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Preparation method of total terpene lactones with low phenolic acid

The technology of total ginkgo lactone and phenolic acid is applied in the field of preparation of natural medicine ginkgo total lactone, which can solve the problems that the safety requirements of ginkgo products cannot be met, and achieve the effects of simple operation, reduction of production cost and solvent saving.

Active Publication Date: 2010-07-14
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] As can be seen from the above, the methods for removing ginkgolic acid are roughly divided into supercritical fluid extraction method, hydrocarbon solvent extraction method and resin method at present, but there is no report for the time being that there is a simple, convenient and stable method for removing ginkgolic acid. The effective method that acid content is reduced to below 1ppm can't meet the increasing requirement to the safety of ginkgo product, so it is necessary to develop a kind of simple, convenient, reliable, suitable for the preparation and deacidification method of ginkgolide of suitability for industrialized production

Method used

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  • Preparation method of total terpene lactones with low phenolic acid
  • Preparation method of total terpene lactones with low phenolic acid
  • Preparation method of total terpene lactones with low phenolic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Take 1000 grams of ginkgo extract as raw material, put it in an extraction tank, use water-saturated ethyl acetate as a solvent, the weight-to-volume ratio of the extract to the solvent is 1:3 (W / V), stir and extract at 60°C for 1 hour, filter , concentrate the filtrate to get medicinal extract; after polyamide resin adsorption, 20% ethanol elutes in the polyamide resin column, collects fraction, concentrates and dries, pulverizes and obtains ginkgo lactone powder, result: powder total lactone content 52.9%, ginkgo biloba Acid content 0.5ppm.

Embodiment 2

[0034] Take 1000 grams of ginkgo extract as raw material, place it in an extraction tank, use water-saturated ethyl acetate as a solvent, the weight-to-volume ratio of the extract to the solvent is 1:2 (W / V), stir and extract at 60°C for 1 hour, Filtrate and concentrate the filtrate to obtain the extract; mix the extract with polyamide, elute with 15% ethanol in the polyamide resin column, collect the fractions, concentrate and dry, and pulverize to obtain the total ginkgo lactone powder. The result: the total lactone content of the powder is 50.2 %, ginkgolic acid content 0.5ppm.

Embodiment 3

[0036] As shown in Example 2, the difference is that the extraction temperature of Example 2 is 60°C, while that of Example 3 is 70°C. Results: The total lactone content of the powder was 51.4%, and the ginkgolic acid content was 0.5ppm.

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Abstract

The invention discloses a preparation method of total terpene lactones with low phenolic acid, which uses ginkgo biloba extract as a raw material, uses ethyl acetate backflow to extract and uses amide resin to purify and deacidify. The preparation method takes the ginkgo biloba extract as the raw material and water saturated ethyl acetate as a solvent; at the weight measurement ratio of extractives to the solvent of 1:1-15, the extractive and solvent are extracted for 0.5-5 hours at the temperature of 20-90 DEG C and filtered; filtrate is concentrated to obtain extractum; after the extractum is adsorbed by polyamide resin, the extractum is eluted by 10-50% of lower alcohol solution; fraction is collected, concerted and dried; and the fraction is smashed to obtain dry powder in which the total terpene lactone content is above 50% and ginkgoic acid is lowered than 1 ppm. The preparation process of the invention has short extract time, low extract temperature, high extract efficiency, small solvent amount, solvent and energy saveing and lowered production cost; the deacidifying process method is convenient to operate and can lower the ginkgolic acid below 1 ppm; and the technical method provided by the invention can effectively remove tannin and pigment in extractives.

Description

technical field [0001] The invention relates to a preparation method of natural medicine ginkgolides. Background technique [0002] The fruit and leaves of Ginkgo biloba, a plant of the Ginkgo family, are commonly used in traditional Chinese medicine. Ginkgo biloba extract has been widely used in the treatment of coronary insufficiency, angina pectoris, myocardial infarction, and cerebral thrombosis caused by arteriosclerosis and hypertension. Among them, the lactone components of Ginkgo biloba extract are unanimously recognized highly active platelet factor antagonists in domestic and foreign literature, and are clinically used to treat ischemic stroke and cerebral infarction. It is of practical significance to strengthen the research and development of the effective part of total ginkgolides. [0003] Modern research has found that the phenolic components of ginkgo extract species can cause strong allergies and contact dermatitis and other diseases in the human body, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P9/10A61P7/02A61K127/00A61K131/00
Inventor 蔡鸿飞钟鸣李金华全一思黄展平汪涛
Owner GUANGZHOU HANFANG PHARMA
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