Medicament composition and preparation method for treating chronic glomerulonephritis

A technology for glomerulonephritis and composition, applied in the field of pharmaceutical composition and preparation thereof, can solve the problems of less than 10% awareness rate, death and the like

Active Publication Date: 2012-07-25
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In my country, there is still a lack of national epidemiological survey and analysis of chronic kidney disease, but the results of the epidemiological survey of chronic kidney disease in Beijing show that the prevalence of chronic kidney disease is 9.3%, and the awareness rate is less than 10%.
Although anticoagulation and blood pressure control can alleviate the condition to a certain extent, they cannot fundamentally solve the problem, and the patient will inevitably develop chronic renal failure, leading to dialysis or death

Method used

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  • Medicament composition and preparation method for treating chronic glomerulonephritis
  • Medicament composition and preparation method for treating chronic glomerulonephritis
  • Medicament composition and preparation method for treating chronic glomerulonephritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Astragalus 503g, Angelica 252g, Chuanshanlong 377g, Bupleurum 252g, Shiwei 302g, Polyporus 302g, Leech 76g; add astragalus, Shiwei, Polyporus, and leech to boil 3 times, add 12 times the amount each time, and cook for 1.5 hours , combined decoction, filtered, and concentrated under reduced pressure to obtain a thick paste. Add 60% ethanol to soak and extract Angelica sinensis, Chuanshanlong and Bupleurum three times, add 5 times the amount each time, soak for 3 days, combine the extracts, concentrate under reduced pressure to obtain a thick paste. The above two thick pastes were combined, dried, and pulverized to obtain a dry powder. Add 1.4 times the amount of dextrin, mix well, add 75% ethanol to granulate in an appropriate amount, dry to make granules, and take 8g orally once a day, twice a day.

Embodiment 2

[0076] Astragalus 470g, Angelica 280g, Chuanshanlong 340g, Bupleurum 290g, Shiwei 260g, Polyporus 340g, Leech 60g; add astragalus, Shiwei, Polyporus, and leech to boil 4 times, add 10 times the amount each time, and cook for 1 hour , combined decoction, filtered, and concentrated under reduced pressure to obtain a thick paste. Danggui, Chuanshanlong and Bupleurum were soaked and extracted 3 times with 70% ethanol, adding 6 times the amount each time, soaked for 4 days, combined the extracts, concentrated under reduced pressure to obtain a thick paste. The above two thick pastes are combined, dried and pulverized to obtain a dry powder, and appropriate amount of auxiliary materials are added to make tablets, which are taken orally 3 times a day, 3-6 tablets each time.

Embodiment 3

[0078] Astragalus 530g, Angelica 210g, Chuanshanlong 420g, Bupleurum 210g, Shiwei 340g, Polyporus 260g, Leech 90g; Astragalus, Shiwei, Polyporus, and leech were boiled twice, adding 15 times the amount each time, and boiled for 2 hours , combined decoction, filtered, and concentrated under reduced pressure to obtain a thick paste. Add 50% ethanol to immerse and extract Angelica sinensis, Chuanshanlong and Bupleurum 3 times, add 4 times the amount each time, soak for 2 days, combine the extracts, concentrate under reduced pressure to obtain a thick paste. The above two thick pastes are combined, dried and crushed to obtain a dry powder, which is made into a soft capsule by adding appropriate auxiliary materials, and taken orally 2-4 capsules each time, 3 times a day.

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Abstract

The invention discloses a medicament composition and a preparation method for treating chronic glomerulonephritis. The medicament composition comprises the components of raw material medicament based on portions by weight: 450 to 550 portions of milk veteh, 200 to 300 portions of angelica, 330 to 430 portions of yam, 200 to 300 portions of bupleurum, 250 to 350 portions of pyrrosia lingua, 250 to350 portions of umbellate pore furgus and 50 to 100 portions of leech. The medicament composition has obvious effect on treating chronic glomerulonephritis, raises high cutting and low cutting of whole blood viscosity, blood plasma and red cell accumulation, reduces the levels of the total protein and the albumin of blood, raises the levels of the nitrogen and the creatinine of blood urea, improves blood haemorheology and raises urinary output by 3h and total urinary output.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating chronic glomerulonephritis and a preparation method thereof. Background technique [0002] Chronic glomerulonephritis (chronic glomerulonephritis) is referred to as chronic nephritis. It is a group of immune inflammatory diseases caused by various etiologies, with different pathological changes, and originating in the glomerulus. The clinical onset is hidden, the disease is protracted, and the progress is slow. , longer course; clinical manifestations are mainly proteinuria, hematuria, hypertension and edema, accompanied by varying degrees of renal dysfunction, and eventually develop into chronic renal failure. The International Society of Nephrology predicts that one in 10 people worldwide suffers from chronic kidney disease. It is estimated that approximately 36 million people worldwide will die from card...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P13/12A61K35/62
Inventor 李平张浩军赵世萍
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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