The invention belongs to the technical field of medicines, and particularly relates to stable Shugeng glucose 
sodium injection and a preparation method thereof. The preparation method comprises the following steps that (1) 
medicine liquid is prepared, specifically, 
inert gas is blown into a liquid preparation tank, dissolved 
oxygen of the water for injection is monitored, raw materials of Shugengglucose 
sodium with prescription quantity are added into the liquid preparation tank and stirred, and the 
inert gas is continuously blown into the liquid preparation tank; (2) filling and sealing areconducted, specifically, after an intermediate is inspected to be qualified, sterilizing and filtering are conducted, after visible foreign matters are inspected to be qualified, filling is conducted,in the filling process, sterile 
inert gas is firstly used for purging an ampule 
bottle, and the ampule 
bottle is filled with the sterile 
inert gas; the ampule 
bottle is filled with the 
medicine liquid; and the ampule bottle filled with the 
medicine liquid is filled with the sterile 
inert gas, and the sealing of the ampule bottle is completed; (3) sterilization and 
leak detection are conducted; and (4) inspection and warehousing are conducted.