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Antifungal medicine composition and its preparing method and use

A technology of antifungal drugs and compositions, applied in the direction of antifungal agents, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc., can solve problems such as toxicity, reduce side effects, and improve the effect of unstable curative effect

Active Publication Date: 2007-06-27
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Certain antifungal drugs are highly toxic to human cells

Method used

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  • Antifungal medicine composition and its preparing method and use
  • Antifungal medicine composition and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1. An antifungal pharmaceutical composition, which is a medicament made of the following raw materials in proportion by weight,

[0031] Snake Oil 50 Miconazole Nitrate 25

[0032] Sophora flavescens 20 Pearl powder 1

[0033] Menthol 1 ice flakes 1,

[0034] Tablets are made by conventional techniques.

Embodiment 2

[0035] Example 2. An antifungal pharmaceutical composition, which is a medicament made of the following raw materials in proportion by weight,

[0036] Snake Oil 100 Miconazole Nitrate 50

[0037] Sophora flavescens 50 Pearl powder 10

[0038] Menthol 5 Poplin 5,

[0039] Made into capsules by conventional techniques.

Embodiment 3

[0040] Example 3. An antifungal pharmaceutical composition, which is a medicament made of the following raw materials in proportion by weight,

[0041] Snake Oil 60 Miconazole Nitrate 40

[0042] Sophora 35 Tapioca 6

[0043] Menthol 3 ice flakes 3,

[0044] The preparation method steps are,

[0045] (1) Soak bitter gourd in 15 times the amount of 60% ethanol, extract by reflux, filter, recover the ethanol from the filtrate until it has no alcohol smell, add glycerin, disodium ethylenediamine tetraacetate, sodium benzoate and deionized water to the concentrate, mix well and make Dissolve and heat to 70°C, keep warm, and set aside;

[0046] (2) Melt stearic acid and glyceryl monostearate, filter, and cool to 70°C, add white petrolatum and vitamin E, mix well to obtain a solution; add miconazole nitrate fine powder and pearl powder to polysorbate Grind in ester 80, then add snake oil, grind evenly, add to the above solution, keep warm at 70°C, and set aside;

[0047] (3) A...

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PUM

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Abstract

The antifungal medicine composition is medicine prepared with the materials including snake oil 50-100 weight portions, Miconazole nitrate 25-50 weight portions, flavescent sophora root 20-50 weight portions, pearl powder 1-10 weight portions, menthol 1-5 weight portions, and borneol 1-5 weight portions. The antifungal medicine composition as one compound Chinese and Western medicine preparation contains effective antifungal components, and components for clearing away heat and toxic material, eliminating swelling, relieving pain, astringing and promoting granulation. It is used in treating tinea corporis, tinea cruris, tinea manuum, tinea pedis, etc caused by mycotic infection, and has stable treating effect and little side effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition, especially an antifungal pharmaceutical composition. The invention also relates to a process for the preparation of the composition. The invention also relates to the medical use of the composition. Background technique [0002] Ringworm is a common disease in dermatology, including tinea corporis, jock itch, and tinea manus and pedis. Ringworm and fungal vaginitis are generally caused by fungal infections. Fungi are usually conditional pathogens for healthy humans. When the body's resistance is reduced and external factors are unfavorable, it may cause systemic or local fungal infections. In recent years, the number of cases of clinical fungal infection has been increasing year by year. The course of treatment for fungal infection is long, and it is often necessary to continue the medication for a period of time after the symptoms subside to consolidate the curative effect. If the course of tr...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61P31/10A61K35/56A61K31/045A61K31/4164A61K35/583A61K35/618
Inventor 李明慧丁岗沈鸣曹亮钱莉亚
Owner JIANGSU KANION PHARMA CO LTD
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