145results about How to "Low heterogeneity" patented technology

A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.

Commercially pure titanium having UFG structure and enhanced mechanical and biomedical characteristics has nanocrystalline alpha-phase grains with a hexagonal close-packed lattice, in which the share of grains with a size of 0.1 . . . 0.5 μm and a grain shape coefficient of no more than 2 in the mutually perpendicular planes makes no less than 90%, over 60% of the grains having high-angle boundaries disoriented in relation to the adjacent grains by the angles from 15 to 90°.The method for making a rod of the material provides for equal-channel angular pressing of a billet at T≦450° C. with the total accumulated true strain e≧4 to effect severe plastic deformation of the billet and subsequent thermomechanical treatment with a gradual decrease of the temperature in the range of 450 . . . 350° C. and the strain rate of 10−2 . . . 10−4 s−1 with the strain degree from 40 to 80% to effect additional plastic deformation.

The present inventors succeeded in improving the antibody constant region to have increased stability under acid conditions, reduced heterogeneity originated from disulfide bonds in the hinge region, reduced heterogeneity originated from the H chain C terminus, and increased stability at high concentrations as well as in discovering novel constant region sequences having reduced Fcγ receptor-binding, while minimizing the generation of novel T-cell epitope peptides. As a result, the present inventors successfully discovered antibody constant regions with improved physicochemical properties (stability and homogeneity), immunogenicity, safety, and pharmacokinetics.

The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy, and more specifically, to nucleotide sequences encoding the fusion proteins, wherein the chimeric fusion proteins comprises at least one targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.

A method for identifying a quantitative trait loci for a complex trait that is exhibited by a plurality of organisms in a population. The population is divided into a plurality of sub-populations using a classification scheme. Depending on what is known about the population, either a supervised or unsupervised classification is used. The classification scheme is derived from a plurality of cellular constituent measurements obtained from each organism in the population. For each sub-population in the plurality of sub-populations, a quantitative genetic analysis is performed on the sub-population in order to identify one or more quantitative trait loci for the complex trait.

The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.

The present invention relates to a lane keeping control method of the vehicle and an apparatus thereof. More specifically, the present invention relates to a method and an apparatus for calculating a torque for the lane keeping of the vehicle. In particular, the present invention provides a lane keeping control device that includes: a receiving unit that is configured to receive sensed information containing lane information from one or more sensors in the vehicle; a target torque calculating unit that is configured to calculate a target torque for the lane keeping of the vehicle based on the sensed information; and a final torque calculating unit that is configured to calculate a final torque for the lane keeping based on a driver steering torque and the target torque according to the input of the driver steering torque, and further provides a lane keeping control method.

The quality of an image read from a degraded image of an original document can be improved. Hence, a specific pixel of an image is selected, and additional information to be added to the image is generated from the position information and color information of the selected pixel. The image of an original document is read, position information and color information added to the original document are extracted, and the color information of a pixel corresponding to the position information is acquired from the read image. The color of the read image is corrected based on the extracted color information and the acquired color information.