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Deacidified gingko leaf and its extract and its preparing process and application

A technology of ginkgo biloba and extracts, applied in the field of medicine, can solve the problems of no public detection and control methods

Inactive Publication Date: 2002-11-27
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country has also gradually set limits on the content of ginkgolic acid in ginkgo biloba pharmaceutical preparations and ginkgo leaf extracts for export, but there is no public detection and control method yet

Method used

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  • Deacidified gingko leaf and its extract and its preparing process and application
  • Deacidified gingko leaf and its extract and its preparing process and application
  • Deacidified gingko leaf and its extract and its preparing process and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Deacidification of Ginkgo biloba coarse powder: Weigh 20 grams of Ginkgo biloba coarse powder, put it into the paper bucket of the reflux part of the Soxhlet extractor, add 500 ml of petroleum ether, heat and reflux in a water bath for 2 hours, recover petroleum ether, and put the Ginkgo biloba leaf The crude fraction is removed under reduced pressure to remove residual petroleum ether to obtain deacidified ginkgo biloba coarse powder.

[0017] Detection of deacidification effect: Weigh each 5 grams of ginkgo leaf powder and deacidification ginkgo leaf powder, put them into a round bottom flask respectively, and use 50 milliliters of methanol to reflux on a water bath to extract for 2 hours, then use high performance liquid chromatography to determine The content of ginkgolic acid in the two methanol extracts.

[0018] Detection of flavonoid glycosides content: Weigh 5 grams each of Ginkgo biloba powder and deacidified Ginkgo biloba powder, respectively put them into ro...

Embodiment 2

[0024] Deacidification of Ginkgo biloba extract: Weigh 10 grams of Ginkgo biloba extract, put it into the paper barrel of the reflux part of the Soxhlet extractor, add 100 ml of petroleum ether, heat and reflux in a water bath for 2 hours, recover the petroleum ether, and put the Ginkgo biloba Extract under reduced pressure to remove residual petroleum ether to obtain deacidified Ginkgo biloba extract.

[0025] Detection of deacidification effect: Weigh 1 g of Ginkgo biloba extract and 1 g of deacidified Ginkgo biloba extract, put them into graduated test tubes and dissolve them with 5 ml of methanol, then extract with 5 ml of petroleum ether for 3 times and combine the petroleum ether extracts to concentrate Quantitatively dissolve the activity, and measure the content of ginkgolic acid in the two with high performance liquid chromatography.

[0026] Detection of flavonoid glycosides: Weigh 50 mg of Ginkgo biloba extract and 50 mg of deacidified Ginkgo biloba extract respecti...

Embodiment 3

[0032] Deacidified Ginkgo Leaf Health Tea: Sieve the deacidified Ginkgo Leaf Coarse Powder, sterilize it, mix it with flavorings and spices, pack it into a health tea containing 2 grams of deacidified Ginkgo Leaf Coarse Powder per bag, and each bag of the tea contains Ginkgo Leaf There are a variety of flavonoid glycosides and terpene lactone active ingredients in it, which can be equivalent to about 40 mg of standard ginkgo biloba extract. Drinking 2-3 bags a day has the same effect as taking the same dose of ginkgo biloba pharmaceutical preparations.

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PUM

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Abstract

A deacidified ginkgo leaf and its extract are disclosed. The deacidified ginkgo leaf contains flavone glycoside and terpene lactone, but almost not contains alkylphenate of original ginkgo leaf. The flavone glycoside and terpene lactone can be extracted by organic solvent or supercritical CO2 method. The deacidified ginkgo leaf can be used to prepare medicine for preventing and curing coronary heart disease, angine pectoris, cerebral thrombus and cerebral disfunction, health-care food and health-care tea.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically deacidified ginkgo leaves and deacidified ginkgo leaf extracts and their preparation methods and applications. [0002] The deacidified ginkgo leaves contain effective components of medicinal ginkgo leaf extracts, and can be made into various health foods, especially health teas, which are used to prevent and treat coronary heart disease, angina pectoris, cerebral thrombosis, and brain function decline. Background technique: [0003] Ginkgo biloba (Ginkgo biloba L), also known as Gongsun tree, is the oldest tree species. my country's ginkgo resources account for about 70% of the world's total. In the past ten years, my country's ginkgo planting industry has achieved remarkable development. The medicinal value of ginkgo leaves has been widely recognized by the world. A variety of flavonoid glycosides and terpene lactones in ginkgo leaves have also been proven to be effective ingredi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L33/10A23L33/105A61K31/704A61P9/10B01D11/02C07B63/00C07D493/22C07H1/08C07H17/07
CPCY02P20/54
Inventor 游松贾娴蒋雅红姚新生
Owner SHENYANG PHARMA UNIVERSITY
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