15results about "Acridine dyes" patented technology

The present invention relates to dyes with pH-dependent absorption and fluorescence for pH detection and their applications in biology, medicine and theranostic. In particular, the present invention relates to compounds of the general formulae (I) - (IV), that show pH dependent absorption and fluorescence spectra as well as pH dependent fluorescence quantum yield, methods for their preparation and their application as pH-sensors and labeling groups for the detection of analytes.

The embodiment of the present disclosure discloses a kind of azaxanthene fluorescent dyes and preparation method thereof. Among them, azaxanthene fluorescent dyes have the structure shown in general formula (a);The preparation method of azaxanthene fluorescent dyes includes: halogenated benzoic acid and aniline derivative reaction, generate diphenylamine derivative;Diphenylamine derivative is dehydrated and cyclized to generate azaxanthone derivative;The amino group of the azaxanthone derivative is methylated to generate the first nitrogen methyl anthrone derivative;The first nitrogen methyl anthrone derivative is removed from the first protecting group to generate the second nitrogen methyl anthrone derivative;The phenolic hydroxyl group of the second nitrogen methyl anthrone derivative is protected by the second protecting group to obtain the third nitrogen methyl anthrone derivative;The third nitrogen methyl anthrone derivative is reacted with grignard reagent, and the second protecting group is removed under acidic conditions to obtain azaxanthene fluorescent dye.The azaxanthene fluorescent dye can have high luminous efficiency under acidic conditions.

Described are contact lenses containing light absorbing chromophores, wherein the light absorbing chromophore is concentrated in one or more select regions of the lens. Also described are methods for making such contact lenses.

The present invention relates to organic light emitting elements, comprising thermally activated delayed fluorescence (TADF) emitters and / or hosts of formulawhich have a sufficiently small energy gap between S1 and T1 (ΔEST) to enable up-conversion of the triplet exciton from T1 to S1. The organic light emitting elements show high electroluminescent efficiency.

Disclosed are liquid and solid assay compositions and portable sample reader devices for use in a sample-to-answer diagnostic system for the detection of one or more analytes, preferably the detection of circulating histones in whole blood. Further provided are methods of making and using the assay compositions and portable sample reader, including the collection of a raw sample, testing the sample using the assay compositions, and analyzing the sample via the portable sample reader. More particularly, assay compositions comprising a sacrificial partition, target molecule, detectable label, and sacrificial partition are used in combination with a sample reader comprising an optical system and a housing unit as part of a sample-to-answer diagnostic system for quantifying circulating histones in whole blood as a mechanism of predicting the risk of multiple organ failure.

A method of regenerating a symmetrical redox flow battery includes: a first discharge process having a duration in which a capacity of the redox flow battery in a first polarity and comprising a membrane decreases from a first to a second capacity, the process comprising: flowing a catholyte through a catholyte compartment in the first polarity; flowing an anolyte through an anolyte compartment in the first polarity; wherein: the first polarity of the redox flow battery includes a membrane having a first face in fluid communication with the catholyte compartment and a second face in fluid communication with the anolyte compartment; and the first and the second faces of the membrane being opposing surfaces of the membrane; and a second discharge process comprising: reversing the polarity of the catholyte and anolyte compartments wherein: the redox flow battery in the second polarity exhibits an initial increased capacity compared to the second capacity from the first discharge process.

The present invention relates to a novel substituted acridinium salts as fluorescent dyes, as well as methods of their manufacturing and use of the disclosed compounds for the detection of cardiolipin.

Disclosed are markers comprising dibromopyridazine diones attached to signal molecules, along with methods of production and use thereof. Conjugates of markers attached to analyte-specific binding agents, as well as methods of producing and using the same, are also disclosed. Also disclosed are kits containing the markers and / or conjugates, as well as microfluidic devices containing the same.

The present invention relates to dyes with pH-dependent absorption and fluorescence for pH detection and their applications in biology, medicine and theranostic. In particular, the present invention relates to compounds of the general formulae (I)-(IV), that show pH dependent absorption and fluorescence spectra as well as pH dependent fluorescence quantum yield, methods for their preparation and their application as pH-sensors and labeling groups for the detection of analytes.

The invention relates to a compound, a rubber blend containing said compound, a vehicle tire comprising the rubber blend in at least one component, a process for producing the compound and the use of the compound as ageing protectant and / or antiozonant and / or dye. The compound according to the invention has the formula (I) wherein R1 is selected from the group consisting of benzyl groups, 1-phenylalkyl groups with a total of 7 to 18 carbon atoms and linear, branched and cyclic aliphatic C3 to C12 groups.

The invention relates to a dye for pH detection and having pH-dependent absorption and fluorescence, and application thereof in biology, medicine and diagnosis and treatment. In particular, the present invention relates to: compounds as shown in general formulae (I) to (IV), said compounds exhibiting pH-dependent absorption and fluorescence spectra as well as pH-dependent fluorescence quantum yields; a method for preparing the compound; and the use of said compounds as pH sensors and marker groups in the detection of analytes.

Disclosed are liquid and solid assay compositions and portable sample reader devices for use in a sample-to-answer diagnostic system for the detection of one or more analytes, preferably the detection of circulating histones in whole blood. Further provided are methods of making and using the assay compositions and portable sample reader, including the collection of a raw sample, testing the sample using the assay compositions, and analyzing the sample via the portable sample reader. More particularly, assay compositions comprising a sacrificial partition, target molecule, detectable label, and sacrificial partition are used in combination with a sample reader comprising an optical system and a housing unit as part of a sample-to-answer diagnostic system for quantifying circulating histones in whole blood as a mechanism of predicting the risk of multiple organ failure.

Labels that include dibromopyridazinedione attached to signal molecules are disclosed, along with methods of producing and using same. Also disclosed are conjugates of the label attached to an analyte-specific binder, as well as methods of producing and using same. Kits containing the labels and / or conjugates are also disclosed, along with microfluidics devices containing same.