Decoquinate soluble powder and preparation method thereof

A decoquinate, the technology of decoquinate, applied in the field of soluble powder for livestock and poultry, can solve the problems of hindering the growth and development of chickens, the failure of prevention and control, and the disease of chickens, and achieve the solubility and dissolution rate. The process is simple and easy, and the anti-coccidial effect is enhanced

A decoquinate, the technology of decoquinate, applied in the field of soluble powder for livestock and poultry, can solve the problems of hindering the growth and development of chickens, the failure of prevention and control, and the disease of chickens, and achieve the solubility and dissolution rate. The process is simple and easy, and the anti-coccidial effect is enhanced

CN101606908AActive Publication Date: 2009-12-23广东华农高科生物药业有限公司
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  • Decoquinate soluble powder and preparation method thereof
  • Decoquinate soluble powder and preparation method thereof
  • Decoquinate soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Table 1

[0028] Element

100g (total)

decoquinate

1g

polyethylene glycol 4000

1g

Polyvinylpyrrolidone K30

1g

anhydrous glucose

97g

[0029] The raw material consumption of this embodiment is as shown in Table 1.

[0030] Preparation method and steps: take crushed decoquinate raw materials, polyethylene glycol 4000, polyvinylpyrrolidone K30, mix in a mixer for 30 minutes and then take out; heat the mixed sample in an oven at 125°C for 3 hours to a molten state; take out the melt, dry it at room temperature, and pulverize it; add anhydrous glucose and mix it in a mixer for 30 minutes; subpackage and seal according to the product's loading specification, and obtain 1% (weight) decyl oxide Quincatel soluble powder.

Embodiment 2

[0032] The raw material consumption of this embodiment is as shown in table 2.

[0033] Preparation method and steps: Take the pulverized decoquinate raw material, polyethylene glycol 4000, and polyvinylpyrrolidone K30, and mix them in a mixer for 30 minutes before taking them out; heat the mixed sample in an oven at 135°C for 3 hours to Molten state; take out the melt, dry it at room temperature, and pulverize it; add anhydrous glucose and mix it in a mixer for 30 minutes; subpackage and seal according to the product’s loading specification to get 3% decoquinate soluble pink.

[0034] Table 2

[0035] Element

Embodiment 3

[0037] table 3

[0038] Element

100g (total)

decoquinate

6g

polyethylene glycol 6000

12g

Poloxamer 188

12g

anhydrous glucose

70g

[0039] The raw material consumption of present embodiment is as shown in table 3.

[0040] Preparation method and steps: take the pulverized decoquinate raw material, polyethylene glycol 6000, and poloxamer 188, mix in a mixer for 30 minutes and then take it out; heat the mixed sample in an oven at 130°C for 3 hours to a molten state; take out the melt, dry it at room temperature, and pulverize it; add anhydrous glucose and mix it in a mixer for 30 minutes; subpackage and seal according to the product's loading specification, and obtain 6% decoquinate Soluble powder.

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Abstract

The invention provides ecoquinate soluble powder and a preparation method thereof. The preparation method comprises the steps: evenly mixing ecoquinate and a solid dispersion carrier together; heating the mixture to a fusing state at the temperature of 120DEG C to 150 DEG C; then, airing and crashing the mixture at room temperature; adding anhydrous dextrose to obtain the ecoquinate soluble powder. The decoquinate soluble powder comprises 1 percent to 20 percent of ecoquinate, 4 percent to 80 percent of solid dispersion carrier and anhydrous dextrose. The prepared soluble powder has good solubility and high stability, the property and the solubility of the soluble powder are not changed after being stored for 6 mouths under an accelerating test condition (40DEG C+ / -2DEG C) or being stored for 1 year at room temperature (25DEG C+ / -2DEG C ), the content of the ecoquinate soluble powder is reduced and meets the requirements of galenic pharmacy, the effective period of the ecoquinate soluble powder can be as long as 3 years by calculation, the content reduction is not obvious under an illumination experiment condition, and the content of drug active ingredients can be maintained above 90 percent for four hours in water. A prepared drug preparation has good effect and convenient use and has good popularization and application value.

Description

technical field [0001] The invention relates to a soluble powder process for livestock and poultry, in particular to a soluble powder of anticoccidial drug preparation decoquinate and a preparation method thereof. Background technique [0002] Chicken coccidiosis is mainly caused by intestinal parasites of the genus Eimeria. Chicken coccidiosis has the following characteristics: one is ubiquitous and occurs widely. Coccidiosis occurs in almost all places where chickens are raised, especially in today's development of large-scale and intensive poultry farming, the impact of coccidiosis on poultry has been quite prominent. If coccidiosis cannot be effectively controlled, the incidence rate of chickens can reach 50% to 70%, the mortality rate can reach 20% to 30%, and when it is severe, it can reach 80%, and it is easy to induce other diseases. Coccidiosis has become a global disease hindering the development of intensive chicken production. The second is that it is very har...

Claims

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Application Information

Patent Timeline
23 Dec 2009
Publication
CN101606908A
IPC
A61K9/14; A61K31/47; A61K47/34; A61K47/32; A61P33/02; A61K47/10
Inventors
武力; 陈宝妮