17 results about "Radiolysis" patented technology

To provide a radionuclide complex solution of high concentration and high chemical stability which can be used as a medicine for diagnosis and / or treatment.SOLUTION: Provided is a pharmaceutical composition comprising: (a) a complex formed by: (ai) a radionuclide; and (aii) a gastrin releasing peptide receptor peptide antagonist binding moiety linked to a chelating agent; (b) at least two stabilizers against radiolysis; and (c) optionally a surfactant.SELECTED DRAWING: None

The application discloses a heavy atom enhanced calix cyanine dye radioactivity detection colorimetric sensor, the dye is prepared by introducing heavy atoms in the calix cyanine dye skeleton, and the radiation sensitivity is significantly improved; the dye reacts with hydroxyl radicals generated by water radiolysis under the action of radiation, conjugate structure is destroyed, and color change from green to yellow is generated; the application comprises a colorimetric test strip prepared from the dye, and a detection system integrated with a smartphone image recognition function, the test strip comprises a base material and an additive; the additive comprises a copolymer, and preparation reaction monomers of the copolymer comprise N,N-diethylaminoethyl acrylate and 3-methylpent-2-ene dimethyl acid; the application has the advantages of high sensitivity, low cost, simple operation, portability and the like, can be used for rapid, visual and quantitative detection of radionuclides in water solution, urine and the like samples, and has important application value in the field of nuclear medicine radiation safety monitoring.

The invention provides an experimental device for measuring radiolysis gas yield and recording radiolysis bubble behaviors and an experimental method thereof, and belongs to the technical field of flow measurement. The problem that in the prior art, radiolysis gas yield cannot be measured while radiolysis bubble behaviors cannot be recorded is solved. The device comprises an electron accelerator, a quartz glass container, a gas chromatograph, a helium purging device, a high-speed camera, a light supplementing lamp, a reflecting mirror and a data acquisition system, the electron accelerator and the quartz glass container are connected with the data acquisition system, and the two ends of the quartz glass container are connected with the gas chromatograph and the helium purging device respectively. Reflecting mirrors are arranged on the two sides of the quartz glass container, a light supplementing lamp is arranged below the reflecting mirror close to the helium purging device, a high-speed camera is arranged below the other reflecting mirror, and the high-speed camera is connected with a data acquisition system. The device is mainly used for measuring the yield of radiolysis gas and the behavior of radiolysis bubbles.

In one aspect, the disclosure relates to a method for neuromodulation in a target, wherein the target can be an isolated plurality of cells, an isolated organ, or an animal subject In an aspect, the method includes at least the step of delivering X-ray radiation to one or more neurons in the target, wherein the one or more neurons express dTRPA1(A)10b, and wherein the X-ray radiation generates H2O2 via radiolysis of water. In a further aspect, the H2O2 can increase intracellular calcium ions which can, in turn, stimulate the release of neurotransmitters. Also disclosed are treatments of diseases, disorders, and symptoms thereof using the disclosed method.

This application discloses a method for controlling the operation of a medical isotope production reactor. This method, based on a fuel solution with a specified uranium concentration, pH value, catalyst content, and catalyst content, preliminarily controls the generation of uranium hydrolysis precipitation, corrosion, and fission product precipitation by coupling reactions between uranyl ions and fission, radiolysis, and corrosion products. The method further integrates multiple factors, including reactor power density, solution replenishment rate, operating temperature range, and operating cycle, to design a control strategy for the medical isotope production reactor. This reduces the likelihood of complex chemical reactions occurring due to coupling between uranyl ions and fission, radiolysis, and corrosion products, effectively suppressing precipitation caused by multiple factors during the operation of the medical isotope production reactor. This eliminates the feedback effect of precipitation on core reactivity, ensures the stability of the medical isotope production reactor during operation, and facilitates the rapid extraction of required nuclides.

To provide an organic compound decomposition device that can efficiently decompose organic compounds while reducing the cost, energy consumption, and CO2 emissions associated with the decomposition process. [Solution] The organic compound decomposition apparatus S according to the present invention is characterized by comprising: a radiation source 1 that generates radiation; a radiolysis vessel 2 that uses radiation from the radiation source 1 to decompose an organic compound to be processed and obtain decomposition products with reduced molecular weight; a heat recovery unit 41 that recovers the heat generated from the radiation source 1; and a heat supply unit 42 that supplies the recovered generated heat to the radiolysis vessel 2 or a processing vessel 31 that heats and processes one or more of the organic compound and the decomposition products.

