227 results about "Biogenic substance" patented technology

The invention provides a composition for forming a coating film which comprises (1) a polymer of a monomer mixture containing monomers represented by the following formulae (A) to (D):(wherein Ta, Tb, Tc, Td, Ua1, Ua2, Ub1, Ub2, Ub3, Qa, Qb, Qc, Ra, Rb, Rc, Rd, An−, m and n are as defined herein), where a ratio of a total of the anionic monomer represented by the above-mentioned formula (A) and the cationic monomer represented by the above-mentioned formula (B) based on total monomers contained in the monomer mixture is 40 mol % or more, and (2) a polycarbodiimide containing a structure represented by the following formula (E):—N═C═N—  (E)a coating film which is a cured product thereof and a process for producing the same, and a cured product and a process for producing the same.

Embodiments of the present disclosure are directed to systems, apparatuses, devices and methods for a bioreactor which, in some embodiments, comprises a drawer cage, housing or frame (such terms being used interchangeably throughout), at least one drawer arranged within the drawer cage, where each drawer can be configured to contain a plurality of bioreactors for cultivating biological matter, and a platform upon which the drawer cage is positioned. The platform can include a first axis upon which the drawer cage rotates or tilts thereon.

A fluorescence intensity enhancer containing a water-soluble compound having a melting point of 50 DEG C or higher, a method for enhancing the fluorescence intensity of a fluorescently labeled target biological substance using the fluorescence intensity enhancer, and a fluorescence detection kit containing the fluorescence intensity enhancer.

The present disclosure provides methods and devices for inhibiting or reducing biological contaminants in biological matters during long term preservation while maintaining desired properties of the biological matter by applying the biological matter specific long term isochoric freezing or mild isochoric freezing treatment parameters.

A method of fitting spectrum data to a model of biological substance data is disclosed. The method comprises receiving spectrum data, receiving fitting data for each of a plurality of biological substances, wherein fitting data comprises, for each of the plurality of biological substances: a number of reference multiplets for that biological substance, and for each reference multiplet, the position of the centre of that reference multiplet, the number of peaks for that reference multiplet, the relative amplitude of each peak, and the width of each peak. The method further comprises determining a fitting order of the reference multiplets, wherein the position of each reference multiplet in the fitting order is based on the number of possible overlaps with other reference multiplets comprised in the fitting data, starting with the fewest overlaps and ending with the most.

The invention provides a micro-fluidic chip for coating biological substances through magnetic force and a preparation method thereof.The micro-fluidic chip comprises a substrate and a cover plate, the substrate and the cover plate enclose to form a micro-channel, one end of the micro-channel is connected with a sample adding hole formed in the cover plate, the other end of the micro-channel is connected with a waste liquid area, and the waste liquid area has water absorbability; a marking area and a detection area are arranged in the micro-channel, the marking area and the detection area are sequentially distributed in the flowing direction of a sample, a detection point and a reference point are arranged in the detection area, magnetic blocks are arranged below the substrate corresponding to the detection point and the reference point, a marking antibody is arranged in the marking area, and the magnetic blocks are arranged in the detection area. The detection point is provided with a magnetic particle coupled capture antigen / antibody, and the reference point is provided with a magnetic particle coupled anti-species antibody aiming at the labeled region antibody. According to the micro-fluidic chip, the coating mode of biomolecules on the micro-fluidic chip is improved from a traditional chemical coating mode to a coating mode of adsorbing magnetic particles through magnetism, so that the manufacturing process of the chip is simplified.

Supercooled water or solutions can be destabilized by the nucleation of ice. Constraining water in a constant-volume (isochoric) container minimizes destabilization through thermodynamic, kinetic, and fluid dynamic means, significantly enhancing supercooling stability. Methods and devices are used for stable and transportable supercooling of aqueous solutions or suspensions, and the stable and long-term preservation of biological matter that may be stored therein.

Apparatuses, systems, and methods are disclosed for chemically differentiated sensor arrays and methods of manufacturing and using the same. In one or more examples. An integrated circuit chip includes a chemically differentiated array of graphene field effect transistors with one or more wells configured to receive a volume of biological sample liquid comprising a plurality of different types of biological substances to be distinguished using electrical measurements of output signals of the graphene field effect transistors. At least one electrode is configured to apply a changing gate bias voltage (VGs) that increases and decreases within a predetermined range to the sample liquid and at least one electrode is configured to monitor measurement vectors including slopes of drain current measurements relative to the voltage measurements and differences in slope of the measurement vectors distinguish different biological substances in the sample liquid. Systems and methods utilize the integrated circuit chip.

