Preparation method of intestinal targeting type high-absorption ganoderma lucidum composite fermented drink

By using enzymatic compounding and nano-assembly technology, a highly absorbable Ganoderma lucidum compound fermented beverage with intestinal targeting was constructed. This solved the problems of the active ingredients in liquid being easily destroyed and having low absorption efficiency in the gastric acid environment, and realized the stable and bioavailability of Ganoderma lucidum active ingredients for intestinal targeted delivery and efficient absorption.

CN121970856APending Publication Date: 2026-05-05ZHEJIANG FANGGE PHARMA
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Patent Information

Application Number
CN202610150547.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-03
Publication Date
2026-05-05

AI Technical Summary

Technical Problem

Existing technologies make it difficult to achieve intestinal-targeted delivery and efficient absorption of Ganoderma lucidum active ingredients in liquid beverages. In particular, hydrophobic triterpenoids are easily destroyed in the acidic environment of the stomach and have low absorption efficiency and unstable bioavailability in the intestine.

Method used

Enzymatic compounding was used to glycosylate Ganoderma lucidum polysaccharides and prebiotic oligosaccharides to form a stable polysaccharide-prebiotic complex. The complex was then formed into a pH-responsive coating on a triterpenoid compound through in-situ nanoassembly. Nanoparticles were constructed using electrostatic layer-by-layer self-assembly technology to achieve intestinal-targeted delivery of active ingredients.

Benefits of technology

The product achieves stability and intestinal targeting of Ganoderma lucidum active ingredients in liquid beverages, significantly improving the absorption and bioavailability of active ingredients. The product maintains stable physicochemical properties during its shelf life and has good commercialization potential.

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Abstract

The invention discloses a preparation method of an intestinal targeting type high-absorption ganoderma lucidum composite fermented beverage, and belongs to the technical field of functional food processing. The method comprises the following steps: separating supernate and mycelium from ganoderma lucidum fermentation liquor; ganoderma lucidum polysaccharides are extracted from mycelia and are subjected to enzymatic compounding with prebiotic oligosaccharides under the catalysis of transglycosidase to form a polysaccharide-prebiotic compound, and triterpenoids are loaded on the polysaccharide-prebiotic compound; taking the supernate and tea polyphenol to form a composite core, coating chitosan and citrus pectin through electrostatic layer-by-layer self-assembly, and constructing pH responsive nanoparticles; and finally, mixing the composite system, the nanoparticles and auxiliary materials, and sterilizing and filling to obtain the product. Through the synergistic effect of enzymatic compounding and nano assembly, targeted release and efficient absorption of active ingredients in intestinal tracts are achieved, bioavailability and product stability are remarkably improved, and the preparation method is suitable for preparing functional food for regulating intestinal flora and enhancing immunity.
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