Preparation method of total terpene lactones with low phenolic acid

The technology of total ginkgo lactone and phenolic acid is applied in the field of preparation of natural medicine ginkgo total lactone, which can solve the problems that the safety requirements of ginkgo products cannot be met, and achieve the effects of simple operation, reduction of production cost and solvent saving.
CN101773528AActive Publication Date: 2010-07-14GUANGZHOU HANFANG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU HANFANG PHARMA
Publication Date
2010-07-14

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Abstract

The invention discloses a preparation method of total terpene lactones with low phenolic acid, which uses ginkgo biloba extract as a raw material, uses ethyl acetate backflow to extract and uses amide resin to purify and deacidify. The preparation method takes the ginkgo biloba extract as the raw material and water saturated ethyl acetate as a solvent; at the weight measurement ratio of extractives to the solvent of 1:1-15, the extractive and solvent are extracted for 0.5-5 hours at the temperature of 20-90 DEG C and filtered; filtrate is concentrated to obtain extractum; after the extractum is adsorbed by polyamide resin, the extractum is eluted by 10-50% of lower alcohol solution; fraction is collected, concerted and dried; and the fraction is smashed to obtain dry powder in which the total terpene lactone content is above 50% and ginkgoic acid is lowered than 1 ppm. The preparation process of the invention has short extract time, low extract temperature, high extract efficiency, small solvent amount, solvent and energy saveing and lowered production cost; the deacidifying process method is convenient to operate and can lower the ginkgolic acid below 1 ppm; and the technical method provided by the invention can effectively remove tannin and pigment in extractives.
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Description

technical field

[0001] The invention relates to a preparation method of natural medicine ginkgolides. Background technique

[0002] The fruit and leaves of Ginkgo biloba, a plant of the Ginkgo family, are commonly used in traditional Chinese medicine. Ginkgo biloba extract has been widely used in the treatment of coronary insufficiency, angina pectoris, myocardial infarction, and cerebral thrombosis caused by arteriosclerosis and hypertension. Among them, the lactone components of Ginkgo biloba extract are unanimously recognized highly active platelet factor antagonists in domestic and foreign literature, and are clinically used to treat ischemic stroke and cerebral infarction. It is of practical significance to strengthen the research and development of the effective part of total ginkgolides.

[0003] Modern research has found that the phenolic components of ginkgo extract species can cause strong allergies and contact dermatitis and other diseases in the human body, and ...

Claims

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