The invention discloses a silk fibroin medical adhesive for emergency hemostasis and infection resistance and a preparation method thereof, and belongs to the field of biological material preparation and biomedicine application. Biomimetic marine mussel biological substances such as silk fibroin, sodium alginate and tannic acid are used as components to form the medical adhesive with strong wet adhesion performance, and based on molecular chain entanglement and cross-linking among the materials, the obtained medical adhesive has good biocompatibility and anti-infection performance; in addition, the adhesive has the in-situ spraying capacity, can be directly sprayed on a damaged part, can further derive powder and band-aid forms from the adhesive, and is more convenient to use. The raw materials used by the adhesive prepared by the invention are safe, non-toxic and wide in source, the preparation method is simple, the adhesive is expected to replace a traditional medical adhesive, and high application value is achieved under emergency hemostasis conditions such as battlefields.

The invention relates to the technical field of preparation of quality control products, in particular to a preparation method of a quality control product based on multiple substances. The method comprises the following steps: acquiring biomarkers corresponding to different individuals and carrying out substance sample purification treatment to obtain biological substance component samples corresponding to the biomarkers; obtaining target detection items, and carrying out on-demand combination standardized proportioning and substance mixing preparation to obtain a biomass control mixed solution corresponding to each target detection item; carrying out freeze-drying treatment on the biomass control product mixed solution corresponding to each target detection item, recording in real time, and carrying out freeze-drying activity optimization control preparation and quality control product rehydration treatment by adding a stability enhancer to obtain a quality control product rehydration solution corresponding to each target detection item; and sub-packaging the quality control product rehydration solution into standard kits corresponding to each target detection item, and executing corresponding experimental detection operation. The accuracy and reliability of detection and preparation of the quality control product can be improved.

The present invention provides a novel method and apparatus that employs a signal-enhancing probe in combination with a flow assay strip to bind a target analyte with substantial selectivity, sensitivity, speed, and convenience, through the use of target analyte-specific binding agents and smartphone camera measurement and analysis. The present invention is advantageous for detecting, identifying, quantifying, and analyzing target analytes, such as chemical, biochemical, or biological substances, in analyte samples. The present invention is most effective in detecting, identifying, quantifying, and analyzing drugs, bacterial and viral pathogens in body fluids, such as blood, blood plasma, exhaled breath, nasopharyngeal mucus, and saliva.

Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc / g to 5.0 cc / g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc / g to 5.0 cc / g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

A bio-substance analysis method using a sensing substrate having a fluid channel is disclosed. The method includes mixing retroreflective particles with a detection solution containing a target bio-substance, wherein a first bio-recognition substance selectively reacting with the target bio-substance is modified on the retroreflective particles; placing the sensing substrate so that a bottom is located under a cover in a direction of gravity; injecting the detection solution containing therein the retroreflective particles into a fluid channel and maintaining the solution in the channel for a first time duration; turning the sensing substrate upside down so that the bottom is located above the cover in the direction of gravity and maintaining the sensing substrate in the turned state for a second time duration; irradiating light into the fluid channel through the bottom; and generating and analyzing an image based on light retroreflected from the retroreflective particles.

The present disclosure relates to a method of manipulating magnetic beads in a liquid inside a conduit, wherein the method comprises generating a variable magnetic field using at least one magnet or electromagnet to mix the magnetic beads in the liquid; and wherein a biological or chemical species is attached to the surface of the magnetic beads.

The present invention relates to methods and conjugates for improving the permeability of a biological substance into the tumor microenvironment (TME) for therapeutic purposes, suitably comprising at least: i. A therapeutic domain; ii. A cleavable domain; and iii. A stabilizing domain.

A fluorescence intensity enhancer containing a water-soluble compound having a melting point of 50° C. or higher, a fluorescence intensity enhancing method of a fluorescently labeled target biological substance using the fluorescence intensity enhancer, and a kit for fluorescence detection containing the fluorescence intensity enhancer.

The application discloses an ecological regulation method for relieving the retention of the biogenic substance of a deep and large reservoir, and belongs to the technical field of water resource management and environmental protection technology. The steps are as follows: first, collecting characteristic parameters and multiple types of hydrological and water quality monitoring data of the deep and large reservoir; second, constructing a three-dimensional hydrodynamic-water quality model of the deep and large reservoir; third, based on the three-dimensional hydrodynamic-water quality model of the deep and large reservoir, combining a long series of multiple inputs and multiple output sequences, a data-driven proxy model is constructed; fourth, constructing a reservoir optimization regulation model to deduce suitable regulation rules for decision makers. The application improves the hydrodynamic condition by discharge to reduce the retention of the biogenic substance, and realizes the activation and transportation by using the water temperature stratification condition of the reservoir area, so that the effective biogenic substance is transported to the downstream while the power generation capacity is ensured, thereby realizing the 'quantity, energy and quality comprehensive regulation and control' considering the power generation, ecological flow and biogenic substance, and providing technical support for the comprehensive management of optimizing the utilization of water resources and ecological environment protection of the basin.

