103 results about "Biogenic substance" patented technology

A fluorescence intensity enhancer containing a water-soluble compound having a melting point of 50 DEG C or higher, a method for enhancing the fluorescence intensity of a fluorescently labeled target biological substance using the fluorescence intensity enhancer, and a fluorescence detection kit containing the fluorescence intensity enhancer.

Apparatuses, systems, and methods are disclosed for chemically differentiated sensor arrays and methods of manufacturing and using the same. In one or more examples. An integrated circuit chip includes a chemically differentiated array of graphene field effect transistors with one or more wells configured to receive a volume of biological sample liquid comprising a plurality of different types of biological substances to be distinguished using electrical measurements of output signals of the graphene field effect transistors. At least one electrode is configured to apply a changing gate bias voltage (VGs) that increases and decreases within a predetermined range to the sample liquid and at least one electrode is configured to monitor measurement vectors including slopes of drain current measurements relative to the voltage measurements and differences in slope of the measurement vectors distinguish different biological substances in the sample liquid. Systems and methods utilize the integrated circuit chip.

A bio-substance analysis method using a sensing substrate having a fluid channel is disclosed. The method includes mixing retroreflective particles with a detection solution containing a target bio-substance, wherein a first bio-recognition substance selectively reacting with the target bio-substance is modified on the retroreflective particles; placing the sensing substrate so that a bottom is located under a cover in a direction of gravity; injecting the detection solution containing therein the retroreflective particles into a fluid channel and maintaining the solution in the channel for a first time duration; turning the sensing substrate upside down so that the bottom is located above the cover in the direction of gravity and maintaining the sensing substrate in the turned state for a second time duration; irradiating light into the fluid channel through the bottom; and generating and analyzing an image based on light retroreflected from the retroreflective particles.

The present disclosure relates to a method of manipulating magnetic beads in a liquid inside a conduit, wherein the method comprises generating a variable magnetic field using at least one magnet or electromagnet to mix the magnetic beads in the liquid; and wherein a biological or chemical species is attached to the surface of the magnetic beads.

The present invention relates to methods and conjugates for improving the permeability of a biological substance into the tumor microenvironment (TME) for therapeutic purposes, suitably comprising at least: i. A therapeutic domain; ii. A cleavable domain; and iii. A stabilizing domain.

A fluorescence intensity enhancer containing a water-soluble compound having a melting point of 50° C. or higher, a fluorescence intensity enhancing method of a fluorescently labeled target biological substance using the fluorescence intensity enhancer, and a kit for fluorescence detection containing the fluorescence intensity enhancer.

The application discloses an ecological regulation method for relieving the retention of the biogenic substance of a deep and large reservoir, and belongs to the technical field of water resource management and environmental protection technology. The steps are as follows: first, collecting characteristic parameters and multiple types of hydrological and water quality monitoring data of the deep and large reservoir; second, constructing a three-dimensional hydrodynamic-water quality model of the deep and large reservoir; third, based on the three-dimensional hydrodynamic-water quality model of the deep and large reservoir, combining a long series of multiple inputs and multiple output sequences, a data-driven proxy model is constructed; fourth, constructing a reservoir optimization regulation model to deduce suitable regulation rules for decision makers. The application improves the hydrodynamic condition by discharge to reduce the retention of the biogenic substance, and realizes the activation and transportation by using the water temperature stratification condition of the reservoir area, so that the effective biogenic substance is transported to the downstream while the power generation capacity is ensured, thereby realizing the 'quantity, energy and quality comprehensive regulation and control' considering the power generation, ecological flow and biogenic substance, and providing technical support for the comprehensive management of optimizing the utilization of water resources and ecological environment protection of the basin.

Systems and methods for synthetic image generation and machine learning analysis of biological matter. In one example, a real microscopic image set of an object representing a biological substance is received. Each object corresponds to one or more pixels of the real microscopic image. Features of the real microscopic image and the object are acquired, and a synthetic microscopic image set of the object representative of the biological substance is generated based on the features. In another example, a synthetic microscopic image set is generated using seed intensities and features extracted or known from a real microscopic image set. A seed image set of the synthetic microscopic image is generated from the seed intensities. A trained machine learning model is generated using the synthetic microscopic image and the seed image as training data to generate intensity values for further real microscopic images.

