Preparation method of double-layer type water-proof, anti-bacterial and anti-cicatricial chitosan sponge dressing

A chitosan, double-layer technology, applied in the application field of biomedical materials, can solve the problems of limited protection, difficulty in promoting wound repair, secondary damage, etc.

Inactive Publication Date: 2018-01-09
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional medical dressings are mainly made of gauze and bandages, which passively cover the wound surface to absorb exudate, provide limited protection for the wound surface, and are difficult to promote wound healing. Secondary injury due to adhesion

Method used

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  • Preparation method of double-layer type water-proof, anti-bacterial and anti-cicatricial chitosan sponge dressing
  • Preparation method of double-layer type water-proof, anti-bacterial and anti-cicatricial chitosan sponge dressing
  • Preparation method of double-layer type water-proof, anti-bacterial and anti-cicatricial chitosan sponge dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] First, 3 g of molecular weight 1 × 10 4 Da, the chitosan that deacetylation degree is 80% is dissolved in the acetic acid solution that 300mL volume ratio concentration is 1% (v / v), packs into mold and adds 4mL volume ratio concentration and is 2% (v / v) pentadiene Aldehydes were cross-linked at 35°C for 1 hour to obtain a chitosan hydrogel with a cross-linking degree of 10%, soaked in deionized water, rinsed, and lyophilized after removing acetic acid and excess glutaraldehyde to obtain a chitosan sponge. Then soak half of the sponge with 200mL mass volume ratio concentration of 0.03% (w / v) ethanol solution of lauric acid for 1 hour, dry to form a hydrophobic layer, and the other half of the sponge with 200mL mass volume ratio concentration of 10% (w / v) Soak in the glucosamine aqueous solution for 2 hours, freeze-dry to form a hydrophilic layer, and make a double-layer chitosan sponge dressing after sterilization.

Embodiment 2

[0015] First, 9 g of molecular weight 5 × 10 5 Da, the chitosan that the degree of deacetylation is 70% is dissolved in the acetic acid solution that 300mL volume ratio concentration is 2% (v / v), packs into mold and adds 40mL volume ratio concentration and is 1% (v / v) epoxy resin Chloropropane was cross-linked at 20°C for 3 hours to obtain a chitosan hydrogel with a cross-linking degree of 20%, soaked in deionized water, rinsed, and lyophilized after removing acetic acid and excess epichlorohydrin to obtain chitosan Sponges, then soak half of the sponges with 200mL mass-volume concentration of 0.01% (w / v) stearic acid ethanol solution for 1 hour, dry to form a hydrophobic layer, and the other half of the sponges with 200mL mass-volume concentration of 20% (w / v) / v) soaked in glucosamine aqueous solution for 1 hour, freeze-dried to form a hydrophilic layer, and made a double-layer chitosan sponge dressing after sterilization.

Embodiment 3

[0017] First, 5g of molecular weight is 1×10 5 Da, deacetylation degree is that the chitosan of 85% is dissolved in the acetic acid solution that 300mL volume ratio concentration is 3% (v / v), packs into mold and adds 5mL mass volume ratio concentration and is 10% (w / v) three Sodium polyphosphate was cross-linked at 15°C for 2 hours to obtain a chitosan hydrogel with a cross-linking degree of 10%, soaked in deionized water, rinsed, and lyophilized after removing acetic acid and excess sodium tripolyphosphate to obtain chitosan hydrogel. Sugar sponge, soak half of the sponge with 200mL mass-volume concentration of 0.05% (w / v) palmitic acid ethanol solution for 3 hours, dry to form a hydrophobic layer, and the other half of the sponge with 200mL mass-volume concentration of 30% (w / v) / v) soaked in glucosamine aqueous solution for 2 hours, freeze-dried to form a hydrophilic layer, and made a double-layer chitosan sponge dressing after sterilization.

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Abstract

The invention belongs to the field of application of biomedical materials and particularly relates to a preparation method of double-layer type water-proof, anti-bacterial and anti-cicatricial chitosan sponge dressing. The dressing is a sponge type and is of a double-layer structure, wherein the surface layer is a hydrophobic layer which is water-proof and capable of effectively preventing bacteria from invasion, a lining layer is a hydrophilic layer, has soft texture, is of a uniform three-dimensional porous structure and can rapidly absorb and remove exudate and secreta when contacted with awound and has effects of stopping bleeding and promoting healing, glucosamine is supported in the hydrophilic layer, growth of bacteria can be inhibited by positive charges, additional antibacterialdrugs are not needed, wound repair can be promoted, cicatrization can be inhibited, and therefore, the dressing can be applied to protection and wound repair of multiple types of skin wounds such as burns, trauma, diabetic foot, pressure sores and the like.

Description

technical field [0001] The invention belongs to the application field of biomedical materials, and in particular relates to a preparation method of a double-layer waterproof, antibacterial, anti-scar chitosan sponge dressing. Background technique [0002] The repair after skin injury includes several processes such as coagulation period, inflammation period, proliferation period, and remodeling period. First, after injury, blood vessels contract, release and activate platelets, and coagulate; then, neutrophils kill bacteria and macrophages Phagocytosis of necrotic tissue and cells, digestion and release of various chemical substances, increase blood flow at the wound, edema and pain; after that, new blood vessels are formed, collagen is deposited, granulation tissue is formed, and epithelial cells migrate to the wound to proliferate and differentiate; Finally, the new granulation tissue and epithelial cells are further transformed, collagen fibers are restructured, and the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J9/40
Inventor 陈荆晓徐政伍亚玲陈敬华
Owner JIANGNAN UNIV
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