Systems and methods for synthetic image generation and machine learning analysis of biological matter. In one example, a real microscopic image set of an object representing a biological substance is received. Each object corresponds to one or more pixels of the real microscopic image. Features of the real microscopic image and the object are acquired, and a synthetic microscopic image set of the object representative of the biological substance is generated based on the features. In another example, a synthetic microscopic image set is generated using seed intensities and features extracted or known from a real microscopic image set. A seed image set of the synthetic microscopic image is generated from the seed intensities. A trained machine learning model is generated using the synthetic microscopic image and the seed image as training data to generate intensity values for further real microscopic images.

A biological measurement device (10) comprises a stimulation device (12) comprising at least one stimulation electrode (102a, 102b) and a stimulation circuit. The stimulation circuit is configured to provide an electrical stimulation signal to the at least one stimulation electrode (102a, 102b) such that the at least one stimulation electrode (102a, 102b) generates a predetermined electrodynamic force field applied to the biological substance. The sensing device comprises at least one sensing electrode (202a, 202b) and a sensing circuit, the at least one sensing electrode (202a, 202b) being configured to sense the responsive electrodynamic force field and to provide a corresponding electrical response signal to the sensing circuit. The electrical stimulation signal includes a plurality of different pseudo-random binary sequences, each pseudo-random binary sequence having a length and a data rate that provide a predetermined electrodynamic force field having a frequency range that is different from those provided by the other pseudo-random binary sequences.

A biosensor cartridge is disclosed. The biosensor cartridge according to one aspect of the present invention is a biosensor cartridge that detects a biological substance and generates an electrochemiluminescence signal, and includes an electrode portion including a plurality of electrodes, and a signal chamber that is an overall space provided on the electrode portion, and a dividing portion disposed on the electrode portion so as to divide the signal chamber into N reaction chambers surrounding the signal chamber. The electrode portion includes a first electrode at least a part of which is disposed in the reaction chamber, a second electrode disposed in the signal chamber, and N connection electrodes disposed so as to electrically link the chemical reaction in the reaction chamber and the electrochemiluminescence signal generated in the signal chamber.

A system comprises a source of enzymatic detergent and a cleaning device comprising an elongate member configured for advancement through a lumen within a medical device and at least one cleaning member coupled to a portion of the elongate member. The cleaning member comprises distal and proximal end portions and a central portion between the distal and proximal end portions. The central portion is shaped to create a pressure gradient along the central portion from the distal end portion to the proximal end portion. The combination of the enzymatic detergent and the unique nature of the cleaning device is sufficient to remove pre-existing biomatter from the surfaces of the medical device, such as biomatter that has already formed into a biofilm. The detergent loosens the protective layer of polysaccharides and proteins of the biofilm and the cleaning device then removes both the protective layer and the underlying biomatter.

Compositions, methods, and systems for handling liquids, for example, liquids containing one or more biological substances or chemical reagents, or combinations thereof. The liquid can be an "ink" containing nucleic acids (e.g., DNA) for "nucleic acid "printing" or "writing." These nucleic acids can include one or more components of nucleic acid molecules that encode digital information ("identifiers") that can be used in methods and systems for encoding digital information in nucleic acid. Described in this specification are technologies including an ink supply system and associated ecosystem for a DNA writing device for use with the technologies for encoding, storing, reading, and / or processing digital information in nucleic acid molecules.

The present invention relates to methods and conjugates to improve the penetrability of biological substances into the tumour microenvironment (TME) for therapeutic purposes, suitably the agent comprises at least: i a therapeutic domain; ii. a cleavable domain; and iii. a stabilisation domain.

The invention discloses a biosensor cartridge. A biosensor cartridge according to one embodiment of the present invention detects a biological substance and generates an electrochemiluminescence signal, the biosensor cartridge comprising: an electrode unit including a plurality of electrodes; and a division unit disposed on the electrode unit so as to divide the entire space formed on the electrode unit into a signal chamber and N reaction chambers surrounding the signal chamber, the electrode unit including: a first electrode at least partially disposed in the reaction chambers; a second electrode disposed in the signal chamber; and N connection electrodes arranged so as to link the chemical reaction in the reaction chamber with the electrochemiluminescence signal generated in the signal chamber.