A biological measurement device (10) comprises a stimulation device (12) comprising at least one stimulation electrode (102a, 102b) and a stimulation circuit. The stimulation circuit is configured to provide an electrical stimulation signal to the at least one stimulation electrode (102a, 102b) such that the at least one stimulation electrode (102a, 102b) generates a predetermined electrodynamic force field applied to the biological substance. The sensing device comprises at least one sensing electrode (202a, 202b) and a sensing circuit, the at least one sensing electrode (202a, 202b) being configured to sense the responsive electrodynamic force field and to provide a corresponding electrical response signal to the sensing circuit. The electrical stimulation signal includes a plurality of different pseudo-random binary sequences, each pseudo-random binary sequence having a length and a data rate that provide a predetermined electrodynamic force field having a frequency range that is different from those provided by the other pseudo-random binary sequences.

A biosensor cartridge is disclosed. The biosensor cartridge according to one aspect of the present invention is a biosensor cartridge that detects a biological substance and generates an electrochemiluminescence signal, and includes an electrode portion including a plurality of electrodes, and a signal chamber that is an overall space provided on the electrode portion, and a dividing portion disposed on the electrode portion so as to divide the signal chamber into N reaction chambers surrounding the signal chamber. The electrode portion includes a first electrode at least a part of which is disposed in the reaction chamber, a second electrode disposed in the signal chamber, and N connection electrodes disposed so as to electrically link the chemical reaction in the reaction chamber and the electrochemiluminescence signal generated in the signal chamber.

A system comprises a source of enzymatic detergent and a cleaning device comprising an elongate member configured for advancement through a lumen within a medical device and at least one cleaning member coupled to a portion of the elongate member. The cleaning member comprises distal and proximal end portions and a central portion between the distal and proximal end portions. The central portion is shaped to create a pressure gradient along the central portion from the distal end portion to the proximal end portion. The combination of the enzymatic detergent and the unique nature of the cleaning device is sufficient to remove pre-existing biomatter from the surfaces of the medical device, such as biomatter that has already formed into a biofilm. The detergent loosens the protective layer of polysaccharides and proteins of the biofilm and the cleaning device then removes both the protective layer and the underlying biomatter.

Compositions, methods, and systems for handling liquids, for example, liquids containing one or more biological substances or chemical reagents, or combinations thereof. The liquid can be an "ink" containing nucleic acids (e.g., DNA) for "nucleic acid "printing" or "writing." These nucleic acids can include one or more components of nucleic acid molecules that encode digital information ("identifiers") that can be used in methods and systems for encoding digital information in nucleic acid. Described in this specification are technologies including an ink supply system and associated ecosystem for a DNA writing device for use with the technologies for encoding, storing, reading, and / or processing digital information in nucleic acid molecules.

The present invention relates to methods and conjugates to improve the penetrability of biological substances into the tumour microenvironment (TME) for therapeutic purposes, suitably the agent comprises at least: i a therapeutic domain; ii. a cleavable domain; and iii. a stabilisation domain.

Systems and methods for synthetic image generation and machine learning analysis for biological substances. In one example, a set of real microscopy images representing objects of a biological substance is received. Each object corresponds to one or more pixels of the real microscopy image. Features of the real microscopy image and the objects are accessed and a set of synthetic microscopy images representing the objects of the biological substance is generated based on the features. In another example, a set of synthetic microscopy images is generated using seed intensities and features extracted or known from a set of real microscopy images. A set of seed images for the synthetic microscopy images is generated from the seed intensities. A trained machine learning model is generated to generate intensity values for additional real microscopy images using the synthetic microscopy images and the seed images as training data.

A liquid treatment device is provided that shears a biological substance including cell aggregates (e.g., organoids) and filters out fragments of cell aggregates (or other biological substances) of a selected cutoff size. Further, methods of shearing a biological substance and screening out fragments of the biological substance of a selected cutoff value with a liquid treatment device are provided, including without contacting the device with another solid object.

