32 results about "Rhodamine derivative" patented technology

The invention belongs to an advanced material technology, and relates to a novel rhodamine derivative, in particular to a 2-aminothiazolyl rhodamine 6G derivative as well as a preparation method and application thereof. Rhodamine 6G and 2-aminothiazole are used as raw materials, the 2-aminothiazolyl rhodamine 6G derivative RGAT is prepared through a one-step reaction, on one hand, RGAT shows excellent selectivity and very high sensitivity to Fe < 3 + >, fluorescence enhancement is remarkable, the linear range of Fe < 3 + > is wide, in the Fe < 3 + > concentration range of 0-50 M, a good linear relation with the Fe < 3 + > concentration is shown, and the detection limit is as low as 2.4 nM; on the other hand, the RGAT has better antibacterial performance on gram-positive bacteria and gram-negative bacteria than commercially available bleaching water, and the RGAT is very low in cytotoxicity, so that the RGAT has a good application prospect in the fields of environmental monitoring and biological medicine.

The invention discloses a tetraarylethene modified rhodamine-like derivative as well as a preparation method and application thereof. The rhodamine-like derivative has a structure as shown in a formula I, rhodamine is taken as a core skeleton, a tetraarylethene (TAE) structure with AIE characteristics is introduced into a meso site of the rhodamine, RL-TAE series molecules are obtained, the defect of aggregation-induced quenching (ACQ) is greatly improved through the strategy, the molar absorption coefficient is obviously increased, and the rhodamine-like derivative has a good application prospect. Therefore, a new scheme is provided for developing high-brightness aggregation-induced emission dye. The rhodamine-like derivative disclosed by the invention is simple in preparation method, mild in reaction condition and high in yield, has the characteristics of AIE effect, high molar absorption coefficient and brightness, photobleaching resistance and diamagnetism, is an excellent concentration-brightness correspondence dye, and can realize efficient coding application.

The invention discloses a rhodamine derivative and a preparation method and application thereof.The rhodamine derivative has the structure shown in the following formula, R is selected from one of R1, R2 or R3: # imgabs0. The rhodamine derivative has the advantages of being longer in ultraviolet absorption wavelength, longer in fluorescence emission wavelength and the like compared with rhodamine; the fluorescent probe can be used for research in the fields of fluorescent probes and fluorescent imaging.

The present invention discloses a fluorescent probe based on a silicon-substituted rhodamine derivative, its preparation method, and its application, relating to the field of biochemistry. The present invention provides the structural formula of the fluorescent probe based on the silicon-substituted rhodamine derivative and also provides a corresponding preparation method. The present invention designs a leucine aminopeptidase-responsive near-infrared fluorescent small molecule probe that can effectively identify head and neck squamous cell carcinoma, effectively addressing the low sensitivity, specificity, and response speed issues of existing technologies.

This application discloses a light-converting agent, a method for preparing the light-converting agent, and a light-converting film. The light-converting film in this application is a europium complex copolymer synthesized by free radical copolymerization of an Eu complex and a Rhodamine B derivative. The Eu complex has a double bond structure exposed outside the 5-amino-1,10-phenanthroline molecule, and the exposed double bond position of the Eu complex structure is connected by a substitution reaction between an amino group and an acryloyl chloride. The Rhodamine B derivative has an exposed double bond structure attached to the carboxyl group of Rhodamine B. The method for preparing the light-converting agent in this application sequentially involves synthesizing 5-acrylamido-1,10-phenanthroline, synthesizing the Eu complex, synthesizing the Rhodamine B derivative, and synthesizing the light-converting agent. The light-converting film in this application includes the light-converting agent. The light-converting agent and the light-converting film in this application can convert both ultraviolet and yellow-green light into red light, improving the utilization rate of sunlight in plant photosynthesis.

