Febuxostat tablets and preparation method and detection method thereof
A technology of Buxostat tablets and Febuxostat, which is applied in the field of western medicine and can solve problems affecting the curative effect of Febuxostat
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Embodiment 1
[0236] Embodiment 1: The febuxostat tablet is made of 80g febuxostat, 110g microcrystalline cellulose, 40g lactose, 18g croscarmellose sodium and 2g magnesium stearate. Take febuxostat and lactose, pass through 80-mesh sieve respectively, and set aside; mix 80g febuxostat with 110g microcrystalline cellulose, 40g lactose, and 8g croscarmellose sodium, and add appropriate amount of purified water to prepare Soft material, granulated with 18-mesh sieve, dried at 70°C, granulated with 18-mesh sieve, added the remaining amount of croscarmellose sodium and 2g magnesium stearate, mixed evenly; tested for intermediates, pressed into tablets after passing the test, and obtained Vegetable tablets: Take 370g ethanol and 100g purified water and place them in a blender, add 30g premixed coating powder under constant stirring, continue to stir for 1 hour, filter the coating solution with a 100-mesh sieve, and set aside; Put the tablet in the coating pot, open the coating pot and start the ...
Embodiment 2
[0237] Embodiment 2: the febuxostat tablet is made of 120g febuxostat, 165g microcrystalline cellulose, 60g lactose, 27g croscarmellose sodium and 3g magnesium stearate. Take febuxostat and lactose, pass through 80-mesh sieve respectively, and set aside; mix 120g febuxostat with 165g microcrystalline cellulose, 60g lactose, and 12g croscarmellose sodium, and add appropriate amount of purified water to prepare Soft material, granulated with 18-mesh sieve, dried at 70°C, granulated with 18-mesh sieve, added the remaining amount of croscarmellose sodium and 3g magnesium stearate, mixed evenly; tested for intermediates, pressed into tablets after passing the test, and obtained Vegetable tablets: Take 550g ethanol and 150g purified water and place them in a blender, add 45g premixed coating powder under constant stirring, continue to stir for 1 hour, filter the coating solution with a 100-mesh sieve, and set aside; Put the tablet in the coating pot, open the coating pot and start t...
Embodiment 3
[0238] Embodiment 3: the febuxostat tablet is made of 40g febuxostat, 95g microcrystalline cellulose, 20g lactose, 10g croscarmellose sodium and 1g magnesium stearate. Take febuxostat and lactose, pass through 80-mesh sieve respectively, and set aside; mix 40g febuxostat with 95g microcrystalline cellulose, 20g lactose, 4g croscarmellose sodium, add appropriate amount of purified water to prepare Soft material, granulated with 18-mesh sieve, dried at 70°C, granulated with 18-mesh sieve, added the remaining amount of croscarmellose sodium and 1g magnesium stearate, mixed evenly; tested for intermediates, pressed into tablets after passing the test, and obtained Vegetable tablet: take 185g ethanol, 50g purified water and place in a blender, add 15g premixed coating powder under the condition of constant stirring, continue to stir for 1 hour, and filter the coating solution with a 100 mesh screen, set aside; Put the tablet in the coating pot, open the coating pot and start the ex...
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