57results about How to "More stable" patented technology

The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.

The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs.

Carrier for the rack mounting of two or more data storage devices into a chassis. The carrier includes support members along the length of the carrier, to receive and retain the two or more data storage devices. The carrier further includes a single electrical communication connector to provide an electrical communication interface for all of the data storage devices in the carrier, to and from a mating connector on a board of the chassis. The carrier further includes an interposer to adapt electrical signals from the single electrical communication connector into a form that is usable by the data storage devices.

A telescoping assembly allows the length of an assembly to be readily adjusted. Desirably, the telescoping assembly is used in connection with a table to allow the height of the table to be easily adjusted. The telescoping assembly preferably includes one or more projections formed in telescoping members and the projections provide accurate, low friction contact areas between the telescoping members. Preferably, first and second plurality of projections are provided, and these plurality of projections can be located on either the same telescoping member or different telescoping members. The plurality of projections are preferably evenly distributed about the telescoping members and separated by a given distance, but the projections may be located in any suitable positions and the telescoping assembly can have any appropriate number of projections.

Carrier for the rack mounting of two or more data storage devices into a chassis. The carrier includes support members along the length of the carrier, to receive and retain the two or more data storage devices. The carrier further includes a single electrical communication connector to provide an electrical communication interface for all of the data storage devices in the carrier, to and from a mating connector on a board of the chassis. The carrier further includes an interposer to adapt electrical signals from the single electrical communication connector into a form that is usable by the data storage devices.

Carrier for the rack mounting of two or more data storage devices into a chassis. The carrier includes support members along the length of the carrier, to receive and retain the two or more data storage devices. The carrier further includes a single electrical communication connector to provide an electrical communication interface for all of the data storage devices in the carrier, to and from a mating connector on a board of the chassis. The carrier further includes an interposer to adapt electrical signals from the single electrical communication connector into a form that is usable by the data storage devices.

A method for implementing FRR comprising_starting up an upper layer protocol software to manage and configure a FRR route; an upper layer protocol software sending down a active next hop of the FRR; a driver writing an IP address of the FRR into an ECMP table and creating a software table to record correspondence between a FRR group and ECMP group; informing the driver of a prefix address of a subnet route and the index of the FRR group, and the driver finding the index of the ECMP group, and writing information of the subnet route and the index of the ECMP group into hardware; an upper layer protocol software informing the driver of the index of the FRR and an IP address of a new standby next hop; the driver looking up for the index of the ECMP group, and updating the next hop address of the ECMP group.

A process for grinding edible seeds, such as grain and / or pulses, in a single unit operation in a continuous, short-duration controlled-temperature manner. Grinding may be effected without the need for moving mechanical parts. The granulated product obtained from the grinding treatment is stable to lipid oxidation. It also may be used in preparing instant whole grain food products.

Steering assemblies, methods and systems for powered or engine driven tandem axles used with work vehicles. A heavy duty work vehicle for rough terrain includes a tandem axle wherein engine power is transferred equally to both the front and rear ground following wheels of the tandem axle thru knuckle spindle steerable ends. A fluid system such as a hydraulic system unilaterally can control all four wheels or ground engagement tire positions of a single dual beam tandem or bogie assembly.

A mouse with multiple operation modes comprises a plurality of sensing modules with the same or different characteristics, for generating at least a movement record according to a movement status of the mouse on a reference surface; a switching module, for providing a user to select an operation mode; and a controlling module, connected to the switching module, determining the movement record provided by at least one of the plurality of sensing modules to be the source of the cursor controlling signal according to the operation mode selected by the user. When the mouse has a plurality of sensing modules with different characteristics, the mouse can be more accurate, more stable, or faster for fitting in with different requirements such as high speed, accurately, or stability. Accordingly, it is more convenient for the user to use the mouse.

A pruning shears is revealed. The pruning shears include a first brake arm, a second brake arm, a blade, and at least one connection piece. The first brake arm is disposed with a first toothed part while the second brake arm is arranged with a second toothed part. The first toothed part and the second toothed part are engaged with each other. The connection piece is pivotally connected to the blade, the first brake arm, and the second brake arm. During a cutting process (pruning process), a force applied is reduced due to the connection piece pivotally connected to the first brake arm and the second brake arm. While the first and the second toothed parts are engaged with each other, the connection piece becomes a wall of the first and the second toothed parts for stabilizing the engagement of the first and the second toothed parts.

