39results about "Acridine dyes" patented technology

Sulfonated 2(7)-aminoacridone and 1-aminopyrene dyes and their use as fluorescent tags, in particular for carbohydrate analysis The invention relates to fluorescent dyes with multiple negatively charged groups in their ionized form which are aminoacridone sulfonamides or 1-aminopyrenes having of one of the following general formulae A-D: Formula (A), Formula (B), Formula (C), Formula (D), wherein the ionizable groups X are typically selected from the following: SH, COOH, SO3H, OSO3H, OP(O)(OH)2, OP(O)(OH)Ra, P(O)(OH)2, P(O)(OH)Ra, where Ra═C1-C4alkyl or substituted C1-C4alkyl. The invention further relates to the use of these dyes as fluorescent tags, in particular for reducing sugars and glycans.

A method of regenerating a symmetrical redox flow battery includes: a first discharge process having a duration in which a capacity of the redox flow battery in a first polarity and comprising a membrane decreases from a first to a second capacity, the process comprising: flowing a catholyte through a catholyte compartment in the first polarity; flowing an anolyte through an anolyte compartment in the first polarity; wherein: the first polarity of the redox flow battery includes a membrane having a first face in fluid communication with the catholyte compartment and a second face in fluid communication with the anolyte compartment; and the first and the second faces of the membrane being opposing surfaces of the membrane; and a second discharge process comprising: reversing the polarity of the catholyte and anolyte compartments wherein: the redox flow battery in the second polarity exhibits an initial increased capacity compared to the second capacity from the first discharge process.

The present invention relates to dyes with pH-dependent absorption and fluorescence for pH detection and their applications in biology, medicine and theranostic. In particular, the present invention relates to compounds of the general formulae (I) - (IV), that show pH dependent absorption and fluorescence spectra as well as pH dependent fluorescence quantum yield, methods for their preparation and their application as pH-sensors and labeling groups for the detection of analytes.

This application discloses a method for preparing and using a nucleic acid dye. The method comprises the following steps: preparing an intermediate compound I by reacting acridine orange and an alkynyl-containing compound; and mixing the intermediate compound I with a diazide compound to produce the nucleic acid dye. The nucleic acid dye prepared in this application has a short synthesis process and simple purification. The nucleic acid dye prepared in this application has good performance, as demonstrated by testing its optical properties, such as ultraviolet absorption and fluorescence, as well as by agarose gel electrophoresis.

The embodiment of the present disclosure discloses a kind of azaxanthene fluorescent dyes and preparation method thereof. Among them, azaxanthene fluorescent dyes have the structure shown in general formula (a);The preparation method of azaxanthene fluorescent dyes includes: halogenated benzoic acid and aniline derivative reaction, generate diphenylamine derivative;Diphenylamine derivative is dehydrated and cyclized to generate azaxanthone derivative;The amino group of the azaxanthone derivative is methylated to generate the first nitrogen methyl anthrone derivative;The first nitrogen methyl anthrone derivative is removed from the first protecting group to generate the second nitrogen methyl anthrone derivative;The phenolic hydroxyl group of the second nitrogen methyl anthrone derivative is protected by the second protecting group to obtain the third nitrogen methyl anthrone derivative;The third nitrogen methyl anthrone derivative is reacted with grignard reagent, and the second protecting group is removed under acidic conditions to obtain azaxanthene fluorescent dye.The azaxanthene fluorescent dye can have high luminous efficiency under acidic conditions.

Described are contact lenses containing light absorbing chromophores, wherein the light absorbing chromophore is concentrated in one or more select regions of the lens. Also described are methods for making such contact lenses.

The present invention relates to a method for increasing the chemiluminescent signal in a chemiluminescent reaction of a chemiluminescent compound in a chemiluminescent reaction mixture, comprising oxidizing the chemiluminescent compound in the presence of an effective amount of an enhancer to obtain an increased chemiluminescent signal, and to the use of a compound selected from the group consisting of quaternary amine cationic materials of formula (I) for increasing the chemiluminescent signal in a chemiluminescent reaction of an acridinium compound, preferably an acridinium ester or an acridinium sulfonamide, preferably in a chemiluminescent immunoassay, and to chemiluminescent compositions and kits related thereto.

To provide compounds, conjugates and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.SOLUTION: The invention provides compounds of formula (I), or salts thereof.SELECTED DRAWING: Figure 1

The present invention relates to organic light emitting elements, comprising thermally activated delayed fluorescence (TADF) emitters and / or hosts of formulawhich have a sufficiently small energy gap between S1 and T1 (ΔEST) to enable up-conversion of the triplet exciton from T1 to S1. The organic light emitting elements show high electroluminescent efficiency.

Disclosed are liquid and solid assay compositions and portable sample reader devices for use in a sample-to-answer diagnostic system for the detection of one or more analytes, preferably the detection of circulating histones in whole blood. Further provided are methods of making and using the assay compositions and portable sample reader, including the collection of a raw sample, testing the sample using the assay compositions, and analyzing the sample via the portable sample reader. More particularly, assay compositions comprising a sacrificial partition, target molecule, detectable label, and sacrificial partition are used in combination with a sample reader comprising an optical system and a housing unit as part of a sample-to-answer diagnostic system for quantifying circulating histones in whole blood as a mechanism of predicting the risk of multiple organ failure.