Provided are a preparation method for a ferroptosis inducer, and a use thereof. The preparation method for the ferroptosis inducer comprises: mixing a compound A and aldehyde thiophene boric acid under the catalysis of an inorganic base and a palladium catalyst, then adding a mixed solution of 1,4-dioxane and water, heating and stirring at 78-82℃, and purifying to obtain a compound B; and mixing the compound B and a rhodamine derivative under the catalysis of an acid solution, heating and stirring at 110-120℃, and purifying to obtain the ferroptosis inducer. The preparation method is used for tumor suppression, immune response activation, and imaging, can improve the ability of inhibiting tumor cells by using the advantages of ferroptosis and immune activation, and provides a pathway for further research and translation of a ferroptosis-based immunotherapy strategy.

The present invention belongs to the field of advanced materials technology, and relates to a new rhodamine derivative, specifically to a 2-aminothiazolyl rhodamine 6G derivative and its preparation method and application. The present invention uses rhodamine 6G and 2-aminothiazole as raw materials to prepare the 2-aminothiazolyl rhodamine 6G derivative RGAT in a one-step reaction. On the one hand, RGAT shows excellent selectivity and high sensitivity to Fe<supgt;3+< / supgt>, with a significant fluorescence enhancement, a wide linear range for Fe<supgt;3+< / supgt>, and a good linear relationship with the Fe<supgt;3+< / supgt> concentration in the range of 0-50 µM of Fe<supgt;3+< / supgt> concentration, and the detection limit is as low as 2.4 nM. On the other hand, RGAT has antibacterial properties superior to commercially available bleach against both Gram-positive and Gram-negative bacteria, and RGAT has very low cytotoxicity, showing good application prospects in the fields of environmental monitoring and biomedicine.

This invention discloses a highly sensitive intelligent color-changing textile fiber and its preparation method, belonging to the field of materials. The preparation method includes the following steps: S1: The fiber is impregnated in a color-changing coating solution and then subjected to a first-stage photoinitiated polymerization; the color-changing coating solution is formulated by combining a mechanosensitive group with a vinyl monomer; the mechanosensitive group is a rhodamine derivative mechanosensitive group; S2: The fiber obtained in S1 is subjected to multi-stage impregnation-photoinitiated polymerization in a swelling solution to obtain the intelligent color-changing textile fiber; the swelling solution is formulated by combining a vinyl monomer and a crosslinking agent. This invention has advantages such as highly sensitive intelligent color changing.

The invention relates to a novel fluorescent probe RH based on a rhodamine derivative, which is specially used for rapidly and sensitively detecting hypochlorous acid (HOCl) in an aqueous solution. The fluorescent probe RH disclosed by the invention can effectively eliminate interference of common active small molecules and ensure that accurate detection is realized in a complex physiological environment. Experimental results show that the probe RH can achieve remarkable fluorescence enhancement on HOCl under the fluorescence emission wavelength of 552 nm, the detection limit is as low as 18.6 nM, the response time is short, the response time is 2 minutes, and the good response characteristic is kept when the probe RH and other interfering substances coexist. The invention provides a novel and efficient detection technology for real-time monitoring of HOCl, has a wide application prospect, and can provide a more reliable tool for related research and practical application especially in the fields of biological imaging, environmental monitoring, public health and the like.

The present invention belongs to the field of biological detection and biomedicine technology, and specifically relates to the synthesis and application of a pH-activated photosensitizer. In order to construct a NIR-Ⅱ activated photosensitizer, the present invention uses rhodamine derivatives as raw materials to modify and synthesize a pH-activated photosensitizer. This NIR-Ⅱ region activated photosensitizer itself does not have the ability to emit fluorescence, and needs to be activated by light after H+ stimulation, thereby generating a large amount of reactive oxygen and fluorescence emission. Among them, the reactive oxygen generated will destroy the protein, DNA, and lipids in the cell, leading to cell apoptosis, thereby killing tumor cells; the fluorescence emission can produce a strong fluorescent signal in the NIR-Ⅱ region, and the cancerous site can be imaged in vivo by NIR-Ⅱ. It can be seen that the pH-activated photosensitizer of the present invention can provide new ideas for the design of activated photosensitizers, which has important reference significance for realizing the integration of diagnosis and treatment and overcoming the problem of cancer.

