149 results about "Biogenic substance" patented technology

The invention is directed to a ready-to-use modular cleanroom and facility, in particular for the production of drugs and biological substances, which is equipped with pre-approved manufacturing equipment cores. The modular cleanroom is implemented in the interior space of a container, such as a standard shipping container, and includes at least one bioreactor station. The modular facility can be installed on-site from pre-approved cleanroom modules without further regulatory approval. The cleanroom and facility comply with FDA-approved good manufacturing practices (GMP) and good laboratory practices (GLP).

An electrical detection system and method using an array of conductive sense sites within a sensing substrate for electrically detecting the successful hybridization or binding reaction between two chemical substances, particularly between biogenic substances such as nucleotides, proteins and ligands, and antigens and antibodies. The method and apparatus provide a an inexpensive, robust, small, repeatable, and intuitively easy to use apparatus for detection of low levels of hybridization with large numbers of closely spaced conductive sense sites within a single substrate.

Purified air is provided, having a TVOC content of from less than 5 ppb to about 500 ppb, a Biologicals content of from less than 1 CFU/M³ to 150 CFU/M³ and a Particulate content of from about 1,000 0.3 μm particles per ft³ to about 50,000 0.3 μm particles per ft³, or from about 600 0.5 μm particles per ft³ to about 500,000 0.5 μm particles per ft³.

The invention belongs to the field of microbial engineering and technology, and specifically relates to an alkaline-tolerant and halophilic aspergillus strain and an application thereof in environmental management. The strain is preserved in China General Microbiological Culture Collection Center on April 20th, 2012, with a preservation name of aspergillus JL and a preservation number of CGMCC 6025. The strain has the characteristic of degrading biological substances such as straws in a high salt and alkali environment and can be used for improvement of saline lands and treatment of environmental pollutions.

The present invention relates to methods of preparing biological material, for use in various experimental, diagnostic or therapeutic uses, including immunotherapy treatment or prophylaxy of tumors. More particularly, the present invention relates to methods of preparing membrane vesicles (in particular exosomes) released by various types of mammalian cells, comprising diafiltration and/or density cushion centrifugation. The invention also provides novel methods for characterizing and analyzing exosome preparations, which can be used in quality control assay for the purpose of pharmaceutical product production. The invention is suitable to produce pharmaceutical grade preparations of such membrane vesicles and to fully characterize said preparations, for use in human beings.

The invention is a multiple-probe fibre-optical evanescent-wave biosensor, including the laser exciting light path, the fluoescent receiving light path, the sample flow path and the scan system, respectively used to excite the fluorescence of the measured biological substance on the surface of the fibre-optical core wire, receive the fluorescent signal from the fibre-optical and finish the photoelectric conversion, indraft the sample and make the scanning detection on the fluorescent signal on multiple pieces of fiber-optical.

A method of separating a target biological analyte from a mixture of substances in a fluid sample employs nonlinear magnetophoresis. Magnetic particles having the capacity to bind to the target analyte are contacted with the fluid sample so that the analyte is immobilized on the surface of at least some of the particles. The magnetic particles are provided adjacent an array of micromagnets patterned on a substrate so that the particles are attracted the micromagnets. The magnetic particles are then subjected to a traveling magnetic field operating at or above a frequency effective to sweep those particles not bound to analyte to an adjacent micromagnet. Those magnetic particles bound to analyte have a larger size or smaller magnetic moment that prevents them from being moved to adjacent micromagnets, thereby affording separation of the analyte.

Providing an assay method capable of simultaneously determining the presence or absence of one or more species of biological substances or assaying the amounts thereof with a single assay device, a kit therefor and an assay device thereof. The amount thereof or the presence thereof is detected, by putting a liquid sample containing one or more species of analytes in contact to a reagent including one or more species of marker-labeled ligands and one or more species of nucleic acid-labeled ligands, to generate one or more species of complexes, developing the generated one or more species of complexes through capillary phenomenon in developing element 11 in a sheet form, capturing the complexes through complementary nucleic acid binding onto anti-bond elements consisting of nucleic acids on detection zones 15, 16 and 17 formed depending on each of one or more species of nucleic acids immobilized on the detection zone 14, thereby capturing a complex depending on the analyte species, through the complementary binding between the anti-bond element and the bond element, to form an independent band and to assay the amount or the presence on the detection part.

In fabricating various types of arrays such as a micro array, different kinds of biosubstances, or synthetic substances interacting with the biosubstances, are arranged and immobilized on a support such that the chromosomal order of base sequence blocks, corresponding to the biosubstances, is ascertainable. The biosubstances may be nucleic acids such as DNA, or polypeptides such as protein. The synthetic substances may be compounds that react with the biosubstances. By thus specifying the order of the biosubstances or synthetic substances immobilized on the support, the array can be used, for example, for screening in variety improvement of living organisms.

