7 results about "Polar lipids" patented technology

The invention discloses a structure annotation method for analyzing positions sn-and C = C of lipid based on liquid chromatography-organic matter ion electron collision excitation mass spectrometry. According to the method, a proper amount of 0.1 mM sodium acetate is added during lipid redissolution, so that polar lipid and neutral lipid are analyzed at the same time through one-time sample introduction. Meanwhile, a method for automatically annotating the complex organic matter ion electron collision excitation mass spectrum is developed, and the method comprises the steps of (1) extracting mass spectrum information in original data, (2) identifying lipid subclasses, (3) matching lipid total composition, (4) pairing sn-position, (5) positioning C = C position, and (6) determining annotation level. For 34 lipid standard substances in serum, the annotation accuracy rates of the annotation method on sn-and C = C isomer levels are 100% and 82.3% respectively. A total of 1312 sn-isomers and 1033 C = C isomers are annotated from mixed plasma samples of healthy people and patients with mild cognitive impairment of Alzheimer's disease. In a word, the lipid fine structure analysis method developed by the invention has the characteristics of simple pretreatment, high coverage and efficient annotation of the lipid fine structure.

The present invention relates to enzymatic methods for producing a stable lipid-based liquid crystalline phase of Fd3m or Hll space group, compositions comprising such phases, and uses thereof, wherein the starting mixture comprises 30-65 wt% polar lipids and 35-70 wt % oil which are well dispersed and triacylglycerol lipase is added to produce oil hydrolysate which in presence of aqueous solvent results in liquid crystal formation.

The present disclosure provides a method for delivering a nucleic acid cargo to the liver of a subject, the method comprising administering to the subject a lipid nanoparticle encapsulating the nucleic acid and comprising a non-polar lipid. The lipid nanoparticle may exhibit a blebbed morphology, despite the absence or low levels of phospholipid. The disclosure further provides compositions for delivering nucleic acid cargo to the liver in order to treat various diseases, disorders and conditions in the subject.

The present disclosure provides a lipid nanoparticle comprising: nucleic acid cargo; ionizable lipid; non-polar, neutral lipid, such as a phospholipid; non-polar lipid, such as a glyceride; and sterol, the lipid nanoparticle being unshielded and wherein each mol% content is relative to total lipid present in the lipid nanoparticle.

The present invention relates to a two-step emulsification process for preparing a lipid and protein component-containing composition comprising large lipid globules, preferably coated with polar lipids, and to the compositions thus obtained. Optionally, the composition comprising the lipid and protein components is spray-dried. The resulting compositions are useful for feeding infants.

This application relates to compositions comprising polar lipids for maintaining or increasing mobility and vitality. In particular, the invention relates to the use of milk fat globule membrane materials comprising one or more polar lipids in the manufacture of compositions or pharmaceuticals intended for (a) maintaining or increasing lean muscle mass and / or maintaining or decreasing fat mass in human subjects; (b) increasing daily activity and reducing sedentary time in human subjects; and / or (c) after daily administration of the composition or pharmaceuticals for a period of at least three or four months, and wherein the human subjects exercise at least two days per week, compared to the sedentary time and / or low-intensity physical activity time prior to the commencement of daily administration of the composition or pharmaceuticals, a reduction of at least 7 minutes per day in sedentary time and / or an increase of at least 3 minutes per day in low-intensity physical activity time in human subjects.

The present application relates to the technical field of functional lipid preparation, and particularly relates to a method for enriching high-purity Nannochloropsis polar lipid by enzyme method and a preparation method thereof. The immobilized Lip2 lipase is used to specifically and selectively hydrolyze triglyceride to generate glycerol and free fatty acid, and the polar lipid component is reserved and enriched, and then high-purity Nannochloropsis polar lipid is obtained through centrifugal filtration and molecular distillation. The present application provides a method for preparing high-purity polar lipid by enzymolysis of Nannochloropsis oil using the lipase Lip2 produced by Yarrowia lipolytica. The specific catalytic effect of the Lip2 lipase maximally reserves the polar lipid, and high-purity polar lipid product is obtained. The present application provides a method for high-efficiency enrichment of Nannochloropsis polar lipid, which is mild in reaction condition, friendly to environment, simple in steps and high in purity. The prepared polar lipid product is extremely high in purity, and fills the blank of high-efficiency preparation of Nannochloropsis oil polar lipid in the prior art.