The invention discloses a method for analyzing a polymeric lignin structural unit in watermelon peel, and belongs to the technical field of biological substance composition determination methods, the method comprises the following steps: S1, protective pretreatment: mixing a watermelon peel sample with a protective solution containing triphenylmethyl mercaptan; s2, thioacidolysis: adding a reaction solution containing boron trifluoride and ethanethiol, and heating for depolymerization; s3, in-situ neutralization and derivatization: adding a buffer solution, extracting and drying to obtain an organic phase, and then adding a silanization reagent for derivatization reaction; s4, qualitative and quantitative analysis; through the multi-level design of structure protection, efficient derivation and system integration, the established analysis method shows remarkable advantages in the aspects of inhibiting condensation reaction, improving operation safety, shortening analysis period and realizing quantification, effectively overcomes the technical bottlenecks of low recovery rate, high toxicity, long time consumption, incomplete detection and the like in the prior art, and has wide application prospects. And an excellent technical scheme is provided for composition analysis of the plant polymerized lignin.

The utility model discloses a novel biological experiment chromatography cabinet which comprises a chromatography cabinet main body, an upper air curtain unit, a lower air curtain unit, an internal and external circulation cooling and dehumidifying system and an embedded control panel. Wherein the upper and lower air curtain unit can automatically start an upper air curtain / upper and lower air curtains according to the condition of closing / opening a chromatography cabinet door, and the air volume of the air curtains can also be adjusted; the internal and external circulation cooling and dehumidification system can keep the humidity in the chromatography cabinet not to exceed a set value all the time. Therefore, the service life of the chromatography cabinet and the service life of chromatography equipment in the chromatography cabinet can be effectively prolonged, the safety of experiment operators is guaranteed, and the effects of saving energy and reducing cost are achieved. Meanwhile, due to the design that the control panel is embedded in the glass cabinet door of the chromatography cabinet, the whole chromatography cabinet looks more attractive and elegant and is rich in modern atmosphere. The low-temperature refrigerator not only can provide low-temperature conditions for various chromatographic devices to prepare protein / peptide / carbohydrate substances, but also can be used as a constant-temperature refrigerator for storing various biological substances at low temperature.

Compositions, methods, and systems for handling liquids, for example, liquids containing one or more biological substances or chemical reagents, or combinations thereof. The liquid can be an "ink" containing nucleic acids (e.g., DNA) for "nucleic acid "printing" or "writing." These nucleic acids can include one or more components of nucleic acid molecules that encode digital information ("identifiers") that can be used in methods and systems for encoding digital information in nucleic acid. Described in this specification are technologies including an ink supply system and associated ecosystem for a DNA writing device for use with the technologies for encoding, storing, reading, and / or processing digital information in nucleic acid molecules.

A compound containing two or more phosphor moieties having light absorption characteristics that are equivalent to each other, in which each of the phosphor moieties adjacent to each other is linked through a group containing a structure represented by General Formula (I), and a labeled biological substance using the compound.In the formula, X1 to X3 represent —O—, —S—, >NR1, or >CR2R3, R1 to R3 and R11 represent a hydrogen atom or a substituent, R8 represents a hydrogen atom or a substituent, n represents an integer of 2 or more, and * represents a bonding site.

The present technique pertains to a method of preparation of a succinylated collagen-fibrinogen hydrogel and a succinylated collagen-fibrinogen hydrogel prepared thereby. The method of preparation of a succinylated collagen-fibrinogen hydrogel according to the present technique can produce a collagen-based bio-substance in a simple process, wherein collagen can be prevented from being entangled and an improvement can be brought about in hydrophilicity, cell growth rate, cell compatibility, and cell diffusion capability, whereby the collagen-based bio-substance exhibits excellent biocompatibility in vivo.

1. Name of the designed product: reagent plate (multi-item joint inspection). 2. Use of the designed product: the designed product is used for holding chemical and biological substances. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

To provide a biological material extraction magnetic bead that has favorable biological material extraction efficiency and is less likely to lower examination accuracy of an extracted biological material.SOLUTION: A biological material extraction magnetic bead comprises: a magnetic metal particle; an inorganic oxide layer that covers a surface of the magnetic metal particle and contains an inorganic oxide; a base layer that is provided on a side opposite to the magnetic metal particle of the inorganic oxide layer and contains a metal element forming a gold ion reducing agent or a catalyst for a gold ion reduction reaction; a gold layer that covers a surface of the base layer and contains gold; and an immobilization layer that is bound to the gold layer via an Au-S bond and contains a ligand or a ligand-reactive group, wherein a mass ratio M / Au of a content of the metal element to a content of the gold is 0.03 or more and 19.0 or less.SELECTED DRAWING: Figure 5

This invention provides a treatment device and method for fermentation-based pharmaceutical wastewater. The treatment device includes a pretreatment system, a biochemical treatment system, an advanced treatment system, and a sludge treatment system, which are sequentially connected. The pretreatment system and the biochemical treatment system are respectively connected to the sludge treatment system. The pretreatment system is used to sequentially filter, homogenize, and flocculate the wastewater. The biochemical treatment system is used to degrade organic matter in the wastewater and remove ammonia nitrogen and COD, followed by secondary homogenization and flocculation sedimentation. The advanced treatment system is used to remove recalcitrant biological substances and toxic substances from the wastewater, and then disinfect the wastewater before discharge. The sludge treatment system is used to concentrate and press-filter the generated sludge to form a sludge cake.