The invention discloses a method and system for estimating the concentration of radioactive iodine species in a containment after an accident, and the method comprises the steps: inputting the content of gaseous iodine in the atmosphere of the containment, and calculating the acid content in the wall surface of the containment and the liquid phase of a pit; on the basis of the content of acid in the pit liquid phase and the content of a medicine added into the pit in advance, the pH value in the pit liquid phase is calculated through a pH model; determining the content of iodine which enters the liquid phase of the pit and does not participate in the chemical reaction of the liquid phase; on the basis of the content and the pH value of iodine which can be subjected to chemical reaction in the pool, combining an iodine water chemical equation, and calculating through a liquid phase chemical reaction model to obtain the concentrations of different iodine species in a liquid phase; calculating the mass transfer amount of gaseous iodine in the gas phase between the containment atmosphere and the pit water based on a pool mass transfer model; the content of gaseous iodine in the containment atmosphere is calculated through a gaseous iodine radiolysis and ionization model; determining the content of iodine deposited on the dry wall surface of the containment based on a gaseous iodine deposition model; and finally outputting the concentration of each iodine species in the gas liquid.

The invention discloses a high polymer material radiolysis micromolecule product detection method which comprises the following steps: S1, filling a high polymer material into a solid phase microextraction device to form a negative pressure state; s2, performing gamma ray irradiation on the solid-phase microextraction device; s3, solid-phase microextraction fibers in the solid-phase microextraction device are taken out, and radiolysis micromolecule products adsorbed on the solid-phase microextraction fibers are analyzed through a gas chromatography-mass spectrometer; and S4, analyzing and determining the chemical structure of the radiolysis small molecule product, establishing a quantitative working curve between the peak area and the concentration of the standard product by combining the standard product, and calculating to obtain the content of the radiolysis small molecule product of the high polymer material under the radiation dose. According to the invention, solid-phase microextraction is combined with gas chromatography-mass spectrometry to analyze small molecular substances after high polymer materials such as rubber, resin and the like are irradiated, so that the ray irradiation resistance of the high polymer materials is evaluated; by combining qualitative and quantitative analysis methods, the content of micromolecular products of the high polymer material under different radiation doses can be obtained.

This invention provides a simulation method for the generation of organic iodine based on the Kolbe electrolysis reaction, belonging to the field of spent fuel reprocessing technology. This method introduces iodine into the Kolbe electrolysis reaction and compares the intrinsic ability of different forms of iodine to react with alkyl radicals to generate organic iodine. Compared with traditional simulation experiments under irradiation conditions, the method of this invention can conveniently obtain alkyl radicals through electrochemical reactions, eliminates the interference of water radiolysis products in the irradiation environment, and provides a clear understanding of the organic iodine conversion capabilities of different forms of iodine; moreover, it does not require specific irradiation equipment and shielding measures, facilitating real-time control and sampling analysis of the reaction, and has better simplicity and operability.

The invention provides a sedimentary basin natural hydrogen resource quantity calculation method and application thereof, and relates to the technical field of resource exploration, and the method comprises the following steps: determining the total hydrogen production rate, capture efficiency, hydrogen loss rate and hydrogen residence time of a target area, and calculating the geological resource quantity of natural hydrogen in the target area by using a material balance method; wherein the total hydrogen production rate comprises a hydrogen generation rate from at least one of serpentine reaction, radioactive radiolysis and deep mantle degassing; the capture efficiency is the proportion of effective storage of the generated hydrogen by the geological trap; the hydrogen loss rate is the annual loss amount of hydrogen in the underground system due to physical, chemical and biological loss mechanisms; the hydrogen residence time is the time when the hydrogen stays in the geologic body and is stored. According to the method, key parameters such as the total hydrogen production rate, the capture efficiency, the hydrogen loss rate and the residence time are comprehensively considered, and the natural hydrogen geological resource quantity calculation model suitable for the sedimentary basin scale is constructed for the first time.

The invention discloses a medicine molecule modified by thioimine and application of the medicine molecule. The pharmaceutical molecule has a structure as shown in formula (I) or a pharmaceutically acceptable salt thereof: A-B (I); wherein the structure of the group A is shown in the specification; the group B is an anti-cancer drug group, and S in the group A is connected with amino in the group B through a sulfur imine bond. According to the compound, the cytotoxicity of the anti-cancer drug is shielded through the A group, the cytotoxicity of the anti-cancer drug can be reduced, when the compound enters a tumor tissue, a sulfur imine bond is induced to break, activate and release the anti-cancer drug through radiation, the anti-tumor activity of the original anti-cancer drug is recovered, and particularly, the high radiolysis yield of 240 nM / Gy or above can be achieved. Therefore, the compound can be used as a radiotherapy response drug for treating cancers, can enhance the treatment effects of chemotherapy and radiotherapy, and has the advantages of improving the biological safety and the like.

