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Anti-aging compound

A composition and anti-aging technology, applied in the directions of drug combination, antidote, medical raw materials derived from Ginkgo biloba, etc., to achieve good inhibitory effect

Inactive Publication Date: 2010-10-13
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the anti-aging research on the combination of spirulina polysaccharide and ginkgo biloba extract

Method used

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Examples

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preparation example Construction

[0028] The preparation method of described spirulina polysaccharide is:

[0029] Accurately weigh 30.0 g of Spirulina platensis powder, add 300 mL of petroleum ether to degrease, and stir intermittently for 24 hours. Pour out the petroleum ether, put it in a fume hood, and let it dry naturally to constant weight. Then add 360mL (12 volumes) of NaOH solution at pH 10 to the degreased spirulina powder, and use an ultrasonic cell pulverizer to process it. Put the ultrasonically treated spirulina powder into a water bath at 80°C, stir intermittently, and extract for 4 hours . Centrifuge, discard the filter residue, and collect the supernatant. Add 5% TCA (trichloroacetic acid) to the supernatant until no flocculent precipitates are formed, place in a refrigerator at 4° C. for 24 hours, centrifuge, and collect the supernatant. Then add 5% TCA until there is no flocculent precipitate, centrifuge after 5 hours, and collect the supernatant. Add 5 times the volume of alcohol to the...

Embodiment 1

[0054] 50 male mice of Kunming species, weighing 20-25 g. Randomly divided into blank control group, model group, spirulina polysaccharide group (high, medium and low doses), ginkgo flavonoids group (high, medium and low doses), ginkgolide group (high, medium and low doses), combined drug Groups (high, medium and low doses of spirulina polysaccharide: Ginkgo biloba extract = 1:1, 2:1, 1:2). Make D-galactose into a 0.5% solution with physiological saline. At the same time of administration, the model group and the administration group were aseptically injected with D-galactose 125mg·kg on the nape of the neck every day. -1 d -1 . The same volume of normal saline was subcutaneously administered to the blank control group for eight consecutive weeks. After the experiment, the mice were weighed, blood was collected from the carotid artery under sterile conditions, centrifuged at 3000r / min, the serum was collected, an equal volume of ethanol-chloroform (volume ratio 5:3) mixtur...

Embodiment 2

[0066] Such as figure 1 Shown is the graph of the experimental results of the superoxide anion scavenging rate of the compound spirulina polysaccharide described in the embodiment of the present invention. Among them, the superoxide anion scavenging test is:

[0067] Take 4.5ml of 0.05mol / L Tris-HCl buffer solution with pH 8.2 in a test tube, and preheat it in a water bath at 25°C for 20min. After adding different volumes of the solution to be tested, add 0.4ml of 2.5mmol / L pyrogallol (10mmol / L HCl configuration), mix well and react accurately in a water bath at 25°C for 4min, then immediately add 2 drops of 8mol / L HCl to terminate the reaction , adjusted to zero with distilled water, and measured the absorbance value at 290 nm.

[0068] The blank group replaced different volumes of sample solutions with corresponding volumes of distilled water, and the formula for calculating the scavenging rate of superoxide anions by the samples was: scavenging rate (%)=(A 空白 -A 样品 ) / A ...

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PUM

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Abstract

The invention discloses an anti-aging compound which comprises spirulina polysaccharide and folium ginkgo extract, and the mass ratio of the spirulina polysaccharide to the folium ginkgo extract is 0.35 to 1.5:0.35 to 1.5. The preferred mass ratio of the spirulina polysaccharide to the folium ginkgo extract is 2:1. The spirulina polysaccharide is water-soluble heteropolysaccharide, and the content of the polysaccharide thereof in percentage by mass is more than or equal to 93 percent. The content of general flavone of the folium ginkgo extract in percentage by mass is more than or equal to 24 percent, and the content of terpene lactones thereof in percentage by mass is more than or equal to 6 percent. The anti-aging compound comprises the spirulina polysaccharide and the folium ginkgo extract, can play the cooperative and synergistic roles by combination. because both the spirulina polysaccharide and the folium ginkgo extract contain hydroxyl or phenolic hydroxyl structures, thereby significantly improving the anti-aging effect.

Description

technical field [0001] The present invention relates to a medical preparation containing components derived from plants, animals or minerals, and in particular to an anti-aging composition. Background technique [0002] Aging is a natural law and an inevitable process that organisms carry out spontaneously over time, manifested as structural and functional decline, and decreased adaptability and resistance. Physiologically, aging is regarded as the history of individual development from fertilized egg to old age. Pathologically, aging is the result of the accumulation of stress and strain, injury and infection, diminished immune response, nutritional deficiencies, metabolic disorders, and neglect and abuse. Although it is impossible for people to violate this rule, when people adopt good living habits and health care measures and exercise properly, they can effectively delay aging, reduce the incidence of aging-related diseases, and improve the quality of life. Although so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16C08B37/00A61P39/06A61K31/715A61K127/00
Inventor 高玲王清吉
Owner QINGDAO AGRI UNIV
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