To provide efficient and effective modeling of data set, the data set is initially separated into several subsets which can then be processed independently. The subsets themselves are chosen to have some internal commonality, thus providing effective independent tools where possible. This commonality may include correlation between variables or interaction amongst the variables in the subset. Once separated, each subset is independently modeled, creating a subset model having predictive qualities related to the data subset. Next, the subset models themselves are aggregated to generate a overall final model. This final model is predictive of outcomes based upon all data in the data set, thus providing a more robust stable model.

The invention is directed to binary oligonucleotide probes for nucleic analysis, which probes can be made of DNA or RNA that recognize nucleic acid analytes (both DNA and RNA) with unprecedented high selectivity under mild conditions and are highly sensitive to single nucleotide mismatches (SNP single nucleotide polymorphisms) without PCR amplification. In one group, the binary probes indicate that they have hybridized to a particular nucleic analyte by binding to a molecular beacon that gives off a fluorescent signal. A second group of binary probes bind to a dye such as malachite green, where upon hybridization to analyte the fluorescence of the dye increases dramatically and is easily detected and measured. The new binary probes require only about five minutes at room temperature to generate a detectable signal.

A pair of pruning shears is revealed. The pruning shears include a first brake arm, a second brake arm, a blade, and at least one connection piece. The first brake arm is disposed with a first toothed part while the second brake arm is arranged with a second toothed part. The first toothed part and the second toothed part are engaged with each other. The connection pieces are connected to the blade, the first brake arm, and the second brake arm. During a cutting process, a force applied is reduced due to the connection piece pivotally connected to the first brake arm and the second brake arm. While the first and the second toothed parts are engaged with each other, the connection piece becomes a wall of the first and the second toothed parts for stabilizing the engagement of the first and the second toothed parts.

The present invention relates to an advanced preparation method of organic-transition metal hydride used as hydrogen storage materials, the method including: preparing organic-transition metal-aluminum hydride complexes by reacting the organic-transition metal halide with metal aluminum hydride compounds; and preparing the organic-transition metal hydride by reacting the organic-transition metal aluminum hydride complexes with Lewis bases.Since the preparation method of the organic-transition metal hydride according to the present invention does not use catalysts, it has advantages that it does not cause problems due to poisoning and can prepare the organic-transition metal hydride at high yield under less stringent conditions. The hydrogen storage materials containing the organic-transition metal hydride prepared from the preparation method can safely and reversibly store a large amount of hydrogen.

A hydroxysafflor yellow A sodium compound as shown in a formula (I) and preparation as well as medicinal application thereof are provided. According to the present invention, the safflower is utilized as a raw material. A monomer pharmaceutical compound, the hydroxysafflor yellow A sodium, is obtained by sufficient processes, and a purity thereof is surely above 98.5%. Therefore, the hydroxysafflor yellow A sodium is a monomer compound, which is safer, more effective, more stable and more controllable than hydroxysafflor yellow A, for treating blood circulation disorders such as platelet aggregation, coronary heart disease, angina pectoris and acute cerebral ischemia. Furthermore, the hydroxysafflor yellow A sodium has sufficient solubility and human tolerance.

The present invention relates to a method of preparing an olefin-based polymer including a step of polymerizing an olefin monomer in the presence of a catalyst composition including a cis isomer and a trans isomer. According to the method of preparing an olefin-based polymer according to an embodiment of the present invention, similar level of density and molecular weight may be exhibited with a relatively smaller amount of octene when compared to that of a common polymer. Thus, a stable olefin-based polymer having good copolymerization properties may be prepared.

A preparation method and its use of derivatisation reagent for detecting L-carnitine or D-carnitine are provided. The present reagent is stable. It can be used for detecting L-carnitine or D-carnitine accurately and sensitively. That is to say, the reagent is applied to detecting the amount of synthesized or natural L-carnitine and the amount of mixing D-carnitine. The compound reagent is used for determining the chiral isomers of chemicals, biological reagents, health care reagents, cosmetic, body fluids and various foods, which contain L-carnitine or / and D-carnitine, and optical isomers of other chiral amino acids.

