily skin whitening nanoemulsion (taking 100g as an example)
[0067] 1. Use an analytical balance to accurately weigh disodium ethylenediaminetetraacetic acid (EDTA-Na 2 ) 0.169g is placed in a 100mL Erlenmeyer flask that has been cleaned, and 31.78g triple distilled water is added to fully dissolve it, and then 0.676g citric acid and 0.439g NaOH are added in turn after fully dissolving, weigh and sequentially add 3.02g N- Acetyl glucosamine, 2.7g L-ascorbic acid 2-glucoside, after completely dissolved, then add 3.074g β raspberry ketone glucoside, 3.074g vitamin PP factor, the dissolution of the above substances can be placed in a CQ-10 ultrasonic oscillator Carry out ultrasonic vibration to accelerate the dissolution; then slowly add 5.068 g of Glycyrrhizin application solution. After the solution is completely dissolved, the pH of the solution is determined to be 4.7±0.2. If there is a deviation, adjust the pH to within this range. Use a colored marker to clea...
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