The present invention relates to the fields of ionizing radiation technology and gold extraction technology, and more specifically, to a method for selectively dissolving gold from gold ore using ionizing radiation. The method comprises the following steps: immersing the gold ore to be extracted in a solution of an organic nitrile compound, irradiating it with high-energy radiation to induce radiolysis, thereby selectively dissolving the gold in the ore. This method is gentle, energy-saving, green, efficient, environmentally friendly, and low-cost. It eliminates the need for highly corrosive aqua regia and highly toxic cyanide, and requires no external catalysts or oxidants. It selectively dissolves gold while leaving base metals (such as iron, copper, zinc, and nickel) undissolved.

The invention relates to the technical field of ionizing radiation and metal extraction, in particular to a method for leaching and recycling ternary lithium battery waste through ionizing radiation. The method comprises the following steps: immersing a ternary lithium battery material to be extracted into a dilute sulfuric acid solution, carrying out radiolysis reaction through irradiation by utilizing strong penetrating power of high-energy rays, and reducing high-valence metal by utilizing hydration electrons generated by water decomposition through irradiation, so as to realize extraction of the ternary lithium battery material in a non-oxidizing dilute acid solution. And lithium, cobalt, nickel and manganese in the ternary lithium battery waste are efficiently leached out. The method disclosed by the invention has the advantages of mildness, energy conservation, greenness, high efficiency, environmental protection and low cost, does not depend on oxygen, does not need heating, does not need other additional catalysts and reducing agents, and can efficiently react at room temperature.

The present invention relates to methods and kits for radiolabelling a chelate-functionalized targeting agent with a metal radionuclide being gallium-68, using a stabiliser that prevents radiolysis (product degradation) of the chelate-functionalized targeting agent, wherein said stabiliser is selected from the group consisting of: ascorbic acid, dehydroascorbic acid, gentisic acid, cysteine and methionine, sodium ascorbate, or a salt thereof, preferably as a solution. The invention further relates to the use of said stabilizer against radiolytic decomposition of a radiolabelled chelate-functionalized targeting agent composition and methods of detecting a prostate tumour or cancer using the method for radiolabelling.

The invention discloses a cyanine dye radioactivity detection colorimetric sensor based on heavy atom enhancement, the cyanine dye is prepared by introducing heavy atoms into a cyanine dye skeleton, and the radiation sensitivity of the cyanine dye is obviously improved; the dye reacts with hydroxyl radicals generated by water radiolysis under the radiation effect, a conjugated structure is damaged, and the color change from green to yellow is generated; the dye comprises a colorimetric test strip prepared from the dye and a detection system integrated with an intelligent mobile phone image recognition function, and the test strip comprises a base material and an additive; the additive comprises a copolymer, and preparation reaction monomers of the copolymer comprise acrylic acid N, N-diethylaminoethyl ester and 3-methylpentyl-2-enedioic acid dimethyl ester; the method has the advantages of being high in sensitivity, low in cost, easy and convenient to operate, convenient to carry and the like, can be used for rapidly, visually and quantitatively detecting radionuclides in samples such as water solutions and urine, and has important application value in the field of nuclear medicine radiation safety monitoring.

In one aspect, the disclosure relates to a method for neuromodulation in a target, wherein the target can be an isolated plurality of cells, an isolated organ, or an animal subject. In an aspect, the method includes at least the step of delivering X-ray radiation to one or more neurons in the target, wherein the one or more neurons express dTRPA1(A)10b, and wherein the X-ray radiation generates H2O2 via radiolysis of water. In a further aspect, the H2O2 can increase intracellular calcium ions which can, in turn, stimulate the release of neurotransmitters. Also disclosed are treatments of diseases, disorders, and symptoms thereof using the disclosed method.

The application discloses an organic small-molecule-based superlattice copper selenide composite material and a preparation and application thereof, and belongs to the field of new materials and electrochemistry technology. The application takes aliphatic amine organic small molecules such as diethylenetriamine as a morphology control and superlattice intercalation molecule, utilizes hydration electrons generated by water radiolysis to reduce sodium selenosulfite and copper ions in a precursor solution, and synthesizes the organic small-molecule-based superlattice copper selenide composite material. The composite material has a nanosheet structure, excellent conductivity and reversible zinc storage capacity, and exhibits excellent rate performance and cycle stability as an electrode material of a water-based zinc ion battery. Moreover, the preparation method of one-step radiation reduction has mild conditions, is flexible and controllable, has low energy consumption and small environmental pollution, is favorable for the design of atomic-level defects and weakening of the damage to the structure and morphology of copper selenide in the preparation process.