The present invention belongs to the field of biological detection and biomedicine technology, and specifically relates to a Cu 2+ Synthesis and application of activated photosensitizer. In order to construct a NIR-Ⅱ activated photosensitizer, the present invention uses rhodamine derivatives as raw materials and synthesizes a Cu 2+ Activated photosensitizer, this NIR-Ⅱ region activated photosensitizer itself does not have the ability to emit fluorescence, and needs to be 2+ After stimulation, it can be activated by light, thereby generating a large amount of reactive oxygen species and fluorescence emission. Among them, the reactive oxygen species generated will destroy the proteins, DNA, and lipids in the cells, leading to cell apoptosis, thereby killing tumor cells; the fluorescence emission can produce a strong fluorescence signal in the NIR-Ⅱ region, which can be used for NIR-Ⅱ in vivo imaging of the cancerous site. It can be seen that the Cu 2+ Activated photosensitizers provide new ideas for the design of activated photosensitizers, which are of great reference significance for realizing integrated diagnosis and treatment and overcoming cancer problems.

This invention discloses a highly selective copper ion ratiometric fluorescent probe based on a rhodamine derivative, its preparation method, and its applications, belonging to the field of fluorescent probes. Specifically, the probe of this invention can be used to measure, detect, or screen copper ions, achieving selective recognition of copper ions with strong anti-interference capabilities; it enables rapid and highly sensitive analysis of copper ions; it has colorimetric capabilities, thus facilitating visual detection of copper ions; it is a ratiometric fluorescent probe, eliminating the influence of various environmentally irrelevant factors and improving its sensitivity; it has low cytotoxicity, which is beneficial for application under physiological conditions; and it also has the advantages of simple synthesis, stable properties, and commercial application.

The present invention belongs to the field of antibiotic detection, and in particular to a method for detecting tetracycline in meat products based on a copper-activated upconversion bismuth molybdate sensing system. The steps are: preparing upconversion nanomaterials and rhodamine derivatives, dissolving the two in methanol to obtain two solutions and mixing them in proportion to construct a sensing system. At the same time, the present invention synthesizes a bismuth molybdate-bismuth sulfide complex by a solvent thermal method, effectively improving the decomposition efficiency of tetracycline and copper ion-tetracycline complex in the solution, and shortening the reaction time. By decomposing the copper ion-tetracycline complex and tetracycline, the remaining tetracycline in the complex and the solution can be avoided from continuing to react with the copper ion, further avoiding the interference of the subsequent reaction on the upconversion fluorescence signal, reducing the detection limit of the method, and improving the detection accuracy. In summary, the present invention provides a novel tetracycline detection method, which does not require expensive instruments, reduces the detection cost, can be used for the detection of actual samples, and has broad application prospects.

The invention belongs to the technical field of fluorescent probe materials and detection methods thereof, and discloses a fluorescent probe, a method for detecting stannous ions by the fluorescent probe and application of the fluorescent probe, the fluorescent probe for detecting the stannous ions is an organic compound containing an azide group, and the structural general formula of the fluorescent probe is R-N3; wherein R is a fluorophore emitting fluorescence based on an intramolecular charge transfer mechanism, and comprises any one of a coumarin fluorophore, a phthalimide fluorophore, a 1, 8-naphthalimide fluorophore, a dicyanoisophorone fluorophore and a rhodamine derivative fluorophore. The azide group on the stannous ion fluorescent probe disclosed by the invention is reduced into the amino group by utilizing the characteristic of strong reducibility of Sn < 2 + >, the Sn < 2 + > can be detected by optical / electrochemical / colorimetric / gas signal change, and the stannous ion fluorescent probe disclosed by the invention has the advantages of interference resistance, universality, high sensitivity, multi-mode detection and the like.

The invention provides a rhodamine derivative fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of fluorescence detection. The preparation method comprises the following steps: mixing rhodamine 110 conjugated PEG azide, triethylamine and anhydrous dichloromethane to obtain a mixed solution; and dropwise adding a 2, 4-dinitrobenzenesulfonyl chloride solution into the mixed solution, reacting at low temperature, and reacting at normal temperature in a dark place to obtain the rhodamine derivative fluorescent probe. The rhodamine derivative fluorescent probe shows good stability when being used for detecting the selenocysteine, has low detection limit on the selenocysteine, has high sensitivity and good selectivity, and is suitable for detecting the selenocysteine in livestock and poultry products.

