364results about How to "Easy to refactor" patented technology

A lyophilized solid composition of taxane (preferably docetaxel and paclitaxel), is suitable to prepare a pharmaceutical formulation to be administered to mammals, particularly humans, comprising a taxane, a tensoactive, a lyophilizing excipient, and acid; also essentially free from organic solvents. The solid composition is free from polysorbate 80 and polyoxyethylated castor oil; it is sterile; it is soluble in aqueous solutions in the absence of organic solvent and it has an apparent density from 0.05 g/ml to 0.45 g/ml. A procedure of double lyophilization obtains a solid composition of taxane. A pharmaceutical formulation of a taxane comprises a solid composition of lyophilized taxane and a solubilizing composition. A kit comprises the compositions and a syringe.

The invention provides a navigational constellation slow varying inter-satellite link planning method based on earth station layout constraints. First of all, a satellite-earth link visible model and an inter-satellite visible model are constructed, then inter-satellite/satellite-earth visible time slot preprocessing is carried out, after the topology structure of a constellation is established, a router optimized constraint model and an optimization object function are determined, and a router table of a navigational constellation slow varying inter-satellite link is obtained through solving the model. According to the invention, the problem of managing a global navigational constellation through the slow varying inter-satellite link under the condition of a scarcity of ground measurement and control resources is solved, the model better meets engineering needs, the application value is quite good, and a new router can be rapidly established at a minimum cost in case that nodes are changed.

A pharmaceutical formulation of taxane intended to be administered to mammals, preferably humans, comprises two compositions combined prior to being administered, forming a transparent solution free from precipitates, in which the compositions comprise a solid composition of lyophilized taxane, free from tensoactives, oils, polymers, solubility enhancers, preservatives and excipients; and a solubilizing composition of the lyophilized taxane solid composition that comprises at least one tensoactive. This formulation is free from polysorbate 80 and polyoxyethylated castor oil. A procedure is provided for the preparation of the solid composition by means of the lyophilization of taxane in a lyophilizing organic solvent. A kit for the injectable formulation of taxane comprises a prefilled syringe. Also a pharmaceutical taxane solution for perfusion, free from organic solvent, is provided.

This invention is directed to the novel composition of matter trimetrexate ascorbate, to compositions comprising trimetrexate ascorbate, and to compositions comprising trimetrexate and ascorbic acid. These compositions are useful in the treatment of diseases in mammals such as, but not limited to, cancer, bacterial and protozoal infections, malaria, psoriasis, and rheumatoid arthritis. The invention is further related to methods of stabilizing trimetrexate to degradation caused by heat, light, oxygen, or water.

A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.

The invention relates to a sliding plate conveying system with an accompanied lifting function. The sliding plate conveying system with the accompanied lifting function comprises a railway, sliding plate devices, friction wheel drive devices, a piece-down lifting table device and a piece-up lifting table device, wherein the plurality of sliding plate devices are arranged on the railway and can travel along the railway; the sliding plate devices are used for loading workpieces; the plurality of friction wheel drive devices are arranged along the line of the railway and are used for driving the sliding plate devices; the piece-down lifting table device and the piece-up lifting table device are respectively arranged along the line of the railway; the piece-up lifting table device is used for placing the workpieces on the sliding plate devices; and the piece-down lifting table device is used for taking the workpieces from the sliding plate devices. The sliding plate conveying system with the accompanied lifting function has an ingenious structure, strong functions, high flexibility, a wide application range, and high working reliability. The sliding plate conveying system with the accompanied lifting function cannot only realize the plane conveying of the workpieces on the ground or in the air, but also realize full-space three-dimensional conveying of the workpieces among the ground, the air and the railway; and simultaneously the system can realize station identification and workpiece online lifting functions, reduce labor intensity and improve efficiency.

The invention discloses a single-pixel terahertz holographic imaging device and method. Monochromatic terahertz light emitted by a terahertz laser source is transformed into parallel light with larger beamwidth by a beam expander device, and then divided into object light and reference light through a beam splitter; the object light is encoded by a modulation device in airspace after irradiating an object; the reference light passes through an adjustable phase shifter on the light path after being reflected by a plane mirror; the object light is converged with the reference light on a second beam splitter after being reflected by the plane mirror, enters a single-pixel detector at the focus point of a condenser lens after being converged by the condenser lens; a signal output by the single-pixel detector is fed to a control module to carry out image reconstruction; and terahertz holographic compression sensing imaging of the object is achieved by changing combination of a space code on the modulation device and a phase on the adjustable phase shifter for a plurality of times. The single-pixel terahertz holographic imaging device and method have the advantages that real three-dimensional imaging of the tested object is achieved by combining phase-shifting digital holography with a compression sensing principle, and the single-pixel terahertz holographic imaging device and method are pioneering inventions in the field of terahertz imaging.

Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) mixing said first component and said second component under conditions effective to form a wet paste while essentially preventing degradation of the second component by said first component in a final container or transferring said wet paste into a final container, d) freezing and lyophilizing said paste in said container thereby obtaining a dry and stable hemostatic composition comprising said first and said second component in lyophilized form, and e) finishing said dry and stable hemostatic composition in said final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.

The invention discloses a pedestrian re-recognition method based on an unsupervised deep model and hierarchical attributes. The method includes the steps of first, pre-processing a pedestrian picture and dividing the pedestrian picture into a plurality of overlapping blocks according to body parts; second, constructing a convolutional neural network (CNN) with three hidden layers, training the model through a stacked convolutional auto-encode (CAE), and pre-training and fine-tuning the model using CUHK and VIPeR pedestrian data sets, respectively; third, designing hierarchical attributes for the pedestrian and a classifier for each attribute, and inputting pedestrian features extracted from the CNN to each attribute classifier to obtain the probability of the corresponding attribute; and fourth, obtaining the posterior probability of the category by combining an attribute category mapping relation to determine the category to which the sample belongs. According to the invention, the problem of lacking a labeled training sample is effectively solved by pre-training the CNN model with an unsupervised learning method of the CAE; the accuracy of pedestrian re-recognition is effectively improved by using the characteristics that the CAE can be used to well reconstruct an image; and the re-recognition of pedestrians is more in line with the law of human cognition by introducing the hierarchical attributes, so that the pedestrian re-recognition method is allowed to have a semantic expression ability and a practical application value.

The invention discloses an SIP (Session Initiation Protocol)-based regional ground-to-air radio station voice networking system which comprises a plurality of ground-to-air radio stations and also comprises a tandem scheduling server, an SIP (Session Initiation Protocol) radio station voice communication terminal and a networking node network element device, wherein the networking node network element device is connected between the tandem scheduling server and the SIP (Session Initiation Protocol) radio station voice communication terminal and connected with the ground-to-air radio stations.The SIP (Session Initiation Protocol)-based regional ground-to-air radio station voice networking system can realizes integration with a ground-to-air data link system and can realize goal-oriented ground-to-air voice command which is compatible and coordinated with ground-to-air data link system; and a commander can synchronously obtain the voice command control capacity when seeing a target. Moreover, a communication link for directly implementing the voice command control on first-line task aircrafts is provided for a remote high-level command center within shorter setup time and in more flexible setup mode so that commands of chief executives can reach the first-line aircrafts immediately and the effect that a link can be uses as long as set up is achieved.

The invention discloses a region-division-based three-dimensional reconstruction method for a texture image. The method comprises the following steps: reading texture image information, performing region division on the texture image to obtain texture division regions, and performing region grouping; calculating height values of pixels in the texture image to obtain three-dimensional texture points of the pixels in the texture image by adopting a method of shape from shading; calculating the color roughness of each texture division region, determining the sizes of triangular meshes of different division regions, reconstructing a triangular patch of each division region, and converting the texture image into a three-dimensional texture graph to realize the three-dimensional reconstruction of the texture image. According to the method, the microscopic three-dimensional geometric shape of the surface of a virtual object reflected by the texture image is better reconstructed; microscopic details of the texture image are ensured, and complexity in the three-dimensional reconstruction of the texture image is further lowered; different physical attributes can further be endowed to different regions according to region grouping, so that a foundation is laid for the tactile sensation of the texture image.

The invention discloses a tissue engineering fiber bundle structure body and a preparation method thereof. The invention provides a method A or B for preparing hydrogel fiber filaments containing cellular components. The method A comprises the following steps: 1) compositing a hydrogel material utilized as a matrix with cellular components to obtain a mixture containing cellular components; and 2) putting the mixture obtained in the step 1) into crosslinked fluid corresponding to the matrix to undergo crosslinking, thus obtaining the hydrogel fiber filaments containing cellular components. Experiments prove that the design can comprehensively meet the special bionic requirements of high-density cell composition, good vascularization development trend and achievement of directionally ordered structure in tissue engineering, so that the structure body is good in vascularization development prospect and can hopefully break through the development bottleneck that the tissue engineering can not become large and thick at present.

An optical module conversion device based on modulator multichannel demultiplexing comprises a high-rate pulsed laser, a photon sampling gate, a multichannel demultiplexing module, a radio frequency frequency-synthesizing module, a parallelized photoelectric conversion module, a parallelized electrical sampling module and a data processing unit. The multi-channel demultiplexing is realized by using the optical switch effect of the modulator, and the high-speed optical sampling pulse is demultiplexed by the cascading modulator step by step. Finally, the parallelized photoelectric conversion, electrical sampling and data processing are utilized in a compound mode to realize the acquisition of the sampled signal. The device plays a critical role in improving the performance of microwave photon systems which require high sampling rate, high time precision and high sampling precision, wherein the microwave photonic systems comprise microwave photon radars, optical communication systems and the like.

