Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto

a technology of pyridinyl and pyrimidinyl derivatives, which is applied in the direction of heterocyclic compound active ingredients, drug compositions, and metabolic disorders, can solve the problems of elevated blood glucose levels, serious health problems, and inability to move glucose into the cells of the individual, and achieve the effect of reducing the weight gain of the individual
US20060155128A1Inactive Publication Date: 2006-07-13ARENA PHARMA
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
ARENA PHARMA
Publication Date
2006-07-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to certain substituted pyridinyl and pyrimidinyl derivatives of Fomula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Ser. No. 60 / 642,840, filed Jan. 10, 2005, the disclosure of which is incorporated herein by reference in its entirety.FIELD OF THE INVENTION

[0002] The present invention relates to certain substituted pyridinyl and pyrimidinyl derivatives that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. BACKGROUND OF THE INVENTION

[0003] Diabetes mellitus is a serious disease afflicting over 100 million people worldwide. In the United States, there are more than 12 million diabetics, with 600,000 new cases diagnosed each year.

[0004] Diabetes mellitus is a diagnostic term for a group of disorders characterized by abnormal glucose homeostasis resulting in elevated blood sugar. There are many types of diabetes, but the two most common are Type I (also refe...

Claims

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