21 results about "Fat transplantation" patented technology

The invention relates to the field of medical auxiliary equipment, and discloses an auxiliary fat transplantation device for a scar area, the auxiliary fat transplantation device comprises a syringe, the inner wall of the syringe is slidably connected with a piston, the outer wall of the piston is fixedly connected with a push rod, and the outer wall of the syringe is provided with an adsorption assembly; the adsorption assembly comprises a vacuum cover, the vacuum cover is arranged on the outer wall of the injection barrel, the outer wall of the vacuum cover is fixedly connected with a fixing pipe, the inner wall of the fixing pipe is fixedly connected with a plurality of cross-shaped sealing blocks, the cross-shaped sealing blocks are attached to the outer wall of the injection barrel, and the outer wall of the vacuum cover is fixedly connected with a connecting ring; a first sealing ring is arranged on the lower surface of the connecting ring, and a vacuum adsorption hole is formed in the vacuum cover. By means of the negative pressure adsorption structure, a scar area to be treated is evenly pulled and lifted before operation, fiber bundles in a concave area are preliminarily released, a stable'safe cortex operation space 'is formed, and the entering depth of a needle head is easier to control.

The invention provides a granular fat low-temperature collecting device for fat transplantation, and relates to the technical field of fat transplantation. The sealing mechanism is fixedly mounted in the storage mechanism; the top of the automatic blocking mechanism is inserted into the storage mechanism and is communicated with the sealing mechanism; the top of the fat granule docking mechanism is connected with the automatic blocking mechanism; the auxiliary cleaning mechanism is mounted at the top of the storage mechanism; during butt joint conveying, injection of excess air can be greatly reduced; the collection and storage barrel is independently arranged in the storage mechanism; butt joint conveying can be matched, and automatic opening, closing and blocking can be carried out; internal cleaning of the multiple sets of collection and storage barrels can be completed rapidly and conveniently; the problems that if air in an internal area of a bearing container contains bacteria or other substances, fat granules can be influenced to a certain extent, and the temperature and the sterile environment in a heat preservation box can be influenced to a certain extent due to frequent opening, closing and taking are solved.

The invention discloses a monitoring system for fat necrosis risk after fat transplantation, and belongs to the technical field of autologous fat transplantation. The fat necrosis risk monitoring system comprises an oxygen saturation detection device used for obtaining oxygen saturation information of a transplantation area and a contrast area; the temperature detection device is used for acquiring temperature information of the transplantation area and the contrast area; the pressure detection device is used for acquiring pressure information of the transplantation area and the contrast area; the data acquisition device is electrically connected to the oxygen saturation detection device, the temperature detection device and the pressure detection device and is used for acquiring information detected by the oxygen saturation detection device, the temperature detection device and the pressure detection device; and the upper computer is electrically connected to the data acquisition device and is used for acquiring the data acquired by the data acquisition device and processing the acquired data. According to the invention, the fat necrosis comprehensive risk coefficient of the transplantation area can be obtained, so that an accurate quantitative index is provided for evaluation and nursing work after fat transplantation.

The invention discloses a medical fat collection device with separation and purification functions, and relates to the technical field of fat extraction and collection, the medical fat collection device comprises an absorption gun and a collection assembly, a connecting pipe is arranged between the absorption gun and the collection assembly, the absorption gun and the collection assembly are connected with a negative pressure pump, and the negative pressure pump is started; by means of the absorption gun, autologous fat is absorbed through the absorption gun, fat mixed liquid is primarily separated in the absorption gun, fat and most blood are separated, the primarily separated fat is conveyed into the collection assembly through the connection pipe by the absorption gun, and after the fat is conveyed to the collection assembly, the fat is separated again in the collection assembly. The fat is further purified, residual blood water in the fat is separated, so that the fat separation and extraction effect is achieved, the rejection problem caused by fat transplantation is avoided by sucking the fat, treating the fat and then transplanting the fat to other parts, and the quality of plastic surgery medicine and wound repair medicine surgery is improved.