The utility model relates to the technical field of marine organism prevention of ships, in particular to a marine organism prevention device for a ship. Comprising a seawater filter used for generating marine organism prevention substances; one end of the return pipe is detachably arranged on the seawater filter; the other end of the return pipe is detachably arranged on the seawater tank; one end of the liquid inlet pipe is connected with the seawater filter, and the other end of the liquid inlet pipe is connected with the seawater tank. According to the marine organism prevention device, the seawater filter and the reaction tank are designed into a whole through ingenious design, on the premise that the device is simplified as much as possible, marine organisms can be effectively prevented from being attached to all positions in a ship seawater system, and particularly, marine organisms in the seawater tank can be effectively prevented from growing through backflow of marine organism prevention substances; and due to the detachable design of all the components and the arrangement of the valves and the water pump, installation, maintenance and overhaul of the device are facilitated, and the reliability and practicability of the device are improved.

A method for recovering a biological substance and a device for recovering a biological substance capable of improving a recovery rate of a target biological substance with a simple configuration are provided. The method for recovering a biological substance uses an electrophoresis device having a gel 13 and recovery holes 11 and 111. The method for recovering a biological substance includes a step of starting application of a voltage for moving a target biological substance toward the recovery hole, after that, a step of removing buffer solution in the recovery hole before the target biological substance reaches the recovery hole, after that, a step of injecting a solvent into the recovery hole, and, after that, a step of recovering the target biological substance that reaches the recovery hole.

The present invention discloses a system for non-invasive optical measurement of bio-substance in a biological tissue, comprising: a light source generator to generate an incident light to irradiate at a target area on an individual; an optical reader to receive a reflect light returning from the target area; and a processor to run an optical feature analysis model to extract an optical feature information from the reflect light and determine a concentration value of a bio-substance in the target area according to the optical feature information. With analysis based on optical rotation angles and light intensity signals, in combination of pressure effects and time delay compensation, effective features can be selected as input to the optical feature analysis model to improve the accuracy bio-substance level detection.

The invention relates to the technical field of biological substance preparation. The invention provides a catechin-phospholipid complex and an emulsion prepared from the catechin-phospholipid complex and capable of improving DHA (docosahexaenoic acid) and improving memory activity. The invention also provides an application of the catechin-phospholipid complex or the emulsion for improving the memory activity of DHA in preparation of health-care products. The emulsion prepared by adopting the catechin-phospholipid compound as an emulsifier can efficiently and synergistically entrap, stably protect and deliver the beta-carotene and the DHA in a targeted manner, so that the bioavailability and the multi-component synergistic effect of the beta-carotene and the DHA are enhanced, and the effect of improving the memory function is realized; meanwhile, good physical and chemical stability and digestion tolerance are also shown.

The present disclosure provides systems and devices for preserving unfrozen biological matter below its equilibrium melting temperature by applying pressure generated by isochoric freezing. The systems and devices include an isochoric chamber segmented into a first volume containing an aqueous solution with a first nucleation temperature and a second volume containing an aqueous solution with a second nucleation temperature, where the second volume increases when cooled below the second nucleation temperature, and also include a boundary separating the two volumes that transmits heat and pressure but not mass. Methods of using the systems and devices for preserving a biological matter without freezing at temperatures below its equilibrium melting point are also provided.

To provide a method for highly sensitive detection of an antigen such as a specific protein of a biological substance including a virus or a cell.SOLUTION: According to one embodiment of the present disclosure, a method for detecting a target substance is provided. The method includes: providing a metal oxide nanowire with a surface modified with gold; modifying the gold with a first antibody of the target substance; capturing the target substance with the first antibody; capturing the target substance with a second antibody of the target substance with an optical label; and detecting the optical label.SELECTED DRAWING: Figure 1