Methyl propionate preparation method

A technology for methanol and carbon monoxide, applied in the field of preparing methyl propionate, can solve the problems of high price, cumbersome preparation of ionic liquid catalysts, high energy consumption for separation of homogeneous palladium catalysts, etc., and achieves easy separation, high catalyst activity, and simple preparation. Effect

Active Publication Date: 2018-05-08
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

However, there are problems in the catalytic system used in the preparation of methyl propionate by the methoxycarbonylation reaction: for example: the homogeneous palladium catalyst has high energy consumption for separation, and the preparation of the ionic liquid catalyst is tedious and expensive. In addition, in the reported catalytic system Most of them need to add additional acid additives, etc., so the development of a high-efficiency and low-cost heterogeneous catalytic system to achieve high-efficiency preparation of methyl propionate has important application prospects

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0038] In a 50mL Teflon-lined reactor, weigh 0.15g of 2wt%Ru / TiO 2 Catalyst, add 4mL of methanol, put in a magnet, fill with 1MPa ethylene and 1.3MPa carbon monoxide gas respectively, airtight, stir and react at 180°C for 8h, after the reaction, confirm the product composition by mass spectrometry, the product mass spectrum and the standard product mass spectrum Figure 1 To, methyl propionate. The product was detected and quantified by gas chromatography, and the yield of methyl propionate is shown in Table 1.

Embodiment 2

[0040] In a 50mL Teflon-lined reactor, weigh 0.15g of 2wt%Ru / CeO 2 Catalyst, add 4mL of methanol, put in a magnet, fill with 1MPa ethylene and 0.1MPa carbon monoxide gas respectively, airtight, stir and react at 180°C for 8h, after the reaction, confirm the composition of the product by mass spectrometry, the mass spectrum of the product and the mass spectrum of the standard product Figure 1 To, methyl propionate. The product was detected and quantified by gas chromatography, and the yield of methyl propionate is shown in Table 1.

Embodiment 3

[0042] In a 50 mL Teflon-lined reactor, weigh 0.15 g of 10 wt% Ru / CeO 2 Catalyst, add 4mL of methanol, put in a magnet, fill with 0.5MPa ethylene and 0.5MPa carbon monoxide gas respectively, airtight, stir and react at 180°C for 8h, after the reaction, confirm the composition of the product by mass spectrometry, the mass spectrum of the product and the mass spectrum of the standard product Figure 1 To, methyl propionate. The product was detected and quantified by gas chromatography, and the yield of methyl propionate is shown in Table 1.

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Abstract

The present invention relates to a methyl propionate preparation method, which comprises: mixing methanol and a ruthenium-supported metal oxide catalyst, placing the obtained mixture in a pressure container, filling with ethylene and carbon monoxide, sealing, and stirring, wherein the reaction temperature is more than or equal to 130 DEG C, the reaction time is more than or equal to 2 h, and the ruthenium-supported metal oxide catalyst is one or a plurality of material selected from Ru/TiO2, Ru/Nb2O5, Ru/CeO2 and Ru/Al2O3. According to the present invention, with the method, the catalyst is easily separated from the reaction system after the reaction, and can be used repeatedly, and the yield of propyl formate is up to 90%.

Description

technical field [0001] The invention relates to a method for preparing methyl propionate, in particular to the preparation of methyl propionate through the methoxy carbonylation reaction of methanol, carbon monoxide and ethylene. Background technique [0002] Methyl propionate has important uses in medicine, chemical industry, fuel, etc. It is mainly used as alkyl esters and derivatives of alkyl esters, and is also an important pharmaceutical intermediate and organic synthesis intermediate. Methyl propionate can be used to synthesize methyl methacrylate (MMA), and MMA is a monomer for synthesizing polymethyl methacrylate (p-MMA), which is widely used in glass, medical equipment and other fields. [0003] Methods for the preparation of methyl propionate have been reported. Ferreira, A.C et al. (Angew.Chem.Int Ed.2007, 46, 2273), Preparation of methyl propionate by catalyzed methoxycarbonylation of ethylene with boronate as acid promoter in the presence of palladium and phosp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/36C07C69/24
Inventor 王峰安静华王业红张志鑫张健侯婷婷张晓辰
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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