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The present invention provides novel methods for monitoring subject adherence in taking prescribed drugs by detecting markers in exhaled breath after a subject takes the prescribed drug. In particular, the present invention provides novel methods for making additives that are combined with the drug(s). Upon biological breakdown of the drug/additive formulation in a subject's body, markers resulting directly from the biological breakdown of the additives are detected in exhaled breath using sensor technology. In certain embodiments of the invention, the drug adherence monitoring systems and methods include a reporting system capable of tracking subject compliance (either remotely or proximately) and of providing necessary alerts to the subject, caregiver, healthcare provider, and the like.

The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs.

An automatic truck unloader for unloading/unpacking product, such as boxes or cases, from trailers and containers is disclosed. In one embodiment, a mobile base structure provides a support framework for a drive subassembly, conveyance subassembly, an industrial robot, a distance measurement subassembly, and a control subassembly. Under the operation of the control subassembly, an industrial robot having a suction cup-based gripper arm selectively removes boxes from the trailer and places the boxes on a powered transportation path. The control subassembly coordinates the selective articulated movement of the industrial robot and the activation of the drive subassembly based upon the distance measurement subassembly detecting objects, including boxes, within a detection space, and dimensions of the trailer provided to the control subassembly.

Every printing system has characteristic defects which detract from high quality printing. Xerographic printing systems show defects such as banding, mottled colors in large fill areas, trail-edge deletion and starvation where toner concentrations drop at certain color edges, misregistration, and so on. Ink jet printing systems can show ink bleeding, streaking in the direction of head movement, and so on. One approach to reducing printer defects is to refine the electro-mechanics for more precise printing. Another approach which works for predictable defects is to modify the digital data being sent to the printer to pre-compensate for the defect. The prior art does this to a limited extent for individual object types (strokes, fills, images, text, etc.) and for misregistered color edges (trapping). This invention extends the range of edge-related defects that can be both predicted and pre-compensated for. An embodiment of the invention is described which pre-compensates for defects such as trail-edge deletion, starvation, misregistration, halo, etc. by identifying runs of color which meet the criteria likely to cause the effect and applying a function f(edge-distance, object-type) to such runs to modify them appropriately. Both the prediction criteria and the functions applied are anamorphic (the scan direction and process direction are treated differently) and object-optimized (object attributes are taken into account). Further, both prediction criteria and applied correction functions allow user-settable input.

A multi-code multicarrier CDMA system and method for communicating data by transforming a stream of data into a plurality of code sequences selected from a code book by associating symbols of the data stream with the code sequences of the code book, wherein the codebook includes M code sequences and each of the code sequences has a length of N data symbols, copying each of the code sequences onto one or more of a plurality of subcarriers, transmitting the plurality of subcarriers, receiving the plurality of transmitted subcarriers, demodulating the received subcarriers to result in the code sequences, transforming the code sequences back into the stream of data based upon the associations between the code sequences of the code book and the symbols of the data stream, changing at least one of the number M and lengths N of the code sequences in the code book.

A set-top box with a technical configuration and system and method for use of the same are disclosed. In one embodiment of the set-top box, the set-top box executes an technical protocol to make the set-top box and an associated television ready for use. During the installation, maintenance, or repair, a human-readable visual label and a machine-readable optical label are generated that contain information about the status of the technical protocol. The labels are forwarded, via the television output, to the television. The set-top box dynamically updates the human-readable visual label and the machine-readable optical label as the status of the technical protocol changes.

Methods and devices for ophthalmic tissue closure and fixation of ophthalmic prostheses are provided. In accordance with some embodiments, devices for both grasping and clipping a plurality of ocular tissue and ocular prostheses are provided. Various device embodiments are provided for both malleable clips and delivery of normally closed clips (i.e. shape memory). The device may accommodate a plurality of clips which include, but are not limited to: malleable metals, absorbable, shape memory, drug-eluting, and adhesive dispensing. The clips may be pigmented to match the colors of associated tissue (cornea, iris, conjunctiva, sclera, retina) to serve to camouflage fixation clips for healing duration or permanently. According to one aspect, shallow angle access to anatomy may be provided by specialized angulation of device shaft and closure jaws that are intended to access the eye through a small self-healing cornea incision and/or any ocular tissue.