Described herein are fluid management devices (FMDs), including shunts and catheters, that can exhibit improved clog resistance and reduce surgical risk. The FMDs described herein can include a durable, extremely slippery, hydrophobic coating that reduces the ability of biological matter to stick to the device surface and reduces drag for fluid flow. Thus, the FMDs described herein can be particularly well suited for drainage of sticky bodily fluids, such as CSF, that are prone to clogging traditional FMDs. The FMDs described herein can, in some embodiments, possess a reduced inner diameter compared to traditional FMDs due to the lower incidence of clogging. The reduction in clogging in FMDs may also increase the lifetime of the devices in vivo.

Systems and methods for synthetic image generation and machine learning analysis for biological substances. In one example, a set of real microscopy images representing objects of a biological substance is received. Each object corresponds to one or more pixels of the real microscopy image. Features of the real microscopy image and the objects are accessed and a set of synthetic microscopy images representing the objects of the biological substance is generated based on the features. In another example, a set of synthetic microscopy images is generated using seed intensities and features extracted or known from a set of real microscopy images. A set of seed images for the synthetic microscopy images is generated from the seed intensities. A trained machine learning model is generated to generate intensity values for additional real microscopy images using the synthetic microscopy images and the seed images as training data.

A liquid treatment device is provided that shears a biological substance including cell aggregates (e.g., organoids) and filters out fragments of cell aggregates (or other biological substances) of a selected cutoff size. Further, methods of shearing a biological substance and screening out fragments of the biological substance of a selected cutoff value with a liquid treatment device are provided, including without contacting the device with another solid object.

The invention discloses a method for analyzing a polymeric lignin structural unit in watermelon peel, and belongs to the technical field of biological substance composition determination methods, the method comprises the following steps: S1, protective pretreatment: mixing a watermelon peel sample with a protective solution containing triphenylmethyl mercaptan; s2, thioacidolysis: adding a reaction solution containing boron trifluoride and ethanethiol, and heating for depolymerization; s3, in-situ neutralization and derivatization: adding a buffer solution, extracting and drying to obtain an organic phase, and then adding a silanization reagent for derivatization reaction; s4, qualitative and quantitative analysis; through the multi-level design of structure protection, efficient derivation and system integration, the established analysis method shows remarkable advantages in the aspects of inhibiting condensation reaction, improving operation safety, shortening analysis period and realizing quantification, effectively overcomes the technical bottlenecks of low recovery rate, high toxicity, long time consumption, incomplete detection and the like in the prior art, and has wide application prospects. And an excellent technical scheme is provided for composition analysis of the plant polymerized lignin.

The utility model discloses a novel biological experiment chromatography cabinet which comprises a chromatography cabinet main body, an upper air curtain unit, a lower air curtain unit, an internal and external circulation cooling and dehumidifying system and an embedded control panel. Wherein the upper and lower air curtain unit can automatically start an upper air curtain / upper and lower air curtains according to the condition of closing / opening a chromatography cabinet door, and the air volume of the air curtains can also be adjusted; the internal and external circulation cooling and dehumidification system can keep the humidity in the chromatography cabinet not to exceed a set value all the time. Therefore, the service life of the chromatography cabinet and the service life of chromatography equipment in the chromatography cabinet can be effectively prolonged, the safety of experiment operators is guaranteed, and the effects of saving energy and reducing cost are achieved. Meanwhile, due to the design that the control panel is embedded in the glass cabinet door of the chromatography cabinet, the whole chromatography cabinet looks more attractive and elegant and is rich in modern atmosphere. The low-temperature refrigerator not only can provide low-temperature conditions for various chromatographic devices to prepare protein / peptide / carbohydrate substances, but also can be used as a constant-temperature refrigerator for storing various biological substances at low temperature.

The present invention provides an integrated system built on a microfluidics with multiple layers including a cell culture surface and different chambers configured to allow multiple cultivations of a biological agent, formation of three-dimensional multicellular culture model or biofilm, colonization and re-colonization of the biological agent responsive to a stimuli introduced to the integrated system. Such stimuli include physical, chemical and / or biological substance that may affect proliferation, differentiation, and / or function of the biological agent. The biological agent includes a biofilm-forming microbe such as a ubiquitous biofilm-forming bacterial species or biological cells or tissues of a different origin or species such as eukaryotic cells / tissues. The present integrated system can be used in drug screening, establishment of disease model in vitro or in vivo, evaluation of an anti-microbial efficacy, and studying cell-cell interaction.