This invention discloses a fluorescent probe for detecting peroxynitrite in living cells and its synthesis method. The fluorescent probe comprises an amphiphilic group, 4-amino-2-methoxyphenol as a recognition unit, and a rhodamine derivative fluorophore, wherein the recognition unit can interact with ONOO. ‑ A specific oxidation reaction occurs, causing significant changes in fluorescence intensity and emission wavelength, thereby enabling real-time imaging and quantitative analysis of peroxynitrite in the cellular microenvironment. The fluorescent probe of this invention possesses high selectivity, strong anti-interference capabilities, and rapid response, making it suitable for the detection of ONOO at the live-cell level. ‑ Dynamic observation.

This invention belongs to the field of analytical detection, and relates to small molecule fluorescent probes, specifically a near-infrared fluorescent probe, its preparation method, and a dual-response detection method for Cu. 2+ Applications in Aβ aggregates. The probe is modified on the fluorophore of a rhodamine derivative to redshift its emission wavelength to the near-infrared region. The fluorescent probe of this invention is named ( E )-2-amino-6'-(diethylamino)-4'-(4-(piperidin-1-yl)benzylmethyl)-1',2',3',4'-tetrahydrospiro[isoindoline-1,9'-oxanthracene]-3-one, its outstanding feature is: this fluorescent probe can achieve the detection of Cu in Alzheimer's disease (AD). 2+ Simultaneous detection of Aβ aggregates is simple to prepare, and its near-infrared fluorescence emission (765nm) can effectively avoid background interference, exhibiting high sensitivity and good selectivity.

The invention relates to the field of chemical engineering and environment-friendly materials, and discloses a color-changing transparent wood material and a preparation method thereof. The invention provides a color-changing type transparent wood material for the first time. The color-changing type transparent wood material comprises a transparent wood material base body, bridge intermolecules grafted on lignocellulose of the transparent wood material base body and a photochromic type dye, wherein the dye is a rhodamine derivative. By selecting proper bridging molecules NCO-PEG-NCO and through the hydrophilicity of the bridging molecules, the bonding force between the dye and cellulose is improved, the color change stability of the dye is enhanced, and the combination of the dye and lignin is improved and stabilized. The method comprises the following specific steps: preparing a transparent wood material; the preparation method comprises the following steps: soaking a transparent wood material in a DMF (Dimethyl Formamide) solution, heating, keeping the temperature at 60 DEG C, adding a photochromic rhodamine dye containing a urea structure, reacting for 20 minutes, washing, and soaking in deionized water containing polyethylene glycol diisocyanate to obtain the transparent wood material grafted with the rhodamine dye.

The present invention provides an environmentally friendly fluorescent probe RBCMC with high selectivity and high sensitivity. It modifies carboxymethyl cellulose with a rhodamine derivative and successfully realizes the detection of Al<supgt;3+< / supgt; in water. Experiments show that the organic combination of the two endows the fluorescent probe RBCMC with the water solubility of the carboxymethyl cellulose carrier and gives the probe the advantage of specific detection in water. Under the interference of common cations and anions, the fluorescent probe RBCMC exhibits good anti-interference ability, and its lowest detection limit for Al<supgt;3+< / supgt> is 0.239 μM. At the same time, the fluorescent probe RBCMC can be prepared into a hydrogel and successfully applied to the detection of natural water samples. Compared with the prior art, the present invention has low research and development costs, is easy to implement, and has simple operation, and has broad application prospects in the detection of Al<supgt;3+< / supgt> ions.