The invention discloses an application of nano silicate in assisting fat transplantation. The application comprises the following steps: preparing the nano silicate into a silicate ion solution by adopting a serum-free culture medium, mixing the silicate ion solution with a fat aspirator, and performing transplantation injection, meanwhile, the invention discloses a fat graft obtained by mixing a silicate ion solution prepared from the nano silicate by adopting a serum-free culture medium with a fat aspirator, a preparation method of the fat graft, and application of the fat graft as a soft tissue filler. Compared with traditional fat transplantation, the fat graft provided by the invention has the advantages that by synergistically promoting angiogenesis, inhibiting inflammation / fibrosis and protecting early excessive apoptosis of fat cells due to ischemia and hypoxia, the long-term survival quality of transplanted fat can be remarkably optimized, the fat retention rate is increased to 60% or above, and the survival rate of the transplanted fat is increased to 60% or above. Wide application prospects are realized in the aspect of clinical fat transplantation.

The utility model relates to the technical field of fat transplantation, and provides a high-concentration fat treatment system for fat transplantation, which aims at solving the problem that the use requirements of subsequent filling and the like are influenced due to poor separation effect when the existing fat treatment device is used for treating high-concentration fat, and comprises a separation tank body, and a cotton cushion table is erected in the separation tank body; an adsorption cotton cushion can be laid on the surface of the cotton cushion table; a sealing cover is arranged at the top of the separation tank body, a screen is clamped between the top end of the separation tank body and the sealing cover, a feeding pipe is arranged at the top of the sealing cover in a penetrating mode, and a material taking pipe opening is formed in the side wall of the separation tank body in a penetrating mode and located in the side, close to the screen, of the cotton cushion table. According to the device, redundant fat sucked out of the body can be sequentially subjected to stirring screening, adsorption separation, cleaning and other treatment, the treated fat is high in purity and high in treatment efficiency, and the treatment process can be continuously conducted in the separation tank body in a sealed mode.

The utility model discloses a fat filtering collector, and particularly relates to the technical field of fat filtering, the fat filtering collector sequentially comprises a filtering assembly, a waste liquid collecting assembly and a sterilizing assembly from top to bottom, the fat filtering collector is used for aseptically filtering fat, an auxiliary assembly used for improving the filtering efficiency is arranged on the outer side of the filtering assembly, and the filtering assembly comprises a filtering cylinder. A first bottom plate is fixed to the bottom of the inner wall of the filter cylinder, a filter screen for filtering fat is fixed to the inner wall of the filter cylinder, the waste liquid collecting assembly comprises a waste liquid cylinder, a top plate is fixed to the top end of the inner wall of the waste liquid cylinder, and a second bottom plate is fixed to the bottom of the inner wall of the waste liquid cylinder; and the sterilization assembly comprises a sterilization cylinder and an ultraviolet sterilization lamp fixed at the bottom end in the sterilization cylinder. The interior of the collector can be sterilized at any time in the whole fat filtering process, whole-process sterile filtering and storage of fat are achieved, the fat purity is improved, and therefore the survival rate and the effect after fat transplantation are improved.

The utility model discloses an autologous fat transplantation needle, and relates to the technical field of transplantation needles. The end, away from the connecting piece, of the needle tube is of a conical structure, the end, away from the connecting piece, of the needle tube is in a round and blunt state, two transplanting through holes are symmetrically formed in the left side and the right side of the side wall of the needle tube, an auxiliary separation mechanism is arranged on the inner side of the needle tube, and the cross section of the needle tube is oval. Two groups of transplantation through holes symmetrically formed in the side wall of the needle tube and an auxiliary separation mechanism arranged in the needle tube jointly promote uniform distribution and effective transplantation of fat. The oval design and size distribution of the auxiliary separation beads are beneficial to better dispersing fat in the injection process, formation of fat masses is avoided, and therefore the transplantation effect is improved, the end, away from the connecting piece, of the needle tube is in a round and blunt state, the overall cross section of the needle tube is designed to be of an oval structure, and the injection efficiency is improved. By means of the design, damage to the tissue in the operation process can be reduced.

A powder formulation for preserving tissue and organ function, and more particularly to shelf stable powder formulations that can be reconstituted at point of use, including during a fat grafting process, coronary artery bypass graft surgery, and peripheral bypass surgery, or other grafting / transplant surgery prior to or during the medical procedure to preserve the tissues / organs used in these procedures. The powder formulation includes a reducing agent; an antioxidant; a sugar; a nitric oxide substrate; a buffering agent; and physically acceptable salt. Also provided are a method of preparing an organ or tissue preservation solution by reconstituting the powder formulation, and a method of preserving tissue or an organ using same.

