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Saussurea involucrata culture extract and novel purpose thereof

A technology of snow lotus culture and extract, which is applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc., and can solve problems such as untreated dysmenorrhea

Active Publication Date: 2012-03-07
DALIAN PRACTICAL BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing documents and patents do not have its report on the treatment of dysmenorrhea

Method used

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  • Saussurea involucrata culture extract and novel purpose thereof
  • Saussurea involucrata culture extract and novel purpose thereof
  • Saussurea involucrata culture extract and novel purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0018] In this experiment, the content of total flavonoids was used as the index of investigation, and the technological conditions of ultrasonic extraction of total flavonoids from Saussurea sauraceae culture were studied by using the method of orthogonal experiment.

[0019] Determination of total flavonoids in the extract of Saussurea chinensis culture:

[0020] Quercetin was used as the standard reference substance and aluminum nitrate was used as the color reagent to determine the total flavonoids.

[0021] 1. Solution preparation: preparation of reference solution

[0022] Accurately weigh 10mg of rutin reference substance dried at 120°C to constant weight, put it in a 50mL measuring bottle, add methanol to dissolve, dilute to the mark, and shake well.

[0023] 2. Preparation of standard curve

[0024] Precisely draw 1, 2, 3, 4, 5 and 6mL of the reference solution, put them in 25mL measuring bottles, add water to 6mL each, add 1mL of 5% sodium nitrite solution, shake w...

experiment example 2

[0082] Experimental example 2: Zoom-in extraction experiment

[0083] 1. Extraction conditions

[0084] Extraction solvent: 30% ethanol,

[0085] Number of extractions: three times

[0086] Extraction temperature: 45°C

[0087] Extraction time: 1h per level.

[0088] After the liquid is released, centrifuge, mix the second and third grades together, separate the first grade separately, and concentrate using a rotary evaporator

[0089] 2. Experimental data

[0090] Feeding: 960g

[0091] After primary concentration: 24%*2.2kg flavonoid content: 25.67mg / mL

[0092] After the second and third stages of concentration: 9%*3.45kg flavonoid content: 11.99mg / mL

[0093] weight

[0094] Conclusion: Through the scale-up test, it is further proved that the extraction process of Saussurea sauraceae culture extract is extraction solvent: 30% ethanol, extraction times: three times, extraction temperature: 45℃, extraction time: 1h per stage, which has great advantages. ...

experiment example 3

[0095] Experimental Example 3: Clinical Trial of Saussurea Saussurea Culture Extract in Treating Dysmenorrhea

[0096] 1 clinical data

[0097] From January 2010 to December 2010, 58 patients with dysmenorrhea were observed. Randomly divided into treatment group and control group. The treatment group included 30 cases, aged 15 to 37 years, with an average age of 27.2 years; the course of disease was 2 months to 11 years, with an average of 4.5; disease classification: severe in 10 cases, moderate in 15 cases, and mild in 5 cases. There were 28 cases in the control group, aged 15-36 years, with an average of 27.1 years; the course of disease was 3 months to 10 years, with an average of 4.4 years; disease classification: severe in 11 cases, moderate in 11 cases, and mild in 6 cases. The two groups of patients were basically the same in terms of age, course of disease, and condition. After statistical analysis, there was no significant difference (P>0.05), and they were compara...

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Abstract

The invention provides a saussurea involucrata culture extract and a novel purpose thereof. The saussurea involucrata culture extract is used for treating dysmenorrheal, and provides a good curative effect and a high recovery rate. With the extract, obvious toxic or side-effect is not found. The saussurea involucrata culture has functions of kidney warming, yang activating, wind expelling, dampness eliminating, menstruation regulating, and blood flow promoting. The saussurea involucrata culture can be used for treating diseases such as wind-damp-cold arthralgia, rheumatoid arthritis, hypogastrium crymodynia, and menoxenia. According to the saussurea involucrata culture extract, alcohol extraction, condensation, and spray-drying methods are adopted, such that saussurea involucrate flavone and saussurea involucrate polysaccharides with relatively high purities are obtained. Clinical observation results show that, the saussurea involucrata culture extract has certain curative effect against idiopathic dysmenorrheal, and the purpose is valuable for clinical reference and popularization.

Description

technical field [0001] The invention relates to a preparation method and application of Saussurea edulis culture extract, in particular to a new application of Saussurea edulis culture extract in preparing medicines for preventing and treating dysmenorrhea. Background technique [0002] Primary dysmenorrhea refers to women experiencing abdominal pain, low back pain, lower abdominal distension or other discomforts before or after menstruation or during menstruation, which affects life and work. It is more common in unmarried and non-pregnant women. In developing countries, about 25%-50% of adult women and 75% of adolescents experience dysmenorrhea, of which 5%-20% are severe dysmenorrhea. The conventional treatment of dysmenorrhea mainly uses prostaglandin antagonists, hormones or salicylic acid, etc., but the curative effect of analgesic and antispasmodic drugs is not satisfactory. Therefore it is very important to find effective drugs for prevention and treatment of dysmen...

Claims

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Application Information

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IPC IPC(8): A61K36/285A61P15/00
Inventor 刘汉石
Owner DALIAN PRACTICAL BIOTECH
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