The invention discloses a light conversion agent, a preparation method of the light conversion agent and a light conversion film.The light conversion film is a europium complex copolymer synthesized by an Eu complex and a rhodamine B derivative in a free radical copolymerization mode, the Eu complex has a double-bond structure exposed outside 5-amino-1, 10-phenanthroline molecules, and the Eu complex has a double-bond structure exposed outside the 5-amino-1, 10-phenanthroline molecules. The double bond position, exposed outside the molecule, of the Eu complex structure is connected by amino and acryloyl chloride through substitution reaction; the structure of the rhodamine B derivative is that the carboxyl of rhodamine B is connected with a double-bond structure exposed outside a molecule; the preparation method of the light conversion agent sequentially comprises the steps of synthesizing 5-acrylamido-1, 10-phenanthroline, synthesizing an Eu complex, synthesizing a rhodamine B derivative and synthesizing the light conversion agent. The light conversion film provided by the invention comprises the light conversion agent. According to the light conversion agent and the light conversion film, ultraviolet light and yellow-green light can be converted into red light, and the utilization rate of sunlight in the plant photosynthesis process is increased.

The application relates to the technical field of rhodamine derivatives, and specifically discloses a selenium-containing rhodamine derivative and application thereof. The application innovatively proposes a selenium-heavy-atom-containing rhodamine derivative, which has a visible light absorption wavelength close to the near-infrared region of 700 NM, which enables it to penetrate deeper tissue sites for deep treatment; meanwhile, the selenium-heavy-atom-containing rhodamine derivative also exhibits a high triplet state conversion rate, and can efficiently generate reactive oxygen species under light excitation conditions, thereby strengthening the killing effect on cancer cells and cancer tissues. Compared with the prior art, the selenium-heavy-atom-containing rhodamine derivative of the application can realize efficient removal of cancer cells and cancer tissues at a concentration of only nanomolar order, thereby significantly improving the treatment efficiency and reducing the drug dosage; meanwhile, the preparation process of the rhodamine derivative provided by the application is simple and easy to implement, and a relatively high synthesis yield can be obtained, and the rhodamine derivative is more suitable for large-scale, low-cost production and application.

This invention discloses a bifunctional fluorescent probe that simultaneously distinguishes between adenosine triphosphate (ATP) and hydroxyl radicals (·OH). The chemical structure of the bifunctional probe is as follows: This bifunctional fluorescent probe combines a rhodamine derivative and a coumarin derivative through a simple condensation reaction, utilizing the specific interaction between the nitrogen-containing group and ATP, and the aromatic hydroxylation of ·OH, to detect and distinguish between ATP and ·OH. When the probe reacts with ATP, it emits red fluorescence at 590 nm under an excitation wavelength of 520 nm; when it reacts with ·OH, it emits green fluorescence at 496 nm under an excitation wavelength of 420 nm. This probe exhibits excellent selectivity and high sensitivity in detecting ATP and ·OH, and has great application prospects in analytical chemistry, life sciences, biomedicine, and other technical fields.

The invention relates to the technical field of rhodamine derivatives, and particularly discloses a selenium-containing rhodamine derivative and application thereof. The rhodamine derivative containing selenium heavy atoms is innovatively provided, and the visible light absorption wavelength of the rhodamine derivative is close to a near-infrared region of 700 NM, so that the rhodamine derivative can penetrate through deeper tissue parts for deep treatment; meanwhile, the rhodamine derivative containing the selenium heavy atoms also shows a high triplet state conversion rate, and can efficiently generate active oxygen species under an illumination excitation condition, so that the killing effect on cancer cells and cancer tissues is enhanced. Compared with the prior art, the rhodamine derivative containing the selenium heavy atoms can realize efficient removal of cancer cells and cancer tissues by only needing nanomole-level concentration, so that the treatment efficiency is remarkably improved, and the drug use dosage is reduced; meanwhile, the preparation process of the rhodamine derivative is simple and easy to implement, high synthesis yield can be obtained, and the rhodamine derivative is more suitable for large-scale and low-cost production and application.

The invention discloses a difunctional fluorescent probe for simultaneously distinguishing and detecting adenosine triphosphate (ATP) and hydroxyl radicals (. OH). The chemical structural formula of the difunctional probe is as follows: # imgabs0 #. According to the bifunctional fluorescent probe, a rhodamine derivative and a coumarin derivative are combined through a simple condensation reaction, and ATP and. OH are detected and distinguished through specific interaction of a nitrogen-containing group and ATP and aromatic hydroxylation of. OH. When the probe reacts with ATP (adenosine triphosphate), red fluorescence of 590 nm is emitted under the excitation wavelength of 520 nm; when acting with. OH, green fluorescence of 496 nm is emitted under the excitation wavelength of 420 nm. The probe for detecting ATP and. OH has the advantages of good selectivity, high sensitivity and the like, and has a huge application prospect in the technical fields of analytical chemistry, life science, biomedical treatment and the like.