The invention discloses a precise liposuction needle with a force feedback function and a fat transplantation navigation system, and relates to the field of medical instruments. Comprising a liposuction needle and a fat transplantation navigation system which achieve data interaction in a wireless or wired communication mode. The liposuction needle is used for collecting liposuction depth, tissue pressure and image data in real time and transmitting the data to the navigation system, and the navigation system generates body surface projection navigation information based on the received data and dynamically regulates and controls liposuction parameters. By integrating a real-time pressure monitoring system, a liposuction depth feedback system, an image data acquisition system and a body surface projection navigation system, the operation safety is improved, the fat cell survival rate is optimized, and the operation precision and symmetry are improved.

The invention relates to the technical field of medical intelligent control, in particular to a fat transplantation survival rate optimized reinforcement learning injection path planning system, which comprises a near infrared spectrum detection device, a fat cell survival rate distribution diagram, an injection path planning module, an injection path planning module and a fat transplantation survival rate optimization module, the injection path planning module constructs a reinforcement learning reward function based on the survival rate distribution diagram, generates an optimized injection path, and sends the optimized injection path to the injection speed control module and the fat particle distribution simulation module, and the fat particle distribution simulation module simulates the fat particle migration process in the optimized injection path. And a prediction result is generated and sent to the injection speed control module, the injection speed control module generates an injection speed control instruction according to the optimized injection path and the prediction result, the injection speed control instruction is executed through the injection needle, the fat survival rate can be remarkably improved by the system from traditional 30-50% to 70-85%, and repeated operation requirements are reduced.

Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally.

The application relates to the field of biological medicine, and particularly relates to a cold storage solution and application of a combined traditional Chinese medicine compound biological stent drug delivery system in eardrum repair. The cold storage solution comprises a basic solution and L-alanyl-L-glutamine; the basic solution comprises a STEEN solution. The cold storage solution can promote metabolism and synthesis of glutathione of fat grafts, regulate ROS mitochondrial oxidative stress, reduce cold storage damage of the fat grafts, and improve the cold storage quality of the fat grafts. Meanwhile, the application uses Shengji Yuhong collagen sponge which contains an important classical prescription for promoting repair, forms a functional biological material with supporting and pro-angiogenic effects, forms a linkage mode of "double-stage regulation before and after transplantation", closely combines the actual difficulties of cell damage of fat groups and reduction of repair success rate caused by long eardrum repair time in the clinic, explores a brand-new research mode for improving the eardrum repair scheme, and has far-reaching clinical significance.

The invention relates to the technical field of medical cosmetology, and discloses an elastic fat filling and shaping system which comprises a fat pretreatment module, an elastic supporting module, a dynamic injection module, a biological fixation module, a degradation regulation and control module and a postoperative shaping module. The fat pretreatment module comprises a multi-stage centrifugal separation unit, a cell activation unit and a viscoelasticity adjusting unit, the multi-stage centrifugal separation unit adopts a gradient centrifugal device and an fat cell screening membrane, and the cell activation unit is integrated with a low-temperature mixing cavity of fat cells and platelet-rich plasma (PRP); the viscoelasticity adjusting unit preloads temperature-sensitive sodium alginate gel through an injector, and the fat pretreatment module, the elastic supporting module, the dynamic injection module, the biological fixation module, the degradation regulation and control module and the postoperative shaping module are integrated, so that the elastic fat filling and shaping system is simpler and more convenient to operate and can better adapt to individual differences, and the stability of the elastic fat filling and shaping system is improved. The survival rate and the shaping effect of fat transplantation are improved.

The application relates to the technical field of subcutaneous fat transplantation, and particularly relates to application of regulatory T cells (Treg) in improving survival rate and survival quality of subcutaneous fat transplantation. The application first finds that the survival rate and survival quality of subcutaneous fat transplantation have a significant relationship with the proportion of regulatory T cells, and the survival rate of subcutaneous fat tissue mixed with regulatory T cells in a specific proportion is obviously improved, so that the application can be used as an innovative fat transplantation technology to improve the existing clinical solution, and has strong clinical transformation value.

