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Application of cordycepin to preparation of related preparations for preventing and treating male sexual dysfunction

A technology of sexual function and cordycepin, applied in the field of biomedicine, can solve problems such as male sexual dysfunction that have not yet been seen, and achieve safe and effective prevention or treatment, good promotion and application prospects, and high safety effects

Inactive Publication Date: 2019-12-06
江苏集萃工业生物技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the development and application of cordycepin has attracted wide attention in the field of natural products at home and abroad, but there are no related studies and reports on its prevention and treatment of male sexual dysfunction.

Method used

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  • Application of cordycepin to preparation of related preparations for preventing and treating male sexual dysfunction
  • Application of cordycepin to preparation of related preparations for preventing and treating male sexual dysfunction
  • Application of cordycepin to preparation of related preparations for preventing and treating male sexual dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The establishment of embodiment 1 diabetic sexual dysfunction rat model and administration in groups

[0020] This example is a specific example of modeling, that is, artificial intervention is used to create pathological model rats of sexual dysfunction with normal rats.

[0021] Experimental method: 40 male SD rats were adaptively fed for 3 days. After fasting for 12 hours, 10 rats were randomly selected as the normal control group and injected with citric acid-sodium citrate buffer as a control. The remaining animals were intraperitoneally injected with streptozotocin at a dose of 65 mg / kg (the solvent was citrate buffer, pH 4.5). After 7 days, blood glucose higher than 16.7mM suggested the formation of diabetes model. If the blood glucose was lower than 16.7mM, the same dose of streptozotocin was injected intraperitoneally again.

[0022] The sexual dysfunction model was formed in rats with continuous hyperglycemia for 8 weeks, and the sexual dysfunction rats wer...

Embodiment 2

[0023] Embodiment 2 The influence of cordycepin on the sexual behavior of male rats

[0024] Experimental method: Take a number of mouse cages, put one male rat in Example 1 into each cage, place it under dark light, and let it adapt to the environment for 5 minutes. Then put in a female rat, and start to record: the time from the female rat to the male rat for the first time to catch the female rat, that is, the catch latency period; the number of times the male rat catches the female rat within 20 minutes from the female rat .

[0025] Result calculation and statistical analysis: The data of each experimental group is expressed as mean ± standard deviation (mean ± sd), and the statistical software SPSS 17.0 is used to test the homogeneity of variance, and each group with homogeneous variance is analyzed by one-way ANOVA , LSD method was used to compare between groups. P<0.05 was regarded as a statistically significant difference. See Table 1 for specific experimental resu...

Embodiment 3

[0030] Example 3 The effect of cordycepin on the anti-fatigue ability of male rats

[0031] Experimental method: load 5% body weight lead skin on the root of the tail of each group of experimental rats in Example 1, and place them in the swimming box for swimming. The water depth is not less than 60cm, and the water temperature is 25°C±1°C. The time from the start of swimming to exhaustion of the rats is recorded, that is, the weight-bearing swimming time of the rats.

[0032] Result calculation and statistical analysis: The data of each experimental group is expressed as mean ± standard deviation (mean ± sd), and the statistical software SPSS 17.0 is used to test the homogeneity of variance, and each group with homogeneous variance is analyzed by one-way ANOVA , LSD method was used to compare between groups. Pfigure 1 .

[0033] The results showed that, compared with the normal group, the weight-bearing swimming time of rats in the diabetic sexual dysfunction model group wa...

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Abstract

The invention discloses application of cordycepin to preparation of related preparations for preventing and treating male sexual dysfunction. Through research, it is found that the cordycepin has thetreatment effect on male sexual dysfunction caused by diabetes, the number of erection times of penises of mice can be obviously increased, the number of times of catching female mice by the male miceis increased, the inner pressure of corpora cavernosa penises of the mice is increased, the content of serum testosterone is increased, testicles of the mice are protected, a new application field isdeveloped for the cordycepin, and a new idea is provided for further development and utilization of the cordycepin. The cordycepin has the significant prevention and treatment effects on male sexualdysfunction, and also has high safety, application of the cordycepin to preparation of drugs or health food for preventing or treating male sexual dysfunction is safe and effective, and good application and popularization prospects are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of cordycepin in the preparation of related preparations for preventing and treating male sexual dysfunction. Background technique [0002] Male sexual dysfunction is mainly manifested clinically as decreased desire for sexual life in male patients, decreased frequency of erection during sexual life, weakened erectile ability to varying degrees, premature ejaculation, decreased frequency of sexual behavior, etc., and may be accompanied by decreased androgen, gonadal Reduced functionality, etc. According to statistics, 52% of men aged 40 to 70 suffer from different degrees of sexual dysfunction. Excessive fatigue, chronic diseases, endocrine disorders, and damage to reproductive organs and other diseases or the influence of various drugs are all risk factors that induce male sexual dysfunction. Among them, diabetes is a common disease with a high i...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P15/00A61P15/10A23L31/00A23L33/10
CPCA61K31/7076A61P15/00A61P15/10A23L31/00A23L33/10A23V2002/00A23V2200/30A23V2250/208
Inventor 应汉杰陈勇张琪刘庆国唐成伦赵南邹亚男柳东
Owner 江苏集萃工业生物技术研究所有限公司
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