The invention relates to the technical field of fluorescent probes, in particular to a fluorescent probe containing a triphenylamine group as well as a preparation method and application of the fluorescent probe. The fluorescent probe containing the triphenylamine group is obtained by combining the triphenylamine derivative and the hydrazide rhodamine derivative, when the fluorescent probe containing the triphenylamine group is used for occult blood detection, the excellent color development performance is achieved, and the good color development performance is achieved for samples placed for a long time; therefore, powerful help is provided for criminal investigation and case solving, and theoretical possibility is provided for solving an old case.

The invention relates to a preparation method and application of modified cyclodextrin based on a rhodamine B derivative. The preparation method disclosed by the invention is characterized by comprising the following steps: firstly, reacting beta-cyclodextrin with paratoluensulfonyl chloride to generate an active intermediate, namely paratoluensulfonyl cyclodextrin; then, rhodamine B is used as a signal group, propane diamine is used as a connecting body, and 1, 3-propane diamine rhodamine B lactone is prepared; finally, fully reacting p-toluene sulfonated cyclodextrin with amido rhodamine B under the promotion of sodium carbonate to obtain the fluorescent probe. The temperature response type fluorescent probe prepared by the invention is based on the distortion change and non-radiative transition effect in rhodamine molecules, and the ultraviolet absorption and fluorescence intensity of the temperature response type fluorescent probe are in positive correlation with the temperature. According to the invention, cyclodextrin is introduced, so that the water solubility and environmental protection property of the fluorescent probe can be greatly improved, and the probe can realize temperature measurement by monitoring the change of a spectral signal in an aqueous solution. The preparation process is green and non-toxic, and the preparation method of the amido rhodamine B derivatives with different carbon chains is universal and high in controllability.

The invention discloses a preparation method of a flexible color developing film or an array device based on dye and doped metal oxide nanoparticles and application of the flexible color developing film or the array device in oxygen / ammonia gas detection, and belongs to the field of ammonia gas and oxygen gas detection. The preparation method comprises the following steps: S1, respectively preparing a precursor solution containing Cu or Fe-doped metal oxide nanocrystals and a polymer solution; s2, mixing the two solutions prepared in S1, adding rhodamine derivative dye powder, and uniformly stirring and mixing to obtain a mixed solution of dye / metal oxide precursor / polymer; s3-A, carrying out spin coating or blade coating on the mixed solution on the surface of glass to form a film, and then drying to obtain a thin film; or S3-B, dripping the mixed solution into the arrayed grid pattern on the surface of the glass, and drying to obtain the arrayed device. The device has the advantages of low cost and easiness in manufacturing, can be simultaneously applied to the field of oxygen and ammonia gas detection, and can be repeatedly used.

The invention discloses a Si rhodamine derivative for hypoxia imaging and a preparation method and application of the Si rhodamine derivative. The structural formula of the Si rhodamine derivative is # imgabs0 #. The invention further specifically discloses a preparation method of the Si rhodamine derivative for hypoxia imaging and application of the Si rhodamine derivative in imaging of hypoxia environment distribution in cells and cell hypoxia detection. According to the invention, Si rhodamine is used as a parent to prepare a fluorescent dye with a large conjugate structure and hypoxia marker targeting, namely the Si rhodamine derivative, and the Si rhodamine derivative has a symmetrical conjugate group julolidine, positive charges and a hypoxia targeting benzenesulfonamide group. The benzenesulfonamide structure contained in the dye can enable the dye to target hypoxia high-expression carbonic anhydrase, and detection and imaging of cell hypoxia distribution can be realized.

The invention relates to a molecular complex emitting fluorescent light comprising, or consisting essentially of: ⋅—a fluorophore, and ⋅—a nucleic acid molecule, wherein said fluorophore has of the following formula 3