Tetrahydroazepine derivatives useful as dopamine d3 receptor modulators (antipsychotic agents)

A technology of compound and alkyl, applied in the field of novel tetrahydrobenzazepine derivatives
CN1486309AInactive Publication Date: 2004-03-31SMITHKLINE BECKMAN CORP
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SMITHKLINE BECKMAN CORP
Publication Date
2004-03-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides compounds of formula (I), wherein R1-R4, A, B and t are as defined in claim 1. The compounds are modulators of dopamine D3 receptors and have potential in the treatment of psychotic conditions (e.g. schizophrenia) or substance abuse.
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Description

[0001] This invention relates to a novel tetrahydrobenzazepine derivative, its preparation process, intermediates used in the process, pharmaceutical compositions containing this substance, and as dopamine D 3 Receptor modulators, especially for therapeutic use as neuroleptics. Background of the invention

[0002] U.S. Patent No. 5,294,621 describes derivatives of tetrahydropyridine of the formula:

[0003]

[0004] in

[0005]

[0006] is an optionally substituted thienyl or an optionally substituted benzene ring; R 1 , R 2 and R 3 are H atoms; X is (CH 2 ) m NR 7 CO, where m is 2-4; Ar 1 is an optionally substituted heterocycle or an optionally substituted benzene ring. The compound is said to be useful as an antiarrhythmic drug.

[0007] Patent EPA 431,580 describes certain dopaminergic agents useful as tranquillizers, antihypertensives, etc. Patent WO 95 / 10513 describes benzothiophene derivatives and related compounds, which are useful as estrogen agonists....

Claims

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