A dump trailer comprising a U-shaped trailer body having a bottom wall and opposing side walls. The trailer includes a curved front wall and a pivotable tailgate. The front wall is U-shaped when viewed from the top and angles upwardly and forwardly from the bottom wall. A support structure provided adjacent the front wall operatively engages hitch and lift assemblies. The support structure includes spaced-apart supports secured to the front wall; and spaced-apart horizontal beams secured to the supports. The beams extend through apertures in the front wall and into the compartment. This enables the trailer body to be lowered relative to the ground, thus lowering the center of gravity of the trailer. A wheel assembly mounts to the rear end of the trailer via a mounting plate curved complementary to the bottom wall. Cut-outs in the plate reduce the overall weight of the trailer.

Described are stable, starch-rich liquid animal feed suspensions having a high dry matter content and which do not require added heat or suspension agents for starch gelatinization and stabilization of the suspensions. Enzymatic hydrolysis and mechanical grinding are used to release starch and produce a gel-like suspension from a starting grain product, such as seeds or kernels of corn, wheat, barley, millet, oats, or rice, or flours made from the grain seeds or kernels combined with a plant processing by-product such as dried distillers grain solubles, condensed beet molasses solubles, whey, and corn steep liquor. The products produced through the processes of the present invention are flowable, dark brown to golden, gel-like suspensions with a pH of 5-7 and viscosities of 500-1000 cP at ambient temperature. In addition, the products had comparable nutritional profiles to a commercial liquid feed supplement.

The present invention relates to a kind of supercharging device, which comprises: One frame body, which is being formed into a shape of cylindrical tube, has one primary end and one secondary end respectively, wherein the port of said primary end is being formed into the serrated shape along with a plurality of serration structures, however, the port of said secondary end has a smooth plane instead; one axial structure is being formed into the said frame body; there is also a plurality of blades, in which, each blade being formed into a trapezoidal-shaped blade has a upper plate and a lower plate respectively, therein the said upper plate is shorter than the said lower plate; in addition, the said plurality of blades and the said plurality of serration structures have been formed into the same number, and the upper plate of each blade is being connected to each of the said axial structure, the lower plate is being connected to internal surface within the said frame body, and it is extended from the secondary end to the peak portion of said serration structure of the said primary end, and each of blade is corresponding to each of serration structure; wherein, the said supercharging device will be able to supercharge intake air and hence to improve the said engine's horsepower by enlarging air inflow of the engine.

Disclosed are a method and apparatus for detecting the content of oleic acid by optical fiber, and manufacturing method of the apparatus. By the principle of Surface Plasmon Resonance (SPR), a metal layer in a sensing region excites an analyte of oleic acid to produce a plasmon resonance, and a physical property of the plasmon resonance such as a resonant wavelength is measured to define the concentration of oleic acid of the analyte, so that the present invention can measure the concentration of oleic acid accurately and quickly to reduce the time and cost of detecting the oleic acid effectively, so as to improve the efficiency of detecting the oleic acid.

The invention is directed to binary oligonucleotide probes for nucleic analysis, which probes can be made of DNA or RNA that recognize nucleic acid analytes (both DNA and RNA) with unprecedented high selectivity under mild conditions and are highly sensitive to single nucleotide mismatches (SNP single nucleotide polymorphisms) without PCR amplification. In one group, the binary probes indicate that they have hybridized to a particular nucleic analyte by binding to a molecular beacon that gives off a fluorescent signal. A second group of binary probes bind to a dye such as malachite green, where upon hybridization to analyte the fluorescence of the dye increases dramatically and is easily detected and measured. The new binary probes require only about five minutes at room temperature to generate a detectable signal.

A vaccine is described which provides protection against a broad spectrum of viral strains, including but not limited to influenza A strains such as H1N1, H3N2, and H5N1. Embodiments of the present invention offer a number of advantages over conventional vaccine, in that they are cheaper to synthesize, more stable, easily scalable, and amenable to further genetic manipulation. Most importantly, certain embodiments of the present invention contemplate features, including but not limited to endosomal targeting, which result in a more robust immune response.