Nervonic acid composition and application thereof in neuroprotection

A technology of nervonic acid and composition, applied in the field of medicine, can solve the problems such as functional disorders and there is no very effective method, and achieve the effects of improving cerebral blood and cerebral metabolic functions, reducing pain and shortening the course of treatment

Pending Publication Date: 2019-01-01
沈阳高名医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the hospital attaches great importance to the early rehabilitation training after cerebral infarction, and some drugs with neuroprotective agents as the core have some positive effects in clinical practice, but generally speaking, at present, the limbs, language, and consciousness of patients with myocardial infarction and cerebral infarction are not affected. There is no very effective way to deal with dysfunction, especially safe and effective natural medicines or health products, which have not been reported yet.

Method used

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  • Nervonic acid composition and application thereof in neuroprotection
  • Nervonic acid composition and application thereof in neuroprotection
  • Nervonic acid composition and application thereof in neuroprotection

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preparation example Construction

[0066] The preparation method of the nervous acid composition provided by the invention is not particularly limited, as long as the components are mixed.

[0067] The invention provides the application of the nervonic acid composition in the preparation of neuroprotective medicines.

[0068] In the present invention, the neuroprotection preferably includes neuroprotection in establishing collateral circulation after cerebral apoplexy, reducing or avoiding the dysfunction and disability of the patient's limbs, language and spirit, hemiplegia, aphasia, and peripheral neuropathy caused by cerebral apoplexy Aspects, promoting intellectual development, delaying brain aging, repairing nerve cell damage and / or preventing and improving encephalopathy.

[0069] In the present invention, the medicine also includes auxiliary materials. The auxiliary materials include non-dairy creamer, sucrose, maltitol, starch, dextrin, maltodextrin, gelatin, glycerin, water, starch, silicon dioxide, m...

Embodiment 1

[0076] Neural acid-containing vegetable oil extraction

[0077] Remove impurities and shells from the seeds of Maple indica, winnow the seed kernels of Maple indica, grind the seed kernels of Maple ingot into a fine powder with a particle size of less than 300 microns; use petroleum ether as an extraction solvent for ultrasonic extraction; petroleum ether and seeds The mass ratio of kernel powder to liquid is 1:10, the ultrasonic power is 50W, the ultrasonic time is 70min, and the temperature is 38-42°C. Crude oil is refined to obtain oil with a peroxide value lower than 0.20g / 100g.

Embodiment 2

[0079] Production of oil powder

[0080] 1 part of vegetable oil or celery seed oil containing nervous acid, 1.5 parts of sodium starch octenyl succinate, 1.5 times of sodium starch in purified water. Soak octenyl starch sodium succinate in purified water for 6 hours, stir to dissolve, add nervous acid vegetable oil or celery seed oil, cut the material with a shearing machine (12000 rpm) for 10 minutes, and import the material into a homogenizer to control The temperature is 40-60°C, the pressure is 10-18MPa, the material is homogenized twice, and the homogenized material is spray-dried, the spray pressure is 15-20MPa, the inlet temperature is 140-160°C, the exhaust air temperature is 70-80°C, after spraying Dry to obtain powdered oil.

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Abstract

The invention provides a nervonic acid composition and application thereof in neuroprotection, and belongs to the field of medicines. By organically compounding nervonic acid, phosphatidylserine, DHA,celery seed oil, Chinese herb extracts and nutrient supplements according to an assistant and guide principle, the nervonic acid composition integrates a nerve cell nutrient, a nerve fiber repair agent, a neurotransmitter activator, a nerve energy security agent and other mechanisms, so that the permeability of a nerve cell membrane is improved by using multiple systems and multiple ways, the release of a neurotransmitter is promoted, the conduction of nerve impulse is accelerated, a nerve information passage is repaired and dredged, and the brain function is activated or reversed. The nervonic acid composition breaks through the limit and the defect of a certain component which is singly applied, and becomes an important product for preventing and treating encephalopathy. Experiments onmore than 3,000 volunteers by trial products prove that the nervonic acid composition has a comprehensive health-care effect on the nervous system, and particularly has a satisfactory effect of preventing and reversing physical disability, language barrier and mental disorder of patients suffering from cerebral apoplexy.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a nervonic acid composition and its application in neuroprotection. Background technique [0002] Nervous system diseases and cardiovascular diseases are two major types of diseases that threaten human life and health. The causes of the two types of diseases and the process of treatment and rehabilitation are closely related. During the attack period of myocardial infarction and cerebral infarction, blood flow disorder, oxygen and energy interruption or insufficient supply, metabolic disorder, damage to the permeability of cell membrane, and imbalance of internal and external ion transport cause nerve cell damage or apoptosis. The loss of neuron quality is also the direct cause of limb, language and mental dysfunction in patients with myocardial infarction and stroke. And the disability rate is as high as 70%. It brings great pain and heavy economic burden to individuals and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P25/00A61P9/10A61K31/201A61K31/685A61K31/202A61K31/185A61K31/375A61K33/30A61K31/4188A61K31/51A61K31/4415A61K31/405
CPCA61K31/185A61K31/201A61K31/202A61K31/375A61K31/405A61K31/4188A61K31/4415A61K31/51A61K31/685A61K33/30A61K36/064A61K36/16A61K36/23A61K36/254A61K36/258A61P9/10A61P25/00A61K2300/00
Inventor 崔晓廷王悦
Owner 沈阳高名医药科技有限公司
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