Minoxidil film coating agent as well as preparation method and application thereof
By utilizing the film-forming effect of minoxidil coating, the problems of low drug concentration and skin irritation caused by the flow of minoxidil liniment are solved, achieving efficient transdermal absorption and stable release of the drug, thus improving therapeutic efficacy and safety.
CN121102179APending Publication Date: 2025-12-12SHANDONG INOMIC INST OF PHARM RES CO LTD
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Patent Information
- Application Number
- CN202511339587.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-18
- Publication Date
- 2025-12-12
AI Technical Summary
Technical Problem
Existing minoxidil topical solutions are prone to migrating to other parts of the body during administration, resulting in low drug concentrations, reduced efficacy, and potential skin irritation or damage.
Method used
Minoxidil film-forming agents are used, which form a rapid film by using a combination of propylene glycol, polyvinyl alcohol and ethanol, reducing drug flow, increasing local drug concentration and enhancing bioavailability.
Benefits of technology
Minoxidil film-forming agents form a stable film on the skin, reducing drug flow, increasing local drug concentration, enhancing transdermal absorption, reducing irritation to other areas, and improving treatment efficacy and patient compliance.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.
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