39 results about "Primary proliferative polycythemia" patented technology

In part, the present disclosure relates methods for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, and myelofibrosis) or one or more complications of a myeloproliferative disorder. The present disclosure further relates methods for treating, preventing, or reducing the severity of a Janus kinase-associated disorder or one or more complications of a Janus kinase-associated disorder. In certain aspects the disclosure provides TβRII antagonists for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, and myelofibrosis) or a Janus kinase-associated disorder or one or more complications of a myeloproliferative disorder or a Janus kinase-associated disorder.

The invention relates to the technical field of medicines, in particular to application of LY3009120 in preparation of a medicine for treating myeloproliferative tumors. The myeloproliferative tumors comprise polycythemia vera, primary thrombocythemia and myelofibrosis, and particularly, the myeloproliferative tumors resistant to rucotinib. When the LY3009120 is used for treating the myeloproliferative tumors, a new treatment way is provided for the majority of patients with the myeloproliferative tumors, and more choices are provided for clinicians and the patients. For a myeloproliferative tumor patient with drug resistance to rucotinib, LY3009120 can provide continuous oral drug treatment for the patient, and bone marrow transplantation is avoided. LY3009120 can be chemically synthesized, and the cost is lower than that of a biological agent. And through a first-stage clinical experiment, the side reaction is less and lighter, and the tolerance of a clinical patient is good.

The invention discloses traditional Chinese medicine liquid for treating skin itch and a preparation method, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine liquid disclosed by the invention comprises the following effective components: white loosestrife herb, bunge corydalis herb, jasminum polyanthum, garlic, swamp violet, Indian damnacanthus herb, emblic leafflower leaf, japanese white birch bark, alate senna leaf, Chinese juniper leaf, redfruit actinodaphne root and leaf, calabash, nakedflower beautyberry branchlet and leaf, rhizoma nardostachyos, wadalee-gum-tree and arnica montana. The selected medicinal materials in the traditional Chinese medicine liquid disclosed by the invention are properly compatible and accord with the theories of traditional Chinese medicines and modern medicines; furthermore, the traditional Chinese medicine liquid disclosed by the invention has the effects of clearing heat, disinfecting, eliminating blood-heat and stasis, dispelling the wind, dehumidifying, diminishing swelling and relieving itching, has obvious curative effects on skin itch caused by the systematic diseases, such as inflammatory dermatosis, uremia, primary cholestasis, polycythemia vera and the like, and has the advantages of being short in treatment course, rapid in effect, non-recurrent after healing, safe and free from toxic and side effect; the purpose of treating both symptoms and root causes can be achieved, and therefore, the traditional Chinese medicine liquid for treating skin itch disclosed by the invention is worthy of being widely popularized and applied.

The present invention provides hepcidin analogues, and related pharmaceutical compositions and use thereof in treating polycythemia vera.

A pyrrolopyrimidine five-membered azacyclic derivative as a novel JAK kinase (Janus kinase) inhibitor, and use thereof in a preparation of a pharmaceutical product for preventing and / or treating an indication related to a JAK kinase function. The pyrrolopyrimidine five-membered azacyclic derivative is an ideal JAK kinase inhibitor with a high potency, and can be used to treat or prevent diseases such as rheumatoid arthritis, polycythemia vera, psoriasis, primary thrombocytosis, myelofibrosis, and the like.

The invention relates to a novel medicine for treating leukemia and a preparation method thereof and belongs to the technical field of traditional Chinese medicines. The medicine is prepared into different preparations by the conventional method in the following steps: by taking taxus chinensis, sculellaria barbata, oldenlandia diffusa, trigone, curcuma zedoary and silkworm bombycis as main materials and cleavers, American ginseng, prismatomeria tetrandra, isatis roots, tuber fleeceflower stems, Tupistra fimbriata Hand.Mazz., fructus corni, lucid ganoderma, human placenta, ligusticum wallichii and turtle shells as auxiliary materials, dosing; drying; respectively grinding fine powder; uniformly mixing; and then steaming and basking for three times. As taxus chinensis contains the No.1 anti-cancer drug in world: paclitaxel and the auxiliary materials assist, growth and development of cancer cells can be controlled, the anticancer ability of human body is boosted, and meanwhile, cyclic and metabolic functions of the human body can be further enhanced, so that viruses accumulated in the human body are eliminated outside by diuresis and defecation so as to realize the effect of treating leukemia. According to clinical trails, the total effective rate is over 90%. The medicine has the best curative effect on acute myelocytic leukemia, myelodysplastic syndromes and graft-versus-host disease, the second effect on polycythemia vera and chronic myelognous leukia, and then acute promyelocytic leukemia.

The invention discloses a TCM (traditional Chinese medicine) preparation for treating polycythemia vera and a preparing method thereof. The TCM preparation comprises, according to a certain weight ratio, Chinese thorowax root, bitter orange, Turmeric root-tuber, Szechuan lovage rhizome, root of common peony, dried rehamnnia root, tree peony bark, safflower, root of red-rooted salvia, zedoary rhizome, ground beetle, cape jasmine, Chinese angelica, Chinese gentian root, natural indigo, baical skullcap root, goldthread, white peony root, hairyvein agrimonia herb and bud, mole cricket, leaf of purpleflower holly, Yerbadetajo herb and blackend swallowwort root. The TCM preparation has the effects of soothing liver-qi and reliving stagnation, regulating qi to disperse stasis, removing heat to cool blood, and nourishing yin and generating body fluid; the TCM preparation has the effect of treating polycythemia vera.

The invention provides hepcidin analogs and related pharmaceutical compositions and uses thereof in the treatment of polycythemia vera.

The invention discloses a drug combination and application of a preparation of the drug combination to the fields of preparing drugs for treating chronic granulocytic leukemia, polycythemia vera and primary thrombocytosis. The drug combination is formed through compatibility of natural indigo, tree peony bark, fructus forsythiae, hairyvein agrimony and liquorice, and has remarkable effects of treating the chronic granulocytic leukemia, the polycythemia vera and the primary thrombocytosis.

The present invention relates to a pyrrolopyrimidine five-membered azacyclic derivative as a novel JAK kinase inhibitor, and use thereof in a preparation of a pharmaceutical product for preventing and / or treating an indication related to a JAK kinase function. The pyrrolopyrimidine five-membered azacyclic derivative of the invention is an ideal JAK kinase inhibitor with a high potency, and can be used to treat or prevent diseases such as rheumatoid arthritis, polycythemia vera, psoriasis, primary thrombocytosis, myelofibrosis, and the like. The pyrrolopyrimidine five-membered azacyclic derivative has the general formula of formula I

The invention discloses a traditional Chinese medicine for treating polycythemia vera, which is characterized in that the traditional Chinese medicine comprises the following ingredients: 15g radix arnebiae seu lithospermi, 15g semen persicae, 15g pinellia ternata, 15g rhizoma sparganii, 15g radix curcumae, 15g hirudo, 10g rheum officinale, 10g capillary artemisia, 10g rehmannia glutinosa, 8g oysters, 8g radix notoginseng, 8g fructus forsythiae, 8g ligusticum wallichii, 8g radix isatidis, 5g lumbricus and 3g Chinese polyphaga; and a method comprises the steps that the ingredients are decocted with water, decoration liquid is administered one dose every day, and each dose is administered by two times. The traditional Chinese medicine is adapted to polycythemia vera treatment, precludes complications of a blood vessel and a nervous system easily caused due to inappropriate use of the medicine, and solves the problems that the existing traditional Chinese medicine for treating polycythemia vera takes effect slowly, is ordinary in effect and even exerts a reverse action.

The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.