Disclosed herein are compounds, conjugates and methods that can be used to detect the presence of an analyte in a sample, such as a biological sample.

A composition includes a functionalized fluorescent dye. The functionalized fluorescent dye includes an isothiocyanate-containing compound functionalized with a functional group. The functional group includes a primary amine. The functionalized fluorescent dye can be mixed with a fluid to form a tracer fluid for tracing fluid flow in a subterranean formation.

A method of regenerating a symmetrical redox flow battery includes: a first discharge process having a duration in which a capacity of the redox flow battery in a first polarity and comprising a membrane decreases from a first to a second capacity, the process comprising: flowing a catholyte through a catholyte compartment in the first polarity; flowing an anolyte through an anolyte compartment in the first polarity; wherein: the first polarity of the redox flow battery includes a membrane having a first face in fluid communication with the catholyte compartment and a second face in fluid communication with the anolyte compartment; and the first and the second faces of the membrane being opposing surfaces of the membrane; and a second discharge process comprising: reversing the polarity of the catholyte and anolyte compartments wherein: the redox flow battery in the second polarity exhibits an initial increased capacity compared to the second capacity from the first discharge process.

The present invention relates to a novel substituted acridinium salts as fluorescent dyes, as well as methods of their manufacturing and use of the disclosed compounds for the detection of cardiolipin.

Disclosed are markers comprising dibromopyridazine diones attached to signal molecules, along with methods of production and use thereof. Conjugates of markers attached to analyte-specific binding agents, as well as methods of producing and using the same, are also disclosed. Also disclosed are kits containing the markers and / or conjugates, as well as microfluidic devices containing the same.

The present invention relates to dyes with pH-dependent absorption and fluorescence for pH detection and their applications in biology, medicine and theranostic. In particular, the present invention relates to compounds of the general formulae (I)-(IV), that show pH dependent absorption and fluorescence spectra as well as pH dependent fluorescence quantum yield, methods for their preparation and their application as pH-sensors and labeling groups for the detection of analytes.

Labels that include dibromopyridazinedione attached to signal molecules are disclosed, along with methods of producing and using same. Also disclosed are conjugates of the label attached to an analyte-specific binder, as well as methods of producing and using same. Kits containing the labels and / or conjugates are also disclosed, along with microfluidics devices containing same.

The invention discloses a preparation method of a PR207 intermediate and a PR207 pigment, and the preparation method of the PR207 intermediate comprises the following steps: S1, condensation: condensing DMSS, aniline and o-chloroaniline, fully mixing the condensed DMSS, aniline and o-chloroaniline with inorganic acid in an alcoholic solution, and carrying out condensation reaction in a reflux or distillation state to obtain a condensed solution; the method comprises the following steps: S1, condensing a condensed solution, S2, oxidizing, adding an alkali metal hydroxide into the condensed solution, and adding a hydrogen peroxide mixed solution in a reflux state for oxidation, S3, diluting a reaction solution obtained in S2 with water, and filtering to obtain a catalyst and a filtrate, and the step S2 further comprises the following steps: S21, adding 40-60% of the alkali metal hydroxide and the catalyst into the condensed solution, preparing other alkali metal hydroxides into an alkali metal hydroxide solution; s22, slowly raising the temperature to reflux; s23, dropwise adding a 40%-60% hydrogen peroxide mixed solution; and S24, dropwise adding the alkali metal hydroxide solution from the return pipe, and fully stirring after the alkali metal hydroxide solution and the hydrogen peroxide mixed solution are dropwise added.

The invention relates to a compound, a rubber blend containing said compound, a vehicle tire comprising the rubber blend in at least one component, a process for producing the compound and the use of the compound as ageing protectant and / or antiozonant and / or dye. The compound according to the invention has the formula (I) wherein R1 is selected from the group consisting of benzyl groups, 1-phenylalkyl groups with a total of 7 to 18 carbon atoms and linear, branched and cyclic aliphatic C3 to C12 groups.

A composition includes a functionalized fluorescent dye. The functionalized fluorescent dye includes an isothiocyanate-containing compound functionalized with a functional group. The functional group includes a primary amine. The functionalized fluorescent dye can be mixed with a fluid to form a tracer fluid for tracing fluid flow in a subterranean formation.

The invention relates to a dye for pH detection and having pH-dependent absorption and fluorescence, and application thereof in biology, medicine and diagnosis and treatment. In particular, the present invention relates to: compounds as shown in general formulae (I) to (IV), said compounds exhibiting pH-dependent absorption and fluorescence spectra as well as pH-dependent fluorescence quantum yields; a method for preparing the compound; and the use of said compounds as pH sensors and marker groups in the detection of analytes.

Disclosed are liquid and solid assay compositions and portable sample reader devices for use in a sample-to-answer diagnostic system for the detection of one or more analytes, preferably the detection of circulating histones in whole blood. Further provided are methods of making and using the assay compositions and portable sample reader, including the collection of a raw sample, testing the sample using the assay compositions, and analyzing the sample via the portable sample reader. More particularly, assay compositions comprising a sacrificial partition, target molecule, detectable label, and sacrificial partition are used in combination with a sample reader comprising an optical system and a housing unit as part of a sample-to-answer diagnostic system for quantifying circulating histones in whole blood as a mechanism of predicting the risk of multiple organ failure.