A kind of oil-in-water type compound ketoconazole nano medicine and preparation method thereof

Abstract

The invention discloses an oil-in-water compound ketoconazole nano-medicament. The grain diameter of the medicament is 1-100nm. The oil-in-water compound ketoconazole nano medicament comprises the following raw materials in percentage by weight: 0.01-8.0 percent of ketoconazole, 0.01-10 percent of eugenol, 0.001-5.0 percent of clobetasol propionate, 25.0-45.0 percent of surfactant, 0-10.0 percentof cosurfactant, 0.1-25.0 percent of oil and the balance of distilled water. The oil-in-water compound ketoconazole nano-medicament can be used for treating stubborn skin mycotic infection, mycodermatitis, chronic mucocutaneous candidiasis, dermatitis blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis and paracoccidioidomycosis, and dermatomycosis and tinea versicolor caused by dermatophyte and microzyme as well as trichophyton disease, scytitis and pruritus. The oil-in-water compound ketoconazole nano-medicament has the advantages of strong osmosis, favorable stability, favorable infiltrating property, durable acting time, remarkable effect, low cost, simple preparation method and convenience in popularization and application.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new compound dosage form of ketoconazole, eugenol and clobetasol propionate, in particular to an oil-in-water compound ketoconazole nano-medicine and a preparation method thereof. Background technique [0002] At present, the medicines for the clinical treatment of skin diseases mainly include compound ointment, injections, and oral dosage forms, but most of them are only for fungal diseases, mite diseases or eczema, and these diseases often occur at the same time, and there are few reports on the medicines for treating these skin diseases at the same time. Although the oral dosage form dissolves in gastric acid and is easily absorbed, it is widely distributed after absorption, and the blood concentration fluctuates greatly, which will bring many adverse reactions such as nausea, vomiting, abdominal pain, headache, etc., and occasionally liver damage and allergic reactions. Although ointme...

AI Technical Summary

Problems solved by technology

Although the oral dosage form dissolves in gastric acid and is easy to absorb, it is widely distributed after absorption, and the blood concentration fluctuates greatly, which will bring many adverse reactions such as nausea, vomiting, abdominal pain, headache, etc., and occasionally liver damage and allergic reactions

Although ointment and other external dosage forms can reduce adverse reactions and expand the scope of clinical reference, they have the disadvantages of unsatisfactory transdermal effect, poor stability, and low bioavailability. They need to use azone, DMF, DMSO and other skin penetration to promote enhances transdermal absorption

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