The present invention relates to a fat transplantation machine (1) comprising:a fat suction circuit,a filtration device (100) comprising a filter delimiting a centrifugation chamber (160) for an adipose tissue, the filter having a pore size configured to allow a liquid medium to pass and retain an adipose tissue,a rotational drive device (30) connected to the filtration device,a mass measurement device (5) configured to measure the mass of adipose tissue present in the filtration device,a processing unit (10) configured to control the rotational drive device (300) so as to initiate at least one centrifugation filtration sequence as a function of a predetermined mass of suctioned adipose tissue, the processing unit being further configured to calculate an injectable amount of adipose tissue (Qinjectable) after each purification sequence.

This invention discloses a method for preparing high-viability fat grafts, comprising: aseptically transferring adipose tissue in a closed system while maintaining complete isolation from air during the transfer; performing multi-stage liquid washing on the adipose tissue, including an initial washing and a secondary washing, to remove blood components, tissue debris, and drug residues; subjecting the washed adipose tissue to gradient centrifugation, including an initial low-speed centrifugation and a secondary high-speed centrifugation, to achieve uniform separation of fat cells through a sieve; and collecting the centrifuged fat grafts to obtain a final product with high cell viability and a high proportion of concentrated stem cells. By combining multi-stage liquid washing with gradient centrifugation, efficient purification and uniform separation of fat cells are achieved, effectively reducing the risk of inflammation and removing harmful residues such as lidocaine, resulting in a final fat graft with a high proportion of stem cells and excellent biocompatibility, supporting regenerative medicine applications.

A syringe for withdrawing an aspirate including fat cells from a body includes a barrel having an inner wall, a filter for separating the fat cells from the aspirate extends within the barrel, an absorbent positioned between the filter and the barrel inner wall for absorbing aspirate that traversed the filter, and a plunger for longitudinal movement within the barrel. The plunger includes a gasket attached to a proximal end and the absorbent includes fibers and a majority of the fibers are oriented in a substantially radial direction relative a direction of longitudinal movement of the plunger.

This invention discloses a medical fat collection device with separation and purification functions, relating to the field of fat extraction and collection technology. It includes an absorption gun and a collection component, with a connecting tube between the absorption gun and the collection component. A negative pressure pump connects the absorption gun and the collection component. When the negative pressure pump is activated, autologous fat is drawn in through the absorption gun. The fat mixture undergoes preliminary separation within the absorption gun, separating the fat from most of the blood. The pre-separated fat is then transported from the absorption gun to the collection component through the connecting tube. Once in the collection component, the fat undergoes further separation, purifying it further while separating any remaining blood. This achieves the separation and extraction of fat. By aspirating and processing the fat, it can be transplanted to other areas, avoiding rejection problems associated with fat transplantation and improving the quality of plastic surgery and trauma repair procedures.

The invention discloses a method for constructing a prediction model for preventing capsule contracture after implant radiotherapy through fat transplantation, a machine learning model is trained by obtaining rat radiotherapy data of hemispherical prosthesis transplantation and surface fat injection treatment, a basic model is obtained, a machine learning algorithm can process massive multi-dimensional data, potential information can be mined, and the prediction model can be used for predicting capsule contracture. Constructing a prediction model basis of the scientific system; meanwhile, radiotherapy rat data and patient clinical data after the silica gel prosthesis is implanted are integrated, and a cross-species association rule is calculated based on a nuclear canonical correlation analysis model to adjust the basic model. According to the mode, multi-source data information is integrated, the scientificity and systematicness of the model are enhanced, and capsule contracture can be predicted more comprehensively and accurately; kernel canonical correlation analysis can process a non-linear relation, mine internal relation of cross-species data, and reasonably integrate animal experiment mandatory data into a model optimized based on patient data, so that the model gives consideration to mechanism understanding and clinical practice, and the accuracy and reliability of clinical application are improved.

A method of preparing a fat graft includes introducing fat tissue into an internal chamber of a vessel of a cell or tissue isolation, purification, and storage device through a first opening of the vessel. The method also includes introducing an amount of a wash solution effective to wash the fat graft or an amount of a cryoprotectant effective to cryopreserve the fat graft into the internal chamber of the vessel through a second opening of the vessel and mixing the fat tissue with the wash solution or the cryoprotectant. The method further includes either: when wash solution is introduced, centrifuging the device containing the fat graft to separate the fat graft from the wash solution and drawing the wash solution from the first end of the device; or, when cryoprotectant is introduced, cooling the fat graft to a temperature below 0° C.