Lysine-vitamin pharmaceutical composition containing chiral isocompounds and use thereof

A technology of composition and solvent compound, applied in the field of medicine, can solve problems such as unfavorable resource saving, problems in transportation and packaging, discomfort to patients, etc.

Inactive Publication Date: 2015-06-10
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of a single isomer in the composition has not been restricted at present; in addition, the oral liquid or granule of the compound preparation in the prior art is not suitable for patients with hyperchloremia, acidosis and renal insufficiency in some cases. And the current preparations are not limited to the use of L-lysine, inositol, vitamin B 12 composition, which makes the quality or nutritional or therapeutic value of the preparation either limited or not in an optimized or a new state, or poses quality control problems; moreover, the current unit dosage strength is only higher Dosage specifications of lysine hydrochloride 600mg, inositol 100mg, vit

Method used

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  • Lysine-vitamin pharmaceutical composition containing chiral isocompounds and use thereof
  • Lysine-vitamin pharmaceutical composition containing chiral isocompounds and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1L-lysine hydrochloride vitamin B 12 The preparation of composition capsule (specification: L-lysine hydrochloride 150mg / inositol 25mg / vitamin B 12 0.0075mg / tablet, each main drug component is calculated by anhydrous matter or calculated by weight) Prescription: L-lysine hydrochloride 150g, inositol 25g, vitamin B 12 7.5 mg; preparation process: Weigh the prescribed amount of L-lysine hydrochloride and inositol after being crushed and passed through a 100-mesh sieve, mix evenly, and then use the equal-volume incremental dilution method with vitamin B 12 Mix evenly, fill capsules, pack and inspect to obtain finished products.

Embodiment 2

[0053] Example 2 L-lysine hydrochloride vitamin B 12 The preparation of composition capsule (specification: L-lysine hydrochloride 75mg / inositol 12.5mg / vitamin B 12 0.00375mg / grain) prescription: L-lysine hydrochloride 75g, inositol 12.5g, vitamin B 12 3.75 mg; preparation process: Weigh 4 prescription quantities of L-lysine hydrochloride and inositol that have been pulverized and passed through a 80-100 mesh sieve and mixed evenly, and then mixed with vitamin B 12 Mix evenly, measure the content of L-lysine hydrochloride in the granules, fill capsules, pack and inspect to obtain the finished product.

Embodiment 3

[0054] Example 3L-lysine hydrochloride lysine inositol vitamin B 12 The preparation of composition capsule (specification: 120mg / 20mg / vitamin B 12 0.09mg / tablet, each main drug component is calculated by anhydrous matter or calculated by feeding weight) prescription: L-lysine hydrochloride 120g, inositol 20g, vitamin B 12 9.0mg, magnesium stearate 0.5g; preparation process: take the L-lysine hydrochloride and inositol in the prescribed amount after crushing and passing through a 100-mesh sieve and mix evenly, mix the above raw and auxiliary materials, and then use etc. incremental dilution method and vitamin B 12 , magnesium stearate and mixed evenly, measure the content of L-lysine hydrochloride in the granules, fill capsules, pack and inspect to obtain finished products.

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PUM

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Abstract

The invention provides a pharmaceutical composition of lysine and vitamin containing chiral isocompounds, the pharmaceutical composition is mainly used for preventing or treating growth retardation of mammals and human, malnutrition, inappetence, cerebral ischemia, brain trauma, anemia, hair growth, hair loss, fatty liver, hepatitis, atherosclerosis, hyperlipidaemia or oxiunt radical scavenger and the like, the composition can better adapt to patients with metabolic acidosis and hyperchloremia, and the pharmaceutical composition can adapt to new applicable people on clinic use or can have better pertinence or better clinical safety.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides lysine or lysine, which includes chiral isomer compounds, for the prevention or treatment of growth retardation, malnutrition, loss of appetite, traumatic brain injury, cerebral infarction, anemia, etc. in mammals and humans. Lysine Inositol Vitamin B 12 The pharmaceutical composition and its preparation method and application. Background technique [0002] Lysine is a basic amino acid with three basic forms: DL-lysine, D-lysine and L-lysine; lysine contains half of D-lysine and L-lysine, Only L-lysine is easy to be absorbed by the body, and has great utilization value to the human body, while D-lysine is not easy to be absorbed and utilized by the body. L-lysine is one of the eight essential amino acids for the human body. L-lysine provides structural components for the synthesis of carnitine, and carnitine promotes the synthesis of fatty acids in cells. Esp...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61P3/02A61P39/06A23L1/29A61P1/14A61P25/00A61P7/06A61P17/14A61P1/16A61P9/10A61P3/06A61P3/00A61P39/02A61K31/047A61K31/198A23L33/00
Inventor 刘力
Owner 刘力
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