Disclosed are near-infrared light-emitting phosphor nanoparticles with an extremely small particle size, which emit light with a high intensity of emission and which are suitable for a biological substance labeling agent, a method for manufacturing the same, and a biological substance labeling agent employing the same. The near-infrared light-emitting phosphor nanoparticles of the invention are near-infrared light-emitting phosphor nanoparticles with an average particle size of from 2 to 50 nm, which when excited by a near-infrared light with a wavelength in the range of from 700 to 900 nm, emit a near-infrared light with a wavelength in the range of from 700 to 2000 nm, the nanoparticles being characterized in that at least a part of the composition is represented by a specific formula.

The invention provides a highly sensitive immunoassay for detection of a biological species. The immunoassay comprises exposing an electrode to an analyte liquid putatively containing the biological species so as to couple the biological species, if present in the analyte liquid, to a binding antibody on the electrode. The electrode comprises a binding antibody and an anchor group, each being coupled to an electrically conductive substrate, said binding antibody being capable of binding to the biological species and said anchor group being capable of binding to a redox polymer. The electrode is then exposed to an antibody-enzyme liquid comprising an antibody-enzyme species, said antibody-enzyme species comprising a detection antibody capable of binding to the biological species, said detection antibody being coupled to a redox enzyme, whereby, if the analyte liquid comprises the biological species, the redox enzyme couples to the electrode by means of the coupling of both the detection antibody and the binding antibody to the biological species. The electrode is then exposed to a polymer solution comprising the redox polymer and to an enzyme substrate, whereby if the redox enzyme is coupled to the anchor group on the electrode the redox polymer is reduced and couples to the anchor group on the electrode. A voltage is then applied between the electrode and a reference electrode and the electrode is exposed to an oxidisable species, whereby a magnitude of an electric current between said electrode and a reference electrode is indicative of the presence or absence of the biological species.

Described herein are techniques related to the detection and/or `identification of biological cells and/or substances. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

The invention provides a bioelectrochemical tank having an anti-interference function. The bioelectrochemical tank having an anti-interference function comprises 1, an electrode system and 2, a reagent composition for corresponding biological substance detection. After being automatically sucked into the electrode system, a detected sample undergoes a biochemical reaction and an electrochemical reaction with the reagent composition to produce electrons; the electrons are transmitted to a tester by an electrode; and the tester reads data and the data is processed and a detection result is displayed. The bioelectrochemical tank having an anti-interference function improves detection result accuracy, eliminates the influence produced by erythrocytes on detection results, has a high anti-interfering substance capacity, and has an electron transfer rate constant more than 10 times.

Provided are a carrier-enclosed transformable container, a carrier-enclosed transformable container processing apparatus, and a carrier-enclosed transformable container processing method about which a carrier to which various substances such as biogenic substances are bonded or bondable is held in a transformable container as the container to be in a substantially stationary state, thereby making it possible to make the handling of the carrier, measurement, and other treatments effective, speedy, and easy. The container is formed to have: a containing part which can contain liquid and gas at its inside surrounded by a wall face, a part of this wall face having a transformable wall face capable of undergoing a predetermined transformation without changing the entire internal surface area of the wall face substantially; an orifice part which is connected to the containing part and can undergo the inflow and outflow of a liquid sucked and discharged by the expansion and contraction of the inside by the transformation of the transformable wall face, respectively; and a carrier to which a predetermined substance enclosed in the containing part to be in a substantially stationary state is bonded or bondable.

The invention relates to sample support plates with hydrophilic anchors in a strongly hydrophobic environment for mass spectroscopic analysis of biosubstances with ionization by matrix-assisted laser desorption and ionization (MALDI), procedures for manufacturing these sample supports, and connected procedures for loading these sample supports with biomolecular samples. The invention provides areas with affinity adsorbents adjacent to the hydrophilic anchors for purifying biosubstances and, if wanted, for performing an affinity selection of biosubstances, whereby the finally prepared matrix sample crystals with the biosubstances for the MALDI analysis are well localized on the hydrophilic anchors.

The invention discloses saline-alkali-resistant aspergillus flavus as well as a separation method and an application thereof. The method comprises the following steps: coating a PDA culture medium solid flat plate containing 250.0 g/L of NaCl with different concentrations with a straw powder suspension subjected to gradient dilution; treating and repeating for three times, culturing for 4-15 days,picking well-grown single colonies, and inoculating the single colonies onto a screening culture medium CMC-Na solid culture medium to generate transparent ring-shaped strains so as to obtain aspergillus flavus with a preservation name of aspergillus flavus W3 and a preservation number of CGMCC NO.17973. The aspergillus flavus strain disclosed by the invention can degrade straws in a high-saline-alkali environment, the straw degradation capacity is high in a high-saline-alkali environment, the strain can be directly used for decomposing straw fermentation and other biological substances in the field, the capacity of improving secondary salinization or continuous cropping obstacle soil and the capacity of treating environmental pollution are high, and a good treatment effect can be achieved.