Methods and systems are provided for reducing pre-ignition incidence in a variable displacement engine during reactivation from a VDE mode. During conditions when one or more deactivated cylinders are reactivated to elevated engine loads, the reactivated cylinder(s) may be temporarily and preemptively enriched to reduce the possibility of cylinder pre-ignition. The preemptive enrichment is learned and further adjusted in a closed loop fashion.

Disclosed is a method of transporting CO₂ by ship for the purpose of storage in the ocean. The CO₂ is transported at a temperature between −25° C. and +25° C., and under a pressure that is sufficiently high for the CO₂ to be in a liquid or supercritical state. The choice of temperature/pressure conditions for the CO₂ enables the transport of CO₂ one way to be effectively combined with transport of compressed natural gas (CNG) the other way. Ships can be used that have relatively cheap tubular containment equipment similar to the type normally used for CNG but with lower pressure and not subject to cyclic thermal and mechanical effects of pressurizing and depressurizing.

A Gateway Location Register (GLR) for a Public Land Mobile Network (PLMN) stores information relating to each Mobile Subscriber (MS) roaming in the PLMN. The GLR may receive a request from an associated visitor registration entity of the PLMN relating to one MS and, in response, perform an action based on the stored information relating to a plurality of MS. Additionally or alternatively, the GLR selects at least one MS currently roaming in the PLMN and performs an action for at least one selected MS. The action may comprise sending a message to a visitor registration entity of the PLMN associated with each selected MS or be performed in response to a request received from an associated visitor registration entity of the PLMN in respect of a selected MS.

Methods and systems are provided for improving a margin to surge. A compressor recirculation valve is held at a semi-open position during steady-state boosted engine operation and operation in a soft surge region. The valve is fully opened to reduce hard surge, or fully closed to meet a transient increase in boost demand.

A securement for crawler cranes and system and method for use of the same are disclosed. In one embodiment of the system, a pair of structural securements are spaced at approximately a track-distance apart with respect to the crawler crane and coupled together by multiple transverse support members. When the crawler crane is driven onto the structural securements and fastened thereto, the tipping fulcrum of the crawler crane is shifted, thereby requiring a greater tipping force to tip and adding stability during high wind events.

A geolocationing system and method for providing awareness in a multi-space environment, such as a hospitality environment or educational environment, are presented. In one embodiment of the geolocationing system, a vertical and horizontal array of gateway devices is provided. Each gateway device includes a gateway device identification providing an accurately-known fixed location within the multi-space environment. Each gateway device includes a wireless transceiver that receives a beacon signal from a proximate wireless-enabled personal locator device. The gateway devices, in turn, send gateway signals to a server, which determines estimated location of the wireless-enabled personal locator device with transmitted signal strength modeling.

A controller-based apparatus for diagnosis and treatment of a subject with acquired brain injury and dysfunction. Various embodiments of the invention described herein recognize that different body postures affect the autonomic nervous system differently, and therefore various external stimuli may have different therapeutic efficacies when a patient or subject is in each body posture. Postures, such as walking, sitting, standing, prone and supine, have different effects on the autonomic nervous system, and therefore some stimuli have different physiological efficacies while a patient or subject is in a given body posture. Disclosed embodiments of the present invention leverage this relationship to provide a controller-based apparatus that determines a combination of posture and stimulus that has optimal therapeutic effect, while minimizing health practitioner involvement. The controller based apparatus provides a treatment that stimulates the nervous system through a combination of noninvasive therapies that stimulate brain cells to increase their efficiency—this promotes the formation of pathways that help transfer information throughout the brain in such a way that in the end, the affected area of the brain and overall brain function are improved without medication or surgery.

Method and kit based on real-time PCR with specific primers and probes that allow to achieve a high degree of subtyping of the complete HLA-B locus. The main advantages are the greater speed (65 minutes, including the interpretation); the ease of automation, since only eighteen tubes are necessary to obtain a good level of resolution (typing of 300 groups); reduction of the total cost per test thanks to the ease of automation and the simplicity; a surprisingly high degree of allele definition is achieved; and the risk of sample contamination is reduced because the amplified products always remain in the tubes and no post-PCR steps are necessary.

An oxygen therapy monitoring device includes an oscillation chamber with in a gas flow path adapted to pass a gas flow from a source to a breathing interface for a person. The oscillation chamber induces an oscillation in the gas flow that varies as a function of a flow rate of the gas flow. A measurement arrangement measures the oscillation induced in the gas flow and determines the flow rate on the basis of the oscillation that is measured.