The invention discloses a genetic evolution image rebuilding method based on a Ridgelet redundant dictionary, and the method is used for solving the problem that the image rebuilt by the existing L0 norm rebuilding technology is poor in visual effect. A rebuilding process comprises the following steps of: clustering all partitioning observation vectors according to the level of similarity by selecting a proper clustering algorithm; initiating clusters; carrying out the common genetic evolution on the initiated clusters; rebuilding an initial image; updating by means of filtering and convex projecting; judging whether evolution algebra reaches a maximum value or not; updating the sparsity; updating the clusters; carrying out the independent genetic evolution on the image blocks; and rebuilding the image. In the method, the similar clusters of the image blocks are used, and the optimal Ridgelet redundant dictionary base atom is found for each image block of each cluster by a genetic evolution computation thought, so that the time complexity of the algorithm is reduced, the blocking effect in the rebuilt image is removed by means of filtering and convex projecting, the search space of the optimal solution is shortened, the image is high in rebuilding precision, and the image is good in rebuilding effect, so that the method can be used for the fields of image processing and computer vision.

The present invention relates to a method for identifying and/or validating candidate substances for the treatment of Friedreich Ataxia (FRDA). Furthermore, the present invention relates to the use of selenium, Ebselen and Glutathione peroxidase (GPX) mimetics for the preparation of a medicament for the treatment of FRDA. Another aspect of the present invention relates to the use of cells with reduced frataxin expression for identifying and/or validating candidate substances for the treatment of Friedreich Ataxia.

The invention discloses a method for reconstructing multi-spectral information calculation based on principal component analysis. The method comprises the following steps of: 1, acquiring two paths of multi-spectral images; 2, performing principal component analysis on the spectral information of sampling points of the multi-spectral images to obtain a principal component spectral vector basis; and 3, reconstructing the spectral information on the unknown spectral points according to the principal component spectral vector basis, red, green and blue (RGB) vectors which are acquired by a camera, an R channel integral curve of the camera, a G channel integral curve of the camera and a B channel integral curve of the camera. By the method, multi-spectral information can be more simply and more quickly reconstructed; the required scene spectral sampling points are few; and principal components of the multi-spectral information can provide instructive significance for related research.

A distributed control system for one or more multi-freedom robots features that an industrial computer is connected via Ethernet to one or more multi-freedom robot movement plan controllers A, which is connected via CAN-bus to one or more DSP-based modular robot' s individual joint controllers B, and a DC power supply is connected with one or more said controller A and controllers B.

The invention discloses a super-resolution image reconstruction method based on structure self-similarity and sparse representation. The method includes the main steps of firstly, filtering a set of training sample image to extract features; then, extracting small patches to construct a dictionary including a high-resolution image block and a low-resolution image block in pair, conducting interpolation amplifying on an inputted low-resolution image, conducting filtering to extract the features, solving a reconstructed weight matrix W, conducting iteration to renew a sparse coefficient {alpha i} and a high-resolution image X to be reconstructed; finally, recovering a satisfying high-resolution image till the iteration is convergent. According to the method, the structure self-similarity of the image is used for solving the problem that an existing method is not high in quality. The operation time is short, the efficiency of image reconstruction is high, the quality of the reconstructed image is high, and various natural images which include non-texture images such as animal and plant images and human images and strong-texture images such as architecture images can be reconstructed.

The invention provides a ground object tracking device based on image key point characteristic coupling. The device comprises a field programmable gate array FPGA and a digital signal processor DSP. The FPGA is used for extracting the image characteristic of an external camera feed image sequence, thus completing adjacent interframe characteristic matching, and transmitting a successful interframe characteristic matching result to the DSP. The cross correlation accurate matching is carried out according to the interframe geometry transformation relation fed by the DSP. The digital signal processor DSP is used for calculating the adjacent image interframe transformation relation according to the characteristic coupling result outputted by the FPGA. According to the ground object tracking device, a complex target tracking method based a characteristic point is completed realized in an embedded FPGA, the interframe transition relation calculation is realized on the DSP, the algorithm complexity and low-power requirement of an embedded board are considered, a lot of image data is processed in real time, and compared with the prior art, the algorithm processing speed is improved by an order of magnitude.

The invention discloses a layered parallel connection two-degree-of-freedom precise positioning platform based on flexible beams. The positioning platform comprises a lower layer guiding platform, an upper layer decoupling platform, an X-axis driving assembly and a Y-axis driving assembly. The lower guiding platform provides a guide for the upper layer motion structure platform and structurally mainly comprises four sets of flexible guide rails based on flexible hinges; the upper motion decoupling platform is composed of four sets of flexible hinges and a bearing platform, wherein the four sets of flexible hinges and the bearing platform are used for achieving motion decoupling; a motor installing and locking mechanism comprises motor connectors, flexible push rods, motor installation plates and a motor shaft locking mechanism. The upper layer motion decoupling platform is connected with the lower layer flexible guiding platform through eight locking screws. Precision linear motors are connected with the motor connectors through screws. The motor installation plates are connected with the guiding flexible platform through screws in a rigid mode, and two threaded holes are respectively provided for the installation of the motor connectors.