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Structure dressing with compounding of oxidized graphene and nanofiber and preparation method

A graphene composite, nanofiber technology, applied in dressings, non-adhesive dressings, coatings, etc., can solve the problems of promoting tissue healing, unable to provide wound moisturizing and nutrient supply, etc., to promote healing, avoid secondary infection, Simple preparation method

Active Publication Date: 2019-02-22
合肥中科卫云科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patented dressing cannot provide wound moisture and nutrition to promote tissue healing, but only isolates the wound structurally, prevents infection in antibacterial aspects, and relies on the patient's own immune ability to heal itself

Method used

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  • Structure dressing with compounding of oxidized graphene and nanofiber and preparation method
  • Structure dressing with compounding of oxidized graphene and nanofiber and preparation method
  • Structure dressing with compounding of oxidized graphene and nanofiber and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of graphene oxide composite nanofiber structure dressing is as follows, as figure 1 Shown:

[0035] (1) Preparation of the supporting layer 100: Mix and stir the solution of nano-titanium dioxide, zeolite and PVA (the dosage ratio is 1:0.2:0.03) to form a slurry evenly, and apply it on the surface of non-woven fabric, fabric or mesh, and dry it before Spray a layer of 1% sodium alginate solution 50ml / m 2 , Dry at 50°C for 30 minutes to form a thin layer.

[0036] (2) Preparation of the middle layer 200: the surface of the thin layer prepared in step (1) is covered with the nanofibrous membrane PVA200. The weight of the fiber membrane is 2g / m 2 .

[0037] (3) Preparation of the inner layer 300: a slurry composed of graphene oxide, sodium alginate, zinc hyaluronate, vitamin B2, vitamin B12 and water is coated on the upper part of the middle layer. The mass composition of the slurry is as follows: 100 parts of water, 0.5 part of graphene oxide, ...

Embodiment 2

[0039] The preparation method of graphene oxide composite nanofiber structure dressing is as follows:

[0040] (1) Preparation of the support layer 100: Mix and stir the nano-titanium dioxide, zeolite and PVA (1:1:0.02) solution evenly to form a slurry, apply it on the surface of non-woven fabric, fabric or mesh, and spray a layer before drying 0.2% sodium alginate solution (25ml / m 2 ), dried at 45°C for 25 minutes to form a thin layer.

[0041] (2) Preparation of the middle layer 200: the surface of the thin layer is covered with a nanofibrous film of PVA. The weight of the fiber membrane is 2g / m 2 .

[0042] (3) Preparation of the inner layer 300: the upper part of the middle layer is coated with a slurry composed of graphene oxide, sodium alginate, zinc hyaluronate, vitamin B2, and vitamin B12. The composition of the slurry is as follows: 100 parts of water, oxidized 3 parts of graphene, 1.6 parts of sodium alginate, 2.6 parts of zinc hyaluronate, 0.10 parts of vitamin ...

Embodiment 3

[0044] The preparation method of graphene oxide composite nanofiber structure dressing is as follows:

[0045] (1) Preparation of the support layer 100: mix and stir the nano-titanium dioxide, zeolite and PVA (1:2.8:0.08) solution evenly to form a slurry, apply it on the surface of non-woven fabric, fabric or mesh, and spray a layer before drying 0.5% sodium alginate solution (80ml / m 2 ), dried at 70°C for 45min to form a thin layer.

[0046] (2) Preparation of the middle layer 200: the surface of the thin layer is covered with a nanofibrous film of PVA. The weight of the fiber membrane is 3.5g / m 2 .

[0047] (3) Preparation of the inner layer 300: the upper part of the middle layer is coated with a slurry composed of graphene oxide, sodium alginate, zinc hyaluronate, vitamin B2, vitamin B12, etc. The composition of the slurry is as follows: 100 parts of water, 7.3 parts of graphene oxide, 2.4 parts of sodium alginate, 3.7 parts of zinc hyaluronate, 0.17 parts of vitamin B...

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Abstract

The invention provides a structure dressing with compounding of oxidized graphene and nanofiber and a preparation method. The preparation method comprises the following steps: firstly mixing and stirring nano titanium dioxide, zeolite and PVA (Polyvinyl Alcohol) solution to be uniform so as to form slurry, and coating on the surface of a supporting layer; before drying, spraying a layer of 0.2-2%sodium alginate solution, and drying at a temperature of 40-75 DEG C to form a thin layer; then covering a layer of nanofiber on the surface of the thin layer, then coating slurry prepared from the oxidized graphene, the sodium alginate, zinc hyaluronate, vitamin B2 and vitamin B12, drying, and spraying a little amount of zinc salt solution to cure. The structure dressing provided by the inventionhas the beneficial effects that on the basis of the physical sterilization mechanism of the graphene and by combination with the breathable blocking action of a nanofiber film, the structure dressingis prepared by loading effective components; by adsorption and disinfection of all layers to tissue transudate, the aseptic condition of wounds is kept, and necessary nutritional substances are provided, so that secondary infection of the wounds is avoided, the heeling is enhanced and the preparation method is simple.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a graphene oxide composite nanofiber dressing and a preparation method thereof. Background technique [0002] After the skin is traumatized, the tissue is separated to form a wound. There are different degrees of tissue necrosis and blood vessel rupture and bleeding in the local wound, and an inflammatory reaction occurs within a few hours, manifested as hyperemia, serous exudation and leukocyte exudation, so the local area is red and swollen. Complications such as infection may occur. Wound repair is a process of tissue continuity and functional restoration. A wound dressing is a functional medical accessory that covers a wound surface to assist the body in promoting wound healing. It can temporarily isolate the wound from the external environment and avoid infection by the external environment. At the same time, loading specific substances in the dressing can promo...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/24A61L15/28A61L15/44A61F13/00
CPCA61L15/18A61L15/24A61L15/28A61L15/44A61F13/00063A61F13/00987A61L2300/606A61L2300/45A61L2300/428A61L2300/216A61F13/01029C08L29/04C08L5/04C08L5/08
Inventor 阚建国陈丹李军杨桂萍肖洁
Owner 合